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Volumn 29, Issue 1, 1997, Pages 37-53

Non-insulin-dependent diabetes mellitus - A collision between thrifty genes and an affluent society

Author keywords

Genetics; Insulin action; Insulin secretion; Non insulin dependent diabetes mellitus

Indexed keywords

INSULIN;

EID: 0031026938     PISSN: 07853890     EISSN: None     Source Type: Journal    
DOI: 10.3109/07853899708998742     Document Type: Review
Times cited : (68)

References (179)
  • 1
    • 0342662350 scopus 로고
    • Diabetes care and prevention - Around the world in 80 days
    • Rifkin HCJ, Taylor SI, eds. Elsevier
    • Zimmet P. Diabetes care and prevention - around the world in 80 days. In: Rifkin HCJ, Taylor SI, eds. Diabetes. Elsevier, 1991: 721-9.
    • (1991) Diabetes , pp. 721-729
    • Zimmet, P.1
  • 2
    • 0020621081 scopus 로고
    • Genetics of diabetes in Nauru: Effects of foreign admixture, HLA antigens, and the insulin-gene linked polymorphism
    • Serjeantson S, Owerbach D, Zimmet P, Nerup J, Thoma K. Genetics of diabetes in Nauru: Effects of foreign admixture, HLA antigens, and the insulin-gene linked polymorphism. Diabetologia 1983; 25: 13-17.
    • (1983) Diabetologia , vol.25 , pp. 13-17
    • Serjeantson, S.1    Owerbach, D.2    Zimmet, P.3    Nerup, J.4    Thoma, K.5
  • 3
    • 0018605827 scopus 로고
    • Diabetes among the three affiliated tribes: Correlation with degree of Indian inheritance
    • Brosseau J, Eelkema R, Crawford A, Abe T. Diabetes among the three affiliated tribes: correlation with degree of Indian inheritance. Am J Public Health 1979; 69: 1277-8.
    • (1979) Am J Public Health , vol.69 , pp. 1277-1278
    • Brosseau, J.1    Eelkema, R.2    Crawford, A.3    Abe, T.4
  • 5
    • 0026641354 scopus 로고
    • Concordance for type 1 and type 2 diabetes mellitus in a population-based cohort of twins in Finland
    • Kaprio J, Tuomilehto J, Koskenvuo M, et al. Concordance for type 1 and type 2 diabetes mellitus in a population-based cohort of twins in Finland. Diabetologia 1992; 35: 1060-7.
    • (1992) Diabetologia , vol.35 , pp. 1060-1067
    • Kaprio, J.1    Tuomilehto, J.2    Koskenvuo, M.3
  • 6
    • 0002872316 scopus 로고
    • Empiricial risk figures for first-degree relatives of non-insulin-dependent diabetics
    • Köbberling J, Tattersall R, eds. London: Academic Press
    • Köbberling J, Tillil H. Empiricial risk figures for first-degree relatives of non-insulin-dependent diabetics. In: Köbberling J, Tattersall R, eds. The Genetics of Diabetes Mellitus. London: Academic Press, 1982: 201-9.
    • (1982) The Genetics of Diabetes Mellitus , pp. 201-209
    • Köbberling, J.1    Tillil, H.2
  • 7
    • 0022545225 scopus 로고
    • Metabolic abnormalities in children of non-insulin dependent diabetics
    • Leslie R, Volkmann H, Poncher M, Hanning I, Orskov H, Alberti K. Metabolic abnormalities in children of non-insulin dependent diabetics. BMJ 1986; 293: 840-2.
    • (1986) BMJ , vol.293 , pp. 840-842
    • Leslie, R.1    Volkmann, H.2    Poncher, M.3    Hanning, I.4    Orskov, H.5    Alberti, K.6
  • 8
    • 0028116143 scopus 로고
    • Segregation analysis of NIDDM in Caucasian families
    • Cook J, Shields D, Page R, et al. Segregation analysis of NIDDM in Caucasian families. Diabetologia 1994; 37: 1231-40.
    • (1994) Diabetologia , vol.37 , pp. 1231-1240
    • Cook, J.1    Shields, D.2    Page, R.3
  • 9
    • 0027472907 scopus 로고
    • Distribution of type II diabetes in nuclear families
    • Cook J, Hattersley A, Levy J, et al. Distribution of type II diabetes in nuclear families. Diabetes 1993; 42: 106-12.
    • (1993) Diabetes , vol.42 , pp. 106-112
    • Cook, J.1    Hattersley, A.2    Levy, J.3
  • 10
    • 0025854490 scopus 로고
    • Importance of maternal history of non-insulin-dependent diabetic patients
    • Alcolado J, Alcolado R. Importance of maternal history of non-insulin-dependent diabetic patients. BMJ 1991; 302: 1178-80.
    • (1991) BMJ , vol.302 , pp. 1178-1180
    • Alcolado, J.1    Alcolado, R.2
  • 11
    • 0003014882 scopus 로고    scopus 로고
    • Metabolic consequences of a family history of NIDDM (The Botnia Study)
    • Groop L, Forsblom C, Lehtovirta M, et al. Metabolic consequences of a family history of NIDDM (The Botnia Study). Diabetes 1996; 45: 1585-93.
    • (1996) Diabetes , vol.45 , pp. 1585-1593
    • Groop, L.1    Forsblom, C.2    Lehtovirta, M.3
  • 12
    • 0028011772 scopus 로고
    • Maternal effect and familial aggregation in NIDDM. The CODIAB Study
    • Thomas F, Balkau B, Vauzelle-Kervroedan F, Papoz L. Maternal effect and familial aggregation in NIDDM. The CODIAB Study. Diabetes 1994; 43: 63-7.
    • (1994) Diabetes , vol.43 , pp. 63-67
    • Thomas, F.1    Balkau, B.2    Vauzelle-Kervroedan, F.3    Papoz, L.4
  • 14
    • 0030046495 scopus 로고    scopus 로고
    • Mitochondria and diabetes. Genetic, biochemical, and clinical implications of the cellular energy circuit
    • Gerbitz K-D, Gempel K, Brdiczka. Mitochondria and diabetes. Genetic, biochemical, and clinical implications of the cellular energy circuit. Diabetes 1996; 45: 113-26.
