β-Catenin downregulation attenuates ischemic cardiac remodeling through enhanced resident precursor cell differentiation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 50, 2008, Pages 19762-19767

  Zelarayán, Laura C ^a   Noack, Claudia ^a   Sekkali, Belaid ^b   Kmecova, Jana ^b   Gehrke, Christina ^c   Renger, Anke ^a   Zafiriou, Maria Patapia ^a   Van Der Nagel, Roel ^d   Dietz, Rainer ^c   De Windt, Leon J ^d   Balligand, Jean Luc ^b   Bergmann, Martin W ^a,c  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b UNIVERSITY OF LOUVAIN MEDICAL SCHOOL   (Belgium)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; BETA CATENIN; BETA GALACTOSIDASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; KI 67 ANTIGEN; MYOSIN HEAVY CHAIN; STEM CELL ANTIGEN 1; STEM CELL FACTOR; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR TBX5; TROPONIN T;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CELL LINEAGE; CELL POPULATION; CELL PROLIFERATION; CELL SURVIVAL; COCULTURE; CONTROLLED STUDY; DOWN REGULATION; ENDOCARDIUM; EPICARDIUM; GENETIC RECOMBINATION; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HEART VENTRICLE REMODELING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; REPORTER GENE; STEM CELL; ANIMAL; GENETICS; METABOLISM; MYOBLAST; PATHOLOGY; PHYSIOLOGY; REGENERATION; TRANSGENIC MOUSE;

MUS;

ANIMALS; BETA CATENIN; BETA-GALACTOSIDASE; CELL DIFFERENTIATION; CELL PROLIFERATION; DOWN-REGULATION; GENES, REPORTER; MICE; MICE, TRANSGENIC; MYOBLASTS, CARDIAC; MYOCARDIAL INFARCTION; REGENERATION; VENTRICULAR REMODELING;

EID: 58149384424     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0808393105     Document Type: Article

References (28)

1. Virag JA, et al. (2007) Fibroblast growth factor-2 regulates myocardial infarct repair. Effects on cell proliferation, scar contraction, and ventricular function. Am J Pathol 171:1431-1440.
2. Hsieh PCH, et al. (2007) Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat Med 13:970-974.
3. Oka T, Xu J, Molkentin JD (2007) Re-employment of developmental transcription factors in adult heart disease. Sem Cell Dev Biol 18:117-131.
4. Oh H, et al. (2003) Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction. Proc Natl Acad Sci USA 100:5834-5839.
5. Foley AC, Mercola M (2005) Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex. Genes Dev 19:387-396.
6. Lickert H, et al. (2002) Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm. Dev Cell 3:171-181.
7. Qyang Y, et al. (2007) The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell 1:165-179.
8. Doss MX, et al. (2007) Global transcriptome analysis of murine embryonic stem cell-derived cardiomyocytes. Genome Biol 8:992.
9. Baurand A, et al. (2007) Beta-Catenin downregulation is required for adaptive cardiac remodeling. Circ Res 100:1353-1362.
10. Zambrowicz BP, et al. (1997) Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. Proc Natl Acad Sci USA 94:3789-3794.
11. Harada N, et al. (1999) Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. EMBO J 18:5931-5942.
12. Sohal DS, et al. (2001) Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein. Circ Res 89:20-25.
13. Mori AD, et al. (2006) Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis. Dev Biol 297:566-586.
14. Bruneau BG, et al. (1999) Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome. Dev Biol 211:100-108.
15. Barandon L, et al. (2003) Reduction of infarct size and prevention of cardiac rupture in transgenic mice overexpressing FrzA. Circulation 108:2282-2289.
16. Beltrami AP, et al. (2003) Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 114:763-776.
17. Klaus A, Saga Y, Taketo MM, Tzahor E, BirchmeierW(2007) Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis. Proc Natl Acad Sci USA 104:18531-18536.
18. Cohen ED, et al. (2007) Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling. J Clin Invest 117:1794-1804.
19. Lin L, et al. (2007) beta-Catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. Proc Natl Acad Sci USA 104:9313-9318.
20. Kwon C, et al. (2007) Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc Natl Acad Sci USA 104:10894-10899.
21. Urbanek K, et al. (2005) Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure. Proc Natl Acad Sci USA 102:8692-8697.
22. Lepilina A, et al. (2006) A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. Cell 127:607-619.
23. Liebner S, et al. (2004) β-Catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse. J Cell Biol 166:359-367.
24. Kruithof BP, et al. (2006) BMP and FGF regulate the differentiation of multipotential pericardial mesoderm into the myocardial or epicardial lineage. Dev Biol 295:507-522.
25. Naito AT, et al. (2006) Developmental stage-specific biphasic roles of Wnt/beta-catenin signaling in cardiomyogenesis and hematopoiesis. Proc Natl Acad Sci USA 103:19812-19817.
26. Ueno S, et al. (2007) Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells. Proc Natl Acad Sci USA 104:9685-9690.
27. Anton R, Kestler HA, Kuhl M (2007) β-Catenin signaling contributes to stemness and regulates early differentiation in murine embryonic stem cells. FEBS Lett 581:5247-5254.
28. Soriano P (1999) Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21:70-71.