First gallamine-tacrine hybrid: Design and characterization at cholinesterases and the M2 muscarinic receptor

Journal of Medicinal Chemistry

Volumn 50, Issue 23, 2007, Pages 5685-5695

  Elsinghorst, Paul W ^a   Cieslik, Julia S ^a   Mohr, Klaus ^a   Tränkle, Christian ^a   Gütschow, Michael ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIUM DERIVATIVE; BINDING PROTEIN; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DIMER; GALLAMINE; GALLAMINE TRIETHIODIDE; MUSCARINIC M2 RECEPTOR; N,N,N TRIETHYL 2 [5 [[[6 [2 (1,2,3,4 TETRAHYDROACRIN 9 YL)HYDRAZINO] 6 OXOHEXYL]AMINO]CARBONYL] 2,3 BIS[(2 TRIETHYLAMMONIO)ETHOXY]PHENOXY]ETHANAMMONIUM TRIBROMIDE; TACRINE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; IC 50; NONHUMAN; STRUCTURE ANALYSIS;

ACETYLCHOLINESTERASE; ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; DRUG DESIGN; GALLAMINE TRIETHIODIDE; HUMANS; LIGANDS; MODELS, MOLECULAR; MYOCARDIUM; RADIOLIGAND ASSAY; RECEPTOR, MUSCARINIC M2; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; TACRINE;

EID: 36148930959     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070859s     Document Type: Article

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