Clavulanic acid inactivation of SHV-1 and the inhibitor-resistant S130G SHV-1 β-lactamase: Insights into the mechanism of inhibition

Journal of Biological Chemistry

Volumn 280, Issue 42, 2005, Pages 35528-35536

  Sulton, Deley ^a   Pagan Rodriguez, Doritza ^a   Zhou, Xiang ^b   Liu, Yiding ^a   Hujer, Andrea M ^c   Bethel, Christopher R ^c   Helfand, Marion S ^c   Thomson, Jodi M ^e   Anderson, Vernon E ^d   Buynak, John D ^f   Ng, Lily M ^a   Bonomo, Robert A ^c,e  

^a CLEVELAND STATE UNIVERSITY   (United States)

^b Mass Spectrometry Facility   (United States)

^c LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

^e CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f SOUTHERN METHODIST UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; ENZYME INHIBITION; ENZYMES; LIQUID CHROMATOGRAPHY; PATHOLOGY;

CLAVULANIC ACID; INACTIVATION PATHWAY; REACTION INTERMEDIATES; ULTRAVIOLET (UV) DIFFERENCE;

BIOCHEMISTRY;

AMOXICILLIN PLUS CLAVULANIC ACID; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; BETA LACTAMASE TEM 1; CLAVULANIC ACID; GLYCINE; PENICILLIN DERIVATIVE; PIPERACILLIN PLUS TAZOBACTAM; SERINE; SHV 1 BETA LACTAMASE; SULBACTAM; SULPERAZON; SULTAMICILLIN; TAZOBACTAM; TIMENTIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVE SITE; ENZYME INACTIVATION; GRAM NEGATIVE BACTERIUM; LIQUID CHROMATOGRAPHY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PENICILLIN RESISTANCE; PRIORITY JOURNAL; ULTRAVIOLET RADIATION;

ANTI-BACTERIAL AGENTS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CHROMATOGRAPHY, LIQUID; CLAVULANIC ACID; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; GLYCINE; KINETICS; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; PEPTIDES; SERINE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS; TRYPSIN; ULTRAVIOLET RAYS;

NEGIBACTERIA;

EID: 27444443501     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501251200     Document Type: Article

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