Deficiency of SP-B reveals protective role of SP-C during oxygen lung injury

Journal of Applied Physiology

Volumn 92, Issue 2, 2002, Pages 519-526

  Ikegami, Machiko ^a   Weaver, Timothy E ^b   Conkright, Juliana J ^a   Sly, Peter D ^b   Ross, Gary F ^a   Whitsett, Jeffrey A ^b   Glasser, Stephan W ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Lung injury; Saturated phosphatidylcholine; Surfactant protein B and C; Transgenic mice

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; OXYGEN; SURFACTANT PROTEIN B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; FILM; GENOTYPE; HETEROZYGOTE; HYPEROXIA; HYSTERESIS; LUNG ALVEOLUS; LUNG FUNCTION; LUNG INJURY; MOUSE; NONHUMAN; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; PROTECTION; PROTEIN DEFICIENCY; PROTEIN FUNCTION; SURFACE TENSION; TRANSGENIC MOUSE;

EID: 0036090002     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00459.2001     Document Type: Article

References (34)

1. Surfactant protein SP-B induces ordering at the surface of model membrane bilayers
2. Hyperoxia-induced alterations of rat alveolar lavage composition and properties
3. Cytokine response during hyperoxia: Sequential production of pulmonary tumor necrosis factor and interleukin-6 in neonatal rats
4. Decreased lung compliance and air trapping in heterozygous SP-B deficient mice
5. Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice
6. Lung function in premature lambs and rabbits treated with a recombinant SP-C surfactant
7. Effects of lung surfactant proteins, SP-B and SP-C, and palmitic acid on monolayer stability
8. Altered stability of pulmonary surfactant in SP-C-deficient mice
9. Input impedance and peripheral inhomogeneity of dog lungs
10. Lung function in premature rabbits treated with recombinant human surfactant protein-C
11. Assay of inorganic and organic phosphorus in the 0.1-5 nanomole range
12. Pulmonary physiological and surfactant changes during injury and recovery from hyperoxia
13. Tolerance of SP-A-deficient mice to hyperoxia or exercise
14. Surfactant metabolism in SP-D gene-targeted mice
15. Evaluation of exogenous surfactant treatment strategies in an adult model of acute lung injury
16. Protein measurement with the Folin phenol reagent
17. Surfactant protein A and surfactant protein D in health and disease
18. Isolation of disaturated phosphatidylcholine with osmium tetroxide
19. Sublethal hyperoxic injury to the alveolar epithelium and the pulmonary surfactant system
20. Positive end-expiratory pressure preserves surfactant function in preterm lambs
21. Effects of different styles of ventilation on cytokine expression in the preterm lamb lung
22. Deficiency of pulmonary surfactant protein B in congenital alveolar proteinosis
23. Changes in alveolar surface area, surfactant protein A, and saturated phosphatidylcholine with postnatal rat lung growth
24. Characterization of lipid insertion into monomolecular layers mediated by lung surfactant proteins SP-B and SP-C
25. Treatment responses to surfactants containing natural surfactant proteins in preterm rabbits
26. Surfactant protein interactions with neutral and acidic phospholipid films
27. The captive bubble method for the evaluation of pulmonary surfactant: Surface tension, area, and volume calculations
28. Formation and structure of surface films: Captive bubble surfactometry
29. Surface properties and sensitivity to protein-inhibition of a recombinant apoprotein-C-based phospholipid mixture in vitro-comparison to natural surfactant
30. Surfactant protein B corrects oxygen-induced pulmonary dysfunction in heterozygous surfactant protein B-deficient mice
31. Aberrant processing of surfactant protein C (SP-C) in hereditary SP-B deficiency
32. Effect of hyperoxia on phosphatidylcholine synthesis, secretion, uptake and stability in the newborn rabbit lung
33. Function of surfactant proteins B and C
34. Role of bovine pulmonary surfactant-associated proteins in the surface-active property of phospholipid mixtures