Differential effects of spinal (R)-ketoprofen and (S)-ketoprofen against signs of neuropathic pain and tonic nociception: Evidence for a novel mechanism of action of (R)-ketoprofen against tactile allodynia

Pain

Volumn 87, Issue 2, 2000, Pages 193-199

  Ossipov, M H ^a   Jerussi, T P ^b   Ren, K ^a   Sun, H ^a   Porreca, F ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

(S) ketoprofen; COX inhibitors; Enantiomers; Neuropathic pain; Rats; Spinal (R) ketoprofen

Indexed keywords

FORMALDEHYDE; KETOPROFEN; MORPHINE; PROSTAGLANDIN SYNTHASE INHIBITOR;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENANTIOMER; HYPERALGESIA; MALE; NERVE LIGATION; NEURALGIA; NEUROPATHY; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RACEMIC MIXTURE; RAT; SPINAL NERVE; TACTILE STIMULATION;

ANALGESICS, OPIOID; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; KETOPROFEN; MALE; MORPHINE; PAIN MEASUREMENT; PAIN THRESHOLD; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM;

EID: 0034255180     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(00)00280-3     Document Type: Article

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