The beneficial effect of l-cysteine supplementation on DNA oxidation induced by forced training

Pharmacological Research

Volumn 53, Issue 4, 2006, Pages 386-390

  Tsakiris, Stylianos ^a   Parthimos, Theodore ^a   Parthimos, Nickolaos ^a   Tsakiris, Theodore ^a   Schulpis, Kleopatra H ^b  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b AGHIA SOPHIA CHILDREN S HOSPITAL   (Greece)

Author keywords

8 OHdG; Cysteine; DNA oxidation; Exercise

Indexed keywords

8 HYDROXY 2 DEOXYGUANOSINE; BIOLOGICAL MARKER; CREATINE KINASE; CYSTEINE; DNA; LACTATE DEHYDROGENASE; UNCLASSIFIED DRUG;

ADOLESCENT; ANALYTIC METHOD; ANTIOXIDANT ACTIVITY; ARTICLE; BASKETBALL; BLOOD SAMPLING; CELL DEATH; CELL PROTECTION; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; DNA DAMAGE; HUMAN; MALE; MEASUREMENT; MUSCLE CELL; NORMAL HUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SUPPLEMENTATION; TRAINING;

ADOLESCENT; BASKETBALL; CREATINE KINASE; CYSTEINE; DEOXYGUANOSINE; DIETARY SUPPLEMENTS; DNA; EXERTION; FREE RADICALS; HUMANS; L-LACTATE DEHYDROGENASE; MALE; OXIDATION-REDUCTION;

EID: 33645985184     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2006.01.008     Document Type: Article

References (32)

