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Volumn 44, Issue 8, 1996, Pages 413-428

Cellular and molecular mechanisms of non-insulin dependent diabetes mellitus

Author keywords

[No Author keywords available]

Indexed keywords

ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1; GLUCOSE; INORGANIC PYROPHOSPHATASE; INSULIN; MEMBRANE PROTEIN; PHOSPHODIESTERASE; RAS PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 0030253348     PISSN: 17088267     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (148)

References (133)
  • 1
    • 0027762766 scopus 로고
    • Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians
    • Lillioja S, Mott DM, Spraul M, Ferraro R, Foley JE, Ravussin E, Knowler WC, Bennett PH, Bogardus C. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med 1993;329:1988-92.
    • (1993) N Engl J Med , vol.329 , pp. 1988-1992
    • Lillioja, S.1    Mott, D.M.2    Spraul, M.3    Ferraro, R.4    Foley, J.E.5    Ravussin, E.6    Knowler, W.C.7    Bennett, P.H.8    Bogardus, C.9
  • 2
    • 0028837903 scopus 로고
    • Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non-insulin-dependent diabetes mellitus
    • Vaag A, Henriksen JE, Madsbad S, Holm N, Beck-Nielsen H. Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non-insulin-dependent diabetes mellitus. J Clin Invest 1995;95:690-8.
    • (1995) J Clin Invest , vol.95 , pp. 690-698
    • Vaag, A.1    Henriksen, J.E.2    Madsbad, S.3    Holm, N.4    Beck-Nielsen, H.5
  • 3
    • 0028229508 scopus 로고
    • Insulin resistance or insulin deficiency: Which is the primary cause of NIDDM?
    • Taylor SI, Accili D, Imai Y. Insulin resistance or insulin deficiency: which is the primary cause of NIDDM? Diabetes 1994;43:735-40.
    • (1994) Diabetes , vol.43 , pp. 735-740
    • Taylor, S.I.1    Accili, D.2    Imai, Y.3
  • 5
    • 0025663581 scopus 로고
    • Slow glucose removal rate and hyperinsulinemia precede the development of Type II diabetes in the offspring of diabetic parents
    • Warram JH, Martin BC, Krolewski AS, Soeldner JS, Kahn CR. Slow glucose removal rate and hyperinsulinemia precede the development of Type II diabetes in the offspring of diabetic parents. Ann Intern Med 1990;13:909-15.
    • (1990) Ann Intern Med , vol.13 , pp. 909-915
    • Warram, J.H.1    Martin, B.C.2    Krolewski, A.S.3    Soeldner, J.S.4    Kahn, C.R.5
  • 6
    • 0029022819 scopus 로고
    • Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM: Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative
    • Pimenta W, Korytkowski M, Mitrakou A, Jenssen T, Yki-Jarvinen H, Evron W, Dailey G, Gerich J. Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM: evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative. JAMA 1995;273:1855-61.
    • (1995) JAMA , vol.273 , pp. 1855-1861
    • Pimenta, W.1    Korytkowski, M.2    Mitrakou, A.3    Jenssen, T.4    Yki-Jarvinen, H.5    Evron, W.6    Dailey, G.7    Gerich, J.8
  • 7
    • 0023951171 scopus 로고
    • Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes
    • O'Rahilly S, Turner RC, Matthews DR. Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes. N Engl J Med 1988;318:1225-30.
    • (1988) N Engl J Med , vol.318 , pp. 1225-1230
    • O'Rahilly, S.1    Turner, R.C.2    Matthews, D.R.3
  • 8
    • 0002806616 scopus 로고
    • Genetics of diabetes mellitus
    • Alberti KGMM, DeFronzo RA, Keen H, Zimmet P. eds. Chichester: John Wiley & Sons Ltd
    • Vadheim CM, Rotter JI. Genetics of diabetes mellitus. In: Alberti KGMM, DeFronzo RA, Keen H, Zimmet P. eds. International textbook of diabetes mellitus. Chichester: John Wiley & Sons Ltd, 1992:31-98.
    • (1992) International Textbook of Diabetes Mellitus , pp. 31-98
    • Vadheim, C.M.1    Rotter, J.I.2
  • 9
    • 0020774420 scopus 로고
    • Estimation and kinetic analysis of insulin independent glucose uptake in human subjects
    • Gottesman I, Mandarino LJ, Gerich J. Estimation and kinetic analysis of insulin independent glucose uptake in human subjects. Am J Physiol 1983;244:E632-5.
    • (1983) Am J Physiol , vol.244
    • Gottesman, I.1    Mandarino, L.J.2    Gerich, J.3
  • 10
    • 0022387842 scopus 로고
    • Rates of noninsulin-mediated glucose uptake are elevated in Type II diabetic subjects
    • Baron AD, Kolterman OG, Bell J, Mandarino LJ, Olefsky JM. Rates of noninsulin-mediated glucose uptake are elevated in Type II diabetic subjects. J Clin Invest 1985;76:1782-8.
    • (1985) J Clin Invest , vol.76 , pp. 1782-1788
    • Baron, A.D.1    Kolterman, O.G.2    Bell, J.3    Mandarino, L.J.4    Olefsky, J.M.5
  • 11
    • 0025648741 scopus 로고
    • Brain glucose metabolism in non-insulin-dependent diabetes mellitus: A study in Pima Indians using positron emission tomography during hyperinsulinemia with euglycemic clamp
    • Eastman RC, Carson RE, Gordon MR, Berg GW, Lillioja S, Larson SM, Roth J, et al. Brain glucose metabolism in non-insulin-dependent diabetes mellitus: a study in Pima Indians using positron emission tomography during hyperinsulinemia with euglycemic clamp. J Clin Endocrinol Metab 1990;71:1602-10.
    • (1990) J Clin Endocrinol Metab , vol.71 , pp. 1602-1610
    • Eastman, R.C.1    Carson, R.E.2    Gordon, M.R.3    Berg, G.W.4    Lillioja, S.5    Larson, S.M.6    Roth, J.7
  • 13
    • 0000044662 scopus 로고
    • The quantitatively minor role of carbohydrate in oxidative metabolism by skeletal muscle in intact man in the basal state. Measurements of oxygen and glucose uptake and carbon dioxide and lactate production in the forearm
    • Andres R, Cader G, Zierler KL. The quantitatively minor role of carbohydrate in oxidative metabolism by skeletal muscle in intact man in the basal state. Measurements of oxygen and glucose uptake and carbon dioxide and lactate production in the forearm. J Clin Invest 1956;35:671-82.
    • (1956) J Clin Invest , vol.35 , pp. 671-682
    • Andres, R.1    Cader, G.2    Zierler, K.L.3
  • 14
    • 0024909192 scopus 로고
    • Hepatic glucose production in insulin-resistant states
    • Ferrannini E, Groop LC. Hepatic glucose production in insulin-resistant states. Diabetes Metab Rev 1989;5:711-25.
    • (1989) Diabetes Metab Rev , vol.5 , pp. 711-725
    • Ferrannini, E.1    Groop, L.C.2
  • 15
    • 0022580145 scopus 로고
    • Regional cerebral glucose transport in insulin-dependent diabetic patients studied using [11C]-3-O-methyl-D-glucose and positron emission tomography
    • Brooks D, Gibbs J, Sharp P, Herold S, Turton D, Luthra S, Kohner E, Bloom S, Jones T. Regional cerebral glucose transport in insulin-dependent diabetic patients studied using [11C]-3-O-methyl-D-glucose and positron emission tomography. J Cereb Blood Flow Metab 1986;6:240-4.
