Possible involvement of potassium channels in peripheral antinociception induced by metamizol: Lack of participation of ATP-sensitive K+ channels

Pharmacology Biochemistry and Behavior

Volumn 74, Issue 2, 2003, Pages 465-470

  Ortiz, Mario I ^a,b   Castañeda Hernández, Gilberto ^a   Granados Soto, Vinicio ^a,c  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b UNIVERSIDAD AUTÓNOMA DEL ESTADO DE HIDALGO   (Mexico)

^c UNIVERSIDAD MICHOACANA DE SAN NICOLÁS DE HIDALGO   (Mexico)

Author keywords

4 Aminopyridine; Antinociception; Apamin; Charybdotoxin; Glibenclamide; K+ channels; Metamizol; Tetraethylammonium; Tolbutamide

Indexed keywords

4 AMINOPYRIDINE; ADENOSINE TRIPHOSPHATE; APAMIN; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CHARYBDOTOXIN; DIPYRONE; FORMALDEHYDE; GLIBENCLAMIDE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; TETRYLAMMONIUM; TOLBUTAMIDE; ABC TRANSPORTER; DIAGNOSTIC AGENT; INWARDLY RECTIFYING POTASSIUM CHANNEL; NONSTEROID ANTIINFLAMMATORY AGENT; UK ATP 1 POTASSIUM CHANNEL; UK-ATP-1 POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; AREA UNDER THE CURVE; DRUG INTERACTION; PAIN ASSESSMENT; PERIPHERAL NERVE; PHYSIOLOGY; WISTAR RAT;

4-AMINOPYRIDINE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APAMIN; AREA UNDER CURVE; ATP-BINDING CASSETTE TRANSPORTERS; CHARYBDOTOXIN; DIPYRONE; DRUG INTERACTIONS; FEMALE; FORMALDEHYDE; GLYBURIDE; PAIN MEASUREMENT; PERIPHERAL NERVES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RATS; RATS, WISTAR; TETRAETHYLAMMONIUM; TOLBUTAMIDE;

EID: 0037212335     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(02)01023-7     Document Type: Article

References (35)