1. Alderton W.K., Cooper C.E., and Knowles R.G. Nitric oxide synthases: structure, function and inhibition. Biochem J 357 (2001) 593-615
2. Halliwell B. Free radicals, proteins and DNA: oxidative damage versus redox regulation. Biochem Soc Trans 24 (1996) 1023-1027
3. Packer L. Oxidants, antioxidant nutrients and the athlete. J Sport Sci 15 (1997) 353-363
4. Dillard C.J., Litov R.E., Savin W.M., Dumelin E.E., and Tappel A.L. Effects of exercise, vitamin E, and ozone on pulmonary function and lipid peroxidation. J Appl Physiol 45 (1978) 927-932
5. Ashton T., Young I.S., Peters J.R., Jones E., Jackson S.K., Davies B., et al. Electron spin resonance spectroscopy, exercise, and oxidative stress: an ascorbic acid intervention study. J Appl Physiol 87 (1999) 2032-2036
6. Bailey D.M., Young I.S., McEneny J., Lawrenson L., Kim J., Barden J., et al. Regulation of free radical outflow from an isolated muscle bed in exercising humans. Am J Physiol Heart Circ Physiol 287 (2004) H1689-H1699
7. Alessio H.M., Hagerman A.E., Fulkerson B.K., Ambrose J., Rice R.E., and Wiley R.L. Generation of reactive oxygen species after exhaustive aerobic and isometric exercise. Med Sci Sports Exerc 32 (2000) 1576-1581
8. Hartmann A., Pfuhler S., Dennog C., Germandnik D., Pigler A., and Speit G. Exercise-induced DNA effects in human leukocytes are not accompanied by increased formation of 8-hydroxy-2′-deoxyguanosine or induction of micronuclei. Free Rad Biol Med 24 (1998) 245-251
9. Cooper C.E., Vollaard N.B., Choueiri T., and Wilson M.T. Exercise, free radicals and oxidative stress. Bioch Soc Trans 30 (2002) 280-285
10. Finkel T., and Holbrook N.J. Oxidants, oxidative stress and the biology of aging. Nature 408 (2000) 239-247
11. Yaki K. Lipid peroxides and related radicals in clinical medicine. In: Armistrong D. (Ed). Free radicals in diagnostic medicine (1999), Plenum Press, New York 1-14
12. Richter C., Park J.W., and Ames B.N. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci USA 85 (1988) 6465-6467
13. Kasai H., Crain P.F., Kuchino Y., Nishimura S., Ootsuyama A., and Tanooka H. Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis 7 (1986) 1849-1851
14. Atmaca G. Antioxidant effects of sulfur-containing amino acids. Yonsei Med J 45 (2004) 776-788
15. Mariotti F., Simbelie K.L., Makarios-Lahham L., Huneau J.F., Laplaize B., Toned D., et al. Acute ingestion of dietary proteins improves post-exercise liver glutathione in rats in a dose-dependent relationship with their cysteine content. J Nutr 134 (2004) 128-131
16. Kinnaert E., Duez P., Morandini R., Dubois J., Van Houtte P., and Ghanem G. Cysteine but not glutathione modulates the radiosensitivity of human melanoma cells by affecting both survival and DNA species. Pigment Cell Res 17 (2004) 275-280
17. Lohnman T.G., Roche A.F., and Martorell R. Anthropometric standardization reference manual (1988), Human Kinetics, Champaign L pp. 380-94
18. Apostolidis N., Nassis G.P., Bolatoglou T., and Geladas N.D. Physiological and technical characteristics of elite young basketball players. J Sports Med Phys Fitness 44 (2004) 157-163
19. Murakami M., and Webb M. A morphological and biochemical study of the effects of l-cysteine on the renal uptake and nephrotoxicity of cadmium. Br J Exp Pathol 62 (1981) 115-130
20. Miller N.J., Rice-Evans C., Davies M.J., Gopinathan V., and Milner A. A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin Sci (Lond) 84 (1993) 407-412
21. Yin B., Whyatt R.M., Perera F.P., Randal M.C., Cooper T.B., and Santella R.M. Determination of 8-hydroxydeoxyguanosine by an immunoaffinity chromatography-monoclonal antibody based ELISA. Free Radic Biol Med 18 (1995) 1023-1032
22. Inoue T., Inoue K., Maeda H., Takayanagi K., and Morroka S. Immunological response to oxidized LDL occurs in association with oxidative DNA damage independently of serum LDL concentrations in dyslipidemic patients. Clin Chim Acta 305 (2000) 115-121
23. Balakrishnan S.D., and Anuradha C.V. Exercise, depletion of antioxidants and antioxidant manipulation. Cell Biochem Func 16 (1998) 269-275
24. Rokitzki L., Logemann E., Sagredos A.N., Murphy M., Wetzel-Roth W., and Keul J. Lipid peroxidation and antioxidative vitamins under extreme endurance stress. Acta Physiol Scand 151 (1994) 149-158
25. Lynch S.M., Campine A.L., and Moore M.K. Plasma thiols inhibit hemin-dependent oxidation of human low-density lipoprotein. Biochim Biophys Acta 1485 (2000) 11-22
26. Chen H.J., Wu S.B., and Chang C.M. Biological and dietary antioxidants protect against DNA nitration by reaction of hypochlorous acid with nitrite. Arch Biochem Biophys 415 (2003) 109-116
27. 2+-ATPase activities: protection of l-cysteine. Basic Clin Pharmacol Toxicol 94 (2004) 112-118
28. Han D., Sen C.K., Roy S., Kobayashi M.S., Tritschler H.J., and Packer L. Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants. Am J Physiol 273 (1997) R1771-R1778
29. Kim Y.G., Kim S.K., and Kwon J.W. Effects of cysteine on amino acid concentrations and transsulfuration enzyme activities in rat liver with protein-calorie malnutrition. Life Sci 72 (2003) 1171-1181
30. Somani S.M., Frank S., and Rybak L.P. Responses of antioxidant system to acute and trained exercise in rat heart subcellular fractions. Pharmacol Biochem Behar 51 (1995) 627-634
31. Lew H., Pyke S., and Quintanilha A. Changes in the glutathione status of plasma, liver and muscle following exhaustive exercise in rats. FEBS Lett 185 (1985) 262-266
32. Beckman K.B., and Ames B.N. Oxidative decay of DNA. J Biol Chem 272 (1997) 19633-19636