Morphine, gabapentin, or their combination for neuropathic pain

New England Journal of Medicine

Volumn 352, Issue 13, 2005, Pages 1324-1334

  Gilron, Ian ^a   Bailey, Joan M ^a   Tu, Dongsheng ^a   Holden, Ronald R ^a   Weaver, Donald F ^b   Houlden, Robyn L ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; CODEINE; GABAPENTIN; LORAZEPAM; M ESLON; MORPHINE; NONSTEROID ANTIINFLAMMATORY AGENT; OXYCODONE; PARACETAMOL; PLACEBO; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; AGED; ANALGESIA; ANXIETY DISORDER; APPETITE DISORDER; ARTICLE; ATAXIA; CLINICAL TRIAL; COGNITIVE DEFECT; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIABETIC NEUROPATHY; DIARRHEA; DIZZINESS; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; EDEMA; FEMALE; HEADACHE; HUMAN; INSOMNIA; MAJOR CLINICAL STUDY; MALE; MAXIMUM TOLERATED DOSE; MOOD; NAUSEA; NEUROPATHIC PAIN; PAIN ASSESSMENT; POSTHERPETIC NEURALGIA; PRIORITY JOURNAL; PRURITUS; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; RESTLESS LEGS SYNDROME; SEDATION; SIDE EFFECT; SUSTAINED RELEASE PREPARATION; TREATMENT OUTCOME; VISUAL IMPAIRMENT; VOMITING; XEROSTOMIA;

ADULT; AGED; AGED, 80 AND OVER; AMINES; ANALGESICS; ANALGESICS, OPIOID; CROSS-OVER STUDIES; CYCLOHEXANECARBOXYLIC ACIDS; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; MIDDLE AGED; MORPHINE; NEURALGIA; PAIN MEASUREMENT; TREATMENT OUTCOME;

EID: 15744389846     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMoa042580     Document Type: Article

References (34)

1. Schmader KE. Epidemiology and impact on quality of life of postherpetic neuralgia and painful diabetic neuropathy. Clin J Pain 2002;18:350-4.
2. Dworkin RH, Backonja M, Rowbotham MC, et al. Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations. Arch Neurol 2003;60:1524-34.
3. Raja SN, Haythornthwaite JA, Pappagallo M, et al. Opioids versus antidepressants in postherpetic neuralgia: a randomized, placebo-controlled trial. Neurology 2002;59:1015-21.
4. Watson CP, Moulin D, Watt-Watson J, Gordon A, Eisenhoffer J. Controlled-release oxycodone relieves neuropathic pain: a randomized controlled trial in painful diabetic neuropathy. Pain 2003;105:71-8.
5. Rowbotham M, Harden N, Stacey B, Bernstein P, Magnus-Miller L. Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. JAMA 1998;280:1837-42.
6. Backonja M, Beydoun A, Edwards KR, et al. Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial. JAMA 1998;280:1831-6.
7. Luo ZD, Calcutt NA, Higuera ES, et al. Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin. J Pharmacol Exp Ther 2002;303:1199-205.
8. Field MJ, Oles RJ, Lewis AS, McCleary S, Hughes J, Singh L. Gabapentin (neurontin) and S-(+)-3-isobutylgaba represent a novel class of selective antihyperalgesic agents. Br J Pharmacol 1997;121:1513-22.
9. Shimoyama M, Shimoyama N, Inturrisi CE, Elliott KJ. Gabapentin enhances the antinociceptive effects of spinal morphine in the rat tail-flick test. Pain 1997;72:375-82.
10. Eckhardt K, Ammon S, Hofmann U, Riebe A, Gugeler N, Mikus G. Gabapentin enhances the analgesic effect of morphine in healthy volunteers. Anesth Analg 2000;91:185-91.
11. Matthews EA, Dickenson AH. A combination of gabapentin and morphine mediates enhanced inhibitory effects on dorsal horn neuronal responses in a rat model of neuropathy. Anesthesiology 2002;96:633-40.
12. Gilron I, Biederman J, Jhamandas K, Hong M. Gabapentin blocks and reverses antinociceptive morphine tolerance in the rat paw-pressure and tail-flick tests. Anesthesiology 2003;98:1288-92.
13. Myoshi HR, Leckband SG. Systemic opioid analgesics. In: Joeser JD, Butler SH, Chapman CR, Turk DC, eds. Bonica's management of pain. 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2001.
14. Marson AG, Kadir ZA, Hutton JL, Chadwick DW. The new antiepileptic drugs: a systematic review of their efficacy and tolerability. Epilepsia 1997;38:859-80.
15. Dickenson AH. Where and how opioids act. In: Gebhart GF, Hammond DL, Jensen TS, eds. Progress in pain research and management. Vol. 2. Seattle: IASP Press, 1994.
16. Singh L, Field MJ, Ferris P, et al. The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by D-serine. Psychopharmacology (Berl) 1996;127:1-9.
17. Carlton SM, Zhou S. Attenuation of formalin-induced nociceptive behaviors following local peripheral injection of gabapentin. Pain 1998;76:201-7.
18. Polydefkis M, Griffin JW, McArthur J. New insights into diabetic polyneuropathy. JAMA 2003;290:1371-6.
19. Fields HL, Rowbotham M, Baron R. Postherpetic neuralgia: irritable nociceptors and deafferentation. Neurobiol Dis 1998;5:209-27.
20. Max MB, Schafer SC, Culnane M, Smoller B, Dubner R, Gracely RH. Amitriptyline, but notlorazepam, relieves postherpetic neuralgia. Neurology 1988;38:1427-32.
21. Dellemijn PL, Vanneste JA. Randomised double-blind active-placebo- controlled cross-over trial of intravenous fentanyl in neuropathic pain. Lancet 1997;349:753-8.
22. Gilron I, Booher SL, Rowan JS, Smoller MS, Max MB. A randomized, controlled trial of high-dose dextromethorphan in facial neuralgias. Neurology 2000;55:964-71.
23. Pocock SJ. Clinical trials: a practical approach. Chichester, England: John Wiley, 1983:116-7.
24. Melzack R. The short-form McGill Pain Questionnaire. Pain 1987;30:191-7.
25. Cleeland CS, Ryan KM. Pain assessment: global use of the Brief Pain Inventory. Ann Acad Med Singapore 1994;23:129-38.
26. Beck AT, Steer RA. Beck Depression Inventory manual. San Antonio, Tex.: Psychological Corporation, 1993.
27. Ware JE, Snow KK, Kosinski MA, Gandek MS. SF-36 Health Survey manual and interpretation guide. Boston: Nimrod Press, 1997.
28. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-98.
29. Farrar JT, Young JP Jr, LaMoreaux L, Werth JL, Poole RM. Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain 2001;94:149-58.
30. Jones B, Kenward MG. Design and analysis of cross-over trials. 2nd ed. Boca Raton, Fla.: Chapman & Hall/CRC, 2003.
31. Hochberg Y, Tamhane AC. Multiple comparison procedures, New York: Wiley, 1987.
32. Agresti A. Categorical data analysis, New York: John Wiley, 1990.
33. Max MB. Combining opioids with other drugs: challenges in clinical trial design. In: Gebhart GF, Hammond DL, Jensen TS, eds. Progress in pain research and management. Vol. 2. Seattle: IASP Press, 1994.
34. Turner JA, Jensen MP, Warms CA, Cardenas DD. Blinding effectiveness and association of pretreatrnent expectations with pain improvement in a double-blind randomized controlled trial. Pain 2002;99:91-9.