Visualizing sequence-governed nucleotide selectivities and mutagenic consequences through a replicative cycle: Processing of a bulky carcinogen N2-dG lesion in a Y-family DNA polymerase

Biochemistry

Volumn 48, Issue 22, 2009, Pages 4677-4690

  Xu, Pingna ^a   Oum, Lida ^a   Lee, Yuan Cho ^a   Geacintov, Nicholas E ^a   Broyde, Suse ^a  

^a NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BENZO [A] PYRENE; DNA POLYMERASE; DYNAMICS SIMULATION; ERROR PRONE; EXPERIMENTAL OBSERVATION; LESION BYPASS; MOLECULAR ORIGINS; PRIMER EXTENSION; RELATIVE DISTORTION; STRUCTURAL INSIGHTS; STRUCTURAL INTERPRETATION; TRANSLESION;

DNA; DYNAMICS; GENES; NUCLEIC ACIDS; NUCLEOTIDES;

POLYMERS;

BENZO[A]PYRENE; CARCINOGEN; DEOXYGUANOSINE; DEOXYGUANOSINE TRIPHOSPHATE; DNA POLYMERASE;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME KINETICS; GENE INSERTION; MOLECULAR DYNAMICS; MOLECULAR MODEL; MUTAGENESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FAMILY; SIMULATION;

ARCHAEAL PROTEINS; BASE SEQUENCE; BENZOPYRENES; CARCINOGENS; CATALYTIC DOMAIN; DEOXYGUANOSINE; DNA ADDUCTS; DNA POLYMERASE BETA; DNA REPLICATION; DNA, ARCHAEAL; MUTAGENESIS, INSERTIONAL; PROTEIN PROCESSING, POST-TRANSLATIONAL; SEQUENCE DELETION; SULFOLOBUS SOLFATARICUS;

EID: 66649115699     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi802363f     Document Type: Article

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