    • (1996) Diabetes , vol.45 , pp. 113-126
    • Gerbitz, K.-D.1    Gempel, K.2    Brdiczka3
  • 15
    • 0029914927 scopus 로고    scopus 로고
    • Maternally inherited diabetes and deafness: A new diabetes subtype
    • Maassen J, Kadowaki T. Maternally inherited diabetes and deafness: a new diabetes subtype. Diabetologia 1996; 39: 375-82.
    • (1996) Diabetologia , vol.39 , pp. 375-382
    • Maassen, J.1    Kadowaki, T.2
  • 16
    • 0026772772 scopus 로고
    • Type 2 diabetes mellitus: The thrifty phenotype hypothesis
    • Hales C, Barker D. Type 2 diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 1992; 35: 595-601.
    • (1992) Diabetologia , vol.35 , pp. 595-601
    • Hales, C.1    Barker, D.2
  • 18
    • 0028365598 scopus 로고
    • Allele specific inactivation of insulin 1 and 2, in the mouse yolk sac, indicates imprinting
    • Giddings S, King C, Harman K, Flood J, Carnaghi L. Allele specific inactivation of insulin 1 and 2, in the mouse yolk sac, indicates imprinting. Nat Genet 1994; 6: 310-3.
    • (1994) Nat Genet , vol.6 , pp. 310-313
    • Giddings, S.1    King, C.2    Harman, K.3    Flood, J.4    Carnaghi, L.5
  • 19
    • 0027511236 scopus 로고
    • Genetics and physiology of myotonic muscle disorders
    • Ptacek L, Johnson K, Griggs R. Genetics and physiology of myotonic muscle disorders. N Engl J Med 1993; 328: 482-9.
    • (1993) N Engl J Med , vol.328 , pp. 482-489
    • Ptacek, L.1    Johnson, K.2    Griggs, R.3
  • 22
    • 0025155386 scopus 로고
    • Acute and chronic effects of hyperglycemia on glucose metabolism
    • Yki-Järvinen H. Acute and chronic effects of hyperglycemia on glucose metabolism. Diabetologia 1990; 33: 579-85.
    • (1990) Diabetologia , vol.33 , pp. 579-585
    • Yki-Järvinen, H.1
  • 23
    • 0024348996 scopus 로고
    • Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus
    • Eriksson J, Franssila-Kallunki A, Ekstrand A, et al. Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N Engl J Med 1989; 321: 337-43.
    • (1989) N Engl J Med , vol.321 , pp. 337-343
    • Eriksson, J.1    Franssila-Kallunki, A.2    Ekstrand, A.3
  • 24
    • 0026575758 scopus 로고
    • Decreased activation of glycogen synthase in skeletal muscle of young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus
    • Vaag A, Henriksen J, Beck-Nielsen H. Decreased activation of glycogen synthase in skeletal muscle of young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1992; 89: 782-8.
    • (1992) J Clin Invest , vol.89 , pp. 782-788
    • Vaag, A.1    Henriksen, J.2    Beck-Nielsen, H.3
  • 25
    • 0026539663 scopus 로고
    • The metabolic profile of NIDDM is fully established in glucosetolerant offspring of two Mexican-American parents
    • Gulli G, Ferrannini E, Stern M, Haffner S, DeFronzo R. The metabolic profile of NIDDM is fully established in glucosetolerant offspring of two Mexican-American parents. Diabetes 1992; 41: 1575-86.
    • (1992) Diabetes , vol.41 , pp. 1575-1586
    • Gulli, G.1    Ferrannini, E.2    Stern, M.3    Haffner, S.4    DeFronzo, R.5
  • 26
    • 23744496655 scopus 로고
    • Impaired glucose tolerance as disorder of insulin action. Longitudinal and cross-sectional studies in Pima Indians
    • Lillioja S, Mott D, Howard B, et al. Impaired glucose tolerance as disorder of insulin action. Longitudinal and cross-sectional studies in Pima Indians. N Engl J Med 1987; 20: 87-93.
    • (1987) N Engl J Med , vol.20 , pp. 87-93
    • Lillioja, S.1    Mott, D.2    Howard, B.3
  • 27
    • 0027762766 scopus 로고
    • Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes meilitus
    • Lillioja S, Mott D, Spraul M, et al. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes meilitus. N Engt J Med 1993; 329: 1988-92.
    • (1993) N Engt J Med , vol.329 , pp. 1988-1992
    • Lillioja, S.1    Mott, D.2    Spraul, M.3
  • 28
    • 0026602267 scopus 로고
    • Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance
    • Mitrakou A, Kelley D, Mokan M, et al. Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance. N Engl J Med 1992; 326: 22-9.
    • (1992) N Engl J Med , vol.326 , pp. 22-29
    • Mitrakou, A.1    Kelley, D.2    Mokan, M.3
  • 29
    • 0029022819 scopus 로고
    • Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM
    • Pimenta W, Korytkowski M, Mitrakou A, et al. Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. JAMA 1995; 273: 1855-61.
    • (1995) JAMA , vol.273 , pp. 1855-1861
    • Pimenta, W.1    Korytkowski, M.2    Mitrakou, A.3
  • 30
    • 0028091753 scopus 로고
    • Metabolic and genetic characterization of prediabetic states. Sequence of events leading to non-insulin-dependent diabetes meilitus
    • Beck-Nielsen H, Groop L. Metabolic and genetic characterization of prediabetic states. Sequence of events leading to non-insulin-dependent diabetes meilitus. J Clin Invest 1994; 94: 1714-21.
    • (1994) J Clin Invest , vol.94 , pp. 1714-1721
    • Beck-Nielsen, H.1    Groop, L.2
  • 31
    • 0026636946 scopus 로고
    • Impaired activation of glycogen synthase in people at increased risk for developing NIDDM
    • Schalin-Jäntti C, Härkönen M, Groop L. Impaired activation of glycogen synthase in people at increased risk for developing NIDDM. Diabetes 1992; 41: 598-604.
    • (1992) Diabetes , vol.41 , pp. 598-604
    • Schalin-Jäntti, C.1    Härkönen, M.2    Groop, L.3
  • 32
    • 0027953703 scopus 로고
    • Insulin action, diabetogenes, and the cause of type II diabetes
    • Kahn R. Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 1994; 43: 1066-84.
