GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury

Pain

Volumn 128, Issue 1-2, 2007, Pages 78-87

  Zhao, Fei Yue ^a   Spanswick, Dave ^a   Martindale, Jo C ^b   Reeve, Alison J ^b   Chessell, Iain P ^b  

^a NEUROSOLUTIONS LTD   (United Kingdom)

^b Neurology CEDD   (United Kingdom)

Author keywords

Chronic constriction injury (CCI); Ectopic discharge; GW406381; Neuropathic pain; Rofecoxib

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; GW 406381; IBUPROFEN; ROFECOXIB;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC DISEASE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG SELECTIVITY; DRUG TREATMENT FAILURE; HYPERALGESIA; INFLAMMATION; MALE; MECHANICAL STIMULATION; NERVE FIBER; NERVE INJURY; NERVE LIGATION; NERVE POTENTIAL; NEUROPATHIC PAIN; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SURAL NERVE;

ACTION POTENTIALS; ANIMALS; CHRONIC DISEASE; CONSTRICTION, PATHOLOGIC; CYCLOOXYGENASE 2 INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HYDROCARBONS, AROMATIC; HYPERALGESIA; LACTONES; MALE; NERVE COMPRESSION SYNDROMES; NITROGEN; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; SULFONES; SURAL NERVE;

EID: 33846839548     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2006.08.032     Document Type: Article

References (49)

