A Role of the Third Complementarity-determining Region in the Affinity Maturation of an Antibody

Journal of Biological Chemistry

Volumn 276, Issue 29, 2001, Pages 27622-27628

  Furukawa, Koji ^a,b   Shirai, Hiroki ^c,e   Azuma, Takachika ^a   Nakamura, Haruki ^d  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d OSAKA UNIVERSITY   (Japan)

^e MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBODIES; ANTIGENS; CONFORMATIONS; MOLECULAR STRUCTURE;

SOMATIC CELLS;

IMMUNOLOGY;

(4 HYDROXY 3 NITROPHENYL)ACETYL DERIVATIVE; ACETIC ACID DERIVATIVE; UNCLASSIFIED DRUG; MONOCLONAL ANTIBODY;

AMINO ACID SEQUENCE; ANTIBODY AFFINITY; ANTIBODY COMBINING SITE; ANTIBODY STRUCTURE; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; IMMUNE RESPONSE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; STRUCTURE ANALYSIS; ANIMAL; C57BL MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; IMMUNOLOGY; PHYSIOLOGY;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; CIRCULAR DICHROISM; COMPLEMENTARITY DETERMINING REGIONS; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; PROTEIN CONFORMATION;

EID: 0035920123     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M102714200     Document Type: Article

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