Homodimeric tacrine congeners as acetylcholinesterase inhibitors

Journal of Medicinal Chemistry

Volumn 45, Issue 11, 2002, Pages 2277-2282

  Hu, Ming Kuan ^a   Wu, Li Ju ^a   Hsiao, George ^b   Yen, Mao Hsiung ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; HEPTYLENE BIS(6 CHLORO)TACRINE; HEPTYLENE BISTACRINE; PYRIDINE DERIVATIVE; TACRINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DETERMINATION; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; NONHUMAN; RAT; STRUCTURE ANALYSIS;

ACETYLCHOLINESTERASE; ANIMALS; BRAIN; BUTYRYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; DIMERIZATION; HUMANS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE;

EID: 0037161599     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010308g     Document Type: Article

References (25)

1. Piecing together Alzheimer's
2. Biological markers and the cholinergic hypothesis in Alzheimer's disease
3. A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease
4. Tacrine: First drug approved for Alzheimer's Disease
5. Hepatotoxic effects of tacrine administration inpatients with Alzheimer's disease
6. Heterogenecity of adverse hepatic reactions to tetrahydroaminoacridine
7. New acetylcholinesterase inhibitors
8. Cholinergic therapies in Alzheimer's disease
9. Effectiveness and safety of velnacrine for the treatment of Alzheimer's disease. A double-blind, placebo-controlled study
10. 9-Amino-1,2,3,4-tetrahydroacridin-1-ols: Synthesis and evaluation as potential Alzheimer's disease therapeutics
11. The synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity of tacrine (Cognex) derivatives
12. SAR of 9-amino-1,2,3,4-tetrahydroacridine-Based acetylcholinesterase inhibitors: Synthesi, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues
13. Binding of tacrine and 6-chlorotacrine by acetylcholinesterase
14. Prediction of the binding site of huperzine a in acetylcholinesterase by docking studies
15. Prediction of the binding site of 1-benzyl-4-[4[(5,6-di-methoxy-1-indanon-2-y1)methyl]piperidine in acetylcholinesterase by docking studies with the SYDOC program
16. Highly potent, selective, and low cost bis-tetrahydroaminoacrine inhibitors of acetylcholinesterase
17. Effects of Bis(7)-tacrine, a novel Anti-Alzheimer's agent, on rat brain ACHE
18. Protection against ischemic injury in primary cultured astrocytes of mouse cerebral cortex by Bis(7)-tacrine, a novel Anti-Alzheimer's agent
19. Heterodimeric tacrine-based acetycholinesterase inhibitors: Investigating ligand-peripheral site interaction
20. Synthesis of alkylene linked Bis-THA and alkylene linked Benzyl-THA as highly potent and selective inhibitors and molecular probes of acetylcholinesterase
21. Evaluation of short-tether bis-THA AChE Inhibitors. A further test of the dual binding site hypothesis
22. The acridine series II. Dialkylaminoalkylamines derived from 9-chloro-1,2,3,4-tetrahydroacridine
23. A facile synthesis of bis-tacrine isosteres
24. Featherstone rapid colorimetric determination of acetylcholinesterase activity
25. Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase