Lack of β-catenin in early life induces abnormal glucose homeostasis in mice

Diabetologia

Volumn 52, Issue 8, 2009, Pages 1608-1617

  Dabernat, S ^a,b,c   Secrest, P ^a   Peuchant, E ^b,c   Moreau Gaudry, F ^b,c   Dubus, P ^b   Sarvetnick, N ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITÉ DE BORDEAUX   (France)

^c INSERM   (France)

Author keywords

Beta cell; Beta catenin; Insulin secretion; Pancreas; WNT

Indexed keywords

BETA CATENIN; GLUCOSE; INSULIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; TRANSCRIPTION FACTOR PDX 1; WNT1 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA CATENIN GENE; CONTROLLED STUDY; GENE DELETION; GLUCOSE HOMEOSTASIS; IN VITRO STUDY; MOUSE; MOUSE STRAIN; MOUSE STRAIN RIP CRE; NONHUMAN; PANCREAS FUNCTION; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS;

EID: 67650670655     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1411-y     Document Type: Article

References (44)

1. JE Nieset AR Redfield F Jin KA Knudsen KR Johnson MJ Wheelock 1997 Characterization of the interactions of alpha-catenin with alpha-actinin and beta-catenin/plakoglobin J Cell Sci 110 1013 1022 (Pubitemid 27216121)
2. H Aberle A Bauer J Stappert A Kispert R Kemler 1997 Beta-catenin is a target for the ubiquitin-proteasome pathway EMBO J 16 3797 3804
3. WJ Nelson R Nusse 2004 Convergence of Wnt, beta-catenin, and cadherin pathways Science (New York, NY) 303 1483 1487 (Pubitemid 38314410)
4. MW Fear DP Kelsell NK Spurr MR Barnes 2000 Wnt-16a, a novel Wnt-16 isoform, which shows differential expression in adult human tissues Biochem Biophys Res Commun 278 814 820
5. RS Heller DS Dichmann J Jensen 2002 Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation Dev Dyn 225 260 270 (Pubitemid 35265801)
6. RS Heller T Klein Z Ling 2003 Expression of Wnt, Frizzled, sFRP, and DKK genes in adult human pancreas Gene Expr 11 141 147 (Pubitemid 37516647)
7. E Hu Y Zhu T Fredrickson 1998 Tissue restricted expression of two human Frzbs in preadipocytes and pancreas Biochem Biophys Res Commun 247 287 293 (Pubitemid 28420815)
8. N Sagara G Toda M Hirai M Terada M Katoh 1998 Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7 Biochem Biophys Res Commun 252 117 122 (Pubitemid 28534636)
9. S Papadopoulou H Edlund 2005 Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function Diabetes 54 2844 2851 (Pubitemid 41401078)
10. J Huelsken R Vogel V Brinkmann B Erdmann C Birchmeier W Birchmeier 2000 Requirement for beta-catenin in anterior-posterior axis formation in mice J Cell Biol 148 567 578 (Pubitemid 30682568)
11. J Dessimoz C Bonnard J Huelsken A Grapin-Botton 2005 Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development Curr Biol 15 1677 1683 (Pubitemid 41323747)
12. LC Murtaugh AC Law Y Dor DA Melton 2005 Beta-catenin is essential for pancreatic acinar but not islet development Development 132 4663 4674 (Pubitemid 41685277)
13. JM Wells F Esni GP Boivin 2007 Wnt/beta-catenin signaling is required for development of the exocrine pancreas BMC Dev Biol 7 4
14. PW Heiser J Lau MM Taketo PL Herrera M Hebrok 2006 Stabilization of β-catenin impacts pancreas growth Development 133 2023 2032 (Pubitemid 43881267)
15. A Strom C Bonal R Ashery-Padan 2007 Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas Development 134 2719 2725 (Pubitemid 47305051)
16. IC Rulifson SK Karnik PW Heiser 2007 Wnt signaling regulates pancreatic beta cell proliferation Proc Natl Acad Sci USA 104 6247 6252 (Pubitemid 47186080)
17. PW Heiser DA Cano L Landsman 2008 Stabilization of beta-catenin induces pancreas tumor formation Gastroenterology 135 1288 1300
18. LC Murtaugh 2008 The what, where, when and how of Wnt/beta-catenin signaling in pancreas development Organogenesis 4 81 86 (Pubitemid 351881304)
19. T Fujino H Asaba MJ Kang 2003 Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion Proc Natl Acad Sci USA 100 229 234 (Pubitemid 36078057)
20. V Lyssenko A Jonsson P Almgren 2008 Clinical risk factors, DNA variants, and the development of type 2 diabetes N Engl J Med 359 2220 2232
