Structures of cytochrome P450 3A4

Trends in Biochemical Sciences

Volumn 30, Issue 1, 2005, Pages 5-7

  Scott, Emily E ^a   Halpert, James R ^b  

^a UNIVERSITY OF KANSAS   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA NAPHTHOFLAVONE; BROMOCRIPTINE; CYCLOSPORIN; CYTOCHROME P450 3A4; ERYTHROMYCIN; METYRAPONE; PROGESTERONE; TESTOSTERONE;

DRUG METABOLISM; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; HETEROTROPHY; HUMAN; METABOLISM; NONHUMAN; PREDICTION; PRIORITY JOURNAL; SHORT SURVEY; TOPOGRAPHY;

ANIMALS; BINDING SITES; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; LIGANDS; MODELS, MOLECULAR; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 11844269181     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibs.2004.11.004     Document Type: Short Survey

References (21)

1. T. Shimada Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians J. Pharmacol. Exp. Ther. 270 1994 414 423
2. Q.Y. Zhang Characterization of human small intestinal cytochromes P-450 Drug Metab. Dispos. 27 1999 804 809
3. F.P. Guengerich Human cytochrome P450 enzymes P.R., Ortiz de Montellano Cytochrome P450 2nd edn 1995 Plenum Press 473 535
4. P.A. Williams Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone Science 305 2004 683 686
5. J.K. Yano The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05 Å resolution J. Biol. Chem. 279 2004 38091 38094
6. P.A. Williams Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity Mol. Cell 5 2000 121 131
7. J. Cosme, and E.F. Johnson Engineering microsomal cytochrome P450 2C5 to be a soluble, monomeric enzyme. Mutations that alter aggregation, phospholipid dependence of catalysis, and membrane binding J. Biol. Chem. 275 2000 2545 2553
8. E.E. Scott An open conformation of mammalian cytochrome P450 2B4 at 1.6 Å resolution Proc. Natl. Acad. Sci. U. S. A. 100 2003 13196 13201
9. P.A. Williams Crystal structure of human cytochrome P450 2C9 with bound warfarin Nature 424 2003 464 468
10. G.A. Schoch Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site J. Biol. Chem. 279 2004 9497 9503
11. M.R. Wester Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 Å resolution: evidence for an induced fit model of substrate binding Biochemistry 42 2003 9335 9345
12. S. Rendic Summary of information on human CYP enzymes: human P450 metabolism data Drug Metab. Rev. 34 2002 83 448
13. G.E. Schwab Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by α-naphthoflavone Mol. Pharmacol. 33 1988 493 499
14. Y.F. Ueng Cooperativity in oxidations catalyzed by cytochrome P450 3A4 Biochemistry 36 1997 370 381
15. B.J. Baas Homotropic cooperativity of monomeric cytochrome P450 3A4 in a nanoscale native bilayer environment Arch. Biochem. Biophys. 430 2004 218 228
16. M. Shou Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site Biochemistry 33 1994 6450 6455
17. K.E. Kenworthy Multisite kinetic models for CYP3A4: simultaneous activation and inhibition of diazepam and testosterone metabolism Drug Metab. Dispos. 29 2001 1644 1651
18. Y.A. He Analysis of homotropic and heterotropic cooperativity of diazepam oxidation by CYP3A4 using site-directed mutagenesis and kinetic modeling Arch. Biochem. Biophys. 409 2003 92 101
19. N.A. Hosea Elucidation of distinct ligand binding sites for cytochrome P450 3A4 Biochemistry 39 2000 5929 5939
20. M.R. Wester Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 Å resolution: evidence for multiple substrate binding modes Biochemistry 42 2003 6370 6379
21. G.R. Harlow, and J.R. Halpert Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics Proc. Natl. Acad. Sci. U. S. A. 95 1998 6636 6641