Dominant role for calpain in thromboxane-induced neuromicrovascular endothelial cytotoxicity

Journal of Pharmacology and Experimental Therapeutics

Volumn 316, Issue 2, 2006, Pages 618-627

  Quiniou, Christiane ^a,c   Sennlaub, Florian ^a,e   Beauchamp, Martin H ^a   Checchin, Daniella ^a,b   Lahaie, Isabelle ^a   Brault, Sonia ^a,b   Gobeil Jr , Fernand ^a,d   Sirinyan, Mirna ^a,b   Kooli, Amna ^a,b   Hardy, Pierre ^a   Pshezhetsky, Alexey ^a,b   Chemtob, Sylvain ^a,b  

^a UNIVERSITY OF MONTREAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d UNIVERSITÉ DE SHERBROOKE   (Canada)

^e INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

(1 ALPHA,2 ALPHA,3 BETA,4 ALPHA) 7 [3 [3 HYDROXY 4 (4 IODOPHENOXY) 1 BUTENYL] 7 OXABICYCLO[2.1.1]HEPT 2 YL] 5 HEPTENOIC ACID; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 5,5',6,6' TETRACHLORO 1,1',3,3' TETRAETHYLBENZIMIDAZOLYLCARBOCYANINE IODIDE; 6,8 DIFLUORO 1,2,3,4 TETRAHYDRO 9 (4 METHYLSULFONYLBENZYL)CARBAZOLE 1 ACETIC ACID; ADENOSINE TRIPHOSPHATE; BENZENE DERIVATIVE; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CALCIUM ION; CALPAIN; CALPASTATIN; CASPASE 3; CASPASE INHIBITOR; FODRIN; HEPTANOIC ACID DERIVATIVE; INOSITOL TRISPHOSPHATE; JC 1; N SUCCINYLLEUCYLLEUCYLVALYLTYROSINE 7 AMINO 4 METHYLCOUMARIN; PHOSPHOLIPASE C; SULFORHODAMINE VALYLARGINYLASPARTYL FLUOROMETHYLKETONE; THROMBOXANE A2; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CELL CULTURE; CELL DEATH; CONTROLLED STUDY; CYTOSOL; DRUG CYTOTOXICITY; ENDOTHELIUM CELL; EXPLANT; MITOCHONDRION; MOLECULAR MIMICRY; MOLECULAR SIZE; NEWBORN; NONHUMAN; POTENTIOMETRY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN TRANSPORT; RAT; RETINA DEGENERATION; VASCULAR ENDOTHELIUM;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; ANIMALS, NEWBORN; CALCIUM; CALPAIN; CARBAZOLES; CELL SURVIVAL; CYTOSOL; ENDOTHELIUM, VASCULAR; INOSITOL PHOSPHATES; MEMBRANE POTENTIALS; MICROCIRCULATION; MITOCHONDRIA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, THROMBOXANE A2, PROSTAGLANDIN H2; RETINAL DEGENERATION; RETINAL VESSELS;

EID: 31144442334     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.093898     Document Type: Article

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