L-cysteine supplementation prevents exercise-induced alterations in human erythrocyte membrane acetylcholinesterase and Na+,K +-ATPase activities

Clinical Chemistry and Laboratory Medicine

Volumn 45, Issue 1, 2007, Pages 67-72

  Parthimos, Theodore ^a   Tsopanakis, Christi ^a   Angelogianni, Panagoula ^a   Schulpis, Kleopatra H ^b   Parthimos, Nickolaos ^a   Tsakiris, Stylianos ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b AGHIA SOPHIA CHILDREN S HOSPITAL   (Greece)

Author keywords

Acetylcholinesterase; Cysteine; Exercise; Na+,K+ ATPase; Oxidation

Indexed keywords

ACETYLCHOLINESTERASE; ADENOSINE TRIPHOSPHATASE (MAGNESIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ANTIOXIDANT; CYSTEINE; FREE RADICAL; LACTIC ACID; PROTEIN; PYRUVIC ACID;

ADULT; ARTICLE; BASKETBALL; BLOOD ANALYSIS; BLOOD LEVEL; BLOOD SAMPLING; DIET SUPPLEMENTATION; ENZYME ACTIVATION; ERYTHROCYTE MEMBRANE; EXERCISE; GAME; HUMAN; LACTATE BLOOD LEVEL; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SPECTROPHOTOMETRY; STATISTICAL SIGNIFICANCE; TRAINING;

ACETYLCHOLINESTERASE; ADULT; ANTIOXIDANTS; CA(2+) MG(2+)-ATPASE; CYSTEINE; DIETARY SUPPLEMENTS; ERYTHROCYTE MEMBRANE; EXERCISE; FREE RADICALS; HUMANS; MALE; NA(+)-K(+)-EXCHANGING ATPASE; OXIDATION-REDUCTION; OXIDATIVE STRESS;

EID: 33846530049     PISSN: 14346621     EISSN: 14346621     Source Type: Journal    
DOI: 10.1515/CCLM.2007.005     Document Type: Article

References (48)

