Quantitative proteomic analysis of mitochondria in aging PS-1 transgenic mice

Cellular and Molecular Neurobiology

Volumn 29, Issue 5, 2009, Pages 649-664

  Fu, You Jun ^a   Xiong, Shuling ^b   Lovell, Mark A ^a,b   Lynn, Bert C ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Alzheimer's disease; LC MS MS; Mitochondria; Presenilin mutation; Proteomics

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ISOTOPE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MITOCHONDRIAL PROTEIN; POTASSIUM; PRESENILIN 1; SODIUM;

AFFINITY LABELING; AGING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM HOMEOSTASIS; COGNITIVE DEFECT; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME REPRESSION; GENE EXPRESSION; GENE IDENTIFICATION; GENE MUTATION; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MEMORY DISORDER; MITOCHONDRION; MOUSE; NERVE DEGENERATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEOMICS; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; TRANSGENIC MOUSE; WESTERN BLOTTING;

AGING; ANIMALS; BLOTTING, WESTERN; MICE; MICE, TRANSGENIC; MITOCHONDRIA; PEPTIDES; PRESENILIN-1; PROTEOMICS; REPRODUCIBILITY OF RESULTS; SEQUENCE ANALYSIS, PROTEIN; TANDEM MASS SPECTROMETRY;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 67650891888     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10571-009-9359-5     Document Type: Article

References (81)