    • (1994) Diabetes , vol.43 , pp. 1066-1084
    • Kahn, R.1
  • 33
    • 0026801899 scopus 로고
    • Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM
    • Laakso M, Edelman S, Brechtel G, Baron A. Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM. Diabetes 1992; 41: 1076-83.
    • (1992) Diabetes , vol.41 , pp. 1076-1083
    • Laakso, M.1    Edelman, S.2    Brechtel, G.3    Baron, A.4
  • 34
    • 0023392223 scopus 로고
    • Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man
    • Lillioja S, Young A, Culter C, et al. Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man. J Clin Invest 1987; 80: 415-24.
    • (1987) J Clin Invest , vol.80 , pp. 415-424
    • Lillioja, S.1    Young, A.2    Culter, C.3
  • 35
    • 0027457357 scopus 로고
    • Abnormal activation of glycogen synthase in fibroblasts from NIDDM patients. Evidence for an abnormality specific to glucose metabolism
    • Wells A, Sutcliffe I, Johnson A, Taylor R. Abnormal activation of glycogen synthase in fibroblasts from NIDDM patients. Evidence for an abnormality specific to glucose metabolism. Diabetes 1993; 42: 583-9.
    • (1993) Diabetes , vol.42 , pp. 583-589
    • Wells, A.1    Sutcliffe, I.2    Johnson, A.3    Taylor, R.4
  • 36
    • 0028340978 scopus 로고
    • Increased skeletal muscle capillary density precedes diabetes development in men with impaired glucose tolerance. A 15-year follow-up study
    • Eriksson K-F, Saltin B, Lindgärde F. Increased skeletal muscle capillary density precedes diabetes development in men with impaired glucose tolerance. A 15-year follow-up study. Diabetes 1994; 43: 805-8.
    • (1994) Diabetes , vol.43 , pp. 805-808
    • Eriksson, K.-F.1    Saltin, B.2    Lindgärde, F.3
  • 37
    • 0024392514 scopus 로고
    • Glucose and free fatty acid metabolism in non-insulin-dependent diabetes meilitus: Evidence for multiple sites of insulin resistance
    • Groop L, Bonadonna R, DelPrato S, et al. Glucose and free fatty acid metabolism in non-insulin-dependent diabetes meilitus: evidence for multiple sites of insulin resistance. J Clin Invest 1989; 84: 205-13.
    • (1989) J Clin Invest , vol.84 , pp. 205-213
    • Groop, L.1    Bonadonna, R.2    DelPrato, S.3
  • 38
    • 0025780748 scopus 로고
    • Insulin resistance, but normal rates of glucose production in patients with newly diagnosed mild diabetes meilitus
    • Hother-Nielsen O, Beck-Nielsen H. Insulin resistance, but normal rates of glucose production in patients with newly diagnosed mild diabetes meilitus. Acta Endocrinol 1991; 124: 637-45.
    • (1991) Acta Endocrinol , vol.124 , pp. 637-645
    • Hother-Nielsen, O.1    Beck-Nielsen, H.2
  • 39
    • 0025630056 scopus 로고
    • Mechanisms of increased gluconeogenesis in noninsulin-dependent diabetes meilitus. Role of alterations in systemic, hepatic and muscle lactate and alanine metabolism
    • Consoli A, Nurjhan N, Reilly J Jr, Bier D, Gerich J. Mechanisms of increased gluconeogenesis in noninsulin-dependent diabetes meilitus. Role of alterations in systemic, hepatic and muscle lactate and alanine metabolism. J Clin Invest 1990; 86: 2038-45.
    • (1990) J Clin Invest , vol.86 , pp. 2038-2045
    • Consoli, A.1    Nurjhan, N.2    Reilly Jr., J.3    Bier, D.4    Gerich, J.5
  • 40
    • 0025994801 scopus 로고
    • No reduction in total hepatic glucose output by inhibition of gluconeogenesis with ethanol in NIDDM patients
    • Puhakainen I, Koivisto V, Yki-Järvinen H. No reduction in total hepatic glucose output by inhibition of gluconeogenesis with ethanol in NIDDM patients. Diabetes 1991; 40: 1319-27.
    • (1991) Diabetes , vol.40 , pp. 1319-1327
    • Puhakainen, I.1    Koivisto, V.2    Yki-Järvinen, H.3
  • 41
    • 0023191508 scopus 로고
    • Insulin resistance in esstential hypertension
    • Ferrannini E, Buzzigoli G, Bonadonna R, et al. Insulin resistance in esstential hypertension. N Engl J Med 1987; 317: 350-7.
    • (1987) N Engl J Med , vol.317 , pp. 350-357
    • Ferrannini, E.1    Buzzigoli, G.2    Bonadonna, R.3
  • 42
    • 0026482195 scopus 로고
    • Insulin resistance in type 2 diabetic patients with hypertriglyceridemia
    • Widén E, Ekstrand A, Saloranta C, et al. Insulin resistance in type 2 diabetic patients with hypertriglyceridemia. Diabetologia 1992; 35: 1140-5.
    • (1992) Diabetologia , vol.35 , pp. 1140-1145
    • Widén, E.1    Ekstrand, A.2    Saloranta, C.3
  • 43
    • 0028919252 scopus 로고
    • Does intraabdominal adipose tissue in black men determine whether NIDDM is insulin-resistant or insulin-sensitive?
    • Banerji M, Chaiken R, Gordon D, Kral J, Lebovitz H. Does intraabdominal adipose tissue in black men determine whether NIDDM is insulin-resistant or insulin-sensitive? Diabetes 1995; 44: 141-6.
    • (1995) Diabetes , vol.44 , pp. 141-146
    • Banerji, M.1    Chaiken, R.2    Gordon, D.3    Kral, J.4    Lebovitz, H.5
  • 44
    • 0028881544 scopus 로고
    • Insulin resistance and abnormal albumin excretion in non-diabetic first-degree relatives of patients with NIDDM
    • Forsblom C, Eriksson J, Ekstrand A, Teppo A-M, Taskinen M-R, Groop L. Insulin resistance and abnormal albumin excretion in non-diabetic first-degree relatives of patients with NIDDM. Diabetolgia 1995; 38: 363-9.
