Efficient internalization of the polo-box of polo-like kinase 1 fused to an antennapedia peptide results in inhibition of cancer cell proliferation

Cancer Research

Volumn 62, Issue 15, 2002, Pages 4186-4190

  Yuan, Juping ^a   Krämer, Andrea ^a   Eckerdt, Frank ^a   Kaufmann, Manfred ^a   Strebhardt, Klaus ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTENNAPEDIA PROTEIN; PEPTIDE; POLO BOX PROTEIN; POLO LIKE KINASE 1; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; CANCER CELL; CELL INTERACTION; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; CENTROSOME; CHROMOSOME ABERRATION; CONTROLLED STUDY; GENE CONTROL; GENE FUNCTION; GENE FUSION; GENE OVEREXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MITOSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION;

AMINO ACID SEQUENCE; ANTENNAPEDIA HOMEODOMAIN PROTEIN; APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE PROTEINS; CHROMOSOMES, HUMAN; CONSERVED SEQUENCE; G2 PHASE; GROWTH INHIBITORS; HOMEODOMAIN PROTEINS; HUMANS; MITOSIS; MITOTIC SPINDLE APPARATUS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RECOMBINANT FUSION PROTEINS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0036682358     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Polo-like kinases: A team that plays throughout mitosis
2. Polo-like kinases: Positive regulators of cell division from start to finish
3. Polo-like kinase, a novel marker for cellular proliferation
4. PLK (polo-like kinase)
5. The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts
6. CDC5 and CKII control adaptation to the yeast DNA damage checkpoint
7. Polo-like kinase-1 is a target of the DNA damage checkpoint
8. Malignant transformation of mammalian cells initiated by constitutive expression of the polo-like kinase
9. The polo-box-dependent induction of ectopic septal structures by mammalian polo kinase, Plk, in Saccharomyces cerevisiae
10. Polo boxes and Cut23 (Apc8) mediate an interaction between polo kinase and the anaphase-promoting complex for fission yeast mitosis
11. Therapeutic peptides revisited
12. Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent
13. Inhibition of cancer cell growth and c-Myc transcriptional activity by a c-Myc helix 1-type peptide fused to an internalization sequence
14. Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumor suppressor molecule
15. Waf1/Cip1 carboxyl-terminal peptide exhibited cyclin-dependent kinase-inhibitory activity and cytotoxicity when introduced into human cells
16. Functional studies on the role of the C-terminal domain of mammalian polo-like kinase
17. Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes
18. Dominant-negative polo-like kinase 1 induces mitotic catastrophe independent of cdc25C function
19. Incomplete cytokinesis and induction of apoptosis by overexpression of the mammalian polo-like kinase. Plk3
20. Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway