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Volumn 16, Issue 2, 2009, Pages 100-106

Clinical translation of genetic predictors for type 2 diabetes

Author keywords

Genome wide association; Pharmacogenetics; Risk prediction; Type 2 diabetes

Indexed keywords

GLICLAZIDE; GLITAZONE DERIVATIVE; GLUCOKINASE; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HEPATOCYTE NUCLEAR FACTOR 1BETA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; INSULIN; METFORMIN; ORAL ANTIDIABETIC AGENT; SULFONYLUREA;

EID: 66149084915     PISSN: 1752296X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MED.0b013e3283292354     Document Type: Review
Times cited : (15)

References (51)
  • 1
    • 0031026938 scopus 로고    scopus 로고
    • Noninsulin-dependent diabetes mellitus: A collision between thrifty genes and an affluent society
    • Groop LC, Tuomi T. Noninsulin-dependent diabetes mellitus: a collision between thrifty genes and an affluent society. Ann Med 1997; 29:37-53.
    • (1997) Ann Med , vol.29 , pp. 37-53
    • Groop, L.C.1    Tuomi, T.2
  • 2
    • 33646074794 scopus 로고    scopus 로고
    • Genetic basis of maturity-onset diabetes of the young
    • Vaxillaire M, Froguel P. Genetic basis of maturity-onset diabetes of the young. Endocrinol Metab Clin North Am 2006; 35:371-384.
    • (2006) Endocrinol Metab Clin North Am , vol.35 , pp. 371-384
    • Vaxillaire, M.1    Froguel, P.2
  • 3
    • 32544451924 scopus 로고    scopus 로고
    • Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
    • Grant SF, Thorleifsson G, Reynisdottir I, et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 2006; 38:320-323.
    • (2006) Nat Genet , vol.38 , pp. 320-323
    • Grant, S.F.1    Thorleifsson, G.2    Reynisdottir, I.3
  • 4
    • 34250655269 scopus 로고    scopus 로고
    • The new type 2 diabetes gene TCF7L2
    • Florez JC. The new type 2 diabetes gene TCF7L2. Curr Opin Clin Nutr Metab Care 2007; 10:391-396.
    • (2007) Curr Opin Clin Nutr Metab Care , vol.10 , pp. 391-396
    • Florez, J.C.1
  • 5
    • 0033624575 scopus 로고    scopus 로고
    • The common PPARg Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
    • Altshuler D, Hirschhorn JN, Klannemark M, et al. The common PPARg Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 2000; 26:76-80.
    • (2000) Nat Genet , vol.26 , pp. 76-80
    • Altshuler, D.1    Hirschhorn, J.N.2    Klannemark, M.3
  • 6
    • 0037317981 scopus 로고    scopus 로고
    • Large-scale association studies of variants in genes encoding the pancreatic b-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
    • Gloyn AL, Weedon MN, Owen KR, et al. Large-scale association studies of variants in genes encoding the pancreatic b-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 2003; 52:568-572.
    • (2003) Diabetes , vol.52 , pp. 568-572
    • Gloyn, A.L.1    Weedon, M.N.2    Owen, K.R.3
  • 7
    • 0037312864 scopus 로고    scopus 로고
    • The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes
    • Nielsen EM, Hansen L, Carstensen B, et al. The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes. Diabetes 2003; 52:573-577.
    • (2003) Diabetes , vol.52 , pp. 573-577
    • Nielsen, E.M.1    Hansen, L.2    Carstensen, B.3
  • 8
    • 2342561802 scopus 로고    scopus 로고
    • Haplotype structure and genotypephenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region
    • Florez JC, Burtt N, de Bakker PI, et al. Haplotype structure and genotypephenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region. Diabetes 2004; 53:1360-1368.
    • (2004) Diabetes , vol.53 , pp. 1360-1368
    • Florez, J.C.1    Burtt, N.2    de Bakker, P.I.3
  • 9
    • 34547536393 scopus 로고    scopus 로고
    • Common variants in WFS1 confer risk of type 2 diabetes
    • Sandhu MS, Weedon MN, Fawcett KA, et al. Common variants in WFS1 confer risk of type 2 diabetes. Nat Genet 2007; 39:951-953.