    • (1995) Diabetolgia , vol.38 , pp. 363-369
    • Forsblom, C.1    Eriksson, J.2    Ekstrand, A.3    Teppo, A.-M.4    Taskinen, M.-R.5    Groop, L.6
  • 45
    • 0027309409 scopus 로고
    • Insulin resistance, hypertension and microalbuminuria in patients with type 2 diabetes mellitus
    • Groop L, Ekstrand A, Forsblom C, et al. Insulin resistance, hypertension and microalbuminuria in patients with type 2 diabetes mellitus. Diabetologia 1993; 36: 642-7.
    • (1993) Diabetologia , vol.36 , pp. 642-647
    • Groop, L.1    Ekstrand, A.2    Forsblom, C.3
  • 47
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease
    • Reaven G. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595-607.
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.1
  • 48
    • 0023851885 scopus 로고
    • Reduced rate of energy expenditure as a risk factor for body-weight gain
    • Ravussin E, Lillioja S, Knowler W, et al. Reduced rate of energy expenditure as a risk factor for body-weight gain. N Engl J Med 1988; 318: 467-72.
    • (1988) N Engl J Med , vol.318 , pp. 467-472
    • Ravussin, E.1    Lillioja, S.2    Knowler, W.3
  • 49
    • 0025109784 scopus 로고
    • Low ratio of fat to carbohydrate oxidation as predictors of weight gain: Study of 24 h RQ
    • Zurlo F, Lillioja S, Esposito-Del Puente A, et al. Low ratio of fat to carbohydrate oxidation as predictors of weight gain: study of 24 h RQ. Am J Physiol 1990; 259: E650-7.
    • (1990) Am J Physiol , vol.259
    • Zurlo, F.1    Lillioja, S.2    Esposito-Del Puente, A.3
  • 50
    • 70349566593 scopus 로고
    • Diabetes mellitus: A 'thrifty' genotype rendered detrimental by progress?
    • Neel V. Diabetes mellitus: a 'thrifty' genotype rendered detrimental by progress? Am J Hum Genet 1962; 14: 352-62.
    • (1962) Am J Hum Genet , vol.14 , pp. 352-362
    • Neel, V.1
  • 51
    • 0018355535 scopus 로고
    • Obesity genes: Beneficial effects in heterozygous mice
    • Coleman D. Obesity genes: beneficial effects in heterozygous mice. Science 1979; 203: 663-5.
    • (1979) Science , vol.203 , pp. 663-665
    • Coleman, D.1
  • 53
    • 0027392074 scopus 로고
    • Tissue distribution of beta-3-adrenergic receptor mRNA in man
    • Krief S, Lönnqvist F, Raimbault S, et al. Tissue distribution of beta-3-adrenergic receptor mRNA in man. J Clin Invest 1993; 91: 344-9.
    • (1993) J Clin Invest , vol.91 , pp. 344-349
    • Krief, S.1    Lönnqvist, F.2    Raimbault, S.3
  • 54
    • 0028347238 scopus 로고
    • Catecholamine resistance in fat cells of women with upper-body obesity due to decreased expression of beta-2-adrenoceptors
    • Reynisdotter S, Wahrenberg H, Carlström K, Rössner S, Arner P. Catecholamine resistance in fat cells of women with upper-body obesity due to decreased expression of beta-2-adrenoceptors. Diabetologia 1994; 37: 428-35.
    • (1994) Diabetologia , vol.37 , pp. 428-435
    • Reynisdotter, S.1    Wahrenberg, H.2    Carlström, K.3    Rössner, S.4    Arner, P.5
  • 55
  • 56
    • 0023868703 scopus 로고
    • Carbohydrate and lipid metabolism of skeletal muscle in type 2 diabetic patients
    • Falholt K, Lindkaer IJ, Jensen S, et al. Carbohydrate and lipid metabolism of skeletal muscle in type 2 diabetic patients. Diabet Med 1987; 5: 27-31.
    • (1987) Diabet Med , vol.5 , pp. 27-31
    • Falholt, K.1    Lindkaer, I.J.2    Jensen, S.3
  • 57
    • 0027395358 scopus 로고
    • The relation between insulin sensitivity and the fatty acid composition of skeletal muscle phospholipids
    • Borkman M, Storlien L, Pan D, Jenkins A, Chisholm D, Campbell L. The relation between insulin sensitivity and the fatty acid composition of skeletal muscle phospholipids. N Engl J Med 1993; 328: 238-44.
    • (1993) N Engl J Med , vol.328 , pp. 238-244
    • Borkman, M.1    Storlien, L.2    Pan, D.3    Jenkins, A.4    Chisholm, D.5    Campbell, L.6
  • 58
    • 0026087478 scopus 로고
    • Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid
    • Storlien L, Jenkins A, Chisholm D, Pasqoe W, Kohouri S, Kraegen E. Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid. Diabetes 1991; 40: 280-9.
    • (1991) Diabetes , vol.40 , pp. 280-289
    • Storlien, L.1    Jenkins, A.2    Chisholm, D.3    Pasqoe, W.4    Kohouri, S.5    Kraegen, E.6
  • 59
    • 0028071690 scopus 로고
    • Insulin sensitivity is related to the fatty acid composition of serum lipids and skeletal muscle phospholipids in 70-year-old men
    • Vessby B, Tengblad S, Lithell H. Insulin sensitivity is related to the fatty acid composition of serum lipids and skeletal muscle phospholipids in 70-year-old men. Diabetologia 1994; 37: 1044-50.
    • (1994) Diabetologia , vol.37 , pp. 1044-1050
    • Vessby, B.1    Tengblad, S.2    Lithell, H.3
  • 61
    • 0014095480 scopus 로고
    • The plasma insulin response to glucose infusion in healthy subjects and in subjects with diabetes mellitus
    • Cerasi E, Luft R. The plasma insulin response to glucose infusion in healthy subjects and in subjects with diabetes mellitus. Acta Endocrinol 1967; 55: 278-304.
    • (1967) Acta Endocrinol , vol.55 , pp. 278-304
    • Cerasi, E.1    Luft, R.2
  • 62
    • 0027458051 scopus 로고
    • Insulin resistance and insulin deficiency in the pathogenesis of type 2 diabetes mellitus: Inborn errors of metabolism or of methods?
    • Groop L, Widén E, Ferrannini E. Insulin resistance and insulin deficiency in the pathogenesis of type 2 diabetes mellitus: inborn errors of metabolism or of methods? Diabetologia 1993; 36: 1326-31.