    • (1986) J Cereb Blood Flow Metab , vol.6 , pp. 240-244
    • Brooks, D.1    Gibbs, J.2    Sharp, P.3    Herold, S.4    Turton, D.5    Luthra, S.6    Kohner, E.7    Bloom, S.8    Jones, T.9
  • 16
    • 0026488079 scopus 로고
    • Increased rate of gluconeogenesis in Type II diabetes mellitus: A 13C nuclear magnetic resonance study
    • Magnusson I, Rothman DL, Katz LD, Shulman RG, Shulman GI. Increased rate of gluconeogenesis in Type II diabetes mellitus: a 13C nuclear magnetic resonance study. J Clin Invest 1992;90:1323-7.
    • (1992) J Clin Invest , vol.90 , pp. 1323-1327
    • Magnusson, I.1    Rothman, D.L.2    Katz, L.D.3    Shulman, R.G.4    Shulman, G.I.5
  • 17
    • 0026518355 scopus 로고
    • Increased lipolysis and its consequences on gluconeogenesis in non-insulin-dependent diabetes mellitus
    • Nurjhan N, Consoli A, Gerich JE. Increased lipolysis and its consequences on gluconeogenesis in non-insulin-dependent diabetes mellitus. J Clin Invest 1992;89:169-75.
    • (1992) J Clin Invest , vol.89 , pp. 169-175
    • Nurjhan, N.1    Consoli, A.2    Gerich, J.E.3
  • 18
    • 0026646940 scopus 로고
    • Lipolysis and gluconeogenesis from glycerol are increased in patients with non-insulin-dependent diabetes mellitus
    • Puhakainen I, Koivisto VA, Yki-Jarvinen H. Lipolysis and gluconeogenesis from glycerol are increased in patients with non-insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1992;75:789-94.
    • (1992) J Clin Endocrinol Metab , vol.75 , pp. 789-794
    • Puhakainen, I.1    Koivisto, V.A.2    Yki-Jarvinen, H.3
  • 19
    • 0025630056 scopus 로고
    • Mechanism of increased gluconeogenesis in non-insulin-dependent diabetes mellitus: Role of alterations in systemic, hepatic, and muscle lactate and alanine metabolism
    • Consoli A, Nurjhan N, Reilly JJ, Bier DM, Gerich JE. Mechanism of increased gluconeogenesis in non-insulin-dependent diabetes mellitus: role of alterations in systemic, hepatic, and muscle lactate and alanine metabolism. J Clin Invest 1990;86:2038-45.
    • (1990) J Clin Invest , vol.86 , pp. 2038-2045
    • Consoli, A.1    Nurjhan, N.2    Reilly, J.J.3    Bier, D.M.4    Gerich, J.E.5
  • 20
    • 0023595214 scopus 로고
    • Insulin action in non-insulin-dependent diabetes mellitus: The relationship between hepatic and extrahepatic insulin resistance and obesity
    • Firth R, Bell P, Rizza R. Insulin action in non-insulin-dependent diabetes mellitus: the relationship between hepatic and extrahepatic insulin resistance and obesity. Metabolism 1987;36:1091-5.
    • (1987) Metabolism , vol.36 , pp. 1091-1095
    • Firth, R.1    Bell, P.2    Rizza, R.3
  • 21
    • 0024392514 scopus 로고
    • Glucose and free fatty acid metabolism in non-insulin dependent diabetes mellitus. Evidence for multiple sites of insulin resistance
    • Groop LC, Bonadonna RC, Del Prato S, Ratheiser K, Zyck K, Ferrannini E, DeFronzo RA. Glucose and free fatty acid metabolism in non-insulin dependent diabetes mellitus. Evidence for multiple sites of insulin resistance. J Clin Invest 1989;84:205-13.
    • (1989) J Clin Invest , vol.84 , pp. 205-213
    • Groop, L.C.1    Bonadonna, R.C.2    Del Prato, S.3    Ratheiser, K.4    Zyck, K.5    Ferrannini, E.6    DeFronzo, R.A.7
  • 22
    • 0023589251 scopus 로고
    • Role of hyperglucagonemia in maintenance of increased rates of hepatic glucose output in type II diabetics
    • Baron AD, Schaeffer L, Shragg P, Kolterman OG. Role of hyperglucagonemia in maintenance of increased rates of hepatic glucose output in type II diabetics. Diabetes 1987;36:274-83.
    • (1987) Diabetes , vol.36 , pp. 274-283
    • Baron, A.D.1    Schaeffer, L.2    Shragg, P.3    Kolterman, O.G.4
  • 23
    • 0013923479 scopus 로고
    • Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver
    • Williamson J, Kreisberg R, Felts P. Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver. Proc Natl Acad Sci USA 1966;56:247-54.
    • (1966) Proc Natl Acad Sci USA , vol.56 , pp. 247-254
    • Williamson, J.1    Kreisberg, R.2    Felts, P.3
  • 24
    • 0022352027 scopus 로고
    • Regulation of flux through pyruvate dehydrogenase and pyruvate carboxylase in rat hepatocytes. Effects of fatty acids and glucagon
    • Agius L, Alberti KGMM. Regulation of flux through pyruvate dehydrogenase and pyruvate carboxylase in rat hepatocytes. Effects of fatty acids and glucagon. Eur J Biochem 1985;152:699-707.
    • (1985) Eur J Biochem , vol.152 , pp. 699-707
    • Agius, L.1    Alberti, K.G.M.M.2
  • 25
    • 0021890981 scopus 로고
    • Multiple disturbances of free fatty acid metabolism in non-insulin-dependent diabetes. Effect of oral hypoglycemic therapy
    • Taskinen MR, Bogardus C, Kennedy A, Howard BV. Multiple disturbances of free fatty acid metabolism in non-insulin-dependent diabetes. Effect of oral hypoglycemic therapy. J Clin Invest 1985;76:637-44.
    • (1985) J Clin Invest , vol.76 , pp. 637-644
    • Taskinen, M.R.1    Bogardus, C.2    Kennedy, A.3    Howard, B.V.4
  • 27
    • 0026598750 scopus 로고
    • Hyperglycemia compensates for the defects in insulin-mediated glucose metabolism and in the activation of glycogen synthase in the skeletal muscle of patients with Type 2 (non-insulin-dependent) diabetes mellitus
    • Vaag A, Damsbo P, Hother-Nielsen O, Beck-Nielsen H. Hyperglycemia compensates for the defects in insulin-mediated glucose metabolism and in the activation of glycogen synthase in the skeletal muscle of patients with Type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1992;35;80-8.
    • (1992) Diabetologia , vol.35 , pp. 80-88
    • Vaag, A.1    Damsbo, P.2    Hother-Nielsen, O.3    Beck-Nielsen, H.4
  • 28
    • 0025066579 scopus 로고
    • Contribution of abnormal muscle and liver glucose metabolism to postprandial hyperglycemia in NIDDM
    • Mitrakou A, Kelley D, Veneman T, Jenssen T, Pangburn T, Reilly J, Gerich J. Contribution of abnormal muscle and liver glucose metabolism to postprandial hyperglycemia in NIDDM. Diabetes 1990;39:1381-90.
    • (1990) Diabetes , vol.39 , pp. 1381-1390
    • Mitrakou, A.1    Kelley, D.2    Veneman, T.3    Jenssen, T.4    Pangburn, T.5    Reilly, J.6    Gerich, J.7
  • 29
    • 0021994683 scopus 로고
    • Effects of insulin on peripheral and splanchnic glucose metabolism in non-insulin-dependent (Type II) diabetes mellitus
    • DeFronzo RA, Gunnarsson R, Bjorkman O, Olsson M, Wahren J. Effects of insulin on peripheral and splanchnic glucose metabolism in non-insulin-dependent (Type II) diabetes mellitus. J Clin Invest 1985;76: 149-55.
    • (1985) J Clin Invest , vol.76 , pp. 149-155
    • DeFronzo, R.A.1    Gunnarsson, R.2    Bjorkman, O.3    Olsson, M.4    Wahren, J.5
  • 30
    • 0025695163 scopus 로고
    • Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in non-insulin-dependent diabetes mellitus
    • Kelley DE, Mandarino LJ. Hyperglycemia normalizes insulin-stimulated skeletal muscle glucose oxidation and storage in non-insulin-dependent diabetes mellitus. J Clin Invest 1990;86:1999-2007.
    • (1990) J Clin Invest , vol.86 , pp. 1999-2007
    • Kelley, D.E.1    Mandarino, L.J.2
  • 34
    • 0018194945 scopus 로고
    • Initial splanchnic extraction of ingested glucose in normal man
    • Radziuk J, McDonald TJ, Rubenstein D, Dapre J. Initial splanchnic extraction of ingested glucose in normal man. Metabolism 1978;27:657-79.
    • (1978) Metabolism , vol.27 , pp. 657-679
    • Radziuk, J.1    McDonald, T.J.2    Rubenstein, D.3    Dapre, J.4
  • 35
    • 0023798610 scopus 로고
    • Relationship of hepatic glucose uptake to intrahepatic glucose concentration in fasted rats after glucose load
    • Niewoehner CB, Nuttall FQ. Relationship of hepatic glucose uptake to intrahepatic glucose concentration in fasted rats after glucose load. Diabetes 1988;37:1559-66.
    • (1988) Diabetes , vol.37 , pp. 1559-1566
    • Niewoehner, C.B.1    Nuttall, F.Q.2
  • 36
    • 0027490102 scopus 로고
    • A concentration gradient of glucose from liver to plasma
    • Wals PA, Katz J. A concentration gradient of glucose from liver to plasma. Metabolism 1993;42:1492-6.
    • (1993) Metabolism , vol.42 , pp. 1492-1496
    • Wals, P.A.1    Katz, J.2
  • 37
    • 0030034219 scopus 로고    scopus 로고
    • Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog
    • Pagliassoti MJ, Holste LC, Moore MC, Neal DW, Cherrington AD. Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog. J Clin Invest 1996;97:81-91.
    • (1996) J Clin Invest , vol.97 , pp. 81-91
    • Pagliassoti, M.J.1    Holste, L.C.2    Moore, M.C.3    Neal, D.W.4    Cherrington, A.D.5
  • 38
    • 0022467301 scopus 로고
    • Postprandial hyperglycemia in patients with non-insulin-dependent diabetes mellitus. Role of hepatic and extrahepatic tissues
    • Firth RG, Bell PM, Marsh HM, Hansen I, Rizza RA. Postprandial hyperglycemia in patients with non-insulin-dependent diabetes mellitus. Role of hepatic and extrahepatic tissues. J Clin Invest 1986;77:1525-32.
    • (1986) J Clin Invest , vol.77 , pp. 1525-1532
    • Firth, R.G.1    Bell, P.M.2    Marsh, H.M.3    Hansen, I.4    Rizza, R.A.5
  • 39
    • 0028962776 scopus 로고
    • A noninvasive method to measure splanchnic glucose uptake after oral glucose administration
    • Ludvik B, Nolan JJ, Baloga J, Joyce M, Bell JM, Olefsky JM. A noninvasive method to measure splanchnic glucose uptake after oral glucose administration. J Clin Invest 1995;95:2232-8.
    • (1995) J Clin Invest , vol.95 , pp. 2232-2238
    • Ludvik, B.1    Nolan, J.J.2    Baloga, J.3    Joyce, M.4    Bell, J.M.5    Olefsky, J.M.6
  • 40
    • 0025979358 scopus 로고
    • Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non-insulin-dependent diabetes mellitus
    • Thorburn AW, Gumbiner B, Bulacan F, Brechtel G, Henry RR. Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non-insulin-dependent diabetes mellitus. J Clin Invest 1991;87:489-95.
    • (1991) J Clin Invest , vol.87 , pp. 489-495
    • Thorburn, A.W.1    Gumbiner, B.2    Bulacan, F.3    Brechtel, G.4    Henry, R.R.5
  • 41
    • 0021086931 scopus 로고
    • Carbohydrate oxidation and storage in obese non-insulin-dependent diabetic patients. Effects of improving glycemic control
    • Boden G, Ray TK, Smith RH, Owen OE. Carbohydrate oxidation and storage in obese non-insulin-dependent diabetic patients. Effects of improving glycemic control. Diabetes 1983;32:982-7.
    • (1983) Diabetes , vol.32 , pp. 982-987
    • Boden, G.1    Ray, T.K.2    Smith, R.H.3    Owen, O.E.4
  • 42
    • 0002298125 scopus 로고
    • The role of fatty acid metabolism in the hypertriglyceridaemia and insulin resistance of Type 2 (non-insulin-dependent) diabetes
    • Marshall SM, Home PD, Rizza RA, eds. Amsterdam: Elsevier Science Publishers
    • Kruszynska YT. The role of fatty acid metabolism in the hypertriglyceridaemia and insulin resistance of Type 2 (non-insulin-dependent) diabetes. In: Marshall SM, Home PD, Rizza RA, eds. The diabetes annual. Amsterdam: Elsevier Science Publishers, 1995;9:107-39.
    • (1995) The Diabetes Annual , vol.9 , pp. 107-139
    • Kruszynska, Y.T.1
  • 43
    • 0028825129 scopus 로고
    • Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin
    • Rebrin K, Steil GM, Getty L, Bergman RN. Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes 1995;44:1038-45.
    • (1995) Diabetes , vol.44 , pp. 1038-1045
    • Rebrin, K.1    Steil, G.M.2    Getty, L.3    Bergman, R.N.4
  • 44
    • 0028342686 scopus 로고
    • Mechanisms of fatty-acid inhibition of glucose uptake
    • Boden G, Chen X, White JV, Rossetti L. Mechanisms of fatty-acid inhibition of glucose uptake. J Clin Invest 1994;93:2438-46.
    • (1994) J Clin Invest , vol.93 , pp. 2438-2446
    • Boden, G.1    Chen, X.2    White, J.V.3    Rossetti, L.4
  • 45
    • 0028997729 scopus 로고
    • The b-cell in diabetes: From molecular genetics to clinical research
    • Polonsky KS. The b-cell in diabetes: from molecular genetics to clinical research. Diabetes 1995;44:705-717.
    • (1995) Diabetes , vol.44 , pp. 705-717
    • Polonsky, K.S.1
  • 46
    • 0027296318 scopus 로고
    • Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and non-insulin-dependent diabetes mellitus
    • O'Meara NM, Sturis J, Van Cauter E, Polonsky KS. Lack of control by glucose of ultradian insulin secretory oscillations in impaired glucose tolerance and non-insulin-dependent diabetes mellitus. J Clin Invest 1993;92:262-71.
