Systemic meloxicam reduces tactile allodynia development after L5 single spinal nerve injury in rats

Regional Anesthesia and Pain Medicine

Volumn 30, Issue 4, 2005, Pages 351-355

  Takahashi, Masahiro ^a   Kawaguchi, Masahiko ^b   Shimada, Keiji ^b   Nakashima, Toshikatsu ^b   Furuya, Hitoshi ^b  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b NONE

Author keywords

COX 2 selective inhibitor; Meloxicam; Neuropathic pain; Spinal nerve injury; Tactile allodynia development

Indexed keywords

MELOXICAM;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DOSE TIME EFFECT RELATION; MALE; NERVE INJURY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SPINAL NERVE;

ANALGESICS, NON-NARCOTIC; ANIMALS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; MALE; PAIN; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, SPRAGUE-DAWLEY; SPINAL NERVES; THIAZINES; THIAZOLES;

EID: 22244471669     PISSN: 10987339     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rapm.2005.04.010     Document Type: Article

References (26)

1. C.I. Svensson, T.L. Yaksh The spinal phospholipase-cyclooxygenase- prostanoid cascade in nociceptive processing Annu Rev Pharmocol Toxicol 42 2002 553 583
2. H. Vanegas, H.G. Schaible Prostaglandins and cyclooxygenases in the spinal cord Prog Neurobiol 64 2001 327 353
3. M.P. Hefferan, D.D. O'Rielly, C.W. Loomis Inhibition of spinal prostaglandin synthesis early after L5/L6 nerve ligation prevents the development of prostaglandin-dependent and prostaglandin-independent allodynia in the rat Anesthesiology 99 2003 1180 1188
4. W. Ma, J.C. Eisenach Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain Eur J Neurosci 15 2002 1037 1047
5. Z. Zhao, S.R. Chen, J.C. Eisenach, D.W. Busija, H.L. Pan Spinal cyclooxygenase-2 involved in development of allodynia after nerve injury in rats Neuroscience 97 2000 743 748
6. M. Takahashi, T. Kita, K. Shimada, N. Konishi, T. Nakashima Early peri-sciatic inflammation contributes to the development of tactile allodynia in single nerve injury rats Jpn J Pharmacol 91 Suppl 1 2003 174
7. M. Takahashi, M. Kawaguchi, K. Shimada, N. Konishi, H. Furuya, T. Nakashima Cyclooxygenase-2 expression in Schwann cells and macrophages in the sciatic nerve after single spinal nerve injury in rats Neurosci Lett 363 2004 203 206
8. M. Takahashi, M. Kawaguchi, K. Shimada, N. Konishi, H. Furuya, T. Nakashima Peri-sciatic administration of indomethacin early after nerve injury can attenuate the development of tactile allodynia in a rat model of L5 single spinal nerve injury Neurosci Lett 356 2004 37 40
9. X. Zhu, J.C. Eisenach Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury Anesthesiology 99 2003 1175 1179
10. H. Suyama, M. Kawamoto, S. Gaus, O. Yuge Effect of etodolac, a COX-2 inhibitor, on neuropathic pain in a rat model Brain Res 1010 2004 144 150
11. G. Engelhardt, D. Homma, K. Schlegel, R. Utzmann, C. Schnitzler Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance Inflamm Res 44 1995 423 433
12. S.H. Kim, J.M. Chung An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat Pain 50 1992 355 363
13. Y. Li, M.J. Dorsi, R.A. Meyer, A.J. Belzberg Mechanical hyperalgesia after an L5 spinal nerve lesion in the rat is not dependent on input from injured nerve fibers Pain 85 2000 493 502
14. S.R. Chaplan, F.W. Bach, J.W. Pogrel, J.M. Chung, T.L. Yaksh Quantitative assessment of tactile allodynia in the rat paw J Neurosci Methods 53 1994 55 63
15. W. Ma, W. Du, J.C. Esenach Role for both spinal cord COX-1 and COX-2 in maintenance of mechanical hypersensitivity following peripheral nerve injury Brain Res 937 2002 94 99
16. W. Ma, W. Du, J.C. Eisenach Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac Anesthesiology 98 2003 203 208
17. J.M. Lashbrook, M.H. Ossipov, J.C. Hunter, R.B. Raffa, R.J. Tallarida, F. Porreca Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX-1 and COX-2 inhibitors in nerve-injured rats Pain 43 1999 205 218
18. W. Ma, J.C. Eisenach Cyclooxygenase-2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injury Neuroscience 121 2003 691 704
19. U. Busch, J. Schmid, G. Heinzel, H. Schmaus, J. Baierl, C. Huber, W. Roth Pharmacokinetics of meloxicam in animals and the relevance to humans Drug Metab Dispos 26 1998 576 584
20. I. Omana-Zapata, K.R. Bley A stable prostacyclin analog enhances ectopic activity in rat sensory neurons following neuropathic injury Brain Res 904 2001 85 92
21. W.C. Covey, T.A. Ignatowski, A.E. Renauld, P.R. Knight, N.D. Nader, R.N. Spengler Expression of neuron-associated tumor necrosis factor alpha in the brain is increased during persistent pain Reg Anesth Pain Med 27 2002 357 366
22. J. Zhou, K. Chung, J.M. Chung Development of purinergic sensitivity in sensory neurons after peripheral nerve injury in the rat Brain Res 915 2001 161 169
23. J.N. Wood, J.P. Boorman, K. Okuse, M.D. Baker Voltage-gated sodium channels and pain pathways J Neurobiol 61 2004 55 71
24. T.P. Doubell, R.J. Mannion, C.J. Woolf The dorsal horn stage-dependent sensory processing, plasticity and the generation of pain P.D. Wall R. Melzack Textbook of Pain 4th ed. 1999 Churchill Livingstone London 165 181
25. A.I. Basbaum Spinal mechanisms of acute and persistent pain Reg Anesth Pain Med 24 1999 59 67
26. M. Zimmermann Pathobiology of neuropathic pain Eur J Pharmacol 429 2001 23 37