Role of sulfur amino acids in controlling nutrient metabolism and cell functions: Implications for nutrition

British Journal of Nutrition

Volumn 101, Issue 8, 2009, Pages 1132-1139

  Tesseraud, Sophie ^a   Métayer Coustard, Sonia ^a   Collin, Anne ^a   Seiliez, Iban ^b  

^a STATION DE RECHERCHES AVICOLES   (France)

^b Unite mixte INRA IFREMER Universite Bordeaux 1 UMR Nuage   (France)

Author keywords

Cysteine; Gene expression; Methionine; Methylation process; Nutrient metabolism; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; ASPARTATE AMMONIA LIGASE; CCAAT ENHANCER BINDING PROTEIN; CYANOCOBALAMIN; CYSTEINE; HYDROGEN SULFIDE; METHIONINE; SULFATE; SULFUR AMINO ACID; VITAMIN B GROUP;

AMINO ACID COMPOSITION; AMINO ACID METABOLISM; ANTIOXIDANT ACTIVITY; CARDIOVASCULAR DISEASE; CELL FUNCTION; CELL METABOLISM; CPG ISLAND; DIET SUPPLEMENTATION; DNA METHYLATION; GENE EXPRESSION REGULATION; GLYCEMIC CONTROL; HUMAN; MATERNAL NUTRITION; METABOLIC REGULATION; NONHUMAN; NUTRIENT AVAILABILITY; NUTRITIONAL REQUIREMENT; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PROTEIN DIET; PROTEIN SYNTHESIS; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; URINARY EXCRETION;

AMINO ACIDS, SULFUR; DNA METHYLATION; GENE EXPRESSION REGULATION; HUMANS; NUTRITIONAL PHYSIOLOGICAL PHENOMENA; OXIDATIVE STRESS;

EID: 67649443909     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114508159025     Document Type: Review

References (101)