    • (1993) Diabetologia , vol.36 , pp. 1326-1331
    • Groop, L.1    Widén, E.2    Ferrannini, E.3
  • 63
    • 0023951171 scopus 로고
    • Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes mellitus
    • O'Rahilly S, Turner R, Matthews D. Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes mellitus. N Engl J Med 1988; 318: 1225-30.
    • (1988) N Engl J Med , vol.318 , pp. 1225-1230
    • O'Rahilly, S.1    Turner, R.2    Matthews, D.3
  • 64
    • 0028679761 scopus 로고
    • Gestational diabetes-type 2 diabetes with relative insulin deficiency
    • in Finnish
    • Forsén T, Eriksson J, Suhonen L, Teramo K, Groop L. Gestational diabetes-type 2 diabetes with relative insulin deficiency. Duodecim 1994; 110: 808-14 (in Finnish).
    • (1994) Duodecim , vol.110 , pp. 808-814
    • Forsén, T.1    Eriksson, J.2    Suhonen, L.3    Teramo, K.4    Groop, L.5
  • 65
    • 0026569238 scopus 로고
    • Insulin resistance and insulin deficiency in the pathogenesis of postransplantation diabetes in man
    • Ekstrand A, Eriksson J, Grönhagen-Riska C, Ahonen P, Groop L. Insulin resistance and insulin deficiency in the pathogenesis of postransplantation diabetes in man. Transplantation 1992; 53: 563-9.
    • (1992) Transplantation , vol.53 , pp. 563-569
    • Ekstrand, A.1    Eriksson, J.2    Grönhagen-Riska, C.3    Ahonen, P.4    Groop, L.5
  • 66
    • 0022570021 scopus 로고
    • Islet cell antibodies identify latent type 1 diabetes in patients aged 35-75 years at diagnosis
    • Groop L, Bottazzo G, Doniach D. Islet cell antibodies identify latent type 1 diabetes in patients aged 35-75 years at diagnosis. Diabetes 1986; 35: 237-41.
    • (1986) Diabetes , vol.35 , pp. 237-241
    • Groop, L.1    Bottazzo, G.2    Doniach, D.3
  • 67
    • 0027391608 scopus 로고
    • Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 65K autoantibody positivity at onset predicts diabetes type
    • Hagopian W, Karlsen A, Gottsäter A, et al. Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 65K autoantibody positivity at onset predicts diabetes type. J Clin Invest 1993; 91: 368-74.
    • (1993) J Clin Invest , vol.91 , pp. 368-374
    • Hagopian, W.1    Karlsen, A.2    Gottsäter, A.3
  • 68
    • 0027500697 scopus 로고
    • Antibodies to glutamic acid decarboxylase (GAD) identify latent IDDM in patients with onset of diabetes after the age of 35 years
    • Tuomi T, Groop L, Zimmet P, Rowley M, Knowles W, Mackay I. Antibodies to glutamic acid decarboxylase (GAD) identify latent IDDM in patients with onset of diabetes after the age of 35 years. Diabetes 1993; 42: 359-62.
    • (1993) Diabetes , vol.42 , pp. 359-362
    • Tuomi, T.1    Groop, L.2    Zimmet, P.3    Rowley, M.4    Knowles, W.5    Mackay, I.6
  • 69
    • 0025663581 scopus 로고
    • Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in offspring of diabetic parents
    • Warram J, Martin B, Krolewski A, Soeldner J, Kahn R. Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in offspring of diabetic parents. Ann Intern Med 1990; 113: 909-15.
    • (1990) Ann Intern Med , vol.113 , pp. 909-915
    • Warram, J.1    Martin, B.2    Krolewski, A.3    Soeldner, J.4    Kahn, R.5
  • 70
    • 0026793446 scopus 로고
    • Role of glucose and insulin resistance in development of type 2 diabetes mellitus: Results of a 25-year follow-up study
    • Martin B, Warram J, Krolewski A, Bergman R, Soeldner J, Kahn C. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet 1992; 340: 925-9.
    • (1992) Lancet , vol.340 , pp. 925-929
    • Martin, B.1    Warram, J.2    Krolewski, A.3    Bergman, R.4    Soeldner, J.5    Kahn, C.6
  • 71
    • 0025861715 scopus 로고
    • Risk factors for developing non-insulin-dependent diabetes mellitus: A 10-year follow-up of men in Uppsala
    • Skarfors E, Selenus K, Lithell H. Risk factors for developing non-insulin-dependent diabetes mellitus: a 10-year follow-up of men in Uppsala. BMJ 1991; 303.
    • (1991) BMJ , pp. 303
    • Skarfors, E.1    Selenus, K.2    Lithell, H.3
  • 72
    • 0022408652 scopus 로고
    • The influence of body fat distribution on the incidence of diabetes mellitus: 13.5 years of follow-up of the participants in the study of men born in 1913
    • Ohlson L, Larsson B, Svärdsudd K, et al. The influence of body fat distribution on the incidence of diabetes mellitus: 13.5 years of follow-up of the participants in the study of men born in 1913. Diabetes 1985; 34: 1055-8.
    • (1985) Diabetes , vol.34 , pp. 1055-1058
    • Ohlson, L.1    Larsson, B.2    Svärdsudd, K.3
  • 73
    • 0024473892 scopus 로고
    • Asymtomatic hyperglycemia is associated with lipid and lipoprotein changes favouring atherosclerosis
    • Laakso M, Barrett-Connor E. Asymtomatic hyperglycemia is associated with lipid and lipoprotein changes favouring atherosclerosis. Arteriosclerosis 1989; 9: 665-72.
    • (1989) Arteriosclerosis , vol.9 , pp. 665-672
    • Laakso, M.1    Barrett-Connor, E.2
  • 74
    • 0027472126 scopus 로고
    • Familial hyperglycemia dua to mutations in the glucokinase gene
    • Froguel P, Zouali H, Velho G, et al. Familial hyperglycemia dua to mutations in the glucokinase gene. N Engl J Med 1993; 328: 697-702.
    • (1993) N Engl J Med , vol.328 , pp. 697-702
    • Froguel, P.1    Zouali, H.2    Velho, G.3
  • 75
    • 0026608764 scopus 로고
    • Close linkage of glucokinase locus on chromosome 7p to early onset non-insulin-dependent diabetes mellitus
    • Froguel P, Vaxillaire M, Sun F, et al. Close linkage of glucokinase locus on chromosome 7p to early onset non-insulin-dependent diabetes mellitus. Nature 1992; 356: 162-7.
