-
1
-
-
0030941803
-
The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
-
Brown MS, Goldstein JL 1997 The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89:331-340
-
(1997)
Cell
, vol.89
, pp. 331-340
-
-
Brown, M.S.1
Goldstein, J.L.2
-
2
-
-
0033613147
-
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
-
Brown MS, Goldstein JL 1999 A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. Proc Natl Acad Sci USA 96:11041-11048
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 11041-11048
-
-
Brown, M.S.1
Goldstein, J.L.2
-
3
-
-
0034681260
-
Regulated intramembrane proteolysis: A control mechanism conserved from bacteria to humans
-
Brown MS, Ye J, Rawson RB, Goldstein JL 2000 Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell 100:391-398
-
(2000)
Cell
, vol.100
, pp. 391-398
-
-
Brown, M.S.1
Ye, J.2
Rawson, R.B.3
Goldstein, J.L.4
-
4
-
-
0027190308
-
Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence
-
Briggs MR, Yokoyama C, Wang X, Brown MS, Goldstein JL 1993 Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence. J Biol Chem 268:14490-14496
-
(1993)
J Biol Chem
, vol.268
, pp. 14490-14496
-
-
Briggs, M.R.1
Yokoyama, C.2
Wang, X.3
Brown, M.S.4
Goldstein, J.L.5
-
5
-
-
0028963743
-
Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain
-
Kim JB, Spotts GD, Halvorsen YD, Shih HM, Ellenberger T, Towle HC, Spiegelman BM 1995 Dual DNA binding specificity of ADD1/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain. Mol Cell Biol 15:2582-2588
-
(1995)
Mol Cell Biol
, vol.15
, pp. 2582-2588
-
-
Kim, J.B.1
Spotts, G.D.2
Halvorsen, Y.D.3
Shih, H.M.4
Ellenberger, T.5
Towle, H.C.6
Spiegelman, B.M.7
-
6
-
-
0027490174
-
SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene
-
Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, Hua X, Goldstein JL, Brown MS 1993 SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell 75:187-197
-
(1993)
Cell
, vol.75
, pp. 187-197
-
-
Yokoyama, C.1
Wang, X.2
Briggs, M.R.3
Admon, A.4
Wu, J.5
Hua, X.6
Goldstein, J.L.7
Brown, M.S.8
-
7
-
-
0027648820
-
ADD1: A novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation
-
Tontonoz P, Kim JB, Graves RA, Spiegelman BM 1993 ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Mol Cell Biol 13:4753-4759
-
(1993)
Mol Cell Biol
, vol.13
, pp. 4753-4759
-
-
Tontonoz, P.1
Kim, J.B.2
Graves, R.A.3
Spiegelman, B.M.4
-
8
-
-
0027139362
-
SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element
-
Hua X, Yokoyama C, Wu J, Briggs MR, Brown MS, Goldstein JL, Wang X 1993 SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc Natl Acad Sci USA 90:11603-11607
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 11603-11607
-
-
Hua, X.1
Yokoyama, C.2
Wu, J.3
Briggs, M.R.4
Brown, M.S.5
Goldstein, J.L.6
Wang, X.7
-
9
-
-
0030961960
-
Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells
-
Shimomura I, Shimano H, Horton JD, Goldstein JL, Brown MS 1997 Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J Clin Invest 99:838-845
-
(1997)
J Clin Invest
, vol.99
, pp. 838-845
-
-
Shimomura, I.1
Shimano, H.2
Horton, J.D.3
Goldstein, J.L.4
Brown, M.S.5
-
10
-
-
0032104180
-
Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2
-