1. Hocquette JF, Tesseraud S, Cassar-Malek I, et al. (2007) Responses to nutrients in farm animals: Implications for production and quality. Animal 1, 1297-1313.
2. Obled C, Papet I & Breuille D (2004) Sulfur-containing amino acids and glutathione in diseases. In Metabolic and Therapeutic Aspects of Amino Acids in Clinical Nutrition, 2nd ed., pp. 667-687 [LA Cynober, editor]. Boca Raton, FL: CRC Press LLC.
3. Le Floc'h N, Melchior D & Obled C (2004) Modifications of protein and amino acid metabolism during inflammation and immune system activation. Livest Prod Sci 87, 37-45.
4. Soeters PB, van de Poll MC, van Gemert WG, et al. (2004) Amino acid adequacy in pathophysiological states. J Nutr 134, 1575S-1582S.
5. van de Poll MC, Dejong CH & Soeters PB (2006) Adequate range for sulfur-containing amino acids and biomarkers for their excess: Lessons from enteral and parenteral nutrition. J Nutr 136, 1694S-1700S.
6. Stipanuk MH, Dominy JE Jr, Lee JI, et al. (2006) Mammalian cysteine metabolism: New insights into regulation of cysteine metabolism. J Nutr 136, 1652S-1659S.
7. Garlick PJ (2006) Toxicity of methionine in humans. J Nutr 136 1722S-1725S.
8. Métayer S, Seiliez I, Collin A, et al. (2008) Mechanisms through which sulfur amino acids control protein metabolism and oxidative status. J Nutr Biochem 19, 207-215.
9. Wu G, Fang YZ, Yang S, et al. (2004) Glutathione metabolism and its implications for health. J Nutr 134, 489-492.
10. Moskovitz J, Rahman MA, Strassman J, et al. (1995) Escherichia coli peptide methionine sulfoxide reductase gene: Regulation of expression and role in protecting against oxidative damage. J Bacteriol 177, 502-507.
11. Levine RL, Mosoni L, Berlett BS, et al. (1996) Methionine residues as endogenous antioxidants in proteins. Proc Natl Acad Sci U S A 93, 15036-15040.
12. Mariotti F, Simbelie KL, Makarios-Lahham L, et al. (2004) Acute ingestion of dietary proteins improves post-exercise liver glutathione in rats in a dose-dependent relationship with their cysteine content. J Nutr 134, 128-131.
13. Diniz YS, Rocha KK, Souza GA, et al. (2006) Effects of N acetylcysteine on sucrose-rich diet-induced hyperglycaemia, dyslipidemia and oxidative stress in rats. Eur J Pharmacol 543 151-157.
14. Dröge W (2006) Redox regulation in anabolic and catabolic processes. Curr Opin Clin Nutr Metab Care 9, 190-195.
15. Blouet C, Mariotti F, Azzout-Marniche D, et al. (2007) Dietary cysteine alleviates sucrose-induced oxidative stress and insulin resistance. Free Radic Biol Med 42, 1089-1097.
16. Blouet C, Mariotti F, Mikogami T, et al. (2007) Meal cysteine improves postprandial glucose control in rats fed a high-sucrose meal. J Nutr Biochem 18, 519-524.
17. Mariotti F, Hermier D, Sarrat C, et al. (2008) Rapeseed protein inhibits the initiation of insulin resistance by a high-saturated fat, high-sucrose diet in rats. Br J Nutr 100, 984-991.
18. Tsakiris S, Parthimos T, Parthimos N, et al. (2006) The beneficial effect of L-cysteine supplementation on DNA oxidation induced by forced training. Pharmacol Res 53, 386-390.
19. +-ATPase activities. Clin Chem Lab Med 45, 67-72.
20. Schulpis KH, Reclos GJ, Parthimos T, et al. (2006) L-Cysteine supplementation protects the erythrocyte glucose-6-phosphate dehydrogenase activity from reduction induced by forced training. Clin Biochem 39, 1002-1006.
21. Lands LC, Grey VL & Smountas AA (1999) Effect of supplementation with a cysteine donor on muscular performance. J Appl Physiol 87, 1381-1385.
22. Jonas CR, Ziegler TR, Gu LH, et al. (2002) Extracellular thiol/ disulfide redox state affects proliferation rate in a human colon carcinoma (Caco2) cell line. Free Radic Biol Med 33, 1499-1506.
23. Nkabyo YS, Go YM, Ziegler TR, et al. (2005) Extracellular cysteine/cystine redox regulates the p44/p42 MAPK pathway by metalloproteinase-dependent epidermal growth factor receptor signaling. Am J Physiol Gastrointest Liver Physiol 289, G70-G78.