    • (1993) J Clin Invest , vol.92 , pp. 262-271
    • O'Meara, N.M.1    Sturis, J.2    Van Cauter, E.3    Polonsky, K.S.4
  • 47
    • 0000301879 scopus 로고
    • Insulin secretion in the normal and diabetic human
    • Alberti KGMM, DeFronzo RA, Keen H, Zimmet P, eds. Chichester: John Wiley & Sons Ltd
    • Wallum BJ, Kahn SE, McCulloch DK, Porte D. Insulin secretion in the normal and diabetic human. In: Alberti KGMM, DeFronzo RA, Keen H, Zimmet P, eds. International textbook of diabetes mellitus. Chichester: John Wiley & Sons Ltd, 1992:285-301.
    • (1992) International Textbook of Diabetes Mellitus , pp. 285-301
    • Wallum, B.J.1    Kahn, S.E.2    McCulloch, D.K.3    Porte, D.4
  • 48
    • 0027333495 scopus 로고
    • Circulating proinsulin-like molecules
    • Yudkin JS: Circulating proinsulin-like molecules. J Diabetes Complications 1993;7:113-23.
    • (1993) J Diabetes Complications , vol.7 , pp. 113-123
    • Yudkin, J.S.1
  • 50
    • 0017250908 scopus 로고
    • Nonketotic diabetes mellitus: Insulin deficiency or insulin resistance?
    • Reaven GM, Bernstein R, Davis B, Olefsky JM. Nonketotic diabetes mellitus: insulin deficiency or insulin resistance? Am J Med 1976;60:80-8.
    • (1976) Am J Med , vol.60 , pp. 80-88
    • Reaven, G.M.1    Bernstein, R.2    Davis, B.3    Olefsky, J.M.4
  • 51
    • 0024216182 scopus 로고
    • Physiological importance of deficiency in early prandial insulin secretion in non-insulin dependent diabetes
    • Bruce DG, Chisholm DJ, Storlien LH, Kraegen EW. Physiological importance of deficiency in early prandial insulin secretion in non-insulin dependent diabetes. Diabetes 1988;37:736-44.
    • (1988) Diabetes , vol.37 , pp. 736-744
    • Bruce, D.G.1    Chisholm, D.J.2    Storlien, L.H.3    Kraegen, E.W.4
  • 53
    • 0023912106 scopus 로고
    • Day-long integrated serum insulin and C-peptide profiles in patients with NIDDM. Correlation with urinary C-peptide excretion
    • Garvey WT, Olefsky JM, Rubenstein AH, Kolterman OG. Day-long integrated serum insulin and C-peptide profiles in patients with NIDDM. Correlation with urinary C-peptide excretion. Diabetes 1988;37:590-9.
    • (1988) Diabetes , vol.37 , pp. 590-599
    • Garvey, W.T.1    Olefsky, J.M.2    Rubenstein, A.H.3    Kolterman, O.G.4
  • 54
    • 0021990787 scopus 로고
    • The effects of insulin treatment on insulin secretion and action in Type II diabetes mellitus
    • Garvey WT, Olefsky JM, Griffin J, Hammon R, Kolterman OG. The effects of insulin treatment on insulin secretion and action in Type II diabetes mellitus. Diabetes 1985;34:222-34.
    • (1985) Diabetes , vol.34 , pp. 222-234
    • Garvey, W.T.1    Olefsky, J.M.2    Griffin, J.3    Hammon, R.4    Kolterman, O.G.5
  • 56
    • 0022504076 scopus 로고
    • The effects of weight loss on the mechanisms of hyperglycemia in obese noninsulin-dependent diabetes mellitus
    • Henry RR, Wallace P, Olefsky JM. The effects of weight loss on the mechanisms of hyperglycemia in obese noninsulin-dependent diabetes mellitus. Diabetes 1986;35:990-8.
    • (1986) Diabetes , vol.35 , pp. 990-998
    • Henry, R.R.1    Wallace, P.2    Olefsky, J.M.3
  • 57
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: Genetic and clinical implications
    • Unger RH. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: genetic and clinical implications. Diabetes 1995;44:863-70.
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.H.1
  • 58
    • 0028985060 scopus 로고
    • Pancreatic β-cells in obesity: Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids
    • Milburn JL, Hirose H, Lee YH, Nagasawa Y, Ogawa A et al. Pancreatic β-cells in obesity: evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids. J Biol Chem 1995;270:1295-9.
    • (1995) J Biol Chem , vol.270 , pp. 1295-1299
    • Milburn, J.L.1    Hirose, H.2    Lee, Y.H.3    Nagasawa, Y.4    Ogawa, A.5
  • 59
    • 0027994097 scopus 로고
    • Overexpression of hexokinase I in isolated islets of langerhans via recombinant adenovirus: Enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels
    • Becker TC, BeltrandelRio H, Noel RJ, Johnson JH, Newgard CB. Overexpression of hexokinase I in isolated islets of langerhans via recombinant adenovirus: enhancement of glucose metabolism and insulin secretion at basal but not stimulatory glucose levels. J Biol Chem 1994;269:21234-8.
    • (1994) J Biol Chem , vol.269 , pp. 21234-21238
    • Becker, T.C.1    BeltrandelRio, H.2    Noel, R.J.3    Johnson, J.H.4    Newgard, C.B.5
  • 60
    • 0029920943 scopus 로고    scopus 로고
    • Defective fatty acid-mediated β-cell compensation in Zucker diabetic rats: Pathogenic implications for obesity-dependent diabetes
    • Hirose H, Lee YH, Inman LR, Nagasawa Y, Johnson JH, Unger RH. Defective fatty acid-mediated β-cell compensation in Zucker diabetic rats: pathogenic implications for obesity-dependent diabetes. J Biol Chem 1996;271:5633-7.
    • (1996) J Biol Chem , vol.271 , pp. 5633-5637
    • Hirose, H.1    Lee, Y.H.2    Inman, L.R.3    Nagasawa, Y.4    Johnson, J.H.5    Unger, R.H.6
  • 61
    • 0019415752 scopus 로고
    • Receptor and postreceptor defects contribute to the insulin resistance in non-insulin dependent diabetes mellitus
    • Kolterman OG, Gray RS, Griffin J, Burstein P, Insel J. Receptor and postreceptor defects contribute to the insulin resistance in non-insulin dependent diabetes mellitus. J Clin Invest 1981;68:957-69.
    • (1981) J Clin Invest , vol.68 , pp. 957-969
    • Kolterman, O.G.1    Gray, R.S.2    Griffin, J.3    Burstein, P.4    Insel, J.5
  • 62
    • 0025098765 scopus 로고
    • Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy
    • Shulman GI, Rothman DL, Jue T, Stein P, DeFronzo RA, Shulman RG. Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. N Engl J Med 1990;322:223-8.
    • (1990) N Engl J Med , vol.322 , pp. 223-228
    • Shulman, G.I.1    Rothman, D.L.2    Jue, T.3    Stein, P.4    DeFronzo, R.A.5    Shulman, R.G.6
  • 63
    • 0002662404 scopus 로고
    • Potential cellular and genetic mechanisms for insulin resistance in common disorders of obesity and diabetes
    • Moller D, ed. Chichester: John Wiley & Sons, Ltd
    • Seely BL, Olefsky JM. Potential cellular and genetic mechanisms for insulin resistance in common disorders of obesity and diabetes. In: Moller D, ed. Insulin resistance and its clinical disorders. Chichester: John Wiley & Sons, Ltd, 1993:187-252.
    • (1993) Insulin Resistance and Its Clinical Disorders , pp. 187-252
    • Seely, B.L.1    Olefsky, J.M.2
  • 64
    • 0028904053 scopus 로고
    • Insulin action and the insulin signaling network
    • Cheatham B, Kahn CR. Insulin action and the insulin signaling network. Endocr Rev 1995;16: 117-142.
