Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptors

Biochemical and Biophysical Research Communications

Volumn 369, Issue 4, 2008, Pages 1007-1011

  Liu, Yu Wei ^a   Li, Chao Ying ^a   Luo, Jia Lie ^b   Li, Wen Ming ^b   Fu, Hong Jun ^b   Lao, Yuan Zhi ^b   Liu, Li Jiang ^a   Pang, Yuan Ping ^c   Chang, Donald C ^b   Li, Zhi Wang ^a   Peoples, Robert W ^d   Ai, Yong Xun ^a   Han, Yi Fan ^b,e  

^a JIANGHAN UNIVERSITY   (China)

^b HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^c MAYO CLINIC CANCER CENTER   (United States)

^d MARQUETTE UNIVERSITY   (United States)

^e HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

Author keywords

Acetylcholinesterase inhibitor; Bis(7) tacrine; Excitotoxicity; Glutamate receptor; Memantine; NMDA receptor

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; BIS(7) TACRINE; CALCIUM; GLUTAMIC ACID; KAINIC ACID; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; TACRINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; EMBRYO; HIPPOCAMPUS; IC 50; MEMBRANE CURRENT; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; CALCIUM; CELLS, CULTURED; CEREBRAL CORTEX; CYTOPROTECTION; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; KAINIC ACID; MEMANTINE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; TACRINE;

RATTUS;

EID: 41149153754     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.02.133     Document Type: Article

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