24. Go YM & Jones DP (2005) Intracellular proatherogenic events and cell adhesion modulated by extracellular thiol/disulfide redox state. Circulation 111, 2973-2980.
25. Jiang S, Moriarty-Craige SE, Orr M, et al. (2005) Oxidant-induced apoptosis in human retinal pigment epithelial cells: Dependence on extracellular redox state. Invest Ophthalmol Vis Sci 46, 1054-1061.
26. Banjac A, Perisic T, Sato H, et al. (2008) The cystine/cysteine cycle: A redox cycle regulating susceptibility versus resistance to cell death. Oncogene 27, 1618-1628.
27. Go YM & Jones DP (2008) Redox compartmentalization in eukaryotic cells. Biochim Biophys Acta 1780, 1273-1290.
28. Blanco RA, Ziegler TR, Carlson BA, et al. (2007) Diurnal variation in glutathione and cysteine redox states in human plasma. Am J Clin Nutr 86, 1016-1023.
29. Nkabyo YS, Gu LH, Jones DP, et al. (2006) Thiol/disulfide redox status is oxidized in plasma and small intestinal and colonic mucosa of rats with inadequate sulfur amino acid intake. J Nutr 136, 1242-1248.
30. Sanz A, Caro P, Ayala V, et al. (2006) Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins. FASEB J 20 1064-1073.
31. Caro P, Gómez J, López-Torres M, et al. (2008) Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver. Biogerontology 9 183-196.
32. López-Torres M & Barja G (2008) Lowered methionine ingestion as responsible for the decrease in rodent mitochondrial oxidative stress in protein and dietary restriction. Possible implications for humans. Biochim Biophys Acta 1780, 1337-1347.
33. Stipanuk MH (2004) Sulfur amino acid metabolism: Pathways for production and removal of homocysteine and cysteine. Annu Rev Nutr 24, 539-577.
34. Abe K & Kimura H (1996) The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci 16, 1066-1071.
35. Eto K, Asada T, Arima K, et al. (2002) Brain hydrogen sulfide is severely decreased in Alzheimer's disease. Biochem Biophys Res Commun 293, 1485-1488.
36. Han Y, Qin J, Chang X, et al. (2005) Hydrogen sulfide may improve the hippocampal damage induced by recurrent febrile seizures in rats. Biochem Biophys Res Commun 327, 431-436.
37. Kimura H (2000) Hydrogen sulfide induces cyclic AMP and modulates the NMDA receptor. Biochem Biophys Res Commun 267, 129-133.
38. Kimura Y & Kimura H (2004) Hydrogen sulfide protects neurons from oxidative stress. FASEB J 18, 1165-1167.
39. 2S as a novel endogenous gaseous KATP channel opener. EMBO J 20, 6008-6016.
40. Tang G, Wu L, Liang W, et al. (2005) Direct stimulation of KATP channels by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cells. Mol Pharmacol 68, 1757-1764.
41. 2S in rat insulin-secreting cells and the underlying mechanisms. J Physiol 569, 519-531.
42. 2S-induced vasorelaxation and underlying cellular and molecular mechanisms. Am J Physiol Heart Circ Physiol 283, H474-H480.
43. Cheng Y, Ndisang JF, Tang G, et al. (2004) Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats. Am J Physiol Heart Circ Physiol 287, H2316-H2323.
44. Hosoki R, Matsuki N & Kimura H (1997) The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide. Biochem Biophys Res Commun 237, 527-531.
45. Kaneko Y, Kimura Y, Kimura H, et al. (2006) L-Cysteine inhibits insulin release from the pancreatic β-cell: Possible involvement of metabolic production of hydrogen sulfide, a novel gasotransmitter. Diabetes 55, 1391-1397.
46. Hamadeh MJ & Hoffer LJ (2001) Use of sulfate production as a measure of short-term sulfur amino acid catabolism in humans. Am J Physiol Endocrinol Metab 280, E857-E866.
47. Hamadeh MJ & Hoffer LJ (2003) Effect of protein restriction on sulfur amino acid catabolism in insulin-dependent diabetes mellitus. Am J Physiol Endocrinol Metab 284, E382-E389.
48. Hoffer LJ, Hamadeh MJ, Robitaille L, et al. (2005) Human sulfate kinetics. Am J Physiol Regul Integr Comp Physiol 289, R1372-R1380.
49. Gregus Z, Kim HJ, Madhu C, et al. (1994) Sulfation of acetaminophen and acetaminophen-induced alterations in sulfate and 3′-phosphoadenosine 5′-phosphosulfate homeostasis in rats with deficient dietary intake of sulfur. Drug Metab Dispos 22, 725-730.