1. Abbate R., Gori A.M., Pinto S., Attanasio M., Paniccia R., Coppo M.et al. Cyclooxygenase and lipoxygenase metabolite synthesis by polymorphonuclear neutrophils: in vitro effect of dipyrone. Prostaglandins Leukot. Essent. Fat. Acids. 41:1990;89-93.
2. Aguirre-Bañuelos P., Granados-Soto V. Evidence for a peripheral mechanism of action for the potentiation of the antinociceptive effect of morphine by dipyrone. J. Pharmacol. Toxicol. Methods. 42:1999;79-85.
3. Aguirre-Bañuelos P., Granados-Soto V. Evidence for the participation of the nitric oxide-cyclic GMP pathway in the antinociceptive action of meloxicam in the formalin test. Eur. J. Pharmacol. 395:2000;9-13.
4. Beirith A., Santos A.R., Rodrigues A.L., Creczynski-Pasa T.B., Calixto J.B. Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action. Eur. J. Pharmacol. 345:1998;233-245.
5. Bolotina V.M., Najibi S., Palacino J.J., Pagano P.J., Cohen R.A. Nitric oxide directly activates calcium dependent potassium channels in vascular smooth muscle. Nature. 368:1994;850-853.
6. Brune K., Alpermann H. Non-acidic pyrazoles: inhibition of prostaglandin production, carrageenan oedema and yeast fever. Agents Actions. 13:1983;360-363.
7. Campos C., De Gregorio R., Garcia-Nieto R., Gago F., Ortiz P., Alemany S. Regulation of cyclooxygenase activity by metamizol. Eur. J. Pharmacol. 378:1999;339-347.
8. Carlsson K.H., Jurna I. The role of descending inhibition in the antinociceptive effects of the pyrazolone derivatives, metamizol (dipyrone) and aminophenazone ("Pyramidon"). Naunyn-Schmiedeberg's Arch. Pharmacol. 335:1987;154-159.
9. Cook N.S., Quast U. Potassium channel pharmacology. Cook N.S. Potassium channels: structure, classification, function and therapeutic potential. 1990;181-255 Ellis Horwood, Chichester.
10. Duarte I.D., Dos Santos I.R., Lorenzetti B.B., Ferreira S.H. Analgesia by direct antagonism of nociceptor sensitization involves the arginine-nitric oxide-cGMP pathway. Eur. J. Pharmacol. 217:1992;225-227.
11. + channels. Annu. Rev. Pharmacol. Toxicol. 33:1993;597-637.
12. Ergun H., Ayhan I.H., Tulunay F.C. Pharmacological characterization of metamizol-induced relaxation in phenylephrine-precontracted rabbit thoracic aorta smooth muscle. Gen. Pharmacol. 33:1999;237-241.
13. Fukao M., Mason H.S., Britton F.C., Kenyon J.L., Horowitz B., Keef K.D. Cyclic GMP-dependent protein kinase activates cloned BKCa channels expressed in mammalian cells by direct phosphorylation at serine 1072. J. Biol. Chem. 274:1999;10927-10935.
14. Granados-Soto V., Flores-Murrieta F.J., Castañeda-Hernández G., Lopez-Muñoz F.J. Evidence for the involvement of nitric oxide in the antinociceptive effect of ketorolac. Eur. J. Pharmacol. 277:1995;281-284.
15. + channels, types Kv1.1, 1.2, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol. Pharmacol. 45:1994;1227-1234.
16. + channels in the central nervous system. Cook N.S. Potassium channels: structure, classification, function and therapeutic potential. 1990;348-381 Ellis Horwood, Chichester.
17. Hernández N., Vanegas H. Antinociception induced by PAG-microinjected dipyrone (metamizol) in rats: involvement of spinal endogenous opioids. Brain Res. 896:2001;175-178.
18. + channel pathway in the antinociceptive action of ketorolac. Eur. J. Pharmacol. 426:2001;39-44.
19. Lorenzetti B.B., Ferreira S.H. Activation of the arginine-nitric oxide pathway in primary sensory neurons contributes to dipyrone-induced spinal and peripheral analgesia. Inflamm. Res. 45:1996;308-311.
20. Mathie A., Wooltorton J.R.A., Watkins C.S. Voltage-activated potassium channels in mammalian neurons and their block by novel pharmacological agents. Gen. Pharmacol. 30:1998;13-24.
21. Muriel-Villoria C., Zungri-Telo E., Diaz-Curiel M., Fernandez-Guerrero M., Moreno J., Puerta J.et al. Comparison of the onset and duration of the analgesic effect of dipyrone, 1 or 2 g, by the intramuscular or intravenous route, in acute renal colic. Eur. J. Clin. Pharmacol. 48:1995;103-107.
22. + channels by diclofenac. Eur. J. Pharmacol. 438:2002;85-91.
23. + channels. Br. J. Pharmacol. 129:2000;110-114.
24. + channels. J. Physiol. (Paris). 79:1984;259-264.
25. i/o protein in the antinociceptive action of the gallic acid ethyl ester. Eur. J. Pharmacol. 379:1999;7-17.
26. Shimada S.G., Otterness I.G., Stitt J.T. A study of the mechanism of action of the mild analgesic dipyrone. Agents Actions. 41:1994;188-192.
27. 2-induced hyperalgesic paw. Br. J. Pharmacol. 134:2001;127-131.
28. + channels: mechanism of peripheral antinociceptive action of the nitric oxide donor, sodium nitroprusside. Eur. J. Pharmacol. 400:2000;67-71.
29. Stretton D., Miura M., Bevisi M.G., Barnes P.J. Calcium-activated potassium channels mediate prejunctional inhibition of peripheral sensory nerves. Proc. Natl. Acad. Sci. U. S. A. 9:1992;1325-1329.
30. Tatsuo M.A., Carvalho W.M., Silva C.V., Miranda A.E., Ferreira S.H., Francischi J.N. Analgesic and anti-inflammatory effects of dipyrone in rat adjuvant arthritis model. Inflammation. 18:1994;399-405.
31. Tonussi C.R., Ferreira S.H. Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization. Eur. J. Pharmacol. 251:1994;173-179.
32. Vlaskovska M., Surcheva S., Ovcharov R. Importance of endogenous opioids and prostaglandins in the action of analgin (metamizol) and verapamil. Farmakol. Toksikol. 52:1989;25-29.
33. Welch S.P., Dunlow L.D. Antinociceptive activity of intrathecally administered potassium channel openers and opioid agonists, a common mechanism of action? J. Pharmacol. Exp. Ther. 267:1993;390-399.
34. Wheeler-Aceto H., Cowan A. Standardization of the rat paw formalin test for the evaluation of analgesics. Psychopharmacology. 104:1991;35-44.
35. Zimmermann M. Ethical guidelines for investigations on experimental pain in conscious animals. Pain. 16:1983;109-110.