    • (1992) Nature , vol.356 , pp. 162-167
    • Froguel, P.1    Vaxillaire, M.2    Sun, F.3
  • 76
    • 0028907342 scopus 로고
    • A gene for early onset non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young) maps to chromosome 12 q
    • Vaxillaire M, Boccio V, Philippi A, et al. A gene for early onset non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young) maps to chromosome 12 q. Natl Genet 1995; 9: 418-23.
    • (1995) Natl Genet , vol.9 , pp. 418-423
    • Vaxillaire, M.1    Boccio, V.2    Philippi, A.3
  • 77
    • 0028907339 scopus 로고
    • Positional cloning moves from perditional to traditional
    • Collins F. Positional cloning moves from perditional to traditional. Nat Genet 1995; 9: 347-50.
    • (1995) Nat Genet , vol.9 , pp. 347-350
    • Collins, F.1
  • 78
    • 0027978110 scopus 로고
    • The diastrophic dysplasia gene encodes a novel sulfate transporter: Positional cloning by fine-structure linkage disequilibrium mapping
    • Hästbacka J, de la Chapelle A, Mahtani M, et al. The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping. Cell 1994; 78: 1073-87.
    • (1994) Cell , vol.78 , pp. 1073-1087
    • Hästbacka, J.1    De La Chapelle, A.2    Mahtani, M.3
  • 79
    • 0030058877 scopus 로고    scopus 로고
    • Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat
    • Galli J, Li L-S, Glaser A, et al. Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat Genet 1996; 12: 31-7.
    • (1996) Nat Genet , vol.12 , pp. 31-37
    • Galli, J.1    Li, L.-S.2    Glaser, A.3
  • 80
    • 9044247460 scopus 로고    scopus 로고
    • Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat
    • Gauguier D, Froguel P, Parent V, et al. Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat. Nat Genet 1996; 12: 38-43.
    • (1996) Nat Genet , vol.12 , pp. 38-43
    • Gauguier, D.1    Froguel, P.2    Parent, V.3
  • 81
    • 0026674886 scopus 로고
    • Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction
    • Liang P, Pardee A. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 1992; 257: 967-71.
    • (1992) Science , vol.257 , pp. 967-971
    • Liang, P.1    Pardee, A.2
  • 82
    • 0027741390 scopus 로고
    • Rad: A member of the ras family overexpressed in muscle of type II diabetic humans
    • Reynet C, Kahn R. Rad: a member of the ras family overexpressed in muscle of type II diabetic humans. Science 1993; 262: 1441-3.
    • (1993) Science , vol.262 , pp. 1441-1443
    • Reynet, C.1    Kahn, R.2
  • 83
    • 13344280348 scopus 로고    scopus 로고
    • Identification of trinucleotide repeat-containing genes in human pancreatic islets
    • Aoki M, Koranyi L, Riggs A, et al. Identification of trinucleotide repeat-containing genes in human pancreatic islets. Diabetes 1996; 45: 157-64.
    • (1996) Diabetes , vol.45 , pp. 157-164
    • Aoki, M.1    Koranyi, L.2    Riggs, A.3
  • 84
    • 0027953703 scopus 로고
    • Insulin action, diabetogenesis, and the cause of type II diabetes
    • Kahn CR. Insulin action, diabetogenesis, and the cause of type II diabetes. Diabetes 1994; 73: 1066-84.
    • (1994) Diabetes , vol.73 , pp. 1066-1084
    • Kahn, C.R.1
  • 85
    • 26844496940 scopus 로고
    • Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus: Effect of weight loss
    • Freidenberg G, Reichart D, Olefsky J, Henry R. Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus: effect of weight loss. J Clin Invest 1991; 88: 1323-30.
    • (1991) J Clin Invest , vol.88 , pp. 1323-1330
    • Freidenberg, G.1    Reichart, D.2    Olefsky, J.3    Henry, R.4
  • 86
    • 0025813375 scopus 로고
    • Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
    • Sun X, Rothenberg P, Kahn R, et al. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 1991; 352: 73-7.
    • (1991) Nature , vol.352 , pp. 73-77
    • Sun, X.1    Rothenberg, P.2    Kahn, R.3
  • 87
    • 0027367546 scopus 로고
    • Aminoacid polymorphism of the insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus
    • Almind K, Bjoerbaek C, Vestergaard H, Hansen T, Echwald S, Pedersen O. Aminoacid polymorphism of the insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus. Lancet 1993; 342: 828-32.
    • (1993) Lancet , vol.342 , pp. 828-832
    • Almind, K.1    Bjoerbaek, C.2    Vestergaard, H.3    Hansen, T.4    Echwald, S.5    Pedersen, O.6
  • 88
    • 0029118510 scopus 로고
    • Insulin resistance: Interactions between obesity and a common variant of the insulin receptor substrate-1
    • Clausen J, Hansen T, Bjoerbaek C, et al. Insulin resistance: interactions between obesity and a common variant of the insulin receptor substrate-1. Lancet 1995; 346: 397-402.
    • (1995) Lancet , vol.346 , pp. 397-402
    • Clausen, J.1    Hansen, T.2    Bjoerbaek, C.3
  • 89
    • 0028032895 scopus 로고
    • Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
    • Arakl E, Lypes M, Patti M, et al. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 1994; 372: 186-90.
    • (1994) Nature , vol.372 , pp. 186-190
    • Arakl, E.1    Lypes, M.2    Patti, M.3
  • 90
    • 0029148591 scopus 로고
    • Role of IRS-2 in insulin and cytokine signalling
    • Sun X, Wang L-M, Zhang Y, et al. Role of IRS-2 in insulin and cytokine signalling. Nature 1995; 377: 173-7.
    • (1995) Nature , vol.377 , pp. 173-177
    • Sun, X.1    Wang, L.-M.2    Zhang, Y.3
  • 91
    • 0028341446 scopus 로고
    • She is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21 ras-GTP formation
    • Sasaoka T, Draznin B, Leitner J, Langlois W, Olefsky J. She is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21 ras-GTP formation. J Biol Chem 1994; 269: 10734-8.
