Use of RNA interference technology for cancer specific gene silencing

Annals of Cancer Research and Therapy

Volumn 13, Issue 1-2, 2005, Pages 23-25

  Sumimoto, Hidetoshi ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cancer gene therapy; RNA interference; siRNA

Indexed keywords

EID: 67650024367     PISSN: 13446835     EISSN: None     Source Type: Journal    
DOI: 10.4993/acrt.13.23     Document Type: Review

References (26)

1. Fire, A., Xu, S., Montgomery, M.K., Kostas, S.A., Driver, S.E. and Mello, C.C. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature, 391: 806-811.
2. Elbashir, S.M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K. and Tuschl, T. (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature, 411: 494-498
3. Zamore, P., Tuschl, T., Sharp, P. and Bartel, D. (2000) RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell, 101: 25-33.
4. Hammond, S.M., Bernstein, E., Beach, D. and Hannon, G. (2000) An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature, 404: 293-296.
5. Lipardi, C., Wei, Q. and Paterson, B.M. (2001) RNAi as random degradative PCR: siRNA primers convert mRNA into dsRNA that are degraded to generate new siRNAs. Cell, 107: 297-307.
6. Schwarz, D.S., Hutvagner, G., Haley, B. and Zamore, P.D. (2002) Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways. Mol. Cell, 10: 537-548.
7. Stark, G.R., et al. (1998) Annu. Rev. Biochem., 67: 227-264.
8. Brummelkamp, T.R., Bernards, R. and Agami, R. (2002) A system for stable expression of short interfering RNAs in mammalian cells. Science, 296: 550-553.
9. Miyagishi, M. and Taira, K. (2002) U6 promoter-driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells. Nature Biotech., 20: 497-500.
10. Lee, N.S., Dohjima, T., Bauer, G., Li, H., Li, M.J., Ehsani, A., Salvaterra, P. and Rossi, J. (2002) Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. Nature Biotech., 20: 500-505.
11. Paddison, P.J., Caudy, A.A., Bernstein, E., Hannon, G.J. and Conklin, D.S. (2002) Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes & Dev., 16: 948-958.
12. Paul, C.P., Good, P.D., Winer, I. and Engelke, D.R. (2002) Effective expression of small interfering RNA in human cells. Nature Biotech., 20: 505-508.
13. Sui, G., Soohoo, C., Affar, E.B., Gay, F., Shi, Y., Forrester, W.C. and Shi, Y. (2002) A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc. Natl. Acad. Sci. USA, 99: 5515-5520.
14. Val promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells. Nucleic Acid Res., 31: 700-707.
15. Burmmelkamp, T.R., Bernards, R. and Agami, R. (2002) Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell, 2: 243-247.
16. Rubinson, D.A., et al. (2003) A lentivirus-based system to functionally silence genes in primary mammalian cells and transgenic mice by RNA interference. Nature Genetics, 33: 401-406.
17. Barton, G.M., and Medzhitov, R. (2002) Retroviral delivery of small interfering RNA into primary cells. Proc. Natl. Acad. Sci. USA, 99: 14943-14945.
18. Abbas-Terki, T., Blanco-Bose, W., Deglon, N., Pralong, W. and Aebischer, P. (2002) Lentiviral-mediated RNA interference. Human Gene Therapy, 13: 2197-2201.
19. Miyagishi, M., et al. (2004) Optimization of an siRNA-expression system with an improved hairpin and its significant suppressive effects in mammalian cells. J Gene Med., 6: 715-723.
20. Miller, V., Xia, H., Marrs, G.L., Gouvion, C.M., Lee, G., Davidson, B.L. and Paulson, H.L. (2003) Alle-specific silencing of dominant disease genes. Proc. Natl. Acad. Sci. USA, 100: 7195-7200.
21. Sumimoto, H., Miyagishi, M., Miyoshi, H., Yamagata, S., Shimizu, A., Taira, K. and Kawakami, Y. (2004) Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference. Oncogene 23: 6031-6039.
22. Sledz, C.A., Holko, M., Veer, M.J., Silverman, R.H. and Williamas, B.R.G. (2003) Activation of the interferon system by short-interfering RNAs. Nature Cell Biol. 5: 834-839.
23. Wilda, M., Fuchs, U., Wossmann, W. and Borkhardt, A. (2002) Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi). Oncogene 21: 5716-5724.
24. Sumimoto, H., Yamagata, S., Shimizu, A., Miyoshi, H., Mizuguchi, H., Hayakawa, T., Miyagishi, M., Taira, K. and Kawakami, Y. (2005) Gene therapy for human small-cell lung carcinoma by inactivation of Skp-2 with virally mediated RNA interference. Gene Therapy 12: 95-100.
25. McCaffrey, A.P., Meuse, L., Pham, T.T., Conklin, D.S., Hannon, G.J. and Kay, M.A. (2002) RNA interference in adult mice. Nature 418: 38-39.
26. Soutschek, J., et al. (2004) Therapeutic silencing of an endogenous gene by systemic administration of modified siRNA. Nature 432: 173-178.