    • (1995) Endocr Rev , vol.16 , pp. 117-142
    • Cheatham, B.1    Kahn, C.R.2
  • 65
    • 0026748806 scopus 로고
    • The role of insulin receptor kinase domain autophosphorylation in receptor mediated activities
    • Wilden PA, Siddle K, Haring H, Backer JM, White ME, Kahn CR. The role of insulin receptor kinase domain autophosphorylation in receptor mediated activities. J Biol Chem 1992;267: 13719-27.
    • (1992) J Biol Chem , vol.267 , pp. 13719-13727
    • Wilden, P.A.1    Siddle, K.2    Haring, H.3    Backer, J.M.4    White, M.E.5    Kahn, C.R.6
  • 66
    • 0023665224 scopus 로고
    • A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis
    • McClain DA, Maegawa H, Lee J, Dull TJ, Ulrich A, Olefsky JM. A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis. J Biol Chem 1987;262:14663-71.
    • (1987) J Biol Chem , vol.262 , pp. 14663-14671
    • McClain, D.A.1    Maegawa, H.2    Lee, J.3    Dull, T.J.4    Ulrich, A.5    Olefsky, J.M.6
  • 67
    • 0346310449 scopus 로고
    • Insulin action is blocked by a monoclonal antibody that inhibits the insulin receptor kinase
    • Morgan DO, Ho L, Korn LJ, Roth RA. Insulin action is blocked by a monoclonal antibody that inhibits the insulin receptor kinase. Proc Natl Acad Sci USA 1986;83:328-32.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 328-332
    • Morgan, D.O.1    Ho, L.2    Korn, L.J.3    Roth, R.A.4
  • 69
    • 0025813375 scopus 로고
    • Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
    • Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA et al. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 1991;352:73-7.
    • (1991) Nature , vol.352 , pp. 73-77
    • Sun, X.J.1    Rothenberg, P.2    Kahn, C.R.3    Backer, J.M.4    Araki, E.5    Wilden, P.A.6
  • 71
    • 0026764502 scopus 로고
    • Evidence that glucose transport is rate-limiting for in vivo glucose uptake
    • Fink RI, Wallace P, Brechtel G, Olefsky JM. Evidence that glucose transport is rate-limiting for in vivo glucose uptake. Metabolism 1992;41:897-902.
    • (1992) Metabolism , vol.41 , pp. 897-902
    • Fink, R.I.1    Wallace, P.2    Brechtel, G.3    Olefsky, J.M.4
  • 72
    • 0040440949 scopus 로고
    • Cellular defects in glucose transport: Lessons from animal models and implications for human insulin resistance
    • Moller DE, ed. Chichester: John Wiley & Sons Ltd.
    • Shepherd PR, Kahn BB. Cellular defects in glucose transport: lessons from animal models and implications for human insulin resistance. In: Moller DE, ed. Insulin resistance. Chichester: John Wiley & Sons Ltd. 1993;253-300.
    • (1993) Insulin Resistance , pp. 253-300
    • Shepherd, P.R.1    Kahn, B.B.2
  • 74
    • 0029159654 scopus 로고
    • Insulin induces translocation of Glut-4 glucose transporters in human skeletal muscle
    • Guma A, Zierath JR, Wallberg-Henriksson H, Klip A. Insulin induces translocation of Glut-4 glucose transporters in human skeletal muscle. Am J Physiol 1995;268:E613-22.
    • (1995) Am J Physiol , vol.268
    • Guma, A.1    Zierath, J.R.2    Wallberg-Henriksson, H.3    Klip, A.4
  • 76
    • 0025910841 scopus 로고
    • Pretranslational suppression of a glucose transporter protein causes cellular insulin resistance in non-insulin-dependent diabetes mellitus and obesity
    • Garvey WT, Maianu L, Huecksteadt TP, Birnbaum MJ, Molina JM, Ciaraldi TP. Pretranslational suppression of a glucose transporter protein causes cellular insulin resistance in non-insulin-dependent diabetes mellitus and obesity. J Clin Invest 1991;87:1072-81.
    • (1991) J Clin Invest , vol.87 , pp. 1072-1081
    • Garvey, W.T.1    Maianu, L.2    Huecksteadt, T.P.3    Birnbaum, M.J.4    Molina, J.M.5    Ciaraldi, T.P.6
  • 77
    • 0020576117 scopus 로고
    • In vitro insulin resistance of human adipocytes isolated from subjects with noninsulin-dependent diabetes mellitus
    • Kashiwagi A, Verso MA, Andrews J, Vasquez B, Reaven G, Foley JE. In vitro insulin resistance of human adipocytes isolated from subjects with noninsulin-dependent diabetes mellitus. J Clin Invest 1983;72:1246-54.
    • (1983) J Clin Invest , vol.72 , pp. 1246-1254
    • Kashiwagi, A.1    Verso, M.A.2    Andrews, J.3    Vasquez, B.4    Reaven, G.5    Foley, J.E.6
  • 78
    • 0024468570 scopus 로고
    • Postreceptor effects of sulfonylurea on skeletal muscle glycogen synthase activity in type II diabetic patients
    • Bak JF, Schmitz O, Sorensen NS, Pedersen O. Postreceptor effects of sulfonylurea on skeletal muscle glycogen synthase activity in type II diabetic patients. Diabetes 1989;38:1343-50.
    • (1989) Diabetes , vol.38 , pp. 1343-1350
    • Bak, J.F.1    Schmitz, O.2    Sorensen, N.S.3    Pedersen, O.4
  • 79
    • 0020409736 scopus 로고
    • Insulin resistance in non-insulin-dependent. Type II diabetes mellitus
    • Kolterman OG, Scarlett JA, Olefsky JM. Insulin resistance in non-insulin-dependent. Type II diabetes mellitus. J Clin Endocrinol Metab 1982;11:363-88.
    • (1982) J Clin Endocrinol Metab , vol.11 , pp. 363-388
    • Kolterman, O.G.1    Scarlett, J.A.2    Olefsky, J.M.3
  • 80
    • 0018379923 scopus 로고
    • Effects of streptozotocin-induced diabetes on insulin binding, glucose transport, and intracellular glucose metabolism in isolated rat adipocytes
    • Kobayashi M, Olefsky JM. Effects of streptozotocin-induced diabetes on insulin binding, glucose transport, and intracellular glucose metabolism in isolated rat adipocytes. Diabetes 1979;28:87-95.
    • (1979) Diabetes , vol.28 , pp. 87-95
    • Kobayashi, M.1    Olefsky, J.M.2
  • 81
    • 0023120916 scopus 로고
    • Decreased kinase activity of insulin receptors from adipocytes of non-insulin dependent diabetic subjects
    • Freidenberg GR, Henry RR, Klein HH, Reichart DR, Olefsky JM. Decreased kinase activity of insulin receptors from adipocytes of non-insulin dependent diabetic subjects. J Clin Invest 1987;79:240-50.
    • (1987) J Clin Invest , vol.79 , pp. 240-250
    • Freidenberg, G.R.1    Henry, R.R.2    Klein, H.H.3    Reichart, D.R.4    Olefsky, J.M.5
  • 82
    • 0019922978 scopus 로고
    • Postreceptor defects causing insulin resistance in normoinsulinemic non-insulin-dependent diabetes mellitus
    • Bolinder J, Ostman J, Arner P. Postreceptor defects causing insulin resistance in normoinsulinemic non-insulin-dependent diabetes mellitus. Diabetes 1982;31:911-6.
