Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 19, 2008, Pages 5186-5189

  Hanan, Emily J ^a   Fucini, Raymond V ^a   Romanowski, Michael J ^a   Elling, Robert A ^a   Lew, Willard ^a   Purkey, Hans E ^a   VanderPorten, Erica C ^a   Yang, Wenjin ^a  

^a Sunesis Pharmaceuticals Inc   (United States)

Author keywords

2 Amino isoxazolopyridines; Kinase inhibitor; Polo like kinase (Plk); SAR

Indexed keywords

2 AMINO ISOXAZOLOPYRIDINE DERIVATIVE; ISOENZYME; PHOSPHOTRANSFERASE INHIBITOR; POLO LIKE KINASE; POLO LIKE KINASE 1; POLO LIKE KINASE 2; POLO LIKE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CRYSTALLOGRAPHY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NONHUMAN; STRUCTURE ACTIVITY RELATION;

CELL CYCLE PROTEINS; COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; ISOENZYMES; ISOXAZOLES; MICROSOMES, LIVER; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 52049110507     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.08.091     Document Type: Article

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