    • (2007) Nat Genet , vol.39 , pp. 951-953
    • Sandhu, M.S.1    Weedon, M.N.2    Fawcett, K.A.3
  • 10
    • 33847361938 scopus 로고    scopus 로고
    • Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes
    • Winckler W, Weedon MN, Graham RR, et al. Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes. Diabetes 2007; 56:685-693.
    • (2007) Diabetes , vol.56 , pp. 685-693
    • Winckler, W.1    Weedon, M.N.2    Graham, R.R.3
  • 11
    • 34247563453 scopus 로고    scopus 로고
    • Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
    • Gudmundsson J, Sulem P, Manolescu A, et al. Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet 2007; 39:631-637.
    • (2007) Nat Genet , vol.39 , pp. 631-637
    • Gudmundsson, J.1    Sulem, P.2    Manolescu, A.3
  • 12
    • 55449120805 scopus 로고    scopus 로고
    • Genetic mapping in human disease
    • Altshuler D, Daly MJ, Lander ES. Genetic mapping in human disease. Science 2008; 322:881-888.
    • (2008) Science , vol.322 , pp. 881-888
    • Altshuler, D.1    Daly, M.J.2    Lander, E.S.3
  • 13
    • 33847176604 scopus 로고    scopus 로고
    • A genome-wide association study identifies novel risk loci for type 2 diabetes
    • Sladek R, Rocheleau G, Rung J, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007; 445:881-885.
    • (2007) Nature , vol.445 , pp. 881-885
    • Sladek, R.1    Rocheleau, G.2    Rung, J.3
  • 14
    • 34249828965 scopus 로고    scopus 로고
    • A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
    • Steinthorsdottir V, Thorleifsson G, Reynisdottir I, et al. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 2007; 39:770-775.
    • (2007) Nat Genet , vol.39 , pp. 770-775
    • Steinthorsdottir, V.1    Thorleifsson, G.2    Reynisdottir, I.3
  • 15
    • 34249895023 scopus 로고    scopus 로고
    • Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    • Zeggini E, Weedon MN, Lindgren CM, et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007; 316:1336-1341.
    • (2007) Science , vol.316 , pp. 1336-1341
    • Zeggini, E.1    Weedon, M.N.2    Lindgren, C.M.3
  • 16
    • 34249885875 scopus 로고    scopus 로고
    • A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    • Scott LJ, Mohlke KL, Bonnycastle LL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007; 316:1341-1345.
    • (2007) Science , vol.316 , pp. 1341-1345
    • Scott, L.J.1    Mohlke, K.L.2    Bonnycastle, L.L.3
  • 17
    • 34249888775 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    • Saxena R, Voight BF, Lyssenko V, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007; 316:1331-1336.
    • (2007) Science , vol.316 , pp. 1331-1336
    • Saxena, R.1    Voight, B.F.2    Lyssenko, V.3
  • 18
    • 42349106044 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    • Zeggini E, Scott LJ, Saxena R, et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 2008; 40:638-645.
    • (2008) Nat Genet , vol.40 , pp. 638-645
    • Zeggini, E.1    Scott, L.J.2    Saxena, R.3
  • 19
    • 34548032087 scopus 로고    scopus 로고
    • Genome-wide association studies provide new insights into type 2 diabetes aetiology
    • Frayling TM. Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet 2007; 8:657-662.
    • (2007) Nat Rev Genet , vol.8 , pp. 657-662
    • Frayling, T.M.1
  • 20
    • 34250631631 scopus 로고    scopus 로고
    • Heterogeneous effect of peroxisome proliferator-activated receptor γ2 Ala12 variant on type 2 diabetes risk
    • Ludovico O, Pellegrini F, Di Paola R, et al. Heterogeneous effect of peroxisome proliferator-activated receptor γ2 Ala12 variant on type 2 diabetes risk. Obesity 2007; 15:1076-1081.