    • (1982) Diabetes , vol.31 , pp. 911-916
    • Bolinder, J.1    Ostman, J.2    Arner, P.3
  • 83
    • 0028079621 scopus 로고
    • Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity
    • Nolan JJ, Freidenberg G, Henry R, Reichart D, Olefsky JM. Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity. J Clin Endocrinol Metab 1993;78:471-7.
    • (1993) J Clin Endocrinol Metab , vol.78 , pp. 471-477
    • Nolan, J.J.1    Freidenberg, G.2    Henry, R.3    Reichart, D.4    Olefsky, J.M.5
  • 84
    • 0025115342 scopus 로고
    • Insulin-receptor autophosphorylation and endogenous substrate phosphorylation in human adipocytes from control, obese, and NIDDM subjects
    • Thies RS, Molina JM, Ciaraldi TP, Freidenberg GR, Olefsky JM. Insulin-receptor autophosphorylation and endogenous substrate phosphorylation in human adipocytes from control, obese, and NIDDM subjects. Diabetes 1990;39:250-9.
    • (1990) Diabetes , vol.39 , pp. 250-259
    • Thies, R.S.1    Molina, J.M.2    Ciaraldi, T.P.3    Freidenberg, G.R.4    Olefsky, J.M.5
  • 85
    • 0023107550 scopus 로고
    • Relationship of insulin binding and insulin stimulated tyrosine kinase activity is altered in type II diabetes
    • Comi RJ, Grunberger G, Gorden P. Relationship of insulin binding and insulin stimulated tyrosine kinase activity is altered in type II diabetes. J Clin Invest 1987;79:453-62.
    • (1987) J Clin Invest , vol.79 , pp. 453-462
    • Comi, R.J.1    Grunberger, G.2    Gorden, P.3
  • 86
    • 0024542180 scopus 로고
    • Mechanism of defective insulin receptor kinase activity in NIDDM: Evidence for two receptor populations
    • Brillon DR, Freidenberg GR, Henry RR, Olefsky JM: Mechanism of defective insulin receptor kinase activity in NIDDM: Evidence for two receptor populations. Diabetes 1989;38:397-403.
    • (1989) Diabetes , vol.38 , pp. 397-403
    • Brillon, D.R.1    Freidenberg, G.R.2    Henry, R.R.3    Olefsky, J.M.4
  • 87
    • 0023798487 scopus 로고
    • Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin dependent diabetes mellitus: Effects of weight loss
    • Freidenberg GR, Reichart D, Olefsky JM, Henry RR. Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin dependent diabetes mellitus: effects of weight loss. J Clin Invest 1988;82:1398-406.
    • (1988) J Clin Invest , vol.82 , pp. 1398-1406
    • Freidenberg, G.R.1    Reichart, D.2    Olefsky, J.M.3    Henry, R.R.4
  • 88
    • 0019990913 scopus 로고
    • Insulin receptor binding to fat and blood cells and insulin action in fat cells from insulin-dependent diabetics
    • Pedersen O, Hjollund E. Insulin receptor binding to fat and blood cells and insulin action in fat cells from insulin-dependent diabetics. Diabetes 1982;31:706-715.
    • (1982) Diabetes , vol.31 , pp. 706-715
    • Pedersen, O.1    Hjollund, E.2
  • 90
    • 0026577332 scopus 로고
    • Restoration of insulin-responsiveness in skeletal muscle of morbidly obese patients after weight loss: Effect on muscle glucose transport and glucose transporter Glut 4
    • Freidman JE, Dohm GL, Leggett-Frazier N et al. Restoration of insulin-responsiveness in skeletal muscle of morbidly obese patients after weight loss: effect on muscle glucose transport and glucose transporter Glut 4. J Clin Invest 1992;89:701-5.
    • (1992) J Clin Invest , vol.89 , pp. 701-705
    • Freidman, J.E.1    Dohm, G.L.2    Leggett-Frazier, N.3
  • 91
    • 0023682344 scopus 로고
    • Correlations between in vivo and in vitro actions of insulin in obesity and diabetes
    • Garvey WT, Kolterman OG. Correlations between in vivo and in vitro actions of insulin in obesity and diabetes. Diabetes Metab Rev 1988;4:543-70.
    • (1988) Diabetes Metab Rev , vol.4 , pp. 543-570
    • Garvey, W.T.1    Kolterman, O.G.2
  • 92
    • 0026504690 scopus 로고
    • Insulin resistance in Type 2 (non-insulin-dependent) diabetic patients and their relatives is not associated with a defect in the expression of the insulin-responsive glucose transporter (GLUT-4) gene in human skeletal muscle
    • Eriksson J, Koranyi L, Bourey R, Schalin-Jantti C, Widen E, Mueckler M, Permutt AM, Groop LC. Insulin resistance in Type 2 (non-insulin-dependent) diabetic patients and their relatives is not associated with a defect in the expression of the insulin-responsive glucose transporter (GLUT-4) gene in human skeletal muscle. Diabetologia 1992;35:143-7.
    • (1992) Diabetologia , vol.35 , pp. 143-147
    • Eriksson, J.1    Koranyi, L.2    Bourey, R.3    Schalin-Jantti, C.4    Widen, E.5    Mueckler, M.6    Permutt, A.M.7    Groop, L.C.8
  • 93
    • 0026747664 scopus 로고
    • Expression of Glut 1 and Glut 4 glucose transporters in skeletal muscle of humans with insulin dependent diabetes mellitus: Regulatory effects of metabolic factors
    • Kahn BB, Rosen AS, Bak JF, et al. Expression of Glut 1 and Glut 4 glucose transporters in skeletal muscle of humans with insulin dependent diabetes mellitus: Regulatory effects of metabolic factors. J Clin Endocrinol Metab 1992;74:1101-9.
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 1101-1109
    • Kahn, B.B.1    Rosen, A.S.2    Bak, J.F.3
  • 94
    • 0026731869 scopus 로고
    • Glucose toxicity
    • Yki-Jarvinen H. Glucose toxicity. Endocr Rev 1992;13:415-31.
    • (1992) Endocr Rev , vol.13 , pp. 415-431
    • Yki-Jarvinen, H.1
  • 95
    • 0026362778 scopus 로고
    • Diacylglycerol-protein kinase C signaling in skeletal muscle: A possible link to insulin resistance
    • Chen KS, Heydrick S, Kurowski T, Ruderman NB. Diacylglycerol-protein kinase C signaling in skeletal muscle: a possible link to insulin resistance. Trans Assoc Amer Physicians 1991;104:206-12.
    • (1991) Trans Assoc Amer Physicians , vol.104 , pp. 206-212
    • Chen, K.S.1    Heydrick, S.2    Kurowski, T.3    Ruderman, N.B.4
  • 96
    • 0026015007 scopus 로고
    • Prevention by protein kinase C inhibitors of glucose-induced insulin receptor tyrosine kinase resistance in rat fat cells
    • Muller HK, Kellerer M, Ermel B, Muhlhofer A, Obermaier-Kusser B, Vogt B, Haring HU. Prevention by protein kinase C inhibitors of glucose-induced insulin receptor tyrosine kinase resistance in rat fat cells. Diabetes 1991;40:1440-8.
