Affinity Maturation Increases the Stability and Plasticity of the Fv Domain of Anti-protein Antibodies

Journal of Molecular Biology

Volumn 374, Issue 1, 2007, Pages 130-146

  Acierno, Juan Pablo ^a   Braden, Bradford C ^b   Klinke, Sebastián ^a   Goldbaum, Fernando A ^a   Cauerhff, Ana ^a  

^a FUNDACIÓN INSTITUTO LELOIR   (Argentina)

^b BOWIE STATE UNIVERSITY   (United States)

Author keywords

affinity maturation; antibody stability; antibody structure; heat capacity changes; VH VL interface

Indexed keywords

D44.1 ANTIBODY; EGG WHITE; EPITOPE; F10.6.6 ANTIBODY; FV ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; LYSOZYME; MONOCLONAL ANTIBODY; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY AFFINITY; ANTIBODY STRUCTURE; ANTIGEN BINDING; ARTICLE; COMPARATIVE STUDY; CONFORMATIONAL TRANSITION; HEN; KINETICS; NONHUMAN; PLASTICITY; PRIORITY JOURNAL; THERMODYNAMICS;

EID: 35349014634     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.09.005     Document Type: Article

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