Synergistic antiallodynic interaction of the metamizol-gabapentin combination

Drug Development Research

Volumn 70, Issue 5, 2009, Pages 386-394

  Ortega Varela, Luis F ^a,b   Herrera, Jorge E ^b   Caram Salas, Nadia L ^c   Rocha Gonzalez, Hector I ^c   Torres López, Jorge E ^d   Granados Soto, Vinicio ^c  

^a UNIVERSIDAD MICHOACANA DE SAN NICOLÁS DE HIDALGO   (Mexico)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^c DEPARTAMENTO DE FÍSICA   (Mexico)

^d UNIVERSIDAD JUÁREZ AUTÓNOMA DE TABASCO   (Mexico)

Author keywords

Antiallodynia; Gabapentin; Isobologram; Metamizol; Spinal nerve ligation; Synergy

Indexed keywords

DIPYRONE; GABAPENTIN;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG POTENTIATION; FEMALE; MOTOR COORDINATION; NERVE LIGATION; NEUROPATHIC PAIN; NEUROPATHY; NONHUMAN; RAT; TREATMENT RESPONSE;

EID: 67650664302     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.20315     Document Type: Article

References (47)

1. Backonja M, Beydoun A, Edwards KR, Schwartz SL, Fonseca V, Hes M, LaMoreaux L, Garofalo E. 1998. Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial. JAMA 280:1831-1836. (Pubitemid 28544423)
2. Beirith A, Santos AR, Rodrigues AL, Creczynski-Pasa TB, Calixto JB. 1998. Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action. Eur J Pharmacol 345:233-245. (Pubitemid 28179563)
3. Bingham S, Beswick P, Bountra C, Brown T, Campbell I, Chessell I, Clayton N, Collins S, Davey P, Goodland H, Gray H, Haslam C, Hatcher J, Hunter J, Lucas FN, Murkit G, Naylor A, Pickup E, Sargent B, Summerfield S, Stevens A, Stratton S, Wiseman J. 2005. The cyclooxigenase-2 inhibitor GW406381X (2-(4-etoxyphenyl)- 3-4-methylsulfonyl-phenyl) pyrazolo (1,5-b pyridazine) is effective in animal models of neuropathic pain and central sensitization. J Pharmacol Exp Ther 312:1161-1169. (Pubitemid 40293777)
4. Boyce S, Wyatt A, Webb JK, O'Donnell R, Mason G, Rugby M, Sirinathsinghji D, Hill RG, Rupniak NM. 1999. Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn. Neuropharmacology 38:611-623. (Pubitemid 29150316)
5. Campos C, de Gregorio R, García-Nieto R, Gago F, Ortiz P, Alemany S. 1999. Regulation of cyclooxygenase activity by metamizol. Eur J Pharmacol 378:339-347.
6. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. 1994. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53:55-63. (Pubitemid 24238751)
7. Cheng JK, Chiou LC. 2006. Mechanisms of the antinociceptive action of gabapentin. J Pharmacol Sci 100:471-486.
8. Coderre TJ, Kumar N, Lefebvre CD, Yu JS. 2005. Evidence tha gabapentin reduces neuropathic pain by inhibiting the spinal release of glutamate. J Neurochem 94:1131-1139. (Pubitemid 41170599)
9. Deshpande MA, Holden RR, Gilron I. 2006. The impact of therapy on quality of life and mood in neuropathic pain: what is the effect of pain reduction. Anesth Analg 102:1473-1479.
10. Dixon WJ. 1980. Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol 20:441-462.
11. Field MJ, McCleary S, Hughes J, Singh L. 1999. Gabapentin and pregabalin, but not morphine and amitriptyline, block both static and dynamic components of mechanical allodynia induced by streptozocin in the rat. Pain 80:391-398. (Pubitemid 29151725)