Horton JD, Shimomura I, Brown MS, Hammer RE, Goldstein JL, Shimano H 1998 Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J Clin Invest 101:2331-2339
-
(1998)
J Clin Invest
, vol.101
, pp. 2331-2339
-
-
Horton, J.D.1
Shimomura, I.2
Brown, M.S.3
Hammer, R.E.4
Goldstein, J.L.5
Shimano, H.6
-
11
-
-
0029797604
-
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
-
Shimano H, Horton JD, Hammer RE, Shimomura I, Brown MS, Goldstein JL 1996 Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J Clin Invest 98:1575-1584
-
(1996)
J Clin Invest
, vol.98
, pp. 1575-1584
-
-
Shimano, H.1
Horton, J.D.2
Hammer, R.E.3
Shimomura, I.4
Brown, M.S.5
Goldstein, J.L.6
-
12
-
-
0033544940
-
Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes
-
Shimano H, Yahagi N, Amemiya-Kudo M, Hasty AH, Osuga J, Tamura Y, Shionoiri F, Iizuka Y, Ohashi K, Harada K, Gotoda T, Ishibashi S, Yamada N 1999 Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes. J Biol Chem 274:35832-35839
-
(1999)
J Biol Chem
, vol.274
, pp. 35832-35839
-
-
Shimano, H.1
Yahagi, N.2
Amemiya-Kudo, M.3
Hasty, A.H.4
Osuga, J.5
Tamura, Y.6
Shionoiri, F.7
Iizuka, Y.8
Ohashi, K.9
Harada, K.10
Gotoda, T.11
Ishibashi, S.12
Yamada, N.13
-
13
-
-
0032568557
-
Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice
-
Horton JD, Bashmakov Y, Shimomura I, Shimano H 1998 Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc Natl Acad Sci USA 95:5987-5992
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 5987-5992
-
-
Horton, J.D.1
Bashmakov, Y.2
Shimomura, I.3
Shimano, H.4
-
14
-
-
0033544869
-
A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids
-
Yahagi N, Shimano H, Hasty AH, Amemiya-Kudo M, Okazaki H, Tamura Y, Iizuka Y, Shionoiri F, Ohashi K, Osuga J, Harada K, Gotoda T, Nagai R, Ishibashi S, Yamada N 1999 A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids. J Biol Chem 274:35840-35844
-
(1999)
J Biol Chem
, vol.274
, pp. 35840-35844
-
-
Yahagi, N.1
Shimano, H.2
Hasty, A.H.3
Amemiya-Kudo, M.4
Okazaki, H.5
Tamura, Y.6
Iizuka, Y.7
Shionoiri, F.8
Ohashi, K.9
Osuga, J.10
Harada, K.11
Gotoda, T.12
Nagai, R.13
Ishibashi, S.14
Yamada, N.15
-
15
-
-
0033551846
-
Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats
-
Xu J, Nakamura MT, Cho HP, Clarke SD 1999 Sterol regulatory element binding protein-1 expression is suppressed by dietary polyunsaturated fatty acids. A mechanism for the coordinate suppression of lipogenic genes by polyunsaturated fats. J Biol Chem 274:23577-23583
-
(1999)
J Biol Chem
, vol.274
, pp. 23577-23583
-
-
Xu, J.1
Nakamura, M.T.2
Cho, H.P.3
Clarke, S.D.4
-
16
-
-
0031963963
-
Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1
-
Kim JB, Sarraf P, Wright M, Yao KM, Mueller E, Solanes G, Lowell BB, Spiegelman BM 1998 Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. J Clin Invest 101:1-9
-
(1998)
J Clin Invest
, vol.101
, pp. 1-9
-
-
Kim, J.B.1
Sarraf, P.2
Wright, M.3
Yao, K.M.4
Mueller, E.5
Solanes, G.6
Lowell, B.B.7
Spiegelman, B.M.8
-
17
-
-
0033520484
-
Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mRNAs
-
Kim HJ, Takahashi M, Ezaki O 1999 Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mRNAs. J Biol Chem 274:25892-25898
-
(1999)
J Biol Chem
, vol.274
, pp. 25892-25898
-
-
Kim, H.J.1
Takahashi, M.2