1. M Aksenov M Aksenova DA Butterfield 2000 Oxidative modification of creatine kinase BB in Alzheimer's disease brain J Neurochem 74 6 2520 2527 10.1046/j.1471-4159.2000.0742520.x
2. KH Ashe 2001 Learning and memory in transgenic modeling Alzheimer's disease Learn Mem 8 301 308 10.1101/lm.43701
3. SM Bailey A Landar V Darley-Usmar 2005 Mitochondrial proteomics in free radical research Free Radic Biol Med 38 175 188 10.1016/j.freeradbiomed.2004.10. 011
4. Begley JG, Duan W, Chan S et al (1999) Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice. J Neurochem 1030-1039. doi: 10.1046/j.1471-4159.1999.0721030.x
5. H Beinert MC Kennedy CD Stout 1996 Aconitase as iron-sulfur protein, enzyme, and iron-regulatory protein Chem Rev 96 7 2335 10.1021/cr950040z
6. H Beinert RH Holm E Munck 1997 Iron-sulfur clusters: nature's modular, multipurpose structures Science 277 5326 653 659 10.1126/science.277.5326.653
7. DA Berkich MS Ola J Cole 2007 Mitochondrial transport proteins of the brain J Neurosci Res 85 3367 3377 10.1002/jnr.21500
8. L Bojarski J Herms J Kuznicki 2008 Calcium dysregulation in Alzheimer's disease Neurochem Int 52 4-5 621 633 10.1016/j.neuint.2007.10.002
9. A Boldyrev E Bulygina 1997 Na/K-ATPase and oxidative stress Ann N Y Acad Sci 834 666 668 10.1111/j.1749-6632.1997.tb52345.x
10. B Brouwers K Sleegers C Van Broeckhoven 2008 Molecular genetics of Alzheimer's disease: an update Ann Med 40 8 562 583 10.1080/07853890802186905
11. P Bubber V Haroutunian G Fisch 2005 Mitochondrial abnormalities in Alzheimer brain: mechanistic implications Ann Neurol 57 695 703 10.1002/ana.20474
12. E Cadenas KJA Davies 2000 Mitochondrial free radical generation, oxidative stress, and aging Free Radic Biol Med 29 3-4 222 230 10.1016/S0891-5849(00)00317-8
13. SM Cardoso MT Proença S Santos 2004 Cytochrome c oxidase is decreased in AD platelets Neurobiol Aging 25 105 110 10.1016/S0197-4580(03) 00033-2
14. CM Chen JK Lin SH Liu SY Lin-Shiau 2008 Novel Regimen through combination of memantine and tea polyphenol for neuroprotection against brain excitotoxicity J Neurosci Res 86 2696 2704 10.1002/jnr.21706
15. 2+ activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin J Biol Chem 282 10 7098 7106 10.1074/jbc.M610491200
16. S Cortassa MA Aon E Marban RL Winslow B O'Rourke 2003 An integrated model of cardiac mitochondrial energy metabolism and calcium dynamics Biophys J 84 2734 2755 10.1016/S0006-3495(03)75079-6 (Pubitemid 36373594)
17. S Da Cruz PA Parone J-C Martinou 2005 Building the mitochondrial proteome Expert Rev Proteomics 2 4 541 551 10.1586/14789450.2.4.541
18. NA Dencher M Frenzel NH Reifscheider 2007 Proteome alterations in rat mitochondria caused by aging Ann N Y Acad Sci 1100 291 298 10.1196/annals.1395. 030
19. K Duff C Eckman C Zehr 1996 Increased Amyloid-beta42(43) in brains of mice expressing mutant presenilin 1 Nature 383 710 713 10.1038/383710a0
20. H Fu RR Subramanian SC Masters 2000 14-3-3 proteins: structure, function, and regulation Annu Rev Pharmacol Toxicol 40 617 647 10.1146/annurev.pharmtox. 40.1.617
21. 2+ as a key regulator of cell life and death Cell Death Differ 14 1267 1274 10.1038/sj.cdd.4402147
22. DR Green JC Reed 1998 Mitochondria and apoptosis Science 281 1309 10.1126/science.281.5381.1309
23. Q Guo BL Sopher K Furukawa 1997 Alzheimer's presenilin mutation sensitizes neral cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals J Neurosci 17 11 4212 4222 (Pubitemid 27220612)
24. Q Guo W Fu BL Sopher MW Miller CB Ware GM Martin MP Mattson 1999 Increased vulnerability of hippocampal neurons to excitoxic necrosis in presenilin-1 mutant knock-in mice Nat Med 5 1 101 106 10.1038/4789
25. SP Gygi B Rist TJ Griffin J Eng R Aebersold 2002 Proteome analysis of low-abundance proteins using multidimensional chromatography and isotope-coded affinity targets J Proteome Res 1 47 54 10.1021/pr015509n
26. DK Han J Eng H Zhou 2001 Quantitative profiling of differentiation- induced microsomal proteins using isotope-coded affinity tags and mass spectrometry Nat Biotechnol 19 946 951 10.1038/nbt1001-946
27. KC Hansen G Schmitt-Ulms RJ Chalkley 2003 Mass spectrometric analysis of protein mixtures at low levels using cleavable 13C-isotope-coded affinity tag and multidimensional chromatography Mol Cell Proteomics 2 299 314
