Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 20, 2008, Pages 5648-5652

  Fucini, Raymond V ^a   Hanan, Emily J ^a   Romanowski, Michael J ^a   Elling, Robert A ^a   Lew, Willard ^a   Barr, Kenneth J ^a   Zhu, Jiang ^a   Yoburn, Joshua C ^a   Liu, Yang ^a   Fahr, Bruce T ^a   Fan, Junfa ^a   Lu, Yafan ^a   Pham, Phuongly ^a   Choong, Ingrid C ^a   VanderPorten, Erica C ^a   Bui, Minna ^a   Purkey, Hans E ^a   Evanchik, Marc J ^a   Yang, Wenjin ^a  

^a Sunesis Pharmaceuticals Inc   (United States)

Author keywords

2 Amino pyrazolopyridine; Kinase inhibitor; Polo like kinase (Plk); SAR

Indexed keywords

2 AMINO PYRAZOLOPYRIDINE DERIVATIVE; 2 BENZAMIDE DERIVATIVE; ADENOSINE TRIPHOSPHATE; POLO LIKE KINASE 1; POLO LIKE KINASE 1 INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS; PHENOTYPE; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; CELL CYCLE; CELL CYCLE PROTEINS; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PYRAZOLES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 53349168412     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.08.095     Document Type: Article

References (17)

1. Eckerdt F., Yuan J., and Strebhardt K. Oncogene 24 (2005) 267
2. Lowery D.M., Lim D., and Yaffe M.B. Oncogene 24 (2005) 248
3. Xie S., Xie B., Lee M.Y., and Dai W. Oncogene 24 (2005) 277
4. Takai N., Hamanaka R., Yoshimatsu J., and Miyakawa I. Oncogene 24 (2005) 287
5. Strebhardt K., and Ullrich A. Nat. Rev. Cancer 6 (2006) 321
6. Plyte S., and Musacchio A. Curr. Biol. 17 (2007) R280
7. Peters U., Cherian J., Kim J.H., Kwok B.H., and Kapoor T.M. Nat. Chem. Biol. 2 (2006) 618
8. Dubois J.E., Boussu M., and Lion C. Tetrahedron Lett. 12 (1971) 829
9. Klapars A., Antilla J.C., Huang X., and Buchwald S.L. J. Am. Chem. Soc. 123 (2001) 7727
10. Zhang H., Cai Q., and Ma D. J. Org. Chem. 70 (2005) 5164
11. Wolfe J.P., and Buchwald S.L. J. Org. Chem. 65 (2000) 1144
12. Dess D.B., and Martin J.C. J. Org. Chem. 48 (1983) 4155
13. Ziegler C.B., and Heck R.F. J. Org. Chem. 43 (1978) 2941
14. Miyaura N., and Suzuki A. Chem. Rev. 95 (1995) 2457
15. Lenart P., Petronczki M., Steegmaier M., Di Fiore B., Jesse L., Hoffmann M., Rettig W., Kraut N., and Peters J.-M. Curr. Biol. 17 (2007) 4
16. Zhang H., Shi X., Paddon H., Hampong M., Dai W., and Pelech S. J. Biol. Chem. 279 (2004) 34
17. Expression, purification, and crystallization of Plk1. Elling R.A., Fucini R.V., and Romanowski M.J. Acta Crystallogr. 64 (2008) 909 Details for this X-ray crystal structure are provided as Supplementary data