21. G da Silva Xavier MK Loder A McDonald 2009 TCF7L2 regulates late events in insulin secretion from pancreatic islet β-cells Diabetes 58 894 905
22. V Brault R Moore S Kutsch 2001 Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development Development 128 1253 1264 (Pubitemid 32409648)
23. C Postic M Shiota KD Niswender 1999 Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase J Biol Chem 274 305 315 (Pubitemid 29035064)
24. S Gorogawa Y Fujitani H Kaneto 2004 Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice Biochem Biophys Res Commun 319 1159 1170 (Pubitemid 38759533)
25. M Pende SC Kozma M Jaquet 2000 Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice Nature 408 994 997 (Pubitemid 32103292)
26. RL Hole MC Pian-Smith GW Sharp 1988 Development of the biphasic response to glucose in fetal and neonatal rat pancreas Am J Physiol 254 E167 E174
27. J Roccisana V Reddy RC Vasavada JA Gonzalez-Pertusa MA Magnuson A Garcia-Ocana 2005 Targeted inactivation of hepatocyte growth factor receptor c-met in beta-cells leads to defective insulin secretion and GLUT-2 downregulation without alteration of beta-cell mass Diabetes 54 2090 2102 (Pubitemid 40911272)
28. I Rooman J Lardon L Bouwens 2002 Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue Diabetes 51 686 690 (Pubitemid 34760176)
29. E Bernal-Mizrachi W Wen S Stahlhut CM Welling MA Permutt 2001 Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia J Clin Invest 108 1631 1638 (Pubitemid 33144873)
30. M Gannon C Shiota C Postic CV Wright M Magnuson 2000 Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas Genesis 26 139 142 (Pubitemid 30158100)
31. G Gu J Dubauskaite DA Melton 2002 Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors Development 129 2447 2457 (Pubitemid 34863851)
32. M Gannon PL Herrera CV Wright 2000 Mosaic Cre-mediated recombination in pancreas using the pdx-1 enhancer/promoter Genesis 26 143 144 (Pubitemid 30158101)
33. C Dai CG Huh SS Thorgeirsson Y Liu 2005 Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance Am J Pathol 167 429 436 (Pubitemid 43026099)
34. NJ Sund MZ Vatamaniuk M Casey 2001 Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia Genes Dev 15 1706 1715 (Pubitemid 32702591)
35. JY Hahn HJ Cho JW Bae 2006 Beta-catenin overexpression reduces myocardial infarct size through differential effects on cardiomyocytes and cardiac fibroblasts J Biol Chem 281 30979 30989
36. LC Zelarayan C Noack B Sekkali 2008 Beta-catenin downregulation attenuates ischemic cardiac remodeling through enhanced resident precursor cell differentiation Proc Natl Acad Sci USA 105 19762 19767
37. M Bogdani K Suenens T Bock M Pipeleers-Marichal P In't Veld D Pipeleers 2005 Growth and functional maturation of beta-cells in implants of endocrine cells purified from prenatal porcine pancreas Diabetes 54 3387 3394 (Pubitemid 43334327)
38. K Inoki H Ouyang T Zhu 2006 TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth Cell 126 955 968 (Pubitemid 44310775)
39. MA Slavik BL Allen-Hoffmann BY Liu CM Alexander 2007 Wnt signaling induces differentiation of progenitor cells in organotypic keratinocyte cultures BMC Dev Biol 7 9
40. MK Loder G da Silva Xavier A McDonald GA Rutter 2008 TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells Biochem Soc Trans 36 357 359 (Pubitemid 351839331)
41. N Cameron EW Demerath 2002 Critical periods in human growth and their relationship to diseases of aging Am J Phys Anthropol Suppl 35 159 184 (Pubitemid 36109386)
42. JY Lee M Ristow X Lin MF White MA Magnuson L Hennighausen 2006 RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function J Biol Chem 281 2649 2653 (Pubitemid 43845726)
43. J Martin SL Hunt P Dubus 2003 Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number Oncogene 22 5261 5269 (Pubitemid 37056088)
44. E Prodi S Obici 2006 Minireview: the brain as a molecular target for diabetic therapy Endocrinology 147 2664 2669 (Pubitemid 43764601)