Ezaki, O.3
-
18
-
-
0034693259
-
Sterol regulatory element-binding proteins (SREBPs): Key regulators of nutritional homeostasis and insulin action
-
Osborne TF 2000 Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action. J Biol Chem 275:32379-32382
-
(2000)
J Biol Chem
, vol.275
, pp. 32379-32382
-
-
Osborne, T.F.1
-
19
-
-
0012473279
-
The nuclear receptor superfamily: The second decade
-
Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P 1995 The nuclear receptor superfamily: the second decade. Cell 83:835-839
-
(1995)
Cell
, vol.83
, pp. 835-839
-
-
Mangelsdorf, D.J.1
Thummel, C.2
Beato, M.3
Herrlich, P.4
Schutz, G.5
Umesono, K.6
Blumberg, B.7
Kastner, P.8
Mark, M.9
Chambon, P.10
-
20
-
-
0029805887
-
An oxysterol signalling pathway mediated by the nuclear receptor LXR α
-
Janowski BA, Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ 1996 An oxysterol signalling pathway mediated by the nuclear receptor LXR α. Nature 383:728-731
-
(1996)
Nature
, vol.383
, pp. 728-731
-
-
Janowski, B.A.1
Willy, P.J.2
Devi, T.R.3
Falck, J.R.4
Mangelsdorf, D.J.5
-
21
-
-
14444285707
-
Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
-
Lehmann JM, Kliewer SA, Moore LB, Smith-Oliver TA, Oliver BB, Su JL, Sundseth SS, Winegar DA, Blanchard DE, Spencer TA, Willson TM 1997 Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway. J Biol Chem 272:3137-3140
-
(1997)
J Biol Chem
, vol.272
, pp. 3137-3140
-
-
Lehmann, J.M.1
Kliewer, S.A.2
Moore, L.B.3
Smith-Oliver, T.A.4
Oliver, B.B.5
Su, J.L.6
Sundseth, S.S.7
Winegar, D.A.8
Blanchard, D.E.9
Spencer, T.A.10
Willson, T.M.11
-
22
-
-
0033612369
-
Nuclear orphan receptors control cholesterol catabolism
-
Russell DW 1999 Nuclear orphan receptors control cholesterol catabolism. Cell 97:539-542
-
(1999)
Cell
, vol.97
, pp. 539-542
-
-
Russell, D.W.1
-
23
-
-
0029035278
-
LXR, a nuclear receptor that defines a distinct retinoid response pathway
-
Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, Mangelsdorf DJ 1995 LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev 9:1033-1045
-
(1995)
Genes Dev
, vol.9
, pp. 1033-1045
-
-
Willy, P.J.1
Umesono, K.2
Ong, E.S.3
Evans, R.M.4
Heyman, R.A.5
Mangelsdorf, D.J.6
-
24
-
-
0028117755
-
Ubiquitous receptor: A receptor that modulates gene activation by retinoic acid and thyroid hormone receptors
-
Song C, Kokontis JM, Hiipakka RA, Liao S 1994 Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors. Proc Natl Acad Sci USA 91:10809-10813
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 10809-10813
-
-
Song, C.1
Kokontis, J.M.2
Hiipakka, R.A.3
Liao, S.4
-
25
-
-
0013199471
-
Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR α
-
Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro JM, Hammer RE, Mangelsdorf DJ 1998 Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR α. Cell 93:693-704
-
(1998)
Cell
, vol.93
, pp. 693-704
-
-
Peet, D.J.1
Turley, S.D.2
Ma, W.3
Janowski, B.A.4
Lobaccaro, J.M.5
Hammer, R.E.6
Mangelsdorf, D.J.7
-
26
-
-
0033997752
-
Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element
-
Luo Y, Tall AR 2000 Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element. J Clin Invest 105:513-520
-
(2000)
J Clin Invest
, vol.105
, pp. 513-520
-
-