    • (1991) Diabetes , vol.40 , pp. 1440-1448
    • Muller, H.K.1    Kellerer, M.2    Ermel, B.3    Muhlhofer, A.4    Obermaier-Kusser, B.5    Vogt, B.6    Haring, H.U.7
  • 97
    • 0029111429 scopus 로고
    • Mechanism of insulin receptor kinase inhibition in non-insulin-dependent diabetes mellitus patients. Phosphorylation of serine 1327 or threonine 1348 is unaltered
    • Kellerer M, Coghlan M, Capp E, Muhlhofer A, Kroder G, Mosthaf L, Galente P, Siddle K, Haring HU. Mechanism of insulin receptor kinase inhibition in non-insulin-dependent diabetes mellitus patients. Phosphorylation of serine 1327 or threonine 1348 is unaltered. J Clin Invest 1995;96:6-11.
    • (1995) J Clin Invest , vol.96 , pp. 6-11
    • Kellerer, M.1    Coghlan, M.2    Capp, E.3    Muhlhofer, A.4    Kroder, G.5    Mosthaf, L.6    Galente, P.7    Siddle, K.8    Haring, H.U.9
  • 98
    • 0024841370 scopus 로고
    • Activation of glucose transport in skeletal muscle by phospholipase C and phorbol ester
    • Henriksen EJ, Rodnick KJ, Holloszy JO. Activation of glucose transport in skeletal muscle by phospholipase C and phorbol ester. J Biol Chem 1989;264:21536-43.
    • (1989) J Biol Chem , vol.264 , pp. 21536-21543
    • Henriksen, E.J.1    Rodnick, K.J.2    Holloszy, J.O.3
  • 100
    • 0027418067 scopus 로고
    • Overexpression of protein kinase C isoenzymes α, βI, γ, and ∈ in cells overexpressing the insulin receptor: Effects on receptor phosphorylation and signaling
    • Chin JE, Dickens M, Tavare JM, Roth RA. Overexpression of protein kinase C isoenzymes α, βI, γ, and ∈ in cells overexpressing the insulin receptor: effects on receptor phosphorylation and signaling. J Biol Chem 1993;268:6338-47.
    • (1993) J Biol Chem , vol.268 , pp. 6338-6347
    • Chin, J.E.1    Dickens, M.2    Tavare, J.M.3    Roth, R.A.4
  • 101
    • 0025855139 scopus 로고
    • Discovery of a metabolic pathway mediating desensitization of the glucose transport system: Role of hexosamine biosynthesis in the induction of insulin resistance
    • Marshall S, Bacote V, Traxinger RR. Discovery of a metabolic pathway mediating desensitization of the glucose transport system: role of hexosamine biosynthesis in the induction of insulin resistance. J Biol Chem 1992;266:4706-12.
    • (1992) J Biol Chem , vol.266 , pp. 4706-4712
    • Marshall, S.1    Bacote, V.2    Traxinger, R.R.3
  • 102
    • 0029115944 scopus 로고
    • In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats
    • Rossetti L, Hawkins M, Chen W, Gindi J, Barzilai N. In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats. J Clin Invest 1995;96:132-40.
    • (1995) J Clin Invest , vol.96 , pp. 132-140
    • Rossetti, L.1    Hawkins, M.2    Chen, W.3    Gindi, J.4    Barzilai, N.5
  • 103
    • 8244244207 scopus 로고
    • Glutamine: Fructose-6-phosphate amidotransferase (GFA) activity in skeletal muscle of patients with IDDM and NIDDM
    • Yki-Jarvinen H, Daniels MC, Makimattila S, Virkamaki A, DeFronzo RA. Glutamine: fructose-6-phosphate amidotransferase (GFA) activity in skeletal muscle of patients with IDDM and NIDDM. Diabetes 1995;44(1 Suppl):16A.
    • (1995) Diabetes , vol.44 , Issue.1 SUPPL.
    • Yki-Jarvinen, H.1    Daniels, M.C.2    Makimattila, S.3    Virkamaki, A.4    DeFronzo, R.A.5
  • 104
    • 0027275367 scopus 로고
    • Pre-exposure to glucosamine induces insulin resistance of glucose transport and glycogen synthesis in isolated rat skeletal muscles: Study of mechanisms in muscle and in rat-1 fibroblasts overexpressing the human insulin receptor
    • Robinson KA, Sens DA, Buse MG. Pre-exposure to glucosamine induces insulin resistance of glucose transport and glycogen synthesis in isolated rat skeletal muscles: study of mechanisms in muscle and in rat-1 fibroblasts overexpressing the human insulin receptor. Diabetes 1993;42:1333-46.
    • (1993) Diabetes , vol.42 , pp. 1333-1346
    • Robinson, K.A.1    Sens, D.A.2    Buse, M.G.3
  • 105
    • 8244234098 scopus 로고
    • Glucosamine (Glmn) induces insulin resistance (IR) in vivo by affecting glut 4 translocation in skeletal muscle: Implications for glucose toxicity
    • Baron AD, Zhu J-S et al. Glucosamine (Glmn) induces insulin resistance (IR) in vivo by affecting glut 4 translocation in skeletal muscle: implications for glucose toxicity. Diabetes 1995;44(1 suppl):15A.
    • (1995) Diabetes , vol.44 , Issue.1 SUPPL.
    • Baron, A.D.1    Zhu, J.-S.2
  • 106
    • 0023124668 scopus 로고
    • Glucose and insulin co-regulate the glucose transport system in primary cultured adipocytes
    • Garvey WT, Olefsky JM, Mathei S, Marshall S. Glucose and insulin co-regulate the glucose transport system in primary cultured adipocytes. J Biol Chem 1987;262:189-97.
    • (1987) J Biol Chem , vol.262 , pp. 189-197
    • Garvey, W.T.1    Olefsky, J.M.2    Mathei, S.3    Marshall, S.4
  • 107
    • 0028587742 scopus 로고    scopus 로고
    • Tumor necrosis factor α: A key component of the obesity-diabetes link
    • Hotamisligil SG, Spiegelman BM. Tumor necrosis factor α: a key component of the obesity-diabetes link. Diabetes 43:1271-8.
    • Diabetes , vol.43 , pp. 1271-1278
    • Hotamisligil, S.G.1    Spiegelman, B.M.2
  • 108
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance
    • Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance. J Clin Invest 1995;95:2409-15.
    • (1995) J Clin Invest , vol.95 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5
  • 110
    • 0026549669 scopus 로고
    • Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output
    • Lang CH, Dobrescu C, Bagby GJ. Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinology 1992;130:43-52.
    • (1992) Endocrinology , vol.130 , pp. 43-52
    • Lang, C.H.1    Dobrescu, C.2    Bagby, G.J.3
  • 111
    • 0027288234 scopus 로고
    • Short-term effects of tumor necrosis factor on energy and substrate metabolism in dogs
    • Sakurai Y, Zhang X, Wolfe RR. Short-term effects of tumor necrosis factor on energy and substrate metabolism in dogs. J Clin Invest 1993;91:2437-45.
    • (1993) J Clin Invest , vol.91 , pp. 2437-2445
    • Sakurai, Y.1    Zhang, X.2    Wolfe, R.R.3
  • 112
    • 0028031569 scopus 로고
    • Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes: Central role of tumor necrosis factor-α
    • Hotamisligil GS, Budavari A, Murray D, Spiegelman BM. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes: central role of tumor necrosis factor-α. J Clin Invest 1994;94:1543-9.
    • (1994) J Clin Invest , vol.94 , pp. 1543-1549
    • Hotamisligil, G.S.1    Budavari, A.2    Murray, D.3    Spiegelman, B.M.4
  • 113
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α and obesity-induced insulin resistance
    • Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α and obesity-induced insulin resistance. Science 1996;271:665-8.