1. Abdi S., Lee D.H., and Chung J.M. The anti-allodynic effects of amitriptyline, gabapentin, and lidocaine in a rat model of neuropathic pain. Anesth Analg 87 (1998) 1360-1366
2. Bennett G.J., and Xie Y.K. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33 (1988) 87-107
3. Beswick P., Bingham S., Bountra C., Brown T., Browning K., Campbell I., et al. Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors. Bioorg Med Chem Lett 14 (2004) 5445-5448
4. Bianchi M., and Broggini M. Anti-hyperalgesic effects of nimesulide: studies in rats and humans. Int J Clin Pract Suppl 128 (2002) 11-19
5. Bingham S., Beswick P.J., Bountra C., Brown T., Campbell I.B., Chessell I.P., et al. The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5- b]pyridazine] is effective in animal models of neuropathic pain and central sensitization. J Pharmacol Exp Ther 312 (2005) 1161-1169
6. Broom D.C., Samad T.A., Kohno T., Tegeder I., Geisslinger G., and Woolf C.J. Cyclooxygenase 2 expression in the spared nerve injury model of neuropathic pain. Neuroscience 124 4 (2004) 891-900
7. Burchiel K.J., Russell L.C., Lee R.P., and Sima A.A. Spontaneous activity of primary afferent neurons in diabetic BB/Wistar rat: a possible mechanism of chronic diabetic neuropathic pain. Diabetes 34 (1985) 1210-1213
8. Campbell J.N., Meyer R.A., and Raja S.N. Is nociceptive activation by alpha-1 adrenoceptors the culprit in sympathetically maintained pain. APS J 1 (1992) 3-11
9. Chen S.R., Xu Z., and Pan H.L. Stereospecific effect of pregabalin on ectopic afferent discharges and neuropathic pain induced by sciatic nerve ligation in rats. Anesthesiology 95 (2001) 1473-1479
10. Clemett D., and Goa K.L. Celecoxib: a review of its use in osteoarthritis, rheumatoid arthritis and acute pain. Drugs 59 (2000) 957-980
11. Collins S.D., and Chessell I.P. Emerging therapies for neuropathic pain. Expert Opin Emerg Drugs 10 (2005) 95-108
12. Devor M., and Seltzer Z. Pathophysiology of damaged nerves in relation to chronic pain. In: Wall P.D., and Melzack R. (Eds). Textbook of pain. 4th ed. (1999), Churchill Livingstone, Edinburgh 129-164
13. Devor M., White D.M., Goetzel E.J., and Levine J.D. Eiscosanoids, but not tachykinins excite C-fiber endings in rat sciatic nerve-end neuromas. Neuroreport 3 (1992) 21-24
14. Devor M., Wall P.D., and Catalan N. Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction. Pain 48 (1992) 261-268
15. De Vry J., Kuhl E., Franken-Kunkel P., and Eckel G. Pharmacological characterization of the chronic constriction injury model of neuropathic pain. Eur J Pharmacol 491 (2004) 137-148
16. Durrenberger P.F., Facer P., Gray R.A., Chessell I.P., Naylor A., Bountra C., et al. Cyclooxygenase-2 (Cox-2) in injured human nerve and a rat model of nerve injury. J Peripher Nerv Syst 9 (2004) 15-25
17. Eliav E., Benoliel R., and Tal M. Inflammation with no axonal damage of the rat saphenous nerve trunk induces ectopic discharge and mechanosensitivity in myelinated axons. Neurosci Lett 311 (2001) 49-52
18. Gracely R.H., Lynch S.A., and Bennett G.J. Painful neuropathy: altered central processing maintained dynamically by peripheral input. Pain 51 (1992) 175-194
19. Han H.C., Lee D.H., and Chung J.M. Characteristics of ectopic discharges in a rat neuropathic pain model. Pain 84 (2000) 253-261
20. Hinz B., and Brune K. Pain and osteoarthritis: new drugs and mechanisms. Curr Opin Rheumatol 16 (2004) 628-633
21. Kajander K.C., and Bennett G.J. Onset of a painful peripheral neuropathy in rat: a partial and differential deafferentation and spontaneous discharge in A beta and A delta primary afferent neurons. J Neurophysiol 68 (1992) 734-744
22. Kajander K.C., Wakisaka S., and Bennett G.J. Spontaneous discharge originates in the dorsal root ganglion at the onset of a painful peripheral neuropathy in the rat. Neurosci Lett 138 (1992) 225-228
23. Lashbrook J.M., Ossipov M.H., Hunter J.C., Raffa R.B., Tallarida R.J., and Porreca F. Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1- and COX2-inhibitors in nerve-injured rats. Pain 82 (1999) 65-72
24. Laverty P.H., Leskovar A., Breur G.J., Coates J.R., Bergman R.L., Widmer W.R., et al. A preliminary study of intravenous surfactants in paraplegic dogs: polymer therapy in canine clinical SCI. J Neurotrauma 21 (2004) 1767-1777
25. Li Y., Dorsi M., Meyer R., and Belzberg A. Mechanical hyperalgesia after an L5 spinal nerve lesion in the rat is not dependent on input from injured nerve fibers. Pain 85 (2000) 493-502
26. Liu C.N., Michaelis M., Amir R., and Devor M. Spinal nerve injury enhances subthreshold membrane potential oscillations in DRG neurons: relation to neuropathic pain. J Neurophysiol 84 (2000) 205-215
27. Liu X., Eschenfelder S., Blenk K.H., Jänig W., and Häbler H.J. Spontaneous activity of axotomized afferent neurons after L5 spinal nerve injury in rats. Pain 84 (2000) 309-318
28. Luo J., Borgens R., and Shi R. Polyethylene glycol improves function and reduces oxidative stress in synaptosomal preparations following spinal cord injury. J Neurotrauma 21 (2004) 994-1007
29. Ma W., and Eisenach J.C. Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain. Eur J Neurosci 15 (2002) 1037-1047
30. Ma W., and Eisenach J.C. Cyclooxygenase 2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injury. Neuroscience 121 (2003) 691-704
31. Ma W., Du W., and Eisenach J.C. Role for both spinal cord COX-1 and COX-2 in maintenance of mechanical hypersensitivity following peripheral nerve injury. Brain Res 937 (2002) 94-99
32. + channels. J Neurophysiol 72 (1994) 349-359
33. Michaelis M., Vogel C Blenk K.-H., Arnarson A., and Jänig W. Inflammatory mediators sensitize acutely aoxotomized nerve fibers to mechanical stimulation in the rat. J Neurosci 18 (1998) 7581-7587
34. Michaelis M., Liu X., and Jänig W. Axotomized and intact muscle afferents but no skin afferents develop ongoing discharges of dorsal root ganglion origin after peripheral nerve lesion. J Neurosci 20 (2000) 2742-2748
35. Omana-Zapata I., and Bley K.R. A stable prostacyclin analog enhances ectopic activity in rat sensory neurons following neuropathic injury. Brain Res 904 (2001) 85-92
36. Padi S.S., and Kulkarni S.K. Differential effects of naproxen and rofecoxib on the development of hypersensitivity following nerve injury in rats. Pharmacol Biochem Behav 79 (2004) 349-358
37. Pan H.L., Eisenach J.C., and Chen S.R. Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats. J Pharmacol Exp Ther 288 (1999) 1026-1030
38. Schäfers M., Marziniak M., Sorkin L.S., Yaksh C., and Sommer C. Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat. Exp Neurol 185 (2004) 160-168
39. Sheen K., and Chung J.M. Signs of neuropathic pain depend on signals form injured nerve fibers in a rat model. Brain Res 610 (1993) 62-68
40. Suyama H., Kawamoto M., Gaus S., and Yuge O. Effect of etodolac, a COX-2 inhibitor, on neuropathic pain in a rat model. Brain Res 1010 (2004) 144-150
41. Takahashi M., Kawaguchi M., Shimada K., Konishi N., Furuya H., and Nakashima T. Cyclooxygenase-2 expression in Schwan cells and macrophages in the sciatic nerve after single spinal nerve injury in rats. Neurosci Lett 363 (2004) 203-206
42. Tal M., and Eliav E. Abnormal discharge originates at the site of the nerve injury in experimental constriction neuropathy (CCI) in the rat. Pain 64 (1996) 511-518
43. Taylor P.M. Newer analgesics. Nonsteroid anti-inflammatory drugs, opioids, and combinations. Vet Clin North Am Small Anim Pract 29 (1999) 719-735
44. Wall P.D., and Gutnick M. Ongoing activity in peripheral nerves: the physiology and pharmacology of impulses originating from a neruoma. Exp Neurol 43 (1974) 580-593
45. Woolf C.J., and Mannion R.J. Neuropathic pain:aetiology, symptoms, mechanisms and management. Lancet 353 (1999) 1959-1964
46. Wu G., Ringkamp M., Hartke T.V., Murinson B.B., Campbell J.N., Griffin J.W., et al. Early onset of spontaneous activity in uninjured C-fiber nociceptors after injury to neighboring nerve fibers. J Neurosci 21 8 (2001) RC140
47. Wu G., Ringkamp M., Murinson B.B., Pogatzki E.M., Hartke T.V., Weerahandi H.M., et al. Degeneration of myelinated efferent fibers induces spontaneous activity in uninjured C-fiber afferents. J Neurosci 22 (2002) 7746-7753
48. Zhang X.L., Peng X.Q., Jing Y.L., Xie W.R., and Xie Y.K. Sialic acid contributes to generation of ectopic spontaneous discharges in rats with neuropathic pain. Neurosci Lett 346 (2003) 65-68
49. Zimmermann M. Pathophysiology of neuropathic pain. Eur J Pharmacol 429 (2001) 23-37