Iron transport and the kidney

Biochimica et Biophysica Acta - General Subjects

Volumn 1790, Issue 7, 2009, Pages 724-730

  Smith, Craig P ^a   Thévenod, Frank ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF WITTEN HERDECKE   (Germany)

Author keywords

DcytB; DMT1; Ferroportin1; Hapheastin; Iron; Kidney; Membrane transport

Indexed keywords

CARRIER PROTEIN; FERROPORTIN; HEPHAESTIN; IRON; METAL; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; NIFEDIPINE;

DRUG ACTIVITY; GLOMERULUS FILTRATION; HEMOCHROMATOSIS; HOMEOSTASIS; HUMAN; IMMUNOLOCALIZATION; IRON ABSORPTION; IRON METABOLISM; IRON OVERLOAD; IRON TRANSPORT; KIDNEY DISEASE; NEPHRITIS; NEPHROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIDEROSIS;

ANIMALS; CATION TRANSPORT PROTEINS; HEMOCHROMATOSIS; HOMEOSTASIS; HUMANS; IRON; KIDNEY; KIDNEY DISEASES; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; SIDEROSIS;

MUS; RATTUS;

EID: 67349278599     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2008.10.010     Document Type: Review

References (87)

1. Ponka P. Cellular iron metabolism. Kidney Inter. 69 Suppl. (1999) S2-S11
2. Nankivell B.J., Boadle R.A., and Harris D.C. Iron accumulation in human chronic renal disease. Am. J. Kidney Dis. 20 (1992) 580-584
3. Bohrer M.P., Deen W.M., Robertson C.R., Troy J.L., and Brenner B.M. Influence of molecular configuration on the passage of macromolecules across the glomerular capillary wall. J. Gen. Physiol. 74 (1979) 583-593
4. Ohlson M., Sorensson J., and Haraldsson B. A gel-membrane model of glomerular charge and size selectivity in series. Am. J. Physiol. Renal Physiol. 280 (2001) F396-F405
5. Deen W.M., Bridges C.R., Brenner B.M., and Myers B.D. Heteroporous model of glomerular size selectivity: application to normal and nephrotic humans. Am. J. Physiol. 249 (1985) F374-F389
6. Burne M.J., Osicka T.M., and Comper W.D. Fractional clearance of high molecular weight proteins in conscious rats using a continuous infusion method. Kidney Int. 55 (1999) 261-270
7. Cutillas P.R., Chalkley R.J., Hansen K.C., Cramer R., Norden A.G., Waterfield M.D., Burlingame A.L., and Unwin R.J. The urinary proteome in Fanconi syndrome implies specificity in the reabsorption of proteins by renal proximal tubule cells. Am. J. Physiol. Renal Physiol. 287 (2004) F353-F364
8. Kozyraki R., Fyfe J., Verroust P.J., Jacobsen C., Dautry-Varsat A., Gburek J., Willnow T.E., Christensen E.I., and Moestrup S.K. Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 12491-12496
9. Ohno Y., Birn H., and Christensen E.I. In vivo confocal laser scanning microscopy and micropuncture in intact rat. Nephron, Exp. Nephrol. 99 (2005) 17-25
10. Abouhamed M., Gburek J., Liu W., Torchalski B., Wilhelm A., Wolff N.A., Christensen E.I., Thévenod F., and Smith C.P. Divalent metal transporter 1 in the kidney proximal tubule is expressed in late endosomes/lysosomal membranes: implications for renal handling of protein-metal complexes. Am. J. Physiol. Renal Physiol. 290 (2006) F1525-F1533
11. Zhang D., Meyron-Holtz E., and Rouault T.A. Renal iron metabolism: transferrin iron delivery and the role of iron regulatory proteins. J. Am. Soc. Nephrol. 18 (2007) 401-406
12. Gunshin H., Mackenzie B., Berger U.V., Gunshin Y., Romero M.F., Boron W.F., Nussberger S., Gollan J.L., and Hediger M.A. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388 (1997) 482-488