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 114
    • 0024358163 scopus 로고
    • Tumor necrosis factor enhances glucose uptake by peripheral tissues
    • Evans, DA, Jacobs DO, Wilmore DW. Tumor necrosis factor enhances glucose uptake by peripheral tissues. Am J Physiol 1989;257:R1182-9.
    • (1989) Am J Physiol , vol.257
    • Evans, D.A.1    Jacobs, D.O.2    Wilmore, D.W.3
  • 115
    • 0027741390 scopus 로고
    • Rad: A member of the ras family overexpressed in muscle of Type II diabetic humans
    • Reynet C, Kahn CR. Rad: A member of the ras family overexpressed in muscle of Type II diabetic humans. Science 1993;262:1441-4.
    • (1993) Science , vol.262 , pp. 1441-1444
    • Reynet, C.1    Kahn, C.R.2
  • 116
    • 0028935733 scopus 로고
    • Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity
    • Zhu J, Reynet C, Caldwell JS, Kahn CR. Characterization of Rad, a new member of Ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity. J Biol Chem 1995;270:4805-12.
    • (1995) J Biol Chem , vol.270 , pp. 4805-4812
    • Zhu, J.1    Reynet, C.2    Caldwell, J.S.3    Kahn, C.R.4
  • 117
    • 33749869880 scopus 로고
    • A role for rad as an inhibitor of insulin-stimulated glucose transport
    • Moyers JS, Reynet C, Zhu J, Bilan PJ, Kahn CR. A role for rad as an inhibitor of insulin-stimulated glucose transport. Diabetes 1995;44(1 Suppl):302.
    • (1995) Diabetes , vol.44 , Issue.1 SUPPL. , pp. 302
    • Moyers, J.S.1    Reynet, C.2    Zhu, J.3    Bilan, P.J.4    Kahn, C.R.5
  • 118
    • 33749830118 scopus 로고
    • Rad expression in human skeletal muscle correlates inversely with insulin-stimulated glucose disposal
    • Patti ME, Vestergaard H, Reynet C, Moyers J, Pedersen O, Kahn CR. Rad expression in human skeletal muscle correlates inversely with insulin-stimulated glucose disposal [abstract]. J Investig Med 1995;43(2 Suppl):322A.
    • (1995) J Investig Med , vol.43 , Issue.2 SUPPL.
    • Patti, M.E.1    Vestergaard, H.2    Reynet, C.3    Moyers, J.4    Pedersen, O.5    Kahn, C.R.6
  • 121
    • 0025981283 scopus 로고
    • Production of inhibitor of insulin-receptor tyrosine kinase in fibroblasts from patients with insulin resistance and NIDDM
    • Sbraccia P, Goodman PA, Maddux BA, Wong KY, Chen YD-I, Reaven GM, Goldfine ID. Production of inhibitor of insulin-receptor tyrosine kinase in fibroblasts from patients with insulin resistance and NIDDM. Diabetes 1991;40:295-9.
    • (1991) Diabetes , vol.40 , pp. 295-299
    • Sbraccia, P.1    Goodman, P.A.2    Maddux, B.A.3    Wong, K.Y.4    Chen, Y.D.-I.5    Reaven, G.M.6    Goldfine, I.D.7
  • 122
    • 0028834040 scopus 로고
    • The genetics of noninsulin-dependent diabetes mellitus
    • Pillay TS, Langlois WJ, Olefsky JM. The genetics of noninsulin-dependent diabetes mellitus. Adv Genet 1995;32:51-98.
    • (1995) Adv Genet , vol.32 , pp. 51-98
    • Pillay, T.S.1    Langlois, W.J.2    Olefsky, J.M.3
  • 123
    • 0027367546 scopus 로고
    • Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus
    • Almind K, Bjorbaek C, Vestergaard H, Hansen T, Echwald S, Pedersen O. Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus. Lancet 1993;342:828-32.
    • (1993) Lancet , vol.342 , pp. 828-832
    • Almind, K.1    Bjorbaek, C.2    Vestergaard, H.3    Hansen, T.4    Echwald, S.5    Pedersen, O.6
  • 124
    • 33749434368 scopus 로고    scopus 로고
    • Transfection studies of insulin receptor substrate-1 with variant sequences found in patients with non-insulin-dependent diabetes mellitus
    • Imai Y, Philippe N, Sesti G, Accili D, Taylor SI. Transfection studies of insulin receptor substrate-1 with variant sequences found in patients with non-insulin-dependent diabetes mellitus [abstract]. J Investig Med 1996;44(3 Suppl):259A.
    • (1996) J Investig Med , vol.44 , Issue.3 SUPPL.
    • Imai, Y.1    Philippe, N.2    Sesti, G.3    Accili, D.4    Taylor, S.I.5
  • 125
    • 0021258643 scopus 로고
    • Correlation between muscle glycogen synthase activity and in vivo insulin action in man
    • Bogardus C, Lillioja S, Stone K, Mott D. Correlation between muscle glycogen synthase activity and in vivo insulin action in man. J Clin Invest 1984;73:1185-90.
    • (1984) J Clin Invest , vol.73 , pp. 1185-1190
    • Bogardus, C.1    Lillioja, S.2    Stone, K.3    Mott, D.4
  • 126
    • 0028804624 scopus 로고
    • Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and phosphatase-1 genes in muscle from NIDDM patients
    • Bjorbaek C, Vik TA, Echwald SM, Yang P-Y, Vestergaard H, Wang JP, Webb GC et al. Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and phosphatase-1 genes in muscle from NIDDM patients. Diabetes 1995;44:90-7.
    • (1995) Diabetes , vol.44 , pp. 90-97
    • Bjorbaek, C.1    Vik, T.A.2    Echwald, S.M.3    Yang, P.-Y.4    Vestergaard, H.5    Wang, J.P.6    Webb, G.C.7
  • 127
    • 0028914027 scopus 로고
    • Amino acid substitutions in hexokinase II among patients with NIDDM
    • Laasko M, Malkki M, Deeb SS. Amino acid substitutions in hexokinase II among patients with NIDDM. Diabetes 1995;44:330-4.
    • (1995) Diabetes , vol.44 , pp. 330-334
    • Laasko, M.1    Malkki, M.2    Deeb, S.S.3
  • 128
    • 0029084088 scopus 로고
    • Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the β3 adrenergic receptor gene
    • Walston J, Silver K, Bogardus C et al. Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the β3 adrenergic receptor gene. N Engl J Med 1995;333:343-7.
    • (1995) N Engl J Med , vol.333 , pp. 343-347
    • Walston, J.1    Silver, K.2    Bogardus, C.3
  • 129
    • 0028978913 scopus 로고
    • Association of a polymorphism in the β3 adrenergic receptor gene with features of insulin resistance syndrome in Finns
    • Widen E, Lehto M, Kanninen T, Walston J, Shuldiner AR, Groop LC. Association of a polymorphism in the β3 adrenergic receptor gene with features of insulin resistance syndrome in Finns. N Engl J Med 1995;333:348-51.
    • (1995) N Engl J Med , vol.333 , pp. 348-351
    • Widen, E.1    Lehto, M.2    Kanninen, T.3    Walston, J.4    Shuldiner, A.R.5    Groop, L.C.6
  • 130
    • 0025887770 scopus 로고
    • Use of DNA polymorphisms for genetic analysis of non-insulin-dependent diabetes mellitus
    • Permutt MA. Use of DNA polymorphisms for genetic analysis of non-insulin-dependent diabetes mellitus. Baillere's Clin Endocrinol Metab 1991;5:495-526.
    • (1991) Baillere's Clin Endocrinol Metab , vol.5 , pp. 495-526
    • Permutt, M.A.1


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