Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation

Developmental Dynamics

Volumn 225, Issue 3, 2002, Pages 260-270

  Heller, R Scott ^a   Dichmann, Darwin S ^a   Jensen, Jan ^b   Miller, Chris ^c   Wong, Gordon ^c   Madsen, Ole D ^a   Serup, Palle ^a  

^a HAGEDORN RESEARCH INSTITUTE   (Denmark)

^b UNIVERSITY OF COLORADO   (United States)

^c PFIZER INC   (United States)

Author keywords

Duodenum; Frizzled; Gene expression; In situ hybridization; Mouse; Pancreas; PCR; sFRP; Stomach; Transgenic mice; Wnt

Indexed keywords

FRIZZLED PROTEIN; PROTEIN; PROTEIN FRP; PROTEIN WNT2B; PROTEIN WNT7B; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; WNT PROTEIN; WNT11 PROTEIN; WNT5A PROTEIN; CELL SURFACE RECEPTOR; FZD2 PROTEIN, HUMAN; FZD2 PROTEIN, MOUSE; FZD4 PROTEIN, MOUSE; FZD5 PROTEIN, MOUSE; FZD6 PROTEIN, HUMAN; FZD6 PROTEIN, MOUSE; FZD7 PROTEIN, MOUSE; FZD9 PROTEIN, MOUSE; FZD9 PROTEIN, RAT; G PROTEIN COUPLED RECEPTOR; GLYCOPROTEIN; NEUROTRANSMITTER RECEPTOR; ONCOPROTEIN; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR; WNT2B PROTEIN, MOUSE; WNT2B PROTEIN, RAT; WNT5A PROTEIN, MOUSE; WNT5B PROTEIN, MOUSE; WNT7B PROTEIN, HUMAN; WNT7B PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASPLENIA; CELL ADHESION; CELL MOTION; DUODENUM; EMBRYO PATTERN FORMATION; FETUS; GENE EXPRESSION; GENE OVEREXPRESSION; IMMUNOCYTOCHEMISTRY; IN SITU HYBRIDIZATION; INTESTINE; MESENCHYME; MORPHOGENESIS; MOUSE; NONHUMAN; PANCREAS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TRANSGENE; TRANSGENIC MOUSE; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; KINETICS; PHYSIOLOGY; PRENATAL DEVELOPMENT; STOMACH;

MUS MUSCULUS;

ANIMALS; DUODENUM; FRIZZLED RECEPTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLYCOPROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; MICE; MICE, TRANSGENIC; PANCREAS; PROTEINS; PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROTRANSMITTER; STOMACH; TRANSCRIPTION FACTORS; WNT PROTEINS;

EID: 0036842027     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/dvdy.10157     Document Type: Article

References (57)