    • (2007) Obesity , vol.15 , pp. 1076-1081
    • Ludovico, O.1    Pellegrini, F.2    Di Paola, R.3
  • 21
    • 50449085998 scopus 로고    scopus 로고
    • Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
    • Yasuda K, Miyake K, Horikawa Y, et al. Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet 2008; 40:1092-1097.
    • (2008) Nat Genet , vol.40 , pp. 1092-1097
    • Yasuda, K.1    Miyake, K.2    Horikawa, Y.3
  • 22
    • 57349103144 scopus 로고    scopus 로고
    • The genetics of type 2 diabetes: A realistic appraisal circa 2008
    • Florez JC. The genetics of type 2 diabetes: a realistic appraisal circa 2008. J Clin Endocrinol Metab 2008; 93:4633-4642.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4633-4642
    • Florez, J.C.1
  • 23
    • 34248594090 scopus 로고    scopus 로고
    • A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    • Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316:889-894.
    • (2007) Science , vol.316 , pp. 889-894
    • Frayling, T.M.1    Timpson, N.J.2    Weedon, M.N.3
  • 24
    • 44749085712 scopus 로고    scopus 로고
    • Newly identified loci highlight β cell dysfunction as a key cause of type 2 diabetes: Where are the insulin resistance genes?
    • Florez JC. Newly identified loci highlight β cell dysfunction as a key cause of type 2 diabetes: where are the insulin resistance genes? Diabetologia 2008; 51:1100-1110.
    • (2008) Diabetologia , vol.51 , pp. 1100-1110
    • Florez, J.C.1
  • 25
    • 0031848798 scopus 로고    scopus 로고
    • Frameshift mutation, A263fsinsGG, in the hepatocyte nuclear factor-1β gene associated with diabetes and renal dysfunction
    • Nishigori H, Yamada S, Kohama T, et al. Frameshift mutation, A263fsinsGG, in the hepatocyte nuclear factor-1β gene associated with diabetes and renal dysfunction. Diabetes 1998; 47:1354-1355.
    • (1998) Diabetes , vol.47 , pp. 1354-1355
    • Nishigori, H.1    Yamada, S.2    Kohama, T.3
  • 26
    • 36849011549 scopus 로고    scopus 로고
    • Grarup N, Rose CS, Andersson EA, et al. Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies. Diabetes 2007; 56:3105-3111. An examination of T2D risk loci identified by the first round of GWAS, and association with quantitative glycemic traits, similar to [27•].
    • Grarup N, Rose CS, Andersson EA, et al. Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies. Diabetes 2007; 56:3105-3111. An examination of T2D risk loci identified by the first round of GWAS, and association with quantitative glycemic traits, similar to [27•].
  • 27
    • 50049119989 scopus 로고    scopus 로고
    • Grarup N, Andersen G, Krarup NT, et al. Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes. Diabetes 2008; 57:2534-2540. An examination of new T2D risk loci identified by DIAGRAM, and association with quantitative glycemic traits in a Danish population.
    • Grarup N, Andersen G, Krarup NT, et al. Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes. Diabetes 2008; 57:2534-2540. An examination of new T2D risk loci identified by DIAGRAM, and association with quantitative glycemic traits in a Danish population.
  • 28
    • 41149178492 scopus 로고    scopus 로고
    • Kirchhoff K, Machicao F, Haupt A, et al. Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia 2008; 51:597-601. An examination of T2D risk loci and association with proinsulin-to-insulin conversion.
    • Kirchhoff K, Machicao F, Haupt A, et al. Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia 2008; 51:597-601. An examination of T2D risk loci and association with proinsulin-to-insulin conversion.
  • 29
    • 44449091627 scopus 로고    scopus 로고
    • A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels
    • This study identifies the polymorphisms in the G6PC2 gene that are associated with FPG, but not with T2D risk
    • Bouatia-Naji N, Rocheleau G, Van Lommel L, et al. A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. Science 2008; 320:1085-1088. This study identifies the polymorphisms in the G6PC2 gene that are associated with FPG, but not with T2D risk.