1. Balakrishnan SD, Anuradha CV. Exercise, depletion of antioxidants and antioxidant manipulation. Cell Biochem Funct 1998;16:269-75.
2. Rokitzki L, Logemann E, Sagredos AN, Murphy M, Wetzel-Roth W, Keul J. Lipid peroxidation and antioxidative vitamins under extreme endurance stress. Acta Physiol Scand 1994;151:149-58.
3. Somani SM, Frank S, Rybak LP. Responses of antioxidant system to acute and trained exercise in rat heart subcellular fractions. Pharmacol Biochem Behav 1995;51:627-34.
4. Lew H, Pyke S, Quintanilha A. Changes in the glutathione status of plasma, liver and muscle following exhaustive exercise in rats. FEBS Lett 1985;185:262-6.
5. Sussman JL, Harel M, Frolow F, Oefner C, Goldman A, Toker L, et al. Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic, acetylcholine-binding protein. Science 1991;253:872-9.
6. Lotti M. Cholinesterase inhibition: complexities in interpretation. Clin Chem 1995;41:1814-8.
7. Sweadner KJ, Goldin SM. Active transport of sodium and potassium ions: mechanism, function and regulation. N Engl J Med 1980;302:777-83.
8. +-ATPase in inhibitors. Can J Physiol Pharmacol 1977;55:170-9.
9. Mata M, Fink DJ, Gainer H, Smith CB, Davidsen L, Savaki H, et al. Activity-dependent energy metabolism in rat posterior pituitary primarily reflects sodium pump activity. J Neurochem 1980;34:213-5.
10. Bogdanski DF, Tissari A, Brodie BB. Role of sodium, potassium, ouabain and reserpine in uptake, storage and metabolism of biogenic amines in synaptosomes. Life Sci 1968;7:419-8.
11. +-ATPase activity possibly regulated by a specific serotonin receptor. Brain Res 1987;408:399-402.
12. Sanui H, Rubin H. The role of magnesium in cell proliferation and transformation. In: Boynton AL, McKeehan WL, Whitfield JF, editors. Ions, cell proliferation and cancer. New York: Academic Press, 1982:517-37.
13. +-ATPase activity in the in vitro galactosaemia: the effect of L-cysteine and glutathione. Metab Brain Dis 2005;20:45-54.
14. 2+-ATPase activities in galactosaemia in vitro. Metab Brain Dis 2005;20:87-95.
15. Lohman TG, Roche AF, Martorell R. Anthropometric standardization reference manual. Champaign, IL: Human Kinetics Books, 1988:380-94.
16. Apostolidis N, Nassis GP, Bolatoglou T, Geladas ND. Physiological and technical characteristics of elite young basketball players. J Sports Med Phys Fitness 2004;44:157-63.
17. Murakami M, Webb M. A morphological and biochemical study of the effects of L-cysteine on the renal uptake and nephrotoxicity of cadmium. Br J Exp Pathol 1981;62:115-30.
18. Miller NJ, Rice-Evans C, Davies MJ, Gopinathan V, Milner A. A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin Sci (Lond) 1993;84:407-12.
19. Galbraith DA, Watts DC. Changes in some cytoplasmic enzymes from red cells fractionated into age groups by centrifugation in Ficoll/Triosil gradients. Comparison of normal humans and patients with Duchenne muscular dystrophy. Biochem J 1980;191:63-70.
20. Kamber E, Poyiagi A, Deliconstantinos G. Modifications in the activities of the membrane-bound enzymes during in vivo ageing of human and rabbit erythrocytes. Comp Biochem Physiol B 1984;77:95-9.
21. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-75.
22. Ellman GL, Courtney KD, Andres V Jr, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961;7:88-95.
23. Tsakiris S, Schulpis KH, Tjamouranis J, Michelakakis H, Karikas GA. Reduced acetylcholinesterase activity in erythrocyte membranes from patients with phenylketonuria. Clin Biochem 2002;35:615-9.
24. Schulpis KH, Karikas GA, Tjamouranis J, Michelakakis H, Tsakiris S. Acetylcholinesterase activity and biogenic amines in phenylketonuria. Clin Chem 2002;48:1794-6.
25. 2+-ATPase activities and biogenic amine concentrations in phenylketonuria. Clin Biochem 2002;35:281-5.
26. Kim YG, Kim SK, Kwon JW, Park OJ, Kim SG, Kim YC, et al. Effects of cysteine on amino acid concentrations and transsulfuration enzyme activities in rat liver with protein-calorie malnutrition. Life Sci 2003;72:1171-81.
27. Han D, Sen CK, Roy S, Kobayashi MS, Tritschler HJ, Packer L. Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants. Am J Physiol 1997;273:R1771-8.
28. Robergs RA, Ghiasvand F, Parker D. Biochemistry of exercise-induced metabolic acidosis. Am J Physiol Regul Integr Comp Physiol 2004;287;R502-16.
29. +-ATPase inhibition induced by free radical. Z Naturforsch 2000;55:271-7.
30. 2+-ATPase activities: protection by L-cysteine. Basic Clinic Pharmacol Toxicol 2004;94:112-8.
31. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967;70:158-69.
32. Schulpis KH, Tsakiris S, Karikas GA, Moukas M, Behrakis P. Effect of diet on plasma total antioxidant status in phenylketonuric patients. Eur J Clin Nutr 2003;57:383-7.
33. +-ATPase activity and acetylcholine release in rat cortical synaptosomes. J Neurochem 1981;36:467-75.
34. Fatranska M, Budai D, Oprsalova Z, Kvetnansky R. Acetylcholine and its enzymes in some brain areas of the rat under stress. Brain Res 1987;424:109-14.
35. Tanaka M, Kohno Y, Nakagawa R, Ida Y, Takeda S, Nagasaki N. Time-related differences in noradrenaline turnover in rat brain regions by stress. Pharmacol Biochem Behav 1982;16:315-9.
36. Tanaka M, Kohno Y, Nakagawa R, Ida Y, Takeda S, Nagasaki N, et al. Regional characteristics of stress-induced increases in brain noradrenaline release in rats. Pharmacol Biochem Behav 1983;19:543-7.
37. +)-stimulated ATPase activity and on bilayer fluidity of dog brain synaptosomal plasma membranes. Neurochem Res 1985;10:1605-3.
38. Koska J, Blazicek P, Marko M, Grna JD, Kvetnansky R, Vigas M. Insulin, catecholamines, glucose and antioxidant enzymes in oxidative damage during different loads in healthy humans. Physiol Res 2000;49:S95-100.
39. 2+-ATPase and acetylcholinesterase activities in the rat cerebrum and cerebellum caused by stress. Pharmacol Biochem Behav 1993;44:339-42.
40. 2+-ATPase activities in patients with galactosaemia. Clin Nutr 2005;24:151-7.
41. Sahlin K, Edstrom L, Sjoholm H, Hultman E. Effect of lactic acid accumulation and ATP decrease on muscle tension and relaxation. Am J Physiol 1981;240:C121-6.
42. Lindinger MI, Heigenhauser GJ. The roles of ion-fluxes in skeletal muscle fatigue. Can J Physiol Pharmacol 1991;69:246-53.
43. Fujino K, Yoshitake T, Inoue O, Ibii N, Kehr J, Ishida J, et al. Increased serotonin release in mice frontal cortex and hippocampus induced by acute physiological stressors. Neurosci Lett 2002;320:91-5.
44. 2+-ATPase activities induced by in vitro galactosaemia. Pharmacol Res 2004;49:475-9.
45. Kinnaert E, Duez P, Morandini R, Dubois J, Van Houtte P, Ghanem G. Cysteine but not glutathione modulates the radiosensitivity of human melanoma cells by affecting both survival and DNA damage. Pigment Cell Res 2004;17:275-80.
46. Kondo T. Impaired glutathione metabolism in hemolytic anemia. Rinsho Byori 1990;38:355-9.
47. Mariotti F, Simbelie KL, Makarios-Lahham L, Huneau JF, Laplaize B, Tome D, et al. Acute ingestion of dietary proteins improves post-exercise liver glutathione in rats in a dose-dependent relationship with their cysteine content. J Nutr 2004;134:128-31.
48. Atmaca G. Antioxidant effects of sulfur-containing amino acids. Yonsei Med J 2004;31:776-88.