    • (1994) J Biol Chem , vol.269 , pp. 10734-10738
    • Sasaoka, T.1    Draznin, B.2    Leitner, J.3    Langlois, W.4    Olefsky, J.5
  • 92
    • 0029149712 scopus 로고
    • Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: Comparison with fat cells
    • Le Marchand-Brustel Y, Gautier N, Cormont M, van Oberghen E. Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: Comparison with fat cells. Endocrinology 1995; 136: 3564-70.
    • (1995) Endocrinology , vol.136 , pp. 3564-3570
    • Le Marchand-Brustel, Y.1    Gautier, N.2    Cormont, M.3    Van Oberghen, E.4
  • 93
    • 0029057336 scopus 로고
    • A single ataxia teleangiectasia gene with product similar to PI-3-kinase
    • Savitsky K, Bar-Shira A, Gilad S, et al. A single ataxia teleangiectasia gene with product similar to PI-3-kinase. Science 1995; 268: 1749-53.
    • (1995) Science , vol.268 , pp. 1749-1753
    • Savitsky, K.1    Bar-Shira, A.2    Gilad, S.3
  • 94
    • 0028928954 scopus 로고
    • Trinucleotide repeats at the rad locus. Allele distributions in NIDDM and mapping to a 3 cM region on chormosome 16q
    • Doria A, Caldwell J, Ji L, et al. Trinucleotide repeats at the rad locus. Allele distributions in NIDDM and mapping to a 3 cM region on chormosome 16q. Diabetes 1995; 44: 243-7.
    • (1995) Diabetes , vol.44 , pp. 243-247
    • Doria, A.1    Caldwell, J.2    Ji, L.3
  • 95
    • 0029926841 scopus 로고    scopus 로고
    • Polymorphism at the rad gene is not associated with NIDDM in Finns
    • Orho M, Carlsson M, Kanninen T, Groop L. Polymorphism at the rad gene is not associated with NIDDM in Finns. Diabetes 1996; 45: 429-33.
    • (1996) Diabetes , vol.45 , pp. 429-433
    • Orho, M.1    Carlsson, M.2    Kanninen, T.3    Groop, L.4
  • 96
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross D, Alessi D, Cohen P, Andjelkovich M, Hemmings B. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995; 378: 785-9.
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.1    Alessi, D.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.5
  • 97
    • 0023251849 scopus 로고
    • Regulation of glycogen synthase and phosphorylase activities by glucose and insulin in human skeletal muscle
    • Yki-Järvinen H, Mott D, Young A, Stone K, Bogardus C. Regulation of glycogen synthase and phosphorylase activities by glucose and insulin in human skeletal muscle. J Clin Invest 1987; 80: 95-100.
    • (1987) J Clin Invest , vol.80 , pp. 95-100
    • Yki-Järvinen, H.1    Mott, D.2    Young, A.3    Stone, K.4    Bogardus, C.5
  • 99
    • 0242416729 scopus 로고
    • Mechanism limiting glycogen storage in muscle during prolonged insulin infusion
    • Richter E, Asp Hansen S, Falck Hansen B. Mechanism limiting glycogen storage in muscle during prolonged insulin infusion. Am J Physiol 1988; 255: E621-8.
    • (1988) Am J Physiol , vol.255
    • Richter, E.1    Asp Hansen, S.2    Falck Hansen, B.3
  • 100
    • 0026624835 scopus 로고
    • Facilatative glucose transporters: Regulatory mechanisms and dysregulation in diabetes
    • Kahn B. Facilatative glucose transporters: regulatory mechanisms and dysregulation in diabetes. J Clin Invest 1992; 89: 1367-74.
    • (1992) J Clin Invest , vol.89 , pp. 1367-1374
    • Kahn, B.1
  • 101
    • 0028328310 scopus 로고
    • Effect of insulin on GLUT-4 mRNA and protein concentrations in skeletal muscle of patients with NIDDM and their first-degree relatives
    • Schalin-Jäntti C, Yki-Järvinen H, Koranyi L, et al. Effect of insulin on GLUT-4 mRNA and protein concentrations in skeletal muscle of patients with NIDDM and their first-degree relatives. Diabetologia 1994; 37: 401-7.
    • (1994) Diabetologia , vol.37 , pp. 401-407
    • Schalin-Jäntti, C.1    Yki-Järvinen, H.2    Koranyi, L.3
  • 102
    • 0029148426 scopus 로고
    • Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4
    • Katz E, Stenbit A, Hatton K, DePinho R, Charron M. Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4. Nature 1995; 377: 151-4.
    • (1995) Nature , vol.377 , pp. 151-154
    • Katz, E.1    Stenbit, A.2    Hatton, K.3    Depinho, R.4    Charron, M.5
  • 103
    • 0028942658 scopus 로고
    • Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4)
    • Gibbs E, Stock J, McCoid S, et al. Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4). J Clin Invest 1995; 95: 1512-8.
    • (1995) J Clin Invest , vol.95 , pp. 1512-1518
    • Gibbs, E.1    Stock, J.2    McCoid, S.3
  • 104
    • 0027169321 scopus 로고
    • Transmembrane glucose transport in skeletal muscle of patients with non-insulin-dependent diabetes
    • Bonadonna R, DelPrato S, Saccomanni M, et al. Transmembrane glucose transport in skeletal muscle of patients with non-insulin-dependent diabetes. J Clin Invest 1993; 92: 486-94.
    • (1993) J Clin Invest , vol.92 , pp. 486-494
    • Bonadonna, R.1    DelPrato, S.2    Saccomanni, M.3
  • 105
    • 0026611962 scopus 로고
    • P-nuclear magnetic resonance measurements of glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity
    • Rothman D, Shulman R, Shulman G. P-nuclear magnetic resonance measurements of glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity. J Clin Invest 1992; 89: 1069-75.
    • (1992) J Clin Invest , vol.89 , pp. 1069-1075
    • Rothman, D.1    Shulman, R.2    Shulman, G.3
  • 106
    • 0028809238 scopus 로고
    • Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus
    • Rothman D, Magnusson I, Cline G, et al. Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 1995; 92: 983-7.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 983-987
    • Rothman, D.1    Magnusson, I.2    Cline, G.3
  • 107
    • 0028789774 scopus 로고
    • Human hexokinase II gene: Exon-intron organization, mutation screening in NIDDM, and its relationship to muscle hexokinase activity
    • Lehto M, Huang X, Davis E, et al. Human hexokinase II gene: exon-intron organization, mutation screening in NIDDM, and its relationship to muscle hexokinase activity. Diabetologia 1995; 38: 1466-74.
