Antiproliferative activity of G-quartet-containing oligonucleotides generated by a novel single-stranded DNA expression system

Cancer Gene Therapy

Volumn 10, Issue 12, 2003, Pages 867-869

  McMicken, Harilyn W ^a   Bates, Paula J ^b   Chen, Yin ^a  

^a CytoGenix Inc   (United States)

^b University of Louisville School of Medicine   (United States)

Author keywords

Antiproliferative activity; G quartet containing oligonucleotides; GRO29A; ssDNA expression vector

Indexed keywords

GRO 29A; GUANINE DERIVATIVE; OLIGONUCLEOTIDE; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DNA VECTOR; DRUG MECHANISM; DRUG SCREENING; DRUG TARGETING; FEMALE; GENE TARGETING; GENE THERAPY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; VALIDATION PROCESS;

CELL DIVISION; DNA, SINGLE-STRANDED; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HUMANS; OLIGONUCLEOTIDES; TUMOR CELLS, CULTURED;

VECTORS;

EID: 0346122779     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700652     Document Type: Article

References (12)

1. Sen D, Gilbert W. Guanine quartet structure. Methods Enzymol. 1992;211:191-199.
2. Han H, Hurley L. G-quadruplex DNA: a potential target for anti-cancer drug design. Trends Pharmacol Sci. 2000;21:136-142.
3. Bates PJ, Kahlon JB, Thomas SD, et al. Antiproliferative activity of G-rich oligonucleotides correlates with protein binding. J Biol Chem. 1999;274:26369-26377.
4. Xu X, Hamhouyia F, Thomas SD, et al. Inhibition of DNA replication and induction of S phase cell cycle arrest by G-rich oligonucleotides. J Biol Chem. 2001;276:43221-43230.
5. Akhtar S, Hughes MD, Khan A, et al. The delivery of antisense therapeutics. Adv Drug Delivery Rev. 2000;44:3-21.
6. Chen Y, Ji Y, Roxby R, Conrad C. In vivo expression of single-stranded DNA in mammalian cells with DNA enzyme sequences targeted to C-raf. Antisense Nucleic Acid Drug Dev. 2000;10:415-422.
7. Chen Y, Ji Y, Conrad C. A novel system for the expression of single-stranded DNA in mammalian cells. Biotechniques. 2003;34:167-171.
8. Datta HJ, Glazer PM. Intracellular generation of single-stranded DNA for chromosomal triplex formation and induced recombination. Nucleic Acid Res. 2001;29:5140-5147.
9. Chen Y. A novel single-stranded DNA expression vector. Expert Opin Biol Ther. 2002;2:735-740.
10. Tanase N, Goff SP. Domain structure of the Moloney murine leukemia virus reverse transcriptase: mutational analysis and separate expression of the DNA polymerase and RNase H activities. Proc Natl Acad Sci USA. 1988;85:1777-1781.
11. Shinnick TM, Lerner RA, Sutcliffe JG. Nucleotide sequence of Moloney murine leukaemia virus. Nature. 1981;293:543-548.
12. Marquet R, Isel C, Ehresmann C, Ehresmann B. tRNAs as primer of reverse transcriptase. Biochimie. 1995;77:113-124.