Luo, Y.1
Tall, A.R.2
-
27
-
-
0034284918
-
Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers
-
Repa JJ, Turley SD, Lobaccaro JA, Medina J, Li L, Lustig K, Shah B, Heyman RA, Dietschy JM, Mangelsdorf DJ 2000 Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. Science 289:1524-1529
-
(2000)
Science
, vol.289
, pp. 1524-1529
-
-
Repa, J.J.1
Turley, S.D.2
Lobaccaro, J.A.3
Medina, J.4
Li, L.5
Lustig, K.6
Shah, B.7
Heyman, R.A.8
Dietschy, J.M.9
Mangelsdorf, D.J.10
-
28
-
-
0034669025
-
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ
-
Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, Shan B, Brown MS, Goldstein JL, Mangelsdorf DJ 2000 Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ. Genes Dev 14:2819-2830
-
(2000)
Genes Dev
, vol.14
, pp. 2819-2830
-
-
Repa, J.J.1
Liang, G.2
Ou, J.3
Bashmakov, Y.4
Lobaccaro, J.M.5
Shimomura, I.6
Shan, B.7
Brown, M.S.8
Goldstein, J.L.9
Mangelsdorf, D.J.10
-
29
-
-
0035047709
-
Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter
-
Yoshikawa T, Shimano H, Amemiya-Kudo M, Yahagi N, Hasty AH, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Kimura S, Ishibashi S, Yamada N 2001 Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter. Mol Cell Biol 21:2991-3000
-
(2001)
Mol Cell Biol
, vol.21
, pp. 2991-3000
-
-
Yoshikawa, T.1
Shimano, H.2
Amemiya-Kudo, M.3
Yahagi, N.4
Hasty, A.H.5
Matsuzaka, T.6
Okazaki, H.7
Tamura, Y.8
Iizuka, Y.9
Ohashi, K.10
Osuga, J.11
Harada, K.12
Gotoda, T.13
Kimura, S.14
Ishibashi, S.15
Yamada, N.16
-
30
-
-
0030602866
-
The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation
-
Schoonjans K, Staels B, Auwerx J 1996 The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta 1302:93-109
-
(1996)
Biochim Biophys Acta
, vol.1302
, pp. 93-109
-
-
Schoonjans, K.1
Staels, B.2
Auwerx, J.3
-
32
-
-
0030047806
-
Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-α, -β, and -γ in the adult rat
-
Braissant O, Foufelle F, Scotto C, Dauca M, Wahli W 1996 Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-α, -β, and -γ in the adult rat. Endocrinology 137:354-366
-
(1996)
Endocrinology
, vol.137
, pp. 354-366
-
-
Braissant, O.1
Foufelle, F.2
Scotto, C.3
Dauca, M.4
Wahli, W.5
-
33
-
-
0028641559
-
Stimulation of adipogenesis in fibroblasts by PPAR γ2, a lipid-activated transcription factor
-
Tontonoz P, Hu E, Spiegelman BM 1994 Stimulation of adipogenesis in fibroblasts by PPAR γ2, a lipid-activated transcription factor. Cell 79:1147-1156
-
(1994)
Cell
, vol.79
, pp. 1147-1156
-
-
Tontonoz, P.1
Hu, E.2
Spiegelman, B.M.3
-
34
-
-
0031886864
-
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
-
Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK 1998 The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 391:79-82
-
(1998)
Nature
, vol.391
, pp. 79-82
-
-
Ricote, M.1
Li, A.C.2
Willson, T.M.3
Kelly, C.J.4
Glass, C.K.5
-
35
-
-
0032540012
-
PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
-
Tontonoz P, Nagy L, Alvarez JG, Thomazy VA, Evans RM 1998 PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93:241-252
-
(1998)
Cell
, vol.93
, pp. 241-252
-
-
Tontonoz, P.1
Nagy, L.2
Alvarez, J.G.3
Thomazy, V.A.4
Evans, R.M.5
-
36
-
-
0032540325
-
Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ
-
Nagy L, Tontonoz P, Alvarez JG, Chen H, Evans RM 1998 Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ. Cell 93:229-240
-
(1998)
Cell
, vol.93
, pp. 229-240
-
-
Nagy, L.1
Tontonoz, P.2
Alvarez, J.G.3
Chen, H.4
Evans, R.M.5
-
37
-
-
0025132245
-
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
-
Issemann I, Green S 1990 Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347:645-650
-
(1990)
Nature
, vol.347
, pp. 645-650
-
-
Issemann, I.1
Green, S.2
-
38
-
-
0026517010
-
Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors
-
Dreyer C, Krey G, Keller H, Givel F, Helftenbein G, Wahli W 1992 Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors. Cell 68:879-887
-
(1992)
Cell
, vol.68
, pp. 879-887
-
-
Dreyer, C.1
Krey, G.2
Keller, H.3
Givel, F.4
Helftenbein, G.5
Wahli, W.6
-
39
-
-
0026551309
-
Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor
-
Gottlicher M, Widmark E, Li Q, Gustafsson JA 1992 Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc Natl Acad Sci USA 89:4653-4657
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 4653-4657
-
-
Gottlicher, M.1
Widmark, E.2
Li, Q.3
Gustafsson, J.A.4
-
40
-
-
0027447461
-
Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers
-
Keller H, Dreyer C, Medin J, Mahfoudi A, Ozato K, Wahli W 1993 Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers. Proc Natl Acad Sci USA 90:2160-2164
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 2160-2164
-
-
Keller, H.1
Dreyer, C.2
Medin, J.3
Mahfoudi, A.4
Ozato, K.5
Wahli, W.6
-
41
-
-
0030952937
-
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta
-
Forman BM, Chen J, Evans RM 1997 Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl Acad Sci USA 94:4312-4317
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4312-4317
-
-
Forman, B.M.1
Chen, J.2
Evans, R.M.3
-
42
-
-
0006132932
-
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
-
Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, Devchand P, Wahli W, Willson TM, Lenhard JM, Lehmann JM 1997 Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ. Proc Natl Acad Sci USA 94:4318-4323
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4318-4323
-
-
Kliewer, S.A.1
Sundseth, S.S.2
Jones, S.A.3
Brown, P.J.4
Wisely, G.B.5
Koble, C.S.6
Devchand, P.7
Wahli, W.8
Willson, T.M.9
Lenhard, J.M.10
Lehmann, J.M.11
-
43
-
-
0030985318
-
Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay
-
Krey G, Braissant O, L'Horset F, Kalkhoven E, Perroud M, Parker MG, Wahli W 1997 Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol Endocrinol 11:779-791
-
(1997)
Mol Endocrinol
, vol.11
, pp. 779-791
-
-
Krey, G.1
Braissant, O.2
L'Horset, F.3
Kalkhoven, E.4
Perroud, M.5
Parker, M.G.6
Wahli, W.7
-
44
-
-
0032699670
-
Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting
-
Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W 1999 Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting. J Clin Invest 103:1489-1498
-
(1999)
J Clin Invest
, vol.103
, pp. 1489-1498
-
-
Kersten, S.1
Seydoux, J.2
Peters, J.M.3
Gonzalez, F.J.4
Desvergne, B.5
Wahli, W.6
-
45
-
-
0033594980
-
A critical role for the peroxisome proliferator-activated receptor alpha (PPARα) in the cellular fasting response: The PPARα-null mouse as a model of fatty acid oxidation disorders