    • (1995) Diabetologia , vol.38 , pp. 1466-1474
    • Lehto, M.1    Huang, X.2    Davis, E.3
  • 108
    • 0028903281 scopus 로고
    • Human hexokinase II mRNA and gene structure
    • Printz R, Ardehali H, Koch S, Granner D. Human hexokinase II mRNA and gene structure. Diabetes 1995; 44: 290-4.
    • (1995) Diabetes , vol.44 , pp. 290-294
    • Printz, R.1    Ardehali, H.2    Koch, S.3    Granner, D.4
  • 109
    • 0027418154 scopus 로고
    • Assignment of the gene encoding gycogen synthase to human chromosome 19, band q13.3
    • Lehto M, Stoffel M, Groop L, Esplnosa R III, LeBeau M, Bell G. Assignment of the gene encoding gycogen synthase to human chromosome 19, band q13.3. Genomics 1993; 15: 460-1.
    • (1993) Genomics , vol.15 , pp. 460-461
    • Lehto, M.1    Stoffel, M.2    Groop, L.3    Esplnosa III, R.4    LeBeau, M.5    Bell, G.6
  • 110
    • 0028803333 scopus 로고
    • Isolation and characterization of the human muscle glycogen synthase gene
    • Orho M, Nikula-Ijäs P, Schalin-Jäntti C, Permutt M, Groop L. Isolation and characterization of the human muscle glycogen synthase gene. Diabetes 1995; 44: 1099-105.
    • (1995) Diabetes , vol.44 , pp. 1099-1105
    • Orho, M.1    Nikula-Ijäs, P.2    Schalin-Jäntti, C.3    Permutt, M.4    Groop, L.5
  • 111
    • 0027511164 scopus 로고
    • Association between polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus
    • Groop L, Kankuri M, Schalin-Jäntti C, et al. Association between polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus. N Engl J Med 1993; 328: 10-4.
    • (1993) N Engl J Med , vol.328 , pp. 10-14
    • Groop, L.1    Kankuri, M.2    Schalin-Jäntti, C.3
  • 112
    • 0027215282 scopus 로고
    • Polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus
    • Zouali H, Velho G, Froguel P. Polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus. N Engl J Med 1993; 328: 1568.
    • (1993) N Engl J Med , vol.328 , pp. 1568
    • Zouali, H.1    Velho, G.2    Froguel, P.3
  • 113
    • 0030048997 scopus 로고    scopus 로고
    • Association of the glycogen synthase locus 19q13 with NIDDM in Pima Indians
    • Majer M, Molt D, Mochizuki H, et al. Association of the glycogen synthase locus 19q13 with NIDDM in Pima Indians. Diabetologia 1996; 39: 314-21.
    • (1996) Diabetologia , vol.39 , pp. 314-321
    • Majer, M.1    Molt, D.2    Mochizuki, H.3
  • 114
    • 0028326488 scopus 로고
    • Simple tandem repeat DNA polymorphism in the human glycogen synthase gene is associated with NIDDM in Japanese subjects
    • Kuroyama H, Sanke T, Ohangi S, Furuta M, Nanjo K. Simple tandem repeat DNA polymorphism in the human glycogen synthase gene is associated with NIDDM in Japanese subjects. Diabetologia 1994; 37: 536-9.
    • (1994) Diabetologia , vol.37 , pp. 536-539
    • Kuroyama, H.1    Sanke, T.2    Ohangi, S.3    Furuta, M.4    Nanjo, K.5
  • 115
    • 0028058980 scopus 로고
    • Molecular scanning of the glycogen synthase and insulin receptor substrate-1 genes in Japanese subjects with non-insulin-dependent diabetes mellitus
    • Shimokawa K, Kadowaki H, Sakura H, et al. Molecular scanning of the glycogen synthase and insulin receptor substrate-1 genes in Japanese subjects with non-insulin-dependent diabetes mellitus. Biochem Biophys Res Commun 1994; 202: 463-9.
    • (1994) Biochem Biophys Res Commun , vol.202 , pp. 463-469
    • Shimokawa, K.1    Kadowaki, H.2    Sakura, H.3
  • 116
    • 0028015567 scopus 로고
    • Description of a second microsatellite marker and linkage analysis of the muscle glycogen synthase gene locus in familial NIDDM
    • Elbein S, Hoffman M, Ridinger D, Otterud B, Leppert M. Description of a second microsatellite marker and linkage analysis of the muscle glycogen synthase gene locus in familial NIDDM. Diabetes 1994; 43: 1061-5.
    • (1994) Diabetes , vol.43 , pp. 1061-1065
    • Elbein, S.1    Hoffman, M.2    Ridinger, D.3    Otterud, B.4    Leppert, M.5
  • 117
    • 0028832263 scopus 로고
    • Linkage analysis of 19 candidate regions for insulin resistance in familial NIDDM
    • Elbein S, Chiu K, Hoffman M, Mayorga R, Bragg K, Leppert M. Linkage analysis of 19 candidate regions for insulin resistance in familial NIDDM. Diabetes 1995; 44: 1259-65.
    • (1995) Diabetes , vol.44 , pp. 1259-1265
    • Elbein, S.1    Chiu, K.2    Hoffman, M.3    Mayorga, R.4    Bragg, K.5    Leppert, M.6
  • 118
    • 0028304854 scopus 로고
    • Glycogen synthase: A putative locus for diet-induced hyperglycemia
    • Seldin M, Mott D, Bhat D, et al. Glycogen synthase: a putative locus for diet-induced hyperglycemia. J Clin Invest 1994; 94: 1-8.
    • (1994) J Clin Invest , vol.94 , pp. 1-8
    • Seldin, M.1    Mott, D.2    Bhat, D.3
  • 119
    • 0028804624 scopus 로고
    • Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients
    • Bjoerbaek C, Vik T, Echwald S, et al. Cloning of a human insulin-stimulated protein kinase (ISPK-1) gene and analysis of coding regions and mRNA levels of the ISPK-1 and the protein phosphatase-1 genes in muscle from NIDDM patients. Diabetes 1995; 44: 90-7.
    • (1995) Diabetes , vol.44 , pp. 90-97
    • Bjoerbaek, C.1    Vik, T.2    Echwald, S.3