Stimulation of G-proteins in human control and Alzheimer's disease brain by FAD mutants of APP714-723: Implication of oxidative mechanisms

Journal of Neuroscience Research

Volumn 79, Issue 3, 2005, Pages 368-374

  Karelson, Ello ^a,b   Fernaeus, Sandra ^a   Reis, Katarina ^a   Bogdanovic, Nenad ^c   Land, Tiit ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b UNIVERSITY OF TARTU   (Estonia)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Antioxidants; Go proteins; Human brain; Mutated APP

Indexed keywords

AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN[714-723]; ANTIOXIDANT; DEFEROXAMINE; FLAVINE ADENINE NUCLEOTIDE; GLUTATHIONE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; BRAIN MEMBRANE; CELL FUNCTION; CONTROL SYSTEM; CONTROLLED STUDY; ENZYME SUBSTRATE; HUMAN; HUMAN TISSUE; LIPID PEROXIDATION; MULTIGENE FAMILY; OXIDATIVE STRESS; PRIORITY JOURNAL; RECEPTOR BINDING; SENSORY STIMULATION; STIMULUS RESPONSE; TEMPORAL CORTEX;

AGED; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANTIOXIDANTS; CELL MEMBRANE; CEREBRAL CORTEX; DEFEROXAMINE; ESTRADIOL; FEMALE; GLUTATHIONE; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; HYDROGEN PEROXIDE; LIPID PEROXIDATION; MALE; MUTATION; NERVE DEGENERATION; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; PROTEIN BINDING;

EID: 14044249497     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.20371     Document Type: Article

References (24)

1. Bogdanovic N, Corder E, Lannfelt L, Winblad B. 2002. APOE polymorphism and clinical duration determine regional neuropathology in Swedish APP 670/671 mutation carriers: implication for the late onset Alzheimer's disease. J Cell Mol Med 6:199-214.
2. Bogdanovic N, Morris JC. 1995. Diagnostic criteria for Alzheimer's disease in multicentre brain banking. In: Cruz-Sanchez FF, Ravid R, Cuziner ML, editors. Neuropathological diagnostic criteria for brain banking. Biomedical and health research series. Amsterdam: IOS Press. p 20-29.
3. Bogdanovic N, Zilmer M, Zilmer K, Rehema A, Karelson E. 2001. The Swedish APP670/671 Alzheimer's disease mutation: the first evidence for strikingly increased oxidative injury in the temporal inferior cortex. Dement Geriatr Cogn Disord 12:364-370.
4. Braak H, Braak E, Bohl J, Bratzke H. 1998. Evolution of Alzheimer's disease related cortical lesions. J Neural Transm Suppl 54:97-106.
5. Butterfield DA, Lauderback CM. 2002. Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress. Free Radic Biol Med 32:1050-1060.
6. Corder EH, Woodburry MA, Volkman I, Madsen DK, Bogdanovic N, Winblad B. 2000. Density profiles of Alzheimer disease regional brain pathology for the Huddinge brain bank: pattern recognition emulates and expands upon Braak staging. Exp Gerontol 35:851-864.
7. Hardy J. 1997. Amyloid, the presenilins and Alzheimer's disease. Trends Neurochem Sci 20:154-159.
8. Jonghe CD, Esselens C, Kumar-Singh S, Craessaerts K, Serneels S, Checler F, Annaert W, Van Broeckhoven CV, De Strooper B. 2001. Pathogenetic APP mutations near the γ-secretase cleavage site differently affect Aβ secretion and APP C-terminal fragment stability. Hum Mol Genet 10:1665-1671.
9. Kanski J, Varadarajan S, Aksenova M, Butterfield DA. 2001. Role of glycine-33 and methionine-35 in Alzheimer's amyloid β-peptide 1-42 associated oxidative stress and neurotoxicity. Biochim Biophys Acta 1586:190-198.
10. Karelson E, Bogdanovic N, Garlind A, Winblad B, Zilmer K, Kullisaar T, Vihalemm T, Kairane C, Zilmer M. 2001. The cerebrocortical areas in normal brain aging and in Alzheimer's disease: noticeable differences in the lipid peroxidation level and in antioxidant defense. Neurochem Res 26:353-361.
11. Karelson E, Laasik J, Sillard R. 1995. Regulation of adenylate cyclase by galanin, neuropeptide Y, secretin and vasoactive intestinal polypeptide in rat frontal cortex, hippocampus and hypothalamus. Neuropeptides 28:21-28.
12. Karelson E, Mahlapuu R, Zilmer M, Soomets U, Bogdanovic N, Langel Ü. 2002. Possible signaling by glutathione and its novel analogue through potent stimulation of frontocortical G-proteins in normal aging and in Alzheimer's disease. Ann N Y Acad Sci 973:537-540.
13. Mahlapuu R, Viht K, Balaspiri L, Bogdanovic N, Saar K, Soomets U, Land T, Zilmer M, Karelson E, Langel Ü. 2003. Amyloid precursor protein carboxy-terminal fragments modulate G-proteins and adenylate cyclase activity in Alzheimer's disease brain. Brain Res Mol Brain Res 117:73-82.
14. Marin R, Guerra B, Morales A, Diaz M, Alonso R. 2003. An oestrogen membrane receptor participates in estradiol actions for the prevention of amyloid-beta peptide 1-40-induced toxicity in septal-derived cholinergic SN56 cells. J Neurochem 85:1180-1189.
15. Mark RJ, Blanc EM, Mattson MP. 1996. Amyloid beta-peptide and oxidative cellular injury in Alzheimer's disease. Mol Neurobiol 12:211-224.
16. o are target proteins of reactive oxygen species. Nature 408:492-495.
17. o by reactive oxygen species. J Biol Chem 277:9036-9042.
18. Nishimoto I. 1998. A new paradigm for neurotoxicity by FAD mutants of βAPP: a signaling abnormality. Neurobiol Aging 19(Suppl):33-38.
19. o. Nature 362:75-79.
20. Selkoe DJ. 1999. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 399:23-31.
21. Soomets U, Mahlapuu R, Tehranian R, Järvet J, Karelson E, Zilmer M, Iverfeldt K, Zorko M, Gräslund A, Langel Ü. 1999. Regulation of GTPase and adenylate cyclase activity by amyloid β-peptide and its fragments in rat brain tissue. Brain Res 850:179-188.
22. Yan SD, Chen X, Fu J, Zhu H, Roher A, Slattery T, Zhao L, Nagashima M, Morser J, Migheli A, Nawroth P, Stern D, Schmidt AM. 1996. RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease. Nature 382:685-691.
23. Yan SD, Roher A, Schmidt AM, Stern DM. 1999. Cellular cofactors for amyloid-β peptide-induced cell stress. Am J Pathol 155:1403-1411.
24. Yan SD, Roher A, Chaney M, Zlokovic B, Schmidt AM, Stern DM. 2000. Cellular cofactors potentiating induction of stress and cytotoxicity by amyloid-β peptide. Biochim Biophys Acta 1502:145-157.