13. Vidal S., Belouchi A.M., Cellier M., Beatty B., and Gros P. Cloning and characterization of a second human NRAMP gene on chromosome 12q13. Mamm. Genome 6 (1995) 224-230
14. Wareing M., Ferguson C.J., Green R., Riccardi D., and Smith C.P. In vivo characterization of renal iron transport in the anaesthetized rat. J. Physiol. 524 (2000) 581-586
15. Robinson J.R. Reflections on Renal Function. second ed. (1988), Blackwell Scientific Publication
16. Ferguson C.J., Wareing M., Ward D.T., Green R., Smith C.P., and Riccardi D. Cellular localization of divalent metal transporter DMT-1 in rat kidney. Am. J. Physiol. Renal Physiol. 280 (2001) F803-F814
17. Canonne-Hergaux F., and Gros P. Expression of the iron transporter DMT1 in kidney from normal and anemic mk mice. Kidney Int. 62 (2002) 147-156
18. Canonne-Hergaux F., Fleming M.D., Levy J.E., Gauthier S., Ralph T., Picard V., Andrews N.C., and Gros P. The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border. Blood 96 (2000) 3964-3970
19. Wareing M., Ferguson C.J., Delannoy M., Cox A.G., McMahon R.F., Green R., Riccardi D., and Smith C.P. Altered dietary iron intake is a strong modulator of renal DMT1 expression. Am. J. Physiol. Renal Physiol. 285 (2003) F1050-F1059
20. Fleming M.D., Romano M.A., Su M.A., Garrick L.M., Garrick M.D., and Andrews N.C. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 1148-1153
21. Su M.A., Trenor C.C., Fleming J.C., Fleming M.D., and Andrews N.C. The G185R mutation disrupts function of the iron transporter Nramp2. Blood 92 (1998) 2157-2163
22. Ferguson C.J., Wareing M., Delannoy M., Fenton R., McLarnon S.J., Ashton N., Cox A.G., McMahon R.F., Garrick L.M., Green R., Smith C.P., and Riccardi D. Iron handling and gene expression of the divalent metal transporter, DMT1, in the kidney of the anemic Belgrade (b) rat. Kidney Int. 64 (2003) 1755-1764
23. Donovan A., Roy C.N., and Andrews N.C. The ins and outs of iron homeostasis. Physiology (Bethesda) 21 (2006) 115-123
24. McKie A.T., Barrow D., Latunde-Dada G.O., Rolfs A., Sager G., Mudaly E., Mudaly M., Richardson C., Barlow D., Bomford A., Peters T.J., Raja K.B., Shirali S., Hediger M.A., Farzaneh F., and Simpson R.J. An iron-regulated ferric reductase associated with the absorption of dietary iron. Science 291 (2001) 1755-1759
25. Ludwiczek S., Theurl I., Bahram S., Schumann K., and Weiss G. Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis. J. Cell Physiol. 204 (2005) 489-499
26. Abboud S., and Haile D.J. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J. Biol. Chem. 275 (2000) 19906-19912
27. McKie A.T., Marciani P., Rolfs A., Brennan K., Wehr K., Barrow D., Miret S., Bomford A., Peters T.J., Farzaneh F., Hediger M.A., Hentze M.W., and Simpson R.J. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol. Cell 5 (2000) 299-309
28. Donovan A., Lima C.A., Pinkus J.L., Pinkus G.S., Zon L.I., Robine S., and Andrews N.C. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab. 1 (2005) 191-200
29. Vulpe C.D., Kuo Y.M., Murphy T.L., Cowley L., Askwith C., Libina N., Gitschier J., and Anderson G.J. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat. Genet. 21 (1999) 195-199
30. Meyron-Holtz E.G., Ghosh M.C., Iwai K., LaVaute T., Brazzolotto X., Berger U.V., Land W., Ollivierre-Wilson H., Grinberg A., Love P., and Rouault T.A. Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis. EMBO J. 23 (2004) 386-395
31. O'Neil J., and Powell L. Clinical aspects of hemochromatosis. Semin. Liver Dis. 25 (2005) 381-391
