An interlocked dimeric parallel-stranded DNA quadruplex: A potent inhibitor of HIV-1 integrase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 3, 2005, Pages 634-639

  Phan, Anh Tuân ^a   Kuryavyi, Vitaly ^a   Ma, Jin Biao ^a   Faure, Aurélie ^b,c   Andréola, Marie Line ^b,c   Patel, Dinshaw J ^a,b,c  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b CNRS   (France)

^c Inst Fed Rech 66 Pathol I/C   (France)

Author keywords

Dimeric quadruplex; DNA aptamer

Indexed keywords

93DEL DIMERIC DNA QUADRUPLEX PROTEIN; APTAMER; DNA; GUANINE DERIVATIVE; HIV 1 INTEGRASE; INTEGRASE INHIBITOR; MONOMER; OLIGONUCLEOTIDE T30177; OLIGONUCLEOTIDE T30695; OLIGONUCLEOTIDE T30923; POTASSIUM ION; UNCLASSIFIED DRUG; VIRUS ENZYME;

ARTICLE; BINDING AFFINITY; DIMERIZATION; DNA SEQUENCE; DNA STRAND; DNA STRUCTURE; DRUG POTENCY; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; STRUCTURE ANALYSIS; VIRUS DNA CELL DNA INTERACTION;

ANTI-HIV AGENTS; BASE SEQUENCE; BINDING SITES; DNA; DRUG DESIGN; HIV INTEGRASE; HUMANS; INTEGRASE INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; NUCLEIC ACID CONFORMATION; POTASSIUM;

HIV 1; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 14144254793     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0406278102     Document Type: Article

References (41)

