Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated

Biochemical Pharmacology

Volumn 71, Issue 1-2, 2005, Pages 13-20

  Cowell, Ian G ^a   Durkacz, Barbara W ^a   Tilby, Michael J ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

ATM; Breast cancer; DNA repair; DNA PK; Histone H2AX; Radiosensitivity

Indexed keywords

2 MORPHOLIN 4 YL 6 THIANTHREN 1 YLPYRAN 4 ONE; 8 DIBENZOTHIOPHEN 4 YL 2 MORPHOLIN 4 YLCHROMEN 4 ONE; ATM PROTEIN; CHROMENE DERIVATIVE; DNA DEPENDENT PROTEIN KINASE; KU 55933; NU 7441; PYRAN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CARCINOMA; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IONIZING RADIATION; PRIORITY JOURNAL; RADIOSENSITIZATION; VALIDATION PROCESS;

BREAST NEOPLASMS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CHROMONES; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; ENZYME INHIBITORS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MORPHOLINES; PHOTOSENSITIZING AGENTS; PROTEIN-SERINE-THREONINE KINASES; PYRONES; RADIATION, IONIZING; RADIATION-SENSITIZING AGENTS; TUMOR SUPPRESSOR PROTEINS;

EID: 28244461575     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.09.029     Document Type: Article

References (32)

1. J.A. Violet, and C. Harmer Breast cancer: improving outcome following adjuvant radiotherapy Br J Radiol 77 2004 811 820
2. S.P. Jackson Sensing and repairing DNA double-strand breaks Carcinogenesis 23 2002 687 696
3. K. Rothkamm, I. Kruger, L.H. Thompson, and M. Lobrich Pathways of DNA double-strand break repair during the mammalian cell cycle Mol Cell Biol 23 2003 5706 5715
4. M. Takata, M.S. Sasaki, E. Sonoda, C. Morrison, M. Hashimoto, and H. Utsumi Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells EMBO J 17 1998 5497 5508
5. Y. Shiloh ATM and related protein kinases: safeguarding genome integrity Nat Rev Cancer 3 2003 155 168
6. N. Foray, A. Priestley, G. Alsbeih, C. Badie, E.P. Capulas, and C.F. Arlett Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks Int J Radiat Biol 72 1997 271 283
7. M. Kuhne, E. Riballo, N. Rief, K. Rothkamm, P.A. Jeggo, and M. Lobrich A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity Cancer Res 64 2004 500 508
8. E. Riballo, M. Kuhne, N. Rief, A. Doherty, G.C. Smith, and M.J. Recio A pathway of double-strand break rejoining dependent upon ATM, artemis, and proteins locating to γ-H2AX Foci Mol. Cell 16 2004 715 724
9. G. Chen, S.S. Yuan, W. Liu, Y. Xu, K. Trujillo, and B. Song Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl J Biol Chem 274 1999 12748 12752
10. C. Morrison, E. Sonoda, N. Takao, A. Shinohara, K. Yamamoto, and S. Takeda The controlling role of ATM in homologous recombinational repair of DNA damage EMBO J 19 2000 463 471
11. R.J. Griffin, G. Fontana, B.T. Golding, S. Guiard, I.R. Hardcastle, and J.J. Leahy Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro J Med Chem 48 2005 569 585
12. S.J. Veuger, N.J. Curtin, C.J. Richardson, G.C. Smith, and B.W. Durkacz Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1 Cancer Res 63 2003 6008 6015
13. I. Hickson, Y. Zhao, C.J. Richardson, S.J. Green, N.M.B. Martin, and A.I. Orr Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia-mutated kinase ATM Cancer Res 64 2004 9152 9159
14. R.A. Izzard, S.P. Jackson, and G.C. Smith Competitive and non-competitive inhibition of the DNA-dependent protein kinase Cancer Res 59 1999 2581 2586
15. K.E. Rosenzweig, M.B. Youmell, S.T. Palayoor, and B.D. Price Radiosensitization of human tumor cells by the phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay Clin Cancer Res 3 1997 1149 1156
16. S. Boulton, S. Kyle, and B.W. Durkacz Mechanisms of enhancement of cytotoxicity in etoposide and ionising radiation-treated cells by the protein kinase inhibitor wortmannin Eur J Cancer 36 2000 535 541
17. C.J. Vlahos, W.F. Matter, K.Y. Hui, and R.F. Brown A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4- one (LY294002) J Biol Chem 269 1994 5241 5248
18. J.J. Leahy, B.T. Golding, R.J. Griffin, I.R. Hardcastle, C. Richardson, and L. Rigoreau Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries Bioorg Med Chem Lett 14 2004 6083 6087
19. C.J. Bakkenist, and M.B. Kastan DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation Nature 421 2003 499 506
20. S. Banin, L. Moyal, S.Y. Shieh, Y. Taya, C.W. Anderson, and L. Chessa Enhanced phosphorylation of p53 by ATM in response to DNA damage Science 281 1998 1674 1677
21. T. Stiff, M. O'Driscoll, N. Rief, K. Iwabuchi, M. Lobrich, and P.A. Jeggo ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation Cancer Res 64 2004 2390 2396
22. H. Wang, M. Wang, H. Wang, W. Bocker, and G. Iliakis Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors J Cell Physiol 202 2005 492 502
23. E.P. Rogakou, C. Boon, C. Redon, and W.M. Bonner Megabase chromatin domains involved in DNA double-strand breaks in vivo J Cell Biol 146 1999 905 916
24. S.H. MacPhail, J.P. Banath, T.Y. Yu, E.H. Chu, H. Lambur, and P.L. Olive Expression of phosphorylated histone H2AX in cultured cell lines following exposure to X-rays Int J Radiat Biol 79 2003 351 358
25. K. Rothkamm, and M. Lobrich Evidence for a lack of DNA double-strand break repair in human cells exposed to very low X-ray doses Proc Natl Acad Sci USA 100 2003 5057 5062
26. J.P. Banath, and P.L. Olive Expression of phosphorylated histone H2AX as a surrogate of cell killing by drugs that create DNA double-strand breaks Cancer Res 63 2003 4347 4350
27. Y.V. Reddy, Q. Ding, S.P. Lees-Miller, K. Meek, and D.A. Ramsden Nonhomologous end-joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends J Biol Chem 2004
28. C. Allen, J. Halbrook, and J.A. Nickoloff Interactive competition between homologous recombination and non-homologous end joining Mol Cancer Res 1 2003 913 920
29. Q. Ding, Y.V. Reddy, W. Wang, T. Woods, P. Douglas, and D.A. Ramsden Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair Mol Cell Biol 23 2003 5836 5848
30. S. Burma, B.P. Chen, M. Murphy, A. Kurimasa, and D.J. Chen ATM phosphorylates histone H2AX in response to DNA double-strand breaks J Biol Chem 276 2001 42462 42467
31. I.M. Ward, and J. Chen Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress J Biol Chem 276 2001 47759 47762
32. L. Zou, and S.J. Elledge Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes Science 300 2003 1542 1548