1. Apelqvist A, Ahlgren U, Edlund H, 1997. Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Current Biol 7:801-804.
2. Bhanot P, Brink M, Samos CH, Hsieh JC, Wang YS, Macke JP, Andrew D, Nathans J, Nusse R. 1996. A new member of the frizzled family from drosophila functions as a wingless receptor. Nature 382:225-230.
3. Bienz M. 1994. Homeotic genes and positional signalling in the Drosophila viscera. TIG 10:22-26.
4. Blume N, Petersen JS, Andersen LC, Kofod H, Dyrberg T, Michelsen BK, Serup P, Madsen OD. 1992. Immature transformed rat islet beta-cells differentially express C-peptides derived from the genes coding for insulin I and II as well a transfected human insulin gene. Mol Endocrinol 6:299-307.
5. Crisera CA, Rose MI, Connely PR, Li M, Colen KL, Longaker MT, Gittes GK. 1999. The Ontogeny of TGF-β1, -β2, -β3, and TGF β receptor II expression in the pancreas: Implications for regulation of growth and differentiation. J Pediatr Surg 34:689-694.
6. Echelard Y, Epstein DJ, St-Jaques Y, Shen L, Mohler J, McMahon J, McMahon A. 1993. Sonic Hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75:1417-1430.
7. Edlund H. 1999. Pancreas: How to get there from the Gut? Curr Opin Cell Biol 11:663-668.
8. Gavin BJ, McMahon JA, McMahon AP. 1990. Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev 4:2319-2332.
9. Gradwohl G, Fode C, Guillemot F. 1996. Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors. Dev Biol 180:227-241.
10. Han M. 1997. Gut reaction to Wnt signaling in worms. Cell 90:581-584.
11. Hogan B, Beddington R, Costantini F, Lacy E. 1994. Manipulating the Mouse Embryo: A Laboratory Manual. 2nd Ed. Cold Spring Harbor: Cold Spring Harbor Press.
12. Hogan B. 1999. Morphogenesis. Cell 96:225-233.
13. Hu E, Zhu Y, Fredrickson T, Barnes M, Kelsell D, Beeley L, Brooks D. 1998. Tissue restricted expression of two human Frzbs in preadipocytes and pancreas. Biochem Biophys Res Commun 247:287-293.
14. Jensen J, Serup P, Karlsen C, Nielsen TF, Madsen OD. 1996. mRNA profiling of rat islet tumors relieves Nkx6.1 as a b-cell specific homeodomain transcription factor. J Biol Chem 271:18749-18758.
15. Jensen J, Heller RS, Nielsen TF, Pedersen EE, Lindsell C, Weinmaster G, Madsen OD, Serup P. 2000. Independent development of pancreatic α and β cells from neurogenin-3 expressing precursors. A role for the notch pathway in repression of premature differentiation. Diabetes 49:163-176.
16. Kim SK, Hebrok M. 2001. Intracellular signals regulating pancreas development and function. Genes Dev 15:111-127.
17. Kim SK, Melton DA. 1998. Pancreas development is promoted by cyclopamine, a hedgehog signalling inhibitor. Proc Natl Acad Sci U S A 95:13036-13041.
18. Kim SK, Hebrok M, Li E, Oh SP, Schrewe H, Harmon EB, Lee JS, Melton DA. 2000. Activin receptor patterning of foregut organogenesis. Genes Dev 14:1866-1871.
19. Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B. 1999. Functional and structural diversity of the human Dickkopf gene family. Gene 238:301-313.
20. Kühl M, Sheldahl LC, Park M, Miller JR, Moon RT. 2000. The Wnt/Ca2+ pathway: A new vertebrate Wnt signaling pathway takes shape. TIG 16:279-283.
21. Lako M, Strachan T, Bullen P, Wilson DI, Robson SC, Lindsay S. 1998. Isolation, characterization and embryonic expression of Wnt11, a gene which maps to 11q13.5 and has possible roles in the development of skeleton, kidney and lung. Gene 219:101-110.
22. Lin Y, Liu A, Zhang S, Ruusunen T, Drummond I, Vanio S. 2001. Induction of ureter branching as a response to Wnt-2b signalling during early kidney organogenesis. Dev Dyn 222:26-39.
23. Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C. 2001. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411:321-325.
24. Malik TH, Shivdasani RA. 2000. Structure and expression of a novel frizzled gene isolated from the developing mouse gut. Biochem J 349:829-834.
25. McMahon AP, Bradley A. 1990. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62:1073-1085.
26. Miller CP, McGehee RE, Habener JF. 1994. IDX-1: A new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostain gene. EMBO J 13: 1145-1156.
27. Miralles F, Czernichow P, Ozaki K, Itoh N, Scharfmann R. 1999. Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas. Proc Natl Acad Sci U S A 96:6267-6272.
