Mitochondria, calcium, and calpain are key mediators of resveratrol-induced apoptosis in breast cancer

Molecular Pharmacology

Volumn 72, Issue 6, 2007, Pages 1466-1475

  Sareen, Dhruv ^a   Darjatmoko, Soesiawati R ^a   Albert, Daniel M ^a,b   Polans, Arthur S ^a,b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM; CALPAIN; CALPASTATIN; CASPASE 3; CASPASE 9; CYTOCHROME C; FODRIN; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE ANTAGONIST; POLYPHENOL; PROTEINASE; RESVERATROL; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CALCIUM CELL LEVEL; CANCER THERAPY; CELL DEATH; CELL LINE; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG MECHANISM; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; MICROSCOPY; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; TREATMENT PLANNING; TUMOR XENOGRAFT;

ANIMALS; APOPTOSIS; BREAST NEOPLASMS; CALCIUM; CALPAIN; CELL LINE, TUMOR; FEMALE; HUMANS; MICE; MICE, NUDE; MITOCHONDRIA; STILBENES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 36348997653     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.107.039040     Document Type: Article

References (40)

1. Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, and Takada Y (2004) Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res 24:2783-2840.
2. Ashkenazi A and Dixit VM (1998) Death receptors: signaling and modulation. Science 281:1305-1308.
3. Banerjee S, Bueso-Ramos C, and Aggarwal BB (2002) Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res 62:4945-4954.
4. 2+ exchanger in excitotoxicity. Cell 120:275-285.
5. Bhat KP, Lantvit D, Christov K, Mehta RG, Moon RC, and Pezzuto JM (2001) Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Cancer Res 61:7456-7463.
6. Bradamante S, Barenghi L, and Villa A (2004) Cardiovascular protective effects of resveratrol. Cardiovasc Drug Rev 22:169-188.
7. Buluc M and Demirel-Yilmaz E (2006) Resveratrol decreases calcium sensitivity of vascular smooth muscle and enhances cytosolic calcium increase in endothelium. Vascul Pharmacol 44:231-237.
8. Delmas D, Lancon A, Colin D, Jannin B, and Latruffe N (2006) Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer. Curr Drug Targets 7:423-442.
9. Delmas D, Rebe C, Lacour S, Filomenko R, Athias A, Gambert P, Cherkaoui-Malki M, Jannin B, Dubrez-Daloz L, Latruffe N, et al. (2003) Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells. J Biol Chem 278:41482-41490.
10. Devarajan E, Sahin AA, Chen JS, Krishnamurthy RR, Aggarwal N, Brun AM, Sapino A, Zhang F, Sharma D, Yang XH, et al. (2002) Down-regulation of caspase-3 in breast cancer: a possible mechanism for chemoresistance. Oncogene 21:8843-8851.
11. Ding WX, Shen HM, and Ong CN (2002) Calpain activation after mitochondrial permeability transition in microcystin-induced cell death in rat hepatocytes. Biochem Biophys Res Commun 291:321-331.
12. Garvin S, Ollinger K, and Dabrosin C (2006) Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo. Cancer Lett 231:113-122.
13. Green DR (2005) Apoptotic pathways: ten minutes to dead. Cell 121:671-674.
14. Green DR and Reed JC (1998) Mitochondria and apoptosis. Science 281:1309-1312.
15. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440-3450.
16. 2+ pump: focus on calpain sensitivity. J Biol Chem 278:38141-38148.
17. Guttmann RP and Johnson GV (1998) Oxidative stress inhibits calpain activity in situ. J Biol Chem 273:13331-13338.
18. Hambrock A, de Oliveira Franz CB, Hiller S, Grenz A, Ackermann S, Schulze DU, Drews G, and Osswald H (2007) Resveratrol binds to the sulfonylurea receptor (SUR) and induces apoptosis in a SUR subtype-specific manner. J Biol Chem 282:3347-3356.
19. Harwood SM, Yaqoob MM, and Allen DA (2005) Caspase and calpain function in cell death: bridging the gap between apoptosis and necrosis. Ann Clin Biochem 42:415-431.
20. Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta RG, et al. (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275:218-220.
21. Jänicke RU, Sprengart ML, Wati MR, and Porter AG (1998) Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem 273:9357-9360.
22. Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C, and Thun MJ (2006) Cancer statistics, 2006. CA Cancer J Clin 56:106-130.
23. Jiang H, Zhang L, Kuo J, Kuo K, Gautam SC, Groc L, Rodriguez AI, Koubi D, Hunter TJ, Corcoran GB, et al. (2005) Resveratrol-induced apoptotic death in human U251 glioma cells. Mol Cancer Ther 4:554-561.
24. Kim YA, Choi BT, Lee YT, Park DI, Rhee SH, Park KY, and Choi YH (2004) Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells. Oncol Rep 11:441-446.
25. Lin HY, Lansing L, Merillon JM, Davis FB, Tang HY, Shih A, Vitrac X, Krisa S, Keating T, Cao HJ, et al. (2006) Integrin alphaVbeta3 contains a receptor site for resveratrol. FASEB J 20:1742-1744.
26. Liu X, Van Vleet T, and Schnellmann RG (2004) The role of calpain in oncotic cell death. Annu Rev Pharmacol Toxicol 44:349-370.
27. Mahyar-Roemer M, Kohler H, and Roemer K (2002) Role of Bax in resveratrol-induced apoptosis of colorectal carcinoma cells. BMC Cancer 2:27.
28. Martinou JC, Desagher S, and Antonsson B (2000) Cytochrome c release from mitochondria: all or nothing. Nat Cell Biol 2:E41-E43.
29. Mohan J, Gandhi AA, Bhavya BC, Rashmi R, Karunagaran D, Indu R, and Santhoshkumar TR (2006) Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancer cells treated with resveratrol. J Biol Chem 281:17599-17611.
30. 2+ uptake by cyclosporin A. Br J Pharmacol 141:263-268.
31. Orrenius S, Zhivotovsky B, and Nicotera P (2003) Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol 4:552-565.
32. Petronilli V, Penzo D, Scorrano L, Bernardi P, and Di Lisa F (2001) The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ. J Biol Chem 276:12030-12034.
33. Potter DA, Tirnauer JS, Janssen R, Croall DE, Hughes CN, Fiacco KA, Mier JW, Maki M, and Herman IM (1998) Calpain regulates actin remodeling during cell spreading. J Cell Biol 141:647-662.
34. Pozo-Guisado E, Merino JM, Mulero-Navarro S, Lorenzo-Benayas MJ, Centeno F, Alvarez-Barrientos A, and Fernandez-Salguero PM (2005) Resveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-kappaB. Int J Cancer 115:74-84.
35. 2+ in a breast cancer cell line using a fluorescence microplate reader. J Biochem Biophys Methods 58:227-237.
36. Sareen D, van Ginkel PR, Takach JC, Mohiuddin A, Darjatmoko SR, Albert DM, and Polans AS (2006)Mitochondria as the primary target of resveratrol-induced apoptosis in human retinoblastoma cells. Invest Ophthalmol Vis Sci 47:3708-3716.
37. Sasaki T, Kikuchi T, Yumoto N, Yoshimura N, and Murachi T (1984) Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates. J Biol Chem 259:12489-12494.
38. Savouret JF and Quesne M (2002) Resveratrol and cancer: a review. Biomed Pharmacother 56:84-87.
39. Sun XM, MacFarlane M, Zhuang J, Wolf BB, Green DR, and Cohen GM (1999) Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. J Biol Chem 274:5053-5060.
40. 2+. Nan Fang Yi Ke Da Xue Xue Bao 26:910-913.