-
Leone TC, Weinheimer CJ, Kelly DP 1999 A critical role for the peroxisome proliferator-activated receptor alpha (PPARα) in the cellular fasting response: the PPARα-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci USA 96:7473-7478
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 7473-7478
-
-
Leone, T.C.1
Weinheimer, C.J.2
Kelly, D.P.3
-
46
-
-
0029084409
-
Peroxisome proliferator-activated receptor mediates cross-talk with thyroid hormone receptor by competition for retinoid X receptor. Possible role of a leucine zipper-like heptad repeat
-
Juge-Aubry CE, Gorla-Bajszczak A, Pernin A, Lemberger T, Wahli W, Burger AG, Meier CA 1995 Peroxisome proliferator-activated receptor mediates cross-talk with thyroid hormone receptor by competition for retinoid X receptor. Possible role of a leucine zipper-like heptad repeat. J Biol Chem 270:18117-18122
-
(1995)
J Biol Chem
, vol.270
, pp. 18117-18122
-
-
Juge-Aubry, C.E.1
Gorla-Bajszczak, A.2
Pernin, A.3
Lemberger, T.4
Wahli, W.5
Burger, A.G.6
Meier, C.A.7
-
47
-
-
0029417198
-
Thyroid hormone (T3) inhibits ciprofibrate-induced transcription of genes encoding beta-oxidation enzymes: Cross talk between peroxisome proliferator and T3 signaling pathways
-
Chu R, Madison LD, Lin Y, Kopp P, Rao MS, Jameson JL, Reddy JK 1995 Thyroid hormone (T3) inhibits ciprofibrate-induced transcription of genes encoding beta-oxidation enzymes: cross talk between peroxisome proliferator and T3 signaling pathways. Proc Natl Acad Sci USA 92:11593-11597
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 11593-11597
-
-
Chu, R.1
Madison, L.D.2
Lin, Y.3
Kopp, P.4
Rao, M.S.5
Jameson, J.L.6
Reddy, J.K.7
-
48
-
-
0029931972
-
The orphan nuclear hormone receptor LXR α interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling
-
Miyata KS, McCaw SE, Patel HV, Rachubinski RA, Capone JP 1996 The orphan nuclear hormone receptor LXR α interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling. J Biol Chem 271:9189-9192
-
(1996)
J Biol Chem
, vol.271
, pp. 9189-9192
-
-
Miyata, K.S.1
McCaw, S.E.2
Patel, H.V.3
Rachubinski, R.A.4
Capone, J.P.5
-
49
-
-
12444295462
-
Cross-talk between peroxisome proliferator-activated receptor (PPAR) α and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling
-
Ide T, Shimano H, Yoshikawa T, Yahagi N, Amemiya-Kudo M, Matsuzaka T, Nakakuki M, Yatoh S, Iizuka Y, Tomita S, Ohashi K, Takahashi A, Sone H, Gotoda T, Osuga J-i, Ishibashi S, Yamada N 2003 Cross-talk between peroxisome proliferator-activated receptor (PPAR) α and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling. Endocrinology 144:1255-1267
-
(2003)
Endocrinology
, vol.144
, pp. 1255-1267
-
-
Ide, T.1
Shimano, H.2
Yoshikawa, T.3
Yahagi, N.4
Amemiya-Kudo, M.5
Matsuzaka, T.6
Nakakuki, M.7
Yatoh, S.8
Iizuka, Y.9
Tomita, S.10
Ohashi, K.11
Takahashi, A.12
Sone, H.13
Gotoda, T.14
Osuga, J.-I.15
Ishibashi, S.16
Yamada, N.17
-
50
-
-
0034613175
-
Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene
-
Amemiya-Kudo M, Shimano H, Yoshikawa T, Yahagi N, Hasty AH, Okazaki H, Tamura Y, Shionoiri F, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Sato R, Kimura S, Ishibashi S, Yamada N 2000 Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene. J Biol Chem 275:31078-1085