32. Halliwell B., and Gutteridge J.M. Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol. 186 (1990) 1-85
33. Shah S.V., Baliga R., Rajapurkar M., and Fonseca V.A. Oxidants in chronic kidney disease. J. Am. Soc. Nephrol. 18 (2007) 16-28
34. Swaminathan S., and Shah S.V. Novel approaches targeted toward oxidative stress for the treatment of chronic kidney disease. Curr. Opin. Nephrol. Hypertens 17 (2008) 143-148
35. Vaziri N.D. Erythropoietin and transferrin metabolism in nephrotic syndrome. Am. J. Kidney Dis. 38 (2001) 1-8
36. Prinsen B.H., de Sain-van der Velden M.G., Kaysen G.A., Straver H.W., van Rijn H.J., Stellaard F., Berger R., and Rabelink T.J. Transferrin synthesis is increased in nephrotic patients insufficiently to replace urinary losses. J. Am. Soc. Nephrol. 12 (2001) 1017-1025
37. Norden A.G., Lapsley M., Lee P.J., Pusey C.D., Scheinman S.J., Tam F.W., Thakker R.V., Unwin R.J., and Wrong O. Glomerular protein sieving and implications for renal failure in Fanconi syndrome. Kidney Int. 60 (2001) 1885-1892
38. Ohno Y., Birn H., and Christensen E.I. In vivo confocal laser scanning microscopy and micropuncture in intact rat. Nephron, Exp. Nephrol. 99 (2005) e17-25
39. Ludwiczek S., Theurl I., Muckenthaler M.U., Jakab M., Mair S.M., Theurl M., Kiss J., Paulmichl M., Hentze M.W., Ritter M., and Weiss G. Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1. Nat. Med. 13 (2007) 448-454
40. Salim S., Asad H., Kumar M.S., Brezin J., Heifets M., and Fyfe B. Renal siderosis in donor allograft: pathologic and clinical sequelae. Am. J. Transp. 4 (2004) 1717-1719
41. Pietrangelo A. Hereditary hemochromatosis. Biochim. Biophys. Acta 1763 (2006) 700-710
42. Pietrangelo A. Hereditary hemochromatosis-a new look at an old disease. N. Engl. J. Med. 350 (2004) 2383-2397
43. Six K.M., and Goyer R.A. The influence of iron deficiency on tissue content and toxicity of ingested lead in the rat. J. Lab. Clin. Med. 79 (1972) 128-136
44. Kushner J.P., Porter J.P., and Olivieri N.F. Secondary iron overload. Hematol. Am. Soc. Hematol. Educ. Program (2001) 47-61
45. Kulaksiz H., Theilig F., Bachmann S., Gehrke S.G., Rost D., Janetzko A., Cetin Y., and Stremmel W. The iron-regulatory peptide hormone hepcidin: expression and cellular localization in the mammalian kidney. J. Endocrinol. 184 (2005) 361-370
46. Zhou X.Y., Tomatsu S., Fleming R.E., Parkkila S., Waheed A., Jiang J., Fei Y., Brunt E.M., Ruddy D.A., Prass C.E., Schatzman R.C., O'Neill R., Britton R.S., Bacon B.R., and Sly W.S. HFE gene knockout produces mouse model of hereditary hemochromatosis. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 2492-2497
47. Trinder D., Olynyk J.K., Sly W.S., and Morgan E.H. Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 5622-5626
48. Barnard III J.A., and Manci E. Idiopathic neonatal iron-storage disease. Gastroenterology 101 (1991) 1420-1427
49. Sergi C., Himbert U., Weinhardt F., Heilmann W., Meyer P., Beedgen B., Zilow E., Hofmann W.J., Linderkamp O., and Otto H.F. Hepatic failure with neonatal tissue siderosis of hemochromatotic type in an infant presenting with meconium ileus. Case report and differential diagnosis of the perinatal iron storage disorders. Pathol. Res. Pract. 197 (2001) 699-709 discussion 711-693
50. Aisen P. Transferrin, the transferrin receptor, and the uptake of iron by cells. Met. Ions Biol. Syst. 35 (1998) 585-631
51. Aisen P. Transferrin receptor 1. Int. J. Biochem. Cell Biol. 36 (2004) 2137-2143
