Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: New insights into the pharmacology of an old analgesic

FASEB Journal

Volumn 21, Issue 10, 2007, Pages 2343-2351

  Hinz, Burkhard ^a   Cheremina, Olga ^a   Bachmakov, Jouri ^a   Renner, Bertold ^a   Zolk, Oliver ^a   Fromm, Martin F ^a   Brune, Kay ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

Dipyrone metabolites; Human whole blood assay; Pharmacokinetics

Indexed keywords

4 AMINOPHENAZONE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DIPYRONE; ISOENZYME; LIPOPOLYSACCHARIDE; NORAMIDOPYRINE; PROSTAGLANDIN E2; THROMBOXANE B2;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; BLOOD CLOTTING; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; EX VIVO STUDY; HUMAN; HUMAN EXPERIMENT; IC 50; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANALGESICS; ARACHIDONIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DIPYRONE; HUMANS; KINETICS;

EID: 34547772738     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-8061com     Document Type: Article

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