1. Craigie, R. (2001) J. Biol. Chem. 276, 23213-23216.
2. Neamati, N., Marchand, C. & Pommier, Y. (2000) Adv. Pharmacol. 49, 147-165.
3. Tarrago-Litvak, L., Andréola, M. L., Fournier, M., Nevinsky, G. A., Parissi, V., de Soultrait, V. R. & Litvak, S. (2002) Curr. Pharm. Des. 8, 595-614.
4. Mazumder, A., Neamati, N., Ojwang. J. O., Sunder, S., Rando, R. F. & Pommier, Y. (1996) Biochemistry 35, 13762-13771.
5. Jing, N., Marchand, C., Liu, J., Mitra, R., Hogan, M. E. & Pommier, Y. (2000) J. Biol. Chem. 275, 21460-21467.
6. de Soultrait, V. R., Lozach, P. Y., Altmeyer, R., Tarrago-Litvak, L., Litvak, S. & Andréola, M. L. (2002) J. Mol. Biol. 324, 195-203.
7. Smith, F. W. & Feigon, J. (1992) Nature 356, 164-168.
8. Haider, S., Parkinson, G. N. & Neidle, S. (2002) J. Mol. Biol. 320, 189-200.
9. Wang, Y. & Patel, D. J. (1993) Structure (London) 1, 263-282.
10. Wang, Y. & Patel, D. J. (1994) Structure (London) 2, 1141-1156.
11. Kettani, A., Kumar, R. A. & Patel, D. J. (1995) J. Mol. Biol. 254, 638-656.
12. Kuryavyi, V., Majumdar, A., Shallop, A., Chernichenko, N., Skripkin, E., Jones, R. & Patel, D. J. (2001) J. Mol. Biol. 310, 181-194.
13. Parkinson, G. N., Lee, M. P. H. & Neidle, S. (2002) Nature 417, 876-880.
14. Phan, A. T. & Patel, D. J. (2003) J. Am. Chem. Soc. 125, 15021-15027.
15. Seenisamy, J., Rezler, E. M., Powell, T. J., Tye, D., Gokhale, V., Joshi, C. S., Siddiqui-Jain, A. & Hurley, L. H. (2004) J. Am. Chem. Soc. 126, 8702-8709.
16. Phan, A. T., Modi, Y. S. & Patel, D. J. (2004) J. Am. Chem. Soc. 126, 8710-8716.
17. Zhang, N., Gorin, A., Majumdar, A., Kettani, A., Chernichenko, N., Skripkin, E. & Patel, D. J. (2001) J. Mol. Biol. 311, 1063-1079.
18. Kettani, A., Gorin, A., Majumdar, A., Hermann, T., Skripkin, E., Zhao, H., Jones, R. & Patel, D. J. (2000) J. Mol. Biol. 297, 627-644.
19. Matsugami, A., Ouhashi, K., Kanagawa, M., Liu, H., Kanagawa, S., Uesugi, S. & Katahira, M. (2001) J. Mol. Biol. 313, 255-269.
20. Wang, J. Y., Ling, H., Yang, W. & Craigie, R. (2001) EMBO J. 20, 7333-7343.
21. Phan, A. T. & Patel, D. J. (2002) J. Am. Chem. Soc. 124, 1160-1161.
22. Phan, A. T., Guéron, M. & Leroy, J. L. (2001) Methods Enzymol. 338, 341-371.
23. Brünger, A. T. (1992) X-PLOR: A System for X-Ray Crystallography and NMR (Yale Univ. Press, New Haven, CT).
24. Katchalski-Katzir, E., Shariv, I., Eisenstein, M., Friesem, A. A., Aflalo, C. & Vakser, I. A. (1992) Proc. Natl. Acad. Sci. USA 89, 2195-2199.
25. Vakser, I. A. (1996) Biopolymers 39, 455-464.
26. Chow, S. A. (1997) Methods 12, 306-317.
27. Phan, A. T. (2000) J. Biomol. NMR 16, 175-178.
28. Kuryavyi, V. V. & Jovin, T. M. (1996) in Proceedings of the IX Conversation in Biomolecular Structure and Dynamics, eds. Sarma, R. H. & Sarma, M. H. (Adenine, Guilderland, NY), pp. 81-103.
29. Phan, A. T. (2001) J. Magn. Reson. 153, 223-226.
30. Balagurumoorthy, P., Brahmachari, S. K., Mohanty, D., Bansal, M. & Sasisekharan, V. (1992) Nucleic Acids Res. 20, 4061-4067.
31. Chow, S. A., Vincent, K. A., Ellison, V. & Brown, P. O. (1992) Science 255, 723-726.
32. Jenkins, T. M., Engelman, A., Ghirlando, R. & Craigie, R. (1996) J. Biol. Chem. 271, 7712-7718.
33. Eijkelenboom, A. P., Lutzke, R. A., Boelens, R., Plasterk, R. H., Kaptein, R. & Hard, K. (1995) Nat. Struct. Biol. 2, 807-810.
34. Cai, M., Zheng, R., Caffrey, M., Craigie, R., Clore, G. M. & Gronenborn, A. M. (1997) Nat. Struct. Biol. 4, 567-577.
35. Goldgur, Y., Dyda, F., Hickman, A. B., Jenkins, T. M., Craigie, R. & Davies, D. R. (1998) Proc. Natl. Acad. Sci. USA 95, 9150-9154.
36. Chen, J. C., Krucinski, J., Miercke, L. J., Finer-Moore, J. S., Tang, A. H., Leavitt, A. D. & Stroud, R. M. (2000) Proc. Natl. Acad. Sci. USA 97, 8233-8238.
37. Rice, P. & Mizzuchi, K. (1995) Cell 82, 209-220.
38. Jing, N., Gao, X., Rando, R. F. & Hogan, M. E. (1997) J. Biomol. Struct. Dyn. 15, 573-585.
39. Jing, N. & Hogan, M. E. (1998) J. Biol. Chem. 273, 34992-34999.
40. Dapic, V., Abdomerovic, V., Marrington, R., Peberdy, J., Rodger, A., Trent, J. O. & Bates, P. J. (2003) Nucleic Acids Res. 31, 2097-2107.
41. Kettani, A., Basu, G., Gorin, A., Majumdar, A., Skripkin, E. & Patel, D. J. (2000) J. Mol. Biol. 301, 129-146.