Roles of mTOR and STAT3 in autophagy induced by telomere 3′ overhang-specific DNA oligonucleotides

Autophagy

Volumn 3, Issue 5, 2007, Pages 496-498

  Yokoyama, Tomohisa ^a   Kondo, Yasuko ^a   Kondo, Seiji ^a,b,c  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

Autophagy; Glioma; mTOR; STAT3; T oligos; Telomere 3 overhang

Indexed keywords

ATM PROTEIN; DNA; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; OLIGONUCLEOTIDE; PROTEIN INHIBITOR OF ACTIVATED STAT; PROTEIN P53; PROTEIN P73; RAPAMYCIN; SINGLE STRANDED DNA; STAT3 PROTEIN; STAT3 PROTEIN INHIBITOR; TELOMERE 3' OVERHANG SPECIFIC DNA OLIGONUCLEOTIDE; UNCLASSIFIED DRUG; WP 1066;

APOPTOSIS; AUTOPHAGY; CANCER CELL; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; GLIOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MEMBRANE DAMAGE; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN MICROARRAY; REGULATORY MECHANISM; REVERSE PHASE PROTEIN MICROARRAY; SHORT SURVEY; TELOMERE; WESTERN BLOTTING;

MAMMALIA;

EID: 34548074436     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.4602     Document Type: Short Survey

References (23)

1. Aoki H, Iwado H, Eller MS, Kondo Y, Fujiwara K, Li GZ, Hess KR, Siwak DR, Sawaya R, Mills GB, Gilchrest BA, Kondo S. Telomere 3′ overhang-specific DNA oligonucleotides induce autophagy in malignant glioma cells. FASEB J 2007; Epub ahead of print.
2. Noda T, Ohsumi Y. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Bio Chem 1998; 273:3963-6.
3. Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, et al. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet 2004; 36:585-95.
4. Takeuchi H, Kondo Y, Fujiwara K, Kanzawa T, Aoki H, Mills GB, Kondo S. Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors. Cancer Res 2005; 65:3336-46.
5. Iwamaru A, Kondo Y, Iwado E, Aoki H, Fujiwara K, Yokoyama T, Mills GB, Kondo S. Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells. Oncogene 2007; 26:1840-51.
6. Iwamaru A, Szymanski S, Iwado E, Aoki H, Yokoyama T, Fokt I, Hess K, Conrad C, Madden T, Sawaya R, Kondo S, Priebe W, Kondo Y. A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. Oncogene 2007; 26:2435-44.
7. Bogler O, Weller M. Apoptosis in gliomas, and its role in their current and future treatment. Front Biosci 2002; 7:e339-53.
8. Kondo S, Barna BP, Morimura T, Takeuchi J, Yuan J, Akbasak A, Barnett GH. Interleukin-1 beta-converting enzyme mediates cisplatin-induced apoptosis in malignant glioma cells. Cancer Res 1995; 55:6166-71.
9. Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD, Levine B. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122:927-39.
10. Marx J. Autophagy: Is it cancer's friend or foe? Science 2006; 312:1160-1.
11. Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2:489-501.
12. Shintani T, Klionsky DJ. Autophagy in health and disease: A double-edged sword. Science 2004; 306:990-5.
13. Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell 2000; 103:253-62.
14. Heim MH. The Jak-STAT pathway: Cytokine signalling from the receptor to the nucleus. J Recept Signal Transduct Res 1999; 19:75-120.
15. Bowman T, Garcia R, Turkson J, Jove R. STATs in oncogenesis. Oncogene 2000; 19:2474-88.
16. Bromberg JF. Activation of STAT proteins and growth control. Bioessays 2001; 23:161-9.
17. Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C, Darnell Jr JE. Stat3 as an oncogene. Cell 1999; 98:295-303.
18. Kiuchi N, Nakajima K, Ichiba M, Fukada T, Narimatsu M, Mizuno K, Hibi M, Hirano T. STAT3 is required for the gp130-mediated full activation of the c-myc gene. J Exp Med 1999; 189:63-73.
19. Epling-Burnette PK, Liu JH, Carlett-Falcone R, Turkson J, Oshiro M, Kothapalli R, Li Y, Wang JM, Yang-Yen HF, Karras J, Jove R, Loughran Jr TP. Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J Clin Invest 2001; 107:351-62.
20. Eller MS, Puri N, Hadshiew IM, Venna SS, Gilchrest BA. Induction of apoptosis by telomere 3′ overhang-specific DNA. Exp Cell Res 2002; 276:185-93.
21. Puri N, Eller MS, Byers HR, Dykstra S, Kubera J, Gilchrest BA. Telomere-based DNA damage responses: A new approach to melanoma. FASEB J 2004; 18:1373-81.
22. Li GZ, Eller MS, Firoozabadi R, Gilchrest BA. Evidence that exposure of the telomere 3′ overhang sequence induces senescence. Proc Natl Acad Sci USA 2003; 100:527-31.
23. Eller MS, Li GZ, Firoozabadi R, Puri N, Gilchrest BA. Induction of a p95/Nbs1-mediated S phase checkpoint by telomere 3′ overhang specific DNA. FASEB J 2003; 17:152-62.