52. Dunn L.L., Rahmanto Y.S., and Richardson D.R. Iron uptake and metabolism in the new millennium. Trends Cell Biol. 17 (2007) 93-100
53. Kowdley K.V. Iron, hemochromatosis, and hepatocellular carcinoma. Gastroenterology 127 (2004) S79-S86
54. Hann H.W., Stahlhut M.W., and Hann C.L. Effect of iron and desferoxamine on cell growth and in vitro ferritin synthesis in human hepatoma cell lines. Hepatology 11 (1990) 566-569
55. Chenoufi N., Loreal O., Drenou B., Cariou S., Hubert N., Leroyer P., Brissot P., and Lescoat G. Iron may induce both DNA synthesis and repair in rat hepatocytes stimulated by EGF/pyruvate. J. Hepatol. 26 (1997) 650-658
56. Hussain S.P., and Harris C.C. Molecular epidemiology and carcinogenesis: endogenous and exogenous carcinogens. Mutat. Res. 462 (2000) 311-322
57. Hussain S.P., Raja K., Amstad P.A., Sawyer M., Trudel L.J., Wogan G.N., Hofseth L.J., Shields P.G., Billiar T.R., Trautwein C., Hohler T., Galle P.R., Phillips D.H., Markin R., Marrogi A.J., and Harris C.C. Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 12770-12775
58. Green R., Esparza I., and Schreiber R. Iron inhibits the nonspecific tumoricidal activity of macrophages. A possible contributory mechanism for neoplasia in hemochromatosis. Ann. N. Y. Acad. Sci. 526 (1988) 301-309
59. Huang X. Iron overload and its association with cancer risk in humans: evidence for iron as a carcinogenic metal. Mutat. Res. 533 (2003) 153-171
60. Okada S. Prevention of free-radical mediated tissue damage and carcinogenesis induced by low-molecular-weight iron. BioMetals 16 (2003) 99-101
61. Bridges C.C., and Zalups R.K. Molecular and ionic mimicry and the transport of toxic metals. Toxicol. Appl. Pharmacol. 204 (2005) 274-308
62. Abouhamed M., Wolff N.A., Lee W.K., Smith C.P., and Thévenod F. Knockdown of endosomal/lysosomal divalent metal transporter 1 by RNA interference prevents cadmium-metallothionein-1 cytotoxicity in renal proximal tubule cells. Am. J. Physiol. Renal Physiol. 293 (2007) F705-F712
63. Thévenod F. Nephrotoxicity and the proximal tubule. Insights from cadmium. Nephron Physiol. 93 (2003) 87-93
64. Wolff N.A., Abouhamed M., Verroust P.J., and Thévenod F. Megalin-dependent internalization of cadmium-metallothionein and cytotoxicity in cultured renal proximal tubule cells. J. Pharmacol. Exp. Ther. 318 (2006) 782-791
65. Wolff N.A., Lee W.K., Abouhamed M., and Thevenod F. Role of ARF6 in internalization of metal-binding proteins, metallothionein and transferrin, and cadmium-metallothionein toxicity in kidney proximal tubule cells. Toxicol. Appl. Pharmacol. 230 (2008) 78-85
66. ATSDR, Agency for Toxic Substance and Disease Registry, U.S. Toxicological Profile for Cadmium., Department of Health and Humans Services, Public Health Service, Centers for Disease Control, Atlanta, GA, U.S.A., 2005.
67. Goumakos W., Laussac J.P., and Sarkar B. Binding of cadmium(II) and zinc(II) to human and dog serum albumins. An equilibrium dialysis and 113Cd-NMR study. Biochem. Cell. Biol. 69 (1991) 809-820
68. Coyle P., Philcox J.C., Carey L.C., and Rofe A.M. Metallothionein: the multipurpose protein. Cell. Mol. Life Sci. 59 (2002) 627-647
69. Dudley R.E., Gammal L.M., and Klaassen C.D. Cadmium-induced hepatic and renal injury in chronically exposed rats: likely role of hepatic cadmium-metallothionein in nephrotoxicity. Toxicol. Appl. Pharmacol. 77 (1985) 414-426