50. Hu JF, Zhao XH, Parpia B, et al. (1993) Dietary intakes and urinary excretion of calcium and acids: A cross-sectional study of women in China. Am J Clin Nutr 58, 398-406.
51. Whiting SJ & Draper HH (1980) The role of sulfate in the calciuria of high protein diets in adult rats. J Nutr 110, 212-222.
52. Thorpe M, Mojtahedi MC, Chapman-Novakofski K, et al. (2008) A positive association of lumbar spine bone mineral density with dietary protein is suppressed by a negative association with protein sulfur. J Nutr 138, 80-85.
53. Jefferson LS & Kimball SR (2001) Amino acid regulation of gene expression. J Nutr 131, 2460S-2466S.
54. Kilberg MS, Pan YX, Chen H, et al. (2005) Nutritional control of gene expression: How mammalian cells respond to amino acid limitation. Annu Rev Nutr 25, 59-85.
55. Jousse C, Averous J, Bruhat A, et al. (2004) Amino acids as regulators of gene expression: Molecular mechanisms. Biochem Biophys Res Commun 313, 447-452.
56. Shigemitsu K, Tsujishita Y, Miyake H, et al. (1999) Structural requirement of leucine for activation of p70 S6 kinase. FEBS Lett 447, 303-306.
57. Stubbs AK, Wheelhouse NM, Lomax MA, et al. (2002) Nutrient-hormone interaction in the ovine liver: Methionine supply selectively modulates growth hormone-induced IGF-I gene expression. J Endocrinol 174 335-341.
58. Tesseraud S, Bigot K & Taouis M (2003) Amino acid availability regulates S6K1 and protein synthesis in avian insulin-insensitive QM7 myoblasts. FEBS Lett 540, 176-180.
59. Kimball SR & Jefferson LS (2005) Role of amino acids in the translational control of protein synthesis in mammals. Semin Cell Dev Biol 16, 21-27.
60. Wek RC, Jiang HY & Anthony TG (2006) Coping with stress: EIF2 kinases and translational control. Biochem Soc Trans 34, 7-11.
61. Tremblay F, Lavigne C, Jacques H, et al. (2007) Role of dietary proteins and amino acids in the pathogenesis of insulin resistance. Annu Rev Nutr 27, 293-310.
62. Averous J, Bruhat A, Jousse C, et al. (2004) Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation. J Biol Chem 279, 5288-5297.
63. Jousse C, Bruhat A, Ferrara M, et al. (2000) Evidence for multiple signaling pathways in the regulation of gene expression by amino acids in human cell lines. J Nutr 130, 1555-1560.
64. Bruhat A, Jousse C, Wang XZ, et al. (1997) Amino acid limitation induces expression of CHOP, a CCAAT/enhancer binding protein-related gene, at both transcriptional and post-transcriptional levels. J Biol Chem 272, 17588-17593.
65. Lee JI, Dominy JE Jr, Sikalidis AK, et al. (2008) HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway. Physiol Genomics 33, 218-229.
66. Roybal CN, Yang S, Sun CW, et al. (2004) Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4. J Biol Chem 279, 14844-14852.
67. Tremblay F & Marette A (2001) Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem 276 38052-38060.
68. Hinault C, Van Obberghen E & Mothe-Satney I (2006) Role of amino acids in insulin signaling in adipocytes and their potential to decrease insulin resistance of adipose tissue. J Nutr Biochem 17, 374-378.
69. Tesseraud S, Métayer-Coustard S, Boussaid S, et al. (2007) Insulin and amino acid availability regulate atrogin-1 in avian QT6 cells. Biochem Biophys Res Commun 357, 181-186.
70. Mihm S, Ennen J, Pessara U, et al. (1991) Inhibition of HIV-1 replication and NF-κB activity by cysteine and cysteine derivatives. AIDS 5, 497-503.
71. Shibanuma M, Kuroki T & Nose K (1994) Inhibition by N acetyl-L-cysteine of interleukin-6 mRNA induction and activation of NFκB by tumor necrosis factor a in a mouse fibroblastic cell line, Balb/3T3. FEBS Lett 353, 62-66.
72. Paterson RL, Galley HF & Webster NR (2003) The effect of N acetylcysteine on nuclear factor-κB activation, interleukin-6, interleukin-8, and intercellular adhesion molecule-1 expression in patients with sepsis. Crit Care Med 31, 2574-2578.
73. Lee KS, Kim SR, Park HS, et al. (2007) A novel thiol compound, N-acetylcysteine amide, attenuates allergic airway disease by regulating activation of NF-κB and hypoxia-inducible factor-1α. Exp Mol Med 39, 756-768.