28. M Hashiguchi K Sobue HK Paudel 2000 14-3-3ζ is an effector of Tau protein phosphorylation J Biol Chem 275 33 25247 25254 10.1074/jbc.M003738200
29. +-ATPase activities in Alzheimer's disease brains Neurosci Lett 254 141 144 10.1016/S0304-3940(98)00654-5
30. LA Huber K Pfaller I Vietor 2003 Organelle proteomics: implications for subcellular fractionation in proteomics Circ Res 92 962 968 10.1161/01.RES. 0000071748.48338.25
31. E Karelson S Fernaeus K Reis 2005 Stimulation of G-proteins in human control and Alzheimer's disease brain by FAD mutants of APP714-723: implication of oxidative mechanisms J Neurosci Res 79 368 374 10.1002/jnr.20371
32. A Keller AI Nesvizhskii E Kolker R Aebersold 2002 Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search Anal Chem 74 5383 5392 10.1021/ac025747h
33. Y Kinnoshita T Uo S Jayadev 2006 Potential applications and limitations of Proteomics in the study of neurological disease Arch Neurol 63 1692 1696 10.1001/archneur.63.12.1692
34. R Layfield J Fergusson A Aitken 1996 Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins Neurosci Lett 209 1 57 60 10.1016/0304-3940(96)12598-2
35. S Leutner C Czech K Schindowski 2000 Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations Neurosci Lett 292 87 90 10.1016/S0304-3940(00)01449-X
36. X Li T Burklen X Yuan 2006 Stabilization of ubiquitous mitochondrial creatine kinase preprotein by APP family proteins Mol Cell Neurosci 31 263 272 10.1016/j.mcn.2005.09.015
37. MA Lovell S Xiong WR Maresbery 2005 Quantitative proteomic analysis of mitochondria from primary neuron cultures treated with amyloid beta peptide Neurochem Res 30 1 113 122 10.1007/s11064-004-9692-5
38. MJ MacCoss CC Wu H Liu 2003 A correlation algorithm for the automated analysis of quantitative proteomics data Anal Chem 75 6912 6921 10.1021/ac034790h
39. MP Mattson 1998 Modification of ion homeostasis by lipid peroxidation: roles in neuronal degeneration and adaptive plasticity Trends Neurosci 20 53 57 10.1016/S0166-2236(97)01188-0
40. MP Mattson 2007 Calcium and neurodegeneration Aging Cell 6 337 350 10.1111/j.1474-9726.2007.00275.x
41. JG McCormack AP Halestrap RM Denton 1990 Role of calcium ions in regulation of mammalian intramitochondrial metabolism Physiol Rev 70 391 425 (Pubitemid 20140186)
42. VK Mootha J Bunkenborg JV Olsen 2003 Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria Cell 115 629 640 10.1016/S0092-8674(03)00926-7
43. PI Moreira MS Santos CR Oliveira 2007 Alzheimer's Disease: a lesson from mitochondrial dysfunction Antioxid Redox Signal 9 10 1621 1630 10.1089/ars.2007.1703
44. AE Moseley MT Williams TL Schaefer 2007 Deficiency in Na, K-ATPase isoform genes alters spatial learning, motor activity, and anxiety in mice J Neurosci 27 3 616 626 10.1523/JNEUROSCI.4464-06.2007
45. 2+ leak function of presenilin 1 J Clin Invest 117 5 1230 1239 10.1172/JCI30447
46. AI Nesvizhskii A Keller E Kolker 2003 A statistical model for identifying proteins by tandem mass spectrometry Anal Chem 75 4646 4658 10.1021/ac0341261
47. M Newman FI Musgrave M Lardelli 2007 Alzheimer's disease: amyloidogenesis, the presenilins and animal models Biochim Biophys Acta 1772 285 297 (Pubitemid 46275437)
48. DG Nicholls SL Budd 2000 Mitochondria and neuronal survival Physiol Rev 80 1 315 360 (Pubitemid 30060567)
49. J Ojaimi CL Masters C McLean 1999 Irregular distribution of cytochrome c oxidase protein subunits in aging and AD Ann Neurol 46 656 660 10.1002/1531-8249(199910)46:4<656::AID-ANA16>3.0.CO;2-Q
50. 2+-stimulated aspartate/glutamate transporters in Mitochondria EMBO J 20 18 5060 5069 10.1093/emboj/20.18.5060
51. A Papassotiropoulos M Fountoulakis T Dunckley 2006 Genetics, transcriptomics, and proteomics of Alzheimer's disease J Clin Psychol 67 652 670 (Pubitemid 43764244)
52. B Pardo L Contreras A Serrano 2006 Essential role of aralar in the transduction of small signals to neuronal mitochondria J Biol Chem 281 2 1039 1047 10.1074/jbc.M507270200
53. MS Parihar GJ Brewer 2007 Mitoenergetic failure in Alzheimer disease Am J Physiol Cell Physiol 292 C8 C23 10.1152/ajpcell.00232.2006
54. N Petrushanko E Bogdanov B Bulygina 2006 Na-K-ATPase in rat cerebellar granule cells is redox sensitive Am J Physiol Regul Integr Comp Physiol 290 R916 R925 10.1152/ajpregu.00038.2005
55. S Raha BH Robinson 2000 Mitochondria, oxygen free radicals, disease and ageing Trends Biochem Sci 25 502 508 10.1016/S0968-0004(00)01674-1
56. PH Reddy S McWeeney BS Park 2004 Gene expression profiles of transcripts in APP transgenic mice Hum Mol Genet 13 1225 10.1093/hmg/ddh140
57. J Reinders RP Zahedi N Pfanner 2006 Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics J Proteome Res 5 1543 1554 10.1021/pr050477f
58. JE Rinholm G Slettalokken P Marcaggi 2007 Subcellular localization of the glutamate transporters GLAST and GLT at the neuromuscular junction in rodents Neuroscience 145 579 591 10.1016/j.neuroscience.2006.12.041
59. AM Rose R Valdes Jr 1994 Understanding the sodium pump and Its relevance to disease Clin Chem 40 9 1674 1685 (Pubitemid 24273087)
60. BP Rutten NM Van der Kolk S Schafer 2005 Age-related loss of synaptophysin immunoreactive presynaptic boutons within the hippocampus of APP751SL, PS-1M146L, and APP751SL/PS-1M146L transgenic mice Am J Pathol 167 161 173
61. U Schlattner M Dolder T Wallimann 2001 Mitochondrial Creatine Kinase and Mitochondrial Outer Membrane Porin Show a Direct Interaction That Is Modulated by Calcium J Biol Chem 276 51 48027 48030
62. Schneider I, Reverse D, Dewachter I, et al (2001) J Biol Chem 276(15):11539-11544. doi: 10.1074/jbc.M010977200
63. SJ Schonberger PF Edgar R Kydd 2001 Proteomic analysis of the brain in the Alzheimer's disease: molecular phenotype of a complex disease process Proteomics 1 1519 1528 10.1002/1615-9861(200111)1:12<1519::AID-PROT1519>3. 0.CO;2-L
64. K Schuessel C Frey C Jourdan 2006 Aging sensitizes toward ROS formation and lipid peroxidation in PS-1M146L transgenic mice Free Radic Biol Med 20 850 862 10.1016/j.freeradbiomed.2005.10.041
65. DJ Selkoe 2002 Alzheimer's disease is a synaptic failure Science 298 789 791 10.1126/science.1074069
66. DJ Selkoe MS Wolfe 2007 Presenilin: running with scissors in the membrane Cell 131 215 221 10.1016/j.cell.2007.10.012
67. o by Alzheimer's disease gene presenilin-1 J Biol Chem 273 26 16281 16288 10.1074/jbc.273.26.16281
68. D Spasic A Tolia K Dillen 2006 Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway J Biol Chem 281 36 26569 26577 10.1074/jbc.M600592200
69. AA Starkov G Fiskum C Chinopoulos 2004 Mitochondrial α- ketoglutarate dehydrogenase complex generates reactive oxygen species J Neurosci 24 36 7779 7788 10.1523/JNEUROSCI.1899-04.2004
70. X Sun V Beglopoulos MP Mattson J Shen 2005 Hippocampal spatial memory impairments caused by the familial Alzheimer's disease-linked presenilin 1M146V mutation Neurodegener Dis 2 6 15 10.1159/000086426
71. Z Suo M Wu BA Citron 2004 Abnormality of G-protein-coupled receptor kinases at prodromal and early stages of Alzheimer's disease: an association with early β-amyloid accumulation J Neurosci 24 13 3444 3452 10.1523/JNEUROSCI.4856-03.2004
72. RH Swerdlow SM Khan 2004 A "mitochondrial cascade hypothesis" for sporadic Alzheimer's disease Med Hypotheses 63 8 20M 10.1016/j.mehy.2003.12. 045
73. G Tian L Lai H Guo 2007 Translational control of glial glutamate transporter EAAT2 expression J Biol Chem 282 3 1727 1737 10.1074/jbc.M609822200
74. 2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations Cell 126 981 993 10.1016/j.cell.2006.06.059
75. R Vlkolinsky N Nigel Cairns M Michael Fountoulakis 2001 Decreased brain levels of 2',3'-cyclic nucleotide-3'-phosphodiesterase in Down syndrome and Alzheimer's disease Neurobiol Aging 22 547 553 10.1016/S0197-4580(01)00218-4
76. TD Vo BO Palsson 2007 Building the power house: recent advances in mitochondrial studies through proteomics and systems biology Am J Physiol Cell Physiol 292 C164 C177 10.1152/ajpcell.00193.2006
77. J Wang S Xiong C Xie WR Markesbery MA Lovell 2005 Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease J Neurochem 93 953 962 10.1111/j.1471-4159.2005.03053.x
78. M Ward 2007 Biomarkers for Alzheimer's disease Expert Rev Mol Diagn 7 5 635 646 10.1586/14737159.7.5.635
79. Z Xie A Askari 2002 Na/K-ATPase as a signal transducer Eur J Biochem 269 2434 2439 10.1046/j.1432-1033.2002.02910.x
80. L-R Yu TP Conrads T Uo 2004 Global analysis of cortical neuron proteome Mol Cell Proteomics 3 396 907 10.1074/mcp.M400034-MCP200
81. C Zoia T Cogliati E Tagliabue 2004 Glutamate transporters in platelets: EAAT1 decrease in aging and in Alzheimer's disease Neurobiol Aging 25 2 149 157 10.1016/S0197-4580(03)00085-X