Increased levels of antimicrobial peptides in tracheal aspirates of newborn infants during infection

American Journal of Respiratory and Critical Care Medicine

Volumn 165, Issue 7, 2002, Pages 992-995

  Schaller Bals, Susanne ^a,b   Schulze, Andreas ^a,b   Bals, Robert ^a,b,c  

^a Department of Obstetrics and Gynecology   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY HOSPITAL MARBURG   (Germany)

Author keywords

Antimicrobial peptide; Cathelicidin; Defensin; Innate immunity; Pneumonia

Indexed keywords

BETA DEFENSIN; CATHELICIDIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; DEFENSIN; DEFENSIN 1; DEFENSIN 2; INTERLEUKIN 8; PEPTIDE; POLYPEPTIDE ANTIBIOTIC AGENT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; ARTIFICIAL VENTILATION; ASPIRATION; CLINICAL ARTICLE; HOST RESISTANCE; HUMAN; INFECTION; LUNG LAVAGE; NEWBORN; PNEUMONIA; PRIORITY JOURNAL; RESPIRATORY SYSTEM; WESTERN BLOTTING;

EID: 0036528903     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.165.7.200110-020     Document Type: Article

References (22)

1. Host defense mechanisms
2. Defensins and host defense
3. Human β-defensin-1 is a salt sensitive antibiotic in lung that is inactivated in cystic fibrosis
4. Human airway epithelia express a β-defensin
5. A peptide antibiotic from human skin
6. The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface
7. Ll-37, The neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, Monocytes and T-cells
8. β-Defensins: Linking innate and adaptive immunity through dendritic and T cell CCR6
9. Novel pathophysiological role of classical chemotactic peptide receptors and their communications with chemokine receptors
10. Mouse β-defensin 1 is a salt-sensitive antimicrobial peptide present in epithelia of the lung and urogenital tract
11. Mouse β defensin-1 is a functional homolog of human β defensin-1
12. The mouse genome encodes a single homolog of the antimicrobial peptide human β-defensin 1
13. Human β-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung
14. Elevated levels of interleukin-8 and transforming growth factor-β in bronchoalveolar lavage fluid from patients with bronchiolitis obliterans syndrome: Proinflammatory role of bronchial epithelial cells
15. Salt-independent abnormality of antimicrobial activity in cystic fibrosis airway surface fluid
16. hBD-1: A novel β-defensin from human plasma
17. Human β-defensin 4: A novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity
18. Human β-defensin 3 is an inducible antimicrobial peptide expressed in epithelial and non-epithelial tissues
19. Antibacterial components in bronchoalveolar lavage fluid from healthy individuals and sarcoidosis patients
20. Mucoid Pseudomonas aeruginosa, TNF-alpha, IL-1β, but not IL-6, induce human β-defensin-2 in respiratory epithelia
21. Expression and regulation of the human β-defensins hBD-1 and hBD-2 in intestinal epithelium
22. The human antimicrobial and chemotactic peptides LL-37 and α-defensins are expressed by specific lymphocyte and monocyte populations