12. Fox A, Gentry C, Patel S, Kesingland A, Bevan S. 2003. Comparative activity of the anti-convulsants oxcarbazepine, carbamazepine, lamotrigine and gabapentin in a model of neuropathic pain in the rat and guinea-pig. Pain 105:355-362. (Pubitemid 37162506)
13. Gee NS, Brown JP, Dissanayake VUK, Offord J, Thurlow R, Woodruff GN. 1996. The novel anticonvulsant drug, gabapentin (neurontin), binds to the a2d subunit of a calcium channel. J Biol Chem 271:5768-5776. (Pubitemid 26083915)
14. Gilron I, Max MB. 2005. Combination pharmacotherapy for neuropathic pain: current evidence and future directions. Expert Rev Neurother 5:823-830. (Pubitemid 41679649)
15. Gilron I, Bailey JM, Holden RR, Weaver DF, Houlden RL. 2005. Morphine, gabapentin, or their combination for neuropathic pain. N Engl J Med 352:1324-1334. (Pubitemid 40411499)
16. Götz E, Feuerstein TJ, Lais A, Meyer DK. 1993. Effects of gabapentin on release of gamma-aminobutyric acid from slices of rat neostriatum. Arzneimittelforschung 43:636-638. (Pubitemid 23176484)
17. Hayashida K, Parker R, Eisenach JC. 2007. Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. Anesthesiology 106:1213-1219. (Pubitemid 46828175)
18. Hefferan MP, O'Rielly DD, Loomis CW. 2003. Inhibition of spinal prostaglandin synthesis early after L5/L6 nerve ligation prevents the development of prostaglandin-dependent and prostaglandin-independent allodynia in the rat. Anesthesiology 99:1180-1188. (Pubitemid 37339466)
19. Hinz B, Cheremina O, Bachmakov J, Renner B, Zolk O, Fromm MF, Brune K. 2007. Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic. FASEB J 21:2343-2351. (Pubitemid 47230664)
20. Hurley RW, Chatterjea D, Rose-Feng M, Taylor CP, Hammond DL. 2002. Gabapentin and pregabalin can interact synergistically with naproxen to produce antihyperalgesia. Anesthesiology 97: 1263-1273. (Pubitemid 35265583)
21. Kim SH, Chung JM. 1992. An experimental model for periphery neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50:355-363.
22. Lashbrook JM, Ossipov MH, Hunter JC, Raffa RB, Tallarida RJ, Porreca F. 1999. Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX-1 and COX-2 inhibitors in nerve-injured rats. Pain 43:205-218.
23. Löscher W, Hönack D, Taylor CP. 1991. Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain. Neurosci Lett 128:150-154.
24. Luo ZD, Calcutt NA, Higuera ES, Valder CR, Song YH, Svensson CI, Myers RR. 2002. Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin. J Pharmacol Exp Ther 303:1199-1205. (Pubitemid 35424406)
25. Ma W, Eisenach JC. 2003. Cyclooxygenase 2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injury. Neuroscience 121:691-704. (Pubitemid 38367508)
26. + channel modulators on the antiallodynic effect of gabapentin. Eur J Pharmacol 484:201-208.
27. Ortega-Varela LF, Herrera JE, Caram-Salas NL, Rocha-González HI, Granados-Soto V. 2007. Isobolographic analyses of the gabapentin-metamizol combination after local peripheral, intrathecal and oral administration in the rat. Pharmacology 79:214-222. (Pubitemid 46848541)
28. + channels. Pharmacol Biochem Behav 74:465-470.
29. Ossipov MH, Jerussi TP, Ren K, Sun H, Porreca F. 2000. Differential effects of spinal (R)-ketoprofen and (S)-ketoprofen against signs of neuropathic pain and tonic nociception: evidence for a novel mechanism of action of (R)-ketoprofen against tactile allodynia. Pain 87:193-199. (Pubitemid 30621451)