    • (2008) Science , vol.320 , pp. 1085-1088
    • Bouatia-Naji, N.1    Rocheleau, G.2    Van Lommel, L.3
  • 30
    • 46749100599 scopus 로고    scopus 로고
    • Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
    • Chen WM, Erdos MR, Jackson AU, et al. Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest 2008; 118:2620-2628.
    • (2008) J Clin Invest , vol.118 , pp. 2620-2628
    • Chen, W.M.1    Erdos, M.R.2    Jackson, A.U.3
  • 31
    • 58149156287 scopus 로고    scopus 로고
    • Prokopenko I, Langenberg C, Florez JC, et al. Variants in MTNR1B influence fasting glucose levels. Nat Genet 2008; 41:77-81. A meta-analysis that identifies the melatonin receptor as associated with FPG and T2D risk.
    • Prokopenko I, Langenberg C, Florez JC, et al. Variants in MTNR1B influence fasting glucose levels. Nat Genet 2008; 41:77-81. A meta-analysis that identifies the melatonin receptor as associated with FPG and T2D risk.
  • 32
    • 58149175143 scopus 로고    scopus 로고
    • A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
    • Results from a GWAS in a French cohort showing an association of variants in the melatonin receptor with FPG
    • Bouatia-Naji N, Bonnefond A, Cavalcanti-Proenca C, et al. A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet 2008; 41:89-94. Results from a GWAS in a French cohort showing an association of variants in the melatonin receptor with FPG.
    • (2008) Nat Genet , vol.41 , pp. 89-94
    • Bouatia-Naji, N.1    Bonnefond, A.2    Cavalcanti-Proenca, C.3
  • 33
    • 58149175669 scopus 로고    scopus 로고
    • Lyssenko V, Nagorny CL, Erdos MR, et al. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet 2008; 41:82-88. This study demonstrates the association of variants in the melatonin receptor and T2D risk and shows that the MTNR1B is expressed on pancreatic b cells.
    • Lyssenko V, Nagorny CL, Erdos MR, et al. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet 2008; 41:82-88. This study demonstrates the association of variants in the melatonin receptor and T2D risk and shows that the MTNR1B is expressed on pancreatic b cells.
  • 34
    • 56749101779 scopus 로고    scopus 로고
    • Meigs JB, Shrader P, Sullivan LM, et al. Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med 2008; 359:2208-2219. This article explores the prognostic benefit of adding 18 T2D-associated loci to known clinical risk predictors in a US cohort from Framingham, Massachusetts.
    • Meigs JB, Shrader P, Sullivan LM, et al. Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med 2008; 359:2208-2219. This article explores the prognostic benefit of adding 18 T2D-associated loci to known clinical risk predictors in a US cohort from Framingham, Massachusetts.
  • 35
    • 55649105963 scopus 로고    scopus 로고
    • Clinical risk factors, DNA variants, and the development of type 2 diabetes
    • This article explores the prognostic benefit of adding 11 T2D-associated loci to known clinical risk predictors in a Finnish cohort
    • Lyssenko V, Jonsson A, Almgren P, et al. Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med 2008; 359:2220-2232. This article explores the prognostic benefit of adding 11 T2D-associated loci to known clinical risk predictors in a Finnish cohort.
    • (2008) N Engl J Med , vol.359 , pp. 2220-2232
    • Lyssenko, V.1    Jonsson, A.2    Almgren, P.3
  • 36
    • 56349096931 scopus 로고    scopus 로고
    • Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk
    • Lango H, Palmer CN, Morris AD, et al. Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes 2008; 57:3129-3135.
    • (2008) Diabetes , vol.57 , pp. 3129-3135
    • Lango, H.1    Palmer, C.N.2    Morris, A.D.3
  • 37
    • 58149333712 scopus 로고    scopus 로고
    • Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: A populationbased study
    • van Hoek M, Dehghan A, Witteman JC, et al. Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a populationbased study. Diabetes 2008; 57:3122-3128.