70. Cherian M.G., and Vostal J.J. Biliary excretion of cadmium in rat. I. Dose-dependent biliary excretion and the form of cadmium in the bile. J. Toxicol. Environ. Health 2 (1977) 945-954
71. Thijssen S., Maringwa J., Faes C., Lambrichts I., and Van Kerkhove E. Chronic exposure of mice to environmentally relevant, low doses of cadmium leads to early renal damage, not predicted by blood or urine cadmium levels. Toxicology 229 (2007) 145-156
72. Zalups R.K., and Ahmad S. Molecular handling of cadmium in transporting epithelia. Toxicol. Appl. Pharmacol. 186 (2003) 163-188
73. Robinson M.K., Barfuss D.W., and Zalups R.K. Cadmium transport and toxicity in isolated perfused segments of the renal proximal tubule. Toxicol. Appl. Pharmacol. 121 (1993) 103-111
74. Friberg L., Elinder C.G., Kjellstrom T., and Nordberg G.F. Cadmium and Health: A Toxicological and Epidemiological Approach (1986), CRC Press, Boca Raton, FL
75. Bernard A., Buchet J.P., Roels H., Masson P., and Lauwerys R. Renal excretion of proteins and enzymes in workers exposed to cadmium. Eur. J. Clin. Invest. 9 (1979) 11-22
76. Wedeen R.P., and De Broe M.E. In: Davison A.M. (Ed). Oxford Textbook of Clinical Nephrology vol. 2 (1998), Oxford University Press, Oxford, U. K. 1175-1189
77. Liu J., Habeebu S.S., Liu Y., and Klaassen C.D. Acute CdMT injection is not a good model to study chronic Cd nephropathy: comparison of chronic CdCl2 and CdMT exposure with acute CdMT injection in rats. Toxicol. Appl. Pharmacol. 153 (1998) 48-58
78. Thévenod F., and Friedmann J.M. Cadmium-mediated oxidative stress in kidney proximal tubule cells induces degradation of Na+/K(+)-ATPase through proteasomal and endo-/lysosomal proteolytic pathways. FASEB J. 13 (1999) 1751-1761
79. Bannon D.I., Abounader R., Lees P.S., and Bressler J.P. Effect of DMT1 knockdown on iron, cadmium, and lead uptake in Caco-2 cells. Am. J. Physiol. Cell Physiol. 284 (2003) C44-C50
80. Bressler J.P., Olivi L., Cheong J.H., Kim Y., and Bannona D. Divalent metal transporter 1 in lead and cadmium transport. Ann. N. Y. Acad. Sci. 1012 (2004) 142-152
81. El-Annan J., Brown D., Breton S., Bourgoin S., Ausiello D.A., and Marshansky V. Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situ. Am. J. Physiol. Cell Physiol. 286 (2004) C768-C778
82. Maranda B., Brown D., Bourgoin S., Casanova J.E., Vinay P., Ausiello D.A., and Marshansky V. Intra-endosomal pH-sensitive recruitment of the Arf-nucleotide exchange factor ARNO and Arf6 from cytoplasm to proximal tubule endosomes. J. Biol. Chem. 276 (2001) 18540-18550
83. Lee W.K., Bork U., Gholamrezaei F., and Thévenod F. Cd2+-induced cytochrome c release in apoptotic proximal tubule cells: role of mitochondrial permeability transition pore and Ca2+ uniporter. Am. J. Physiol. Renal Physiol. 288 (2005) F27-F39
84. Lee W.K., Torchalski B., and Thévenod F. Cadmium-induced ceramide formation triggers calpain-dependent apoptosis in cultured kidney proximal tubule cells. Am. J. Physiol. Cell Physiol. 293 (2007) C839-C847
85. Barbier O., Jacquillet G., Tauc M., Poujeol P., and Cougnon M. Acute study of interaction among cadmium, calcium, and zinc transport along the rat nephron in vivo. Am. J. Physiol. Renal Physiol. 287 (2004) F1067-F1075
86. Friedman P.A., and Gesek F.A. Cadmium uptake by kidney distal convoluted tubule cells. Toxicol. Appl. Pharmacol. 128 (1994) 257-263
87. Olivi L., Sisk J., and Bressler J. Involvement of DMT1 in uptake of Cd in MDCK cells: role of protein kinase C. Am. J. Physiol. Cell Physiol. 281 (2001) C793-C800