-
(2000)
J Biol Chem
, vol.275
, pp. 31078-31085
-
-
Amemiya-Kudo, M.1
Shimano, H.2
Yoshikawa, T.3
Yahagi, N.4
Hasty, A.H.5
Okazaki, H.6
Tamura, Y.7
Shionoiri, F.8
Iizuka, Y.9
Ohashi, K.10
Osuga, J.11
Harada, K.12
Gotoda, T.13
Sato, R.14
Kimura, S.15
Ishibashi, S.16
Yamada, N.17
-
51
-
-
0035138625
-
PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway
-
Chinetti G, Lestavel S, Bocher V, Remaley AT, Neve B, Torra IP, Teissier E, Minnich A, Jaye M, Duverger N, Brewer HB, Fruchart JC, Clavey V, Staels B 2001 PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat Med 7:53-58
-
(2001)
Nat Med
, vol.7
, pp. 53-58
-
-
Chinetti, G.1
Lestavel, S.2
Bocher, V.3
Remaley, A.T.4
Neve, B.5
Torra, I.P.6
Teissier, E.7
Minnich, A.8
Jaye, M.9
Duverger, N.10
Brewer, H.B.11
Fruchart, J.C.12
Clavey, V.13
Staels, B.14
-
52
-
-
17744376173
-
A PPAR γ-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
-
Chawla A, Boisvert WA, Lee CH, Laffitte BA, Barak Y, Joseph SB, Liao D, Nagy L, Edwards PA, Curtiss LK, Evans RM, Tontonoz P 2001 A PPAR γ-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol Cell 7:161-171
-
(2001)
Mol Cell
, vol.7
, pp. 161-171
-
-
Chawla, A.1
Boisvert, W.A.2
Lee, C.H.3
Laffitte, B.A.4
Barak, Y.5
Joseph, S.B.6
Liao, D.7
Nagy, L.8
Edwards, P.A.9
Curtiss, L.K.10
Evans, R.M.11
Tontonoz, P.12
-
53
-
-
0034453225
-
Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-α
-
Tobin KA, Steineger HH, Alberti S, Spydevold O, Auwerx J, Gustafsson JA, Nebb HI 2000 Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-α. Mol Endocrinol 14:741-752
-
(2000)
Mol Endocrinol
, vol.14
, pp. 741-752
-
-
Tobin, K.A.1
Steineger, H.H.2
Alberti, S.3
Spydevold, O.4
Auwerx, J.5
Gustafsson, J.A.6
Nebb, H.I.7
-
54
-
-
0037154974
-
Combinatorial control of gene expression by nuclear receptors and coregulators
-
McKenna NJ, O'Malley BW 2002 Combinatorial control of gene expression by nuclear receptors and coregulators. Cell 108:465-474
-
(2002)
Cell
, vol.108
, pp. 465-474
-
-
McKenna, N.J.1
O'Malley, B.W.2
-
55
-
-
0036013438
-
Characterization of the human PPARα promoter: Identification of a functional nuclear receptor response element
-
Pineda Torra I, Jamshidi Y, Flavell DM, Fruchart JC, Staels B 2002 Characterization of the human PPARα promoter: identification of a functional nuclear receptor response element. Mol Endocrinol 16:1013-1028
-
(2002)
Mol Endocrinol
, vol.16
, pp. 1013-1028
-
-
Pineda Torra, I.1
Jamshidi, Y.2
Flavell, D.M.3
Fruchart, J.C.4
Staels, B.5
-
56
-
-
0030061837
-
Crosstalk between the thyroid hormone and peroxisome proliferator-activated receptors in regulating peroxisome proliferator-responsive genes
-
Hunter J, Kassam A, Winrow CJ, Rachubinski RA, Capone JP 1996 Crosstalk between the thyroid hormone and peroxisome proliferator-activated receptors in regulating peroxisome proliferator-responsive genes. Mol Cell Endocrinol 116:213-221
-
(1996)
Mol Cell Endocrinol
, vol.116
, pp. 213-221
-
-
Hunter, J.1
Kassam, A.2
Winrow, C.J.3
Rachubinski, R.A.4
Capone, J.P.5
-
57
-
-
0346003777
-
Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to PPARγ1 overexpression
-