    • (2008) Diabetes , vol.57 , pp. 3122-3128
    • van Hoek, M.1    Dehghan, A.2    Witteman, J.C.3
  • 38
    • 50449105835 scopus 로고    scopus 로고
    • a wider net for diabetes susceptibility genes
    • McCarthy MI. Casting a wider net for diabetes susceptibility genes. Nat Genet 2008; 40:1039-1040.
    • (2008) Nat Genet , vol.40 , pp. 1039-1040
    • Casting, M.M.I.1
  • 39
    • 4644260056 scopus 로고    scopus 로고
    • Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: Patient characteristics and initial response to sulfonylurea therapy
    • Sagen JV, Raeder H, Hathout E, et al. Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy. Diabetes 2004; 53:2713-2718.
    • (2004) Diabetes , vol.53 , pp. 2713-2718
    • Sagen, J.V.1    Raeder, H.2    Hathout, E.3
  • 40
    • 38949177444 scopus 로고    scopus 로고
    • Effective treatment with oral sulfonylureas in patients with diabetes due to sulfonylurea receptor 1 (SUR1) mutations
    • This study demonstrates that patients with neonatal diabetes due to SUR1 mutations can be transitioned off insulin therapy and be successfully treated with sulfonylureas alone
    • Rafiq M, Flanagan SE, Patch AM, et al. Effective treatment with oral sulfonylureas in patients with diabetes due to sulfonylurea receptor 1 (SUR1) mutations. Diabetes Care 2008; 31:204-209. This study demonstrates that patients with neonatal diabetes due to SUR1 mutations can be transitioned off insulin therapy and be successfully treated with sulfonylureas alone.
    • (2008) Diabetes Care , vol.31 , pp. 204-209
    • Rafiq, M.1    Flanagan, S.E.2    Patch, A.M.3
  • 41
    • 58149335251 scopus 로고    scopus 로고
    • Learning from molecular genetics: Novel insights arising from the definition of genes for monogenic and type 2 diabetes
    • McCarthy MI, Hattersley AT. Learning from molecular genetics: novel insights arising from the definition of genes for monogenic and type 2 diabetes. Diabetes 2008; 57:2889-2898.
    • (2008) Diabetes , vol.57 , pp. 2889-2898
    • McCarthy, M.I.1    Hattersley, A.T.2
  • 42
    • 0142186278 scopus 로고    scopus 로고
    • Genetic cause of hyperglycaemia and response to treatment in diabetes
    • Pearson ER, Starkey BJ, Powell RJ, et al. Genetic cause of hyperglycaemia and response to treatment in diabetes. Lancet 2003; 362:1275-1281.
    • (2003) Lancet , vol.362 , pp. 1275-1281
    • Pearson, E.R.1    Starkey, B.J.2    Powell, R.J.3
  • 43
    • 33744965950 scopus 로고    scopus 로고
    • The E23K variant of KCNJ11 encoding the pancreatic b-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes
    • Sesti G, Laratta E, Cardellini M, et al. The E23K variant of KCNJ11 encoding the pancreatic b-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes. J Clin Endocrinol Metab 2006; 91:2334-2339.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 2334-2339
    • Sesti, G.1    Laratta, E.2    Cardellini, M.3
  • 44
    • 18344417084 scopus 로고    scopus 로고
    • Analysis of the relationship between the Pro12Ala variant in the PPAR-γ2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes
    • Bluher M, Lubben G, Paschke R. Analysis of the relationship between the Pro12Ala variant in the PPAR-γ2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes. Diabetes Care 2003; 26:825-831.
