Guanosine-rich oligodeoxynucleotides induce proliferation of macrophage progenitors in cultures of murine bone marrow cells

European Journal of Immunology

Volumn 29, Issue 11, 1999, Pages 3496-3506

  Lang, Roland ^a   Hültner, Lothar ^b   Lipford, Grayson B ^a   Wagner, Hermann ^a   Heeg, Klaus ^c  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Bone marrow cell; Guanosine rich oligodeoxynucleotides; Macrophage; Proliferation

Indexed keywords

GUANINE; INTERLEUKIN 12; INTERLEUKIN 6; OLIGODEOXYNUCLEOTIDE; PROTEIN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; BONE MARROW CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GEL MOBILITY SHIFT ASSAY; HEMATOPOIETIC STEM CELL; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN NUCLEIC ACID INTERACTION;

AGAR; ANIMALS; BONE MARROW CELLS; CELL DIVISION; CELLS, CULTURED; FEMALE; GRANULOCYTE COLONY-STIMULATING FACTOR; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; GUANOSINE; HEMATOPOIETIC STEM CELLS; IMMUNOPHENOTYPING; INTERLEUKIN-6; MACROPHAGE ACTIVATION; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; MICE; MICE, INBRED C57BL; OLIGODEOXYRIBONUCLEOTIDES; SPLEEN;

EID: 0344286140     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199911)29:11<3496::AID-IMMU3496>3.0.CO;2-3     Document Type: Article

References (41)