30. Padi SS, Kulkarni SK. 2004. Differential effects of naproxen and rofecoxib on the development of hypersensitivity following nerve injury in rats. Pharmacol Biochem Behav 79:349-358. (Pubitemid 40029239)
31. Parris WC, Janicki PK, Jonson B, Horn JL. 1996. Intrathecal ketorolac tromethamine produces analgesia after chronic constriction injury of sciatic nerve in rat. Can J Anaesth 43:867-870. (Pubitemid 26273607)
32. Picazo A, Castañeda-Hernández G, Ortiz MI. 2006. Examination of the interaction between peripheral diclofenac and gabapentin on the 5% formalin test in rats. Life Sci 79:2283-2387. (Pubitemid 44767637)
33. Reyes-García G, Caram-Salas NL, Medina-Santillán R, Granados-Soto V. 2004. Oral administration of B vitamins increases the antiallodynic effect of gabapentin in the rat. Proc West Pharmacol Soc 47:76-79. (Pubitemid 39564886)
34. Rowbotham M, Harden N, Stacey B, Berstein P, Magnus-Miller L. 1998. Gabapentin for the treatment of postherpetic neuralgia. JAMA 280:1837-1842.
35. Shimoyama M, Shimoyama N, Hori Y. 2000. Gabapentin affects glutamatergic excitatory neurotransmission in the rat dorsal horn. Pain 85:405-414. (Pubitemid 30214167)
36. Singh L, Field MJ, Ferris P, Hunter JC, Oles RJ, Williams RG, Woodruff GN. 1996. The antiepileptic agent gabapentin (neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by D-serine. Psychopharmacology 127:1-9. (Pubitemid 26285676)
37. Takahashi M, Kawaguchi M, Shimada K, Konishi N, Furuya H, Nakashima T. 2004. Cyclooxygenase-2 expression in Schwann cells and macrophages in the sciatic nerve after single spinal nerve injury in rats. Neurosci Lett 363:203-206. (Pubitemid 38746513)
38. Takahashi M, Kawaguchi M, Shimada K, Nakashima T, Furuya H. 2005. Systemic meloxicam reduces tactile allodynia development after L5 single spinal nerve injury in rats. Reg Anesth Pain Med 30:351-355. (Pubitemid 40992862)
39. Takeda K, Sawamura S, Tamai H, Sekiyama H, Hanaoka K. 2005. Role for cyclooxygenase 2 in the development and maintenance of neuropathic pain and spinal glial activation. Anesthesiology 103:837-844. (Pubitemid 41415533)
40. Tallarida RJ. 2000. Drug synergism and dose-effect data analysis, 1st ed. New York: Chapman & Hall/CRC Press. p 1-72.
41. Taylor CP, Gee NS, Su TZ, Kocsis JD, Welty DF, Brown JP, Dooley DJ, Boden P, Singh L. 1988. A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res 29:233-249.
42. Yaksh TL, Rudy TA. 1976. Chronic catheterization of the spinal subarachnoid space. Physiol Behav 17:1031-1036. (Pubitemid 8063691)
43. Yoon MH, Yaksh TL. 1999a. The effect of intrathecal gabapentin on pain behavior and hemodynamics on the formalin test in the rat. Anesth Analg 89:434-439. (Pubitemid 29367730)
44. Yoon MH, Yaksh TL. 1999b. Evaluation of the interaction between gabapentin and ibuprofen on the formalin test in rats. Anesthesiology 91:1006-1013. (Pubitemid 29466536)
45. Zhao Z, Chen SR, Eisenach JC, Busija DW, Pan HL. 2000. Spinal cyclooxygenase-2 is involved in development of allodynia after nerve injury in rats. Neuroscience 97:743-748. (Pubitemid 30332181)
46. Zhao FY, Spanswick D, Martindale JC, Reeve AJ, Chessell IP. 2007. GW4063381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. Pain 128:78-87. (Pubitemid 46216601)
47. Zimmermann M. 1983. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16:109-110.