    • (2003) Diabetes Care , vol.26 , pp. 825-831
    • Bluher, M.1    Lubben, G.2    Paschke, R.3
  • 45
    • 2542443906 scopus 로고    scopus 로고
    • Changes in insulin sensitivity in response to troglitazone do not differ between subjects with and without the common, functional Pro12Ala peroxisome proliferator-activated receptor-γ2 gene variant: Results from the Troglitazone in Prevention of Diabetes (TRIPOD) study
    • Snitker S, Watanabe RM, Ani I, et al. Changes in insulin sensitivity in response to troglitazone do not differ between subjects with and without the common, functional Pro12Ala peroxisome proliferator-activated receptor-γ2 gene variant: results from the Troglitazone in Prevention of Diabetes (TRIPOD) study. Diabetes Care 2004; 27:1365-1368.
    • (2004) Diabetes Care , vol.27 , pp. 1365-1368
    • Snitker, S.1    Watanabe, R.M.2    Ani, I.3
  • 46
    • 23444457610 scopus 로고    scopus 로고
    • Effects of Pro12Ala polymorphism of peroxisome proliferator-activated receptor γ2 gene on rosiglitazone response in type 2 diabetes
    • Kang ES, Park SY, Kim HJ, et al. Effects of Pro12Ala polymorphism of peroxisome proliferator-activated receptor γ2 gene on rosiglitazone response in type 2 diabetes. Clin Pharmacol Ther 2005; 78:202-208.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 202-208
    • Kang, E.S.1    Park, S.Y.2    Kim, H.J.3
  • 47
    • 33644669582 scopus 로고    scopus 로고
    • Sequence variation in PPARG may underlie differential response to troglitazone
    • Wolford JK, Yeatts KA, Dhanjal SK, et al. Sequence variation in PPARG may underlie differential response to troglitazone. Diabetes 2005; 54:3319-3325.
    • (2005) Diabetes , vol.54 , pp. 3319-3325
    • Wolford, J.K.1    Yeatts, K.A.2    Dhanjal, S.K.3
  • 48
    • 34147106645 scopus 로고    scopus 로고
    • Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone
    • Florez JC, Jablonski KA, Sun MW, et al. Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone. J Clin Endocrinol Metab 2007; 92:1502-1509.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1502-1509
    • Florez, J.C.1    Jablonski, K.A.2    Sun, M.W.3
  • 49
    • 56149106823 scopus 로고    scopus 로고
    • Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients
    • This article demonstrates that Chinese patients homozygous for the Ala/Ala variant of the sulfonylurea receptor have a statistically significant decrease in FPG compared with Ser/Ser homozygotes
    • Feng Y, Mao G, Ren X, et al. Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients. Diabetes Care 2008; 31:1939-1944. This article demonstrates that Chinese patients homozygous for the Ala/Ala variant of the sulfonylurea receptor have a statistically significant decrease in FPG compared with Ser/Ser homozygotes.
    • (2008) Diabetes Care , vol.31 , pp. 1939-1944
    • Feng, Y.1    Mao, G.2    Ren, X.3
  • 50
    • 34547585382 scopus 로고    scopus 로고
    • Variation in TCF7L2 influences therapeutic response to sulfonylureas: A GoDARTs study
    • A retrospective study suggesting that diabetic individuals with TCF7L2 variants respond differently to sulfonylureas than to metformin
    • Pearson ER, Donnelly LA, Kimber C, et al. Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study. Diabetes 2007; 56:2178-2182. A retrospective study suggesting that diabetic individuals with TCF7L2 variants respond differently to sulfonylureas than to metformin.
    • (2007) Diabetes , vol.56 , pp. 2178-2182
    • Pearson, E.R.1    Donnelly, L.A.2    Kimber, C.3
  • 51
    • 34248156160 scopus 로고    scopus 로고
    • Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
    • This article shows that normoglycemic individuals have differential hypoglycemic responses to metformin based on variation in OCT1
    • Shu Y, Sheardown SA, Brown C, et al. Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest 2007; 117:1422-1431. This article shows that normoglycemic individuals have differential hypoglycemic responses to metformin based on variation in OCT1.
    • (2007) J Clin Invest , vol.117 , pp. 1422-1431
    • Shu, Y.1    Sheardown, S.A.2    Brown, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.