1. Stein, C. A. and Cheng, Y. C., Antisense oligonucleotides as therapeutic agents - is the bullet really magical? Science 1993. 261: 1004-1012.
2. Branch, A. D., A good antisense molecule is hard to find. Trends. Biochem. Sci. 1998. 23: 45-50.
3. Krieg, A. M., Yi, A. K., Matson, S., Waldschmidt, T. J., Bishop, G. A., Teasdale, R., Koretzky, G. A. and Klinman, D. M., CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 1995. 374: 546-549.
4. Sparwasser, T., Miethke, T., Lipford, G., Erdmann, A., Hacker, H., Heeg, K. and Wagner, H., Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock. Eur. J. Immunol. 1997. 27: 1671-1679.
5. Stacey, K. J., Sweet, M. J. and Hume, D. A., Macrophages ingest and are activated by bacterial DNA. J. Immunol. 1996. 157: 2116-2122.
6. Sparwasser, T., Koch, E. S., Vabulas, R. M., Heeg, K., Lipford, G. B., Ellwart, J. W. and Wagner, H., Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur. J. Immunol. 1998. 28: 2045-2054.
7. Jakob, T., Walker, P. S., Krieg, A. M., Udey, M. C. and Vogel, J. C., Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA. J. Immunol. 1998. 161: 3042-3049.
8. Lipford, G. B., Bauer, M., Blank, C., Reiter, R., Wagner, H. and Heeg, K., CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants. Eur. J. Immunol. 1997. 27: 2340-2344.
9. Sun, S., Kishimoto, H. and Sprent, J., DNA as an adjuvant: capacity of insect DNA and synthetic oligodeoxynucleotides to augment T cell responses to specific antigen. J. Exp. Med. 1998. 187: 1145-1150.
10. Chu, R. S., Targoni, O. S., Krieg, A. M., Lehmann, P. V. and Harding, C. V., CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J. Exp. Med. 1997. 186: 1623-1631.
11. Zimmermann, S., Egeter, O., Hausmann, S., Lipford, G. B., Rocken, M., Wagner, H. and Heeg, K., CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis. J. Immunol. 1998. 160: 3627-3630.
12. Davis, H. L., Weeranta, R., Waldschmidt, T. J., Tygrett, L., Schorr, J. and Krieg, A. M., CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J. Immunol. 1998. 160: 870-876.
13. Bird, A. P., CpG-rich islands and the function of DNA methylation. Nature 1986. 321: 209-213.
14. Medzhitov, R. and Janeway, C. A., Jr., Innate immunity: the virtues of a nonclonal system of recognition. Cell 1997. 91: 295-298.
15. Lipford, G. B., Heeg K. and Wagner, H., Bacterial DNA as immune cell activator. Trends. Microbiol. 1998. 6: 496-498.
16. Benimetskaya, L., Loike, J. D., Khaled, Z., Loike, G., Silverstein, S. C., Cao, L., el Khoury, J., Cai, T. Q. and Stein, C. A., Mac-1 (CD11b/CD18) is an oligodeoxynucleotide-binding protein. Nat. Med. 1997. 3: 414-420.
17. Kimura, Y., Sonehara, K., Kuramoto, E., Makino, T., Yamamoto, S., Yamamoto, T., Kataoka, T. and Tokunaga, T., Binding of oligoguanylate to scavenger receptors is required for oligonucleotides to augment NK cell activity and induce IFN. J. Biochem. (Tokyo) 1994. 116: 991-994.
18. Pearson, A. M., Scavenger receptors in innate immunity. Curr. Opin. Immunol. 1996. 8: 20-28.
19. Sasaki, T., Horiuchi, S., Yamazaki, M. and Yui, S., Stimulation of macrophage DNA synthesis by polyanionic substances throug binding to the macrophage scavenger receptor. Biol. Pharm. Bull. 1996. 19: 449-455.
20. Saijo, Y., Uchiyama, B., Abe, T., Satoh, K. and Nukiwa, T., Contiguous four-guanosine sequence in c-myc antisense phosphorothioate oligonucleotides inhibits cell growth on human lung cancer cells: possible involvement of cell adhesion inhibition. Jpn. J. Cancer. Res. 1997. 88: 26-33.
21. Castier, Y., Chemla, E., Nierat, J., Heudes, D., Vasseur, M. A., Rajnoch, C., Bruneval, P., Carpentier, A. and Fabiani, J. N., The activity of c-myb antisense oligonucleotide to prevent intimal hyperplasia is nonspecific. J. Cardiovasc. Surg. (Torino) 1998. 39: 1-7.
22. White, J. R., Gordon-Smith, E. C. and Rutherford, T. R., Phosphorothioate-capped antisense oligonucleotides to Ras GAP inhibit cell proliferation and trigger apoptosis but fail to downregulate GAP gene expression. Biochem. Biophys. Res. Commun. 1996. 227: 118-124.
23. Benimetskaya, L., Berton, M., Kolbanovsky, A., Benimetsky, S. and Stein, C. A., Formation of a G-tetrad and higher structures correlates with biological activity of the RelA (NF-kappaB p65) 'antisense' oligodeoxynucleotide. Nucleic Acids Res. 1997. 25: 2648-2656.
24. Metcalf, D., Nicola, N. A. and Robb, L., Differentiation commitment in normal hemopoiesis and leukemic transformation. J. Cell. Physiol. 1997. 173: 131-134.
25. Staber, F. G. and Metcalf, D., Cellular and molecular basis of the increased splenic hemopoiesis in mice treated with bacterial cell wall components. Proc. Natl. Acad. Sci. USA 1980. 77: 4322-4325.
26. Apte, R. N. and Pluznik, D. H., Genetic control of lipopolysaccharide induced generation of serum colony stimulating factor and proliferation of splenic granulocyte/macrophage precursor cells. J. Cell. Physiol. 1976. 89: 313-323.
27. Sparwasser, T., Miethke, T., Lipford, G., Borschert, K., Häcker, H., Heeg, K. and Wagner, H., Bacterial DNA causes septic shock. Nature 1997. 386: 336-337.
28. Lipford, G. B., Sparwasser, T., Bauer, M., Zimmermann, S., Koch, E. S., Heeg, K. and Wagner, H., Immunostimulatory DNA: sequence-dependent production of potentially harmful or useful cytokines. Eur. J. Immunol. 1997. 27: 3420-3426.
29. Sparwasser, T., Koch, E. S., Hultner, L., Luz, A., Lipford, G. and Wagner, H., Immunostimulatory CpG-oligonucleotides cause extramedullary murine hematopoiesis. J. Immunol. 1999. 162: 2368-2374.
30. Metcalf, D. (Ed.) The hemopoietic colony stimulating factors. Elsevier, Amsterdam 1984, p 198.
31. Wang, W., Chen, H. J., Sun, J., Benimetskaya, L., Schwarz, A., Cannon, P., Stein, C. A. and Rabbani, L. E., A comparison of guanosine-quartet inhibitory effects versus cytidine homopolymer inhibitory effects on rat neointimal formation. Antisense Nucleic Acid. Drug Dev. 1998. 8: 227-236.
32. Vaerman, J. L., Moureau, P., Deldime, F., Lewalle, P., Lammineur, C., Morschhauser, F. and Martiat, P., Antisense oligodeoxyribonucleotides suppress hematologic cell growth through stepwise release of deoxyribonucleotides. Blood 1997. 90: 331-339.
33. Krieg, A. M., Lymphocyte activation by CpG dinucleotide motifs in prokaryotic DNA. Trends Microbiol. 1996. 4: 73-76.
34. McElligott, R. and Wellinger, R. J., The terminal DNA structure of mammalian chromosomes. EMBO J. 1997. 16: 3705-3714.
35. Wright, W. E., Tesmer, V. M., Huffman, K. E., Levene, S. D. and Shay, J. W., Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes Dev. 1997. 11: 2801-2809.
36. Yui, S., Sasaki, T., Araki, N., Horiuchi, S. and Yamazaki, M., Induction of macrophage growth by advanced glycation end products of the Maillard reaction. J. Immunol. 1994. 152: 1943-1949.
37. Tam, R. C., Phan, U. T., Milovanovic, T., Pai, B., Lim, C., Bard, J., and He, L., Oligonucleotide-mediated inhibition of CD28 expression induces human T cell hyporesponsiveness and manifests impaired contact hypersensitivity in mice. J. Immunol. 1997. 158: 200-208.
38. Hultner, L., Staber, F. G., Mergenthaler, H. G. and Dormer, P., Production of murine granulocyte-macrophage colony-stimulating factors (GM-CSF) by bone marrow derived and non-hemopoietic cells in vivo. Exp. Hematol. 1982. 10: 798-808.
39. Coligan, J. E., Kruisbeek, A. M., Margulies, D. H., Shevach, E. M. and Strober, W. (Eds.) Current protocols in Immunology, vol. 3. Wiley and Sons 1994. p A.3C.1.
40. Teasdale, R. M., Matson, S J., Fisher, E. and Krieg, A. M., Inhibition of T4 polynucleotide kinase activity by phosphorothioate and chimeric oligodeoxynucleotides. Antisense. Res. Dev. 1994. 4: 295-297.
41. Latchman, D. S. (Ed.): Transcription factors - A practical approach. Oxford University Press, Oxford 1993, p10.