Inhibition of Class A and Class C β-Lactamases by Penems: Crystallographic Structures of a Novel 1,4-Thiazepine Intermediate

Biochemistry

Volumn 42, Issue 45, 2003, Pages 13152-13159

  Nukaga, Michiyoshi ^a   Abe, Takao ^b   Venkatesan, Aranapakam M ^c   Mansour, Tarek S ^c   Bonomo, Robert A ^d   Knox, James R ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b Department of Pharmacokinetics   (Japan)

^c WYETH RESEARCH   (United States)

^d LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACIDS; CHEMICAL BONDS; CRYSTAL ORIENTATION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ESTERS; HYDROLYSIS; QUENCHING; STEREOCHEMISTRY; SUBSTRATES; WATER; X RAY DIFFRACTION ANALYSIS;

ACYL ESTER BONDS;

ENZYMES;

5,6 DIHYDRO 8H IMIDAZO[2,1 C][1,4]OXAZINE; BETA LACTAMASE INHIBITOR; PENEM DERIVATIVE; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS; IC 50; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STEREOCHEMISTRY; X RAY DIFFRACTION;

APOENZYMES; BETA-LACTAMASES; BETA-LACTAMS; BINDING SITES; CARBAPENEMS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ENTEROBACTER CLOACAE; ENZYME INHIBITORS; ENZYME STABILITY; KLEBSIELLA PNEUMONIAE; LACTAMS; MODELS, MOLECULAR; THIAZEPINES;

THIA;

EID: 0242569199     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034986b     Document Type: Article

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