28. Niehrs C. 1999. Head in the WNT: The molecular nature of the Spemann's head organizer. Trends Genet 15:314-319.
29. Nusse R, Varmus HE. 1992. Wnt genes. Cell 69:1073-1087.
30. Nusse R. Wnt. Available at: http://www.stanford.edu/musse/wntwindow.html. (August 2002).
31. Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BLM, Wright CVE. 1996. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122:983-995.
32. Parr BA, McMahon AP. 1994. Wnt genes and vertebrate development. Curr Opin Genet Dev 4:523-528.
33. Parr BA, McMahon AP. 1995. Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature 374:350-353.
34. Pictet R, Rutter WJ. 1972. Development of the embryonic endocrine pancreas. In: Steiner DF, Frenkel N, editors. Handbook of Physiology. Sect. 7. Vol. 1, American Physiological Society. Washington DC: Williams and Wilkins. p 25-66.
35. Pinson KL, Brenan J, Monkley S, Avery BJ, Skarnes WC. 2000. An LDL-receptor related protein mediates Wnt signaling in mice. Nature 407:535-538.
36. Rattner A, Hsieh JC, Smallwood PM, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J. 1997. A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A 94:2859-2863.
37. Sarkar L, Cobourne M, Naylor S, Smalley M, Dale T, Sharpe PT. 2000. Wnt7b and Shh interactions regulate ectodermal boundary formation during mammalian tooth development. Proc Natl Acad Sci U S A 97:4520-4524.
38. Sanvito F, Herrera P-L, Huarte J, Nichols A, Montesano R, Orci L, Vassalli J-D. 1994. TGF-β1 influences the relative development of the exocrine and endocrine pancreas in vitro. Development 120:3451-3462.
39. Sasaki H, Hogan BLM. 1994. HNF-3β as a regulator of floor plate development. Cell 76:103-115.
40. Schaeren-Wiemers N, Gerfin-Moser A. 1993. A single protocol to detect transcripts of carious types and expression levels in neural tissue and cultured cells: In situ hybridization using digoxigenin-labeled cRNA probes. Histochemistry 100:431-440.
41. Shibamoto S, Higano K, Takada R, Ito F, Takeichi M, Takada S. 1998. Cytoskeletal reorganisation by soluble Wnt3a protein signaling. Genes Cells 3:659-670.
42. Slack JMW. 1995. Developmental biology of the pancreas. Development 121:1569-1580.
43. Stark K, Vainio S, Vassileva G, McMahon AP. 1994. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature 372:679-683.
44. Stoffers DS, Heller RS, Miller, CP, Habener JF. 1999. Developmental expression of the homeodomain protein IDX-1 in mice transgenic for an IDX-1 promoter/LacZ transcriptional reporter. Endocrinology 140:5374-5381.
45. Tamai K, Semenov M, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP, He X. 2000. LDL-receptor related proteins in Wnt Signal transduction. Nature 407:530-535.
46. Torres MA, Yang-Snyder JA, Purcell SM, DeMarais AA, McGrew LL, Moon RT. 1996. Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development. J Cell Biol 133:1123-1137.
47. Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J. 1996. A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem 271:4468- 4476.
48. Wang S, Krinks M, Lin K, Luyten FP, Moos M Jr. 1997a. Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8. Cell 88:757-766.
49. Wang S, Krinks M, Moos M Jr. 1997b. Frzb-1, an antagonist of Wnt1 and Wnt8, does not block signaling by Wnts-3a, -5a, or -11. Biochem Biophys Res Commun 236:502-504.
50. Wang YK, Sporle R, Paperna T, Schughart K, Francke U. 1999. Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome. Genomics 57:235-248.
51. Warburton D, Zhao J, Berberich A, Bernfield M. 1999. Molecular embryology of the lung: Then, now and in the future. Am J Physiol 276:L697-L704.
52. Wells JM, Melton DA. 2000. Vertebrate endoderm development. Annu Rev Cell Dev Biol 15:393-410.
53. Wodarz A, Nusse R. 1998. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 14:59-88.
54. Wu W, Glinka A, Delius H, Niehrs C. 2000. Mutual antagonism between Dickkopf 1 and dickkopf2 regulates Wnt/beta-catenin signaling. Curr Biol 10:1611-1614.
55. Yamaguchi TP. 2001. Heads or tails: Wnts and anterior-posterior patterning. Curr Biol 11:R713-R724.
56. Yamaguchi TP, Bradley A, McMahon AP, Jones S. 1999. A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development 126:1211-1223.
57. Zorn AM. 2001. Wnt signaling: Antagonistic Dickkopts. Current Biol 11(15):R592-595.