Yu S, Matsusue K, Kashireddy P, Cao WQ, Yeldandi V, Yeldandi AV, Rao MS, Gonzalez F J, Reddy JK 2003 Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to PPARγ1 overexpression. J Biol Chem 278:498-505
-
(2003)
J Biol Chem
, vol.278
, pp. 498-505
-
-
Yu, S.1
Matsusue, K.2
Kashireddy, P.3
Cao, W.Q.4
Yeldandi, V.5
Yeldandi, A.V.6
Rao, M.S.7
Gonzalez, F.J.8
Reddy, J.K.9
-
58
-
-
0035065450
-
Disturbances in the normal regulation of SREBP-sensitive genes in PPAR α-deficient mice
-
Patel DD, Knight BL, Wiggins D, Humphreys SM, Gibbons GF 2001 Disturbances in the normal regulation of SREBP-sensitive genes in PPAR α-deficient mice. J Lipid Res 42:328-337
-
(2001)
J Lipid Res
, vol.42
, pp. 328-337
-
-
Patel, D.D.1
Knight, B.L.2
Wiggins, D.3
Humphreys, S.M.4
Gibbons, G.F.5
-
59
-
-
18544388579
-
Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements
-
Yoshikawa T, Shimano H, Yahagi N, Ide T, Amemiya-Kudo M, Matsuzaka T, Nakakuki M, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Takahashi A, Sone H, Osuga Ji J, Gotoda T, Ishibashi S, Yamada N 2002 Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements. J Biol Chem 277:1705-1711
-
(2002)
J Biol Chem
, vol.277
, pp. 1705-1711
-
-
Yoshikawa, T.1
Shimano, H.2
Yahagi, N.3
Ide, T.4
Amemiya-Kudo, M.5
Matsuzaka, T.6
Nakakuki, M.7
Tomita, S.8
Okazaki, H.9
Tamura, Y.10
Iizuka, Y.11
Ohashi, K.12
Takahashi, A.13
Sone, H.14
Osuga Ji, J.15
Gotoda, T.16
Ishibashi, S.17
Yamada, N.18
-
61
-
-
0032793068
-
Regulation of peroxisome proliferator-activated receptor γ expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: Implications for adipocyte differentiation and metabolism
-
Fajas L, Schoonjans K, Gelman L, Kim JB, Najib J, Martin G, Fruchart JC, Briggs M, Spiegelman BM, Auwerx J 1999 Regulation of peroxisome proliferator-activated receptor γ expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism. Mol Cell Biol 19:5495-5503
-
(1999)
Mol Cell Biol
, vol.19
, pp. 5495-5503
-
-
Fajas, L.1
Schoonjans, K.2
Gelman, L.3
Kim, J.B.4
Najib, J.5
Martin, G.6
Fruchart, J.C.7
Briggs, M.8
Spiegelman, B.M.9
Auwerx, J.10
-
62
-
-
0028839010
-
Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver
-
Sheng Z, Otani H, Brown MS, Goldstein JL 1995 Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Proc Natl Acad Sci USA 92:935-938
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 935-938
-
-
Sheng, Z.1
Otani, H.2
Brown, M.S.3
Goldstein, J.L.4
-
63
-
-
0017746829
-
Insulin control of rat hepatocyte glycogen synthase and phosphorylase in the absence of glucose
-
Massague J, Guinovart JJ 1977 Insulin control of rat hepatocyte glycogen synthase and phosphorylase in the absence of glucose. FEBS Lett 82:317-320
-
(1977)
FEBS Lett
, vol.82
, pp. 317-320
-
-
Massague, J.1
Guinovart, J.J.2
-
64
-
-
0035932990
-
Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR
-
Ou J, Tu H, Shan B, Luk A, DeBose-Boyd RA, Bashmakov Y, Goldstein JL, Brown MS 2001 Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR. Proc Natl Acad Sci USA 98:6027-6032
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 6027-6032
-
-
Ou, J.1
Tu, H.2
Shan, B.3
Luk, A.4
DeBose-Boyd, R.A.5
Bashmakov, Y.6
Goldstein, J.L.7
Brown, M.S.8
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