74. Barnes PJ & Karin M (1997) Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336, 1066-1071.
75. Chen F, Castranova V, Shi X, et al. (1999) New insights into the role of nuclear factor-κB, a ubiquitous transcription factor in the initiation of diseases. Clin Chem 45, 7-17.
76. Grimble RF (2006) The effects of sulfur amino acid intake on immune function in humans. J Nutr 136, Suppl. 6, 1660S-1665S.
77. Oda H (2006) Functions of sulfur-containing amino acids in lipid metabolism. J Nutr 136, Suppl. 6, 1666S-1669S.
78. Troen AM, Lutgens E, Smith DE, et al. (2003) The atherogenic effect of excess methionine intake. Proc Natl Acad Sci U S A 100, 15089-15094.
79. Gerhard GT & Duell PB (1999) Homocysteine and atherosclerosis. Curr Opin Lipidol 10, 417-428.
80. Zhou J, Werstuck GH, Lhoták S, et al. (2008) Hyperhomocysteinemia induced by methionine supplementation does not independently cause atherosclerosis in C57BL/6J mice. FASEB J 22, 2569-2578.
81. Liu C, Wang Q, Guo H, et al. (2008) Plasma S adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in apolipoprotein E-deficient mice fed high dietary methionine. J Nutr 138, 311-315.
82. Jamison RL, Hartigan P, Kaufman JS, et al. (2007) Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: A randomized controlled trial. JAMA 298, 1163-1170.
83. Albert CM, Cook NR, Gaziano JM, et al. (2008) Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: A randomized trial. JAMA 299, 2027-2036.
84. Egger G, Liang G, Aparicio A, et al. (2004) Epigenetics in human disease and prospects for epigenetic therapy. Nature 429, 457-463.
85. Ulrey CL, Liu L, Andrews LG, et al. (2005) The impact of metabolism on DNA methylation. Hum Mol Genet 14, Spec. no. 1 R139-R147.
86. Gronbaek K, Hother C & Jones PA (2007) Epigenetic changes in cancer. APMIS 115, 1039-1059.
87. Waterland RA & Michels KB (2007) Epigenetic epidemiology of the developmental origins hypothesis. Annu Rev Nutr 27, 363-388.
88. Nafee TM, Farrell WE, Carroll WD, et al. (2008) Epigenetic control of fetal gene expression. BJOG 115, 158-168.
89. Waterland RA (2006) Assessing the effects of high methionine intake on DNA methylation. J Nutr 136, Suppl. 6, 1706S-1710S.
90. Brosnan JT, da Silva R & Brosnan ME (2007) Amino acids and the regulation of methyl balance in humans. Curr Opin Clin Nutr Metab Care 10, 52-57.
91. Williams KT & Schalinske KL (2007) New insights into the regulation of methyl group and homocysteine metabolism. J Nutr 137, 311-314.
92. Dunlevy LP, Burren KA, Chitty LS, et al. (2006) Excess methionine suppresses the methylation cycle and inhibits neural tube closure in mouse embryos. FEBS Lett 580, 2803-2807.
93. Reed MC, Nijhout HF, Sparks R, et al. (2004) A mathematical model of the methionine cycle. J Theor Biol 226, 33-43.
94. Reed MC, Nijhout HF, Neuhouser ML, et al. (2006) A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. J Nutr 136, 2653-2661.
95. Pogribny IP, Ross SA, Wise C, et al. (2006) Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency. Mutat Res 593, 80-87.
96. Pogribny IP, Karpf AR, James SR, et al. (2008) Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet. Brain Res 1237 25-34.
97. Lu X, Freund JN, Muller M, et al. (2008) Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors. Biochimie 90, 697-704.
98. Rees WD, Wilson FA & Maloney CA (2006) Sulfur amino acid metabolism in pregnancy: The impact of methionine in the maternal diet. J Nutr 136, Suppl. 6, 1701S-1705S.
99. Waterland RA, Dolinoy DC, Lin JR, et al. (2006) Maternal methyl supplements increase offspring DNA methylation at Axin Fused. Genesis 44, 401-406.
100. Rees WD (2002) Manipulating the sulfur amino acid content of the early diet and its implications for long-term health. Proc Nutr Soc 61, 71-77.
101. Sinclair KD, Allegrucci C, Singh R, et al. (2007) DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc Natl Acad Sci U S A 104, 19351-19356.