Knockdown of endosomal/lysosomal divalent metal transporter 1 by RNA interference prevents cadmium-metallothionein-1 cytotoxicity in renal proximal tubule cells

American Journal of Physiology - Renal Physiology

Volumn 293, Issue 3, 2007, Pages

  Abouhamed, Marouan ^a,c   Wolff, Natascha A ^a   Lee, Wing Kee ^a   Smith, Craig P ^b   Thévenod, Frank ^a  

^a UNIVERSITY OF WITTEN HERDECKE   (Germany)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

DMT1; Endocytosis; Heavy metals; Metallothionein

Indexed keywords

CADMIUM; CUBULIN; FLUORESCENT DYE; MEGALIN; MESSENGER RNA; METALLOTHIONEIN I; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; ENDOCYTOSIS; ENDOSOME; GENETIC TRANSFECTION; GLOMERULUS; IMMUNOBLOTTING; INTERNALIZATION; ION TRANSPORT; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE DAMAGE; LONG TERM EXPOSURE; LYSOSOME; NEPHROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA VECTOR; SIGNAL TRANSDUCTION;

EID: 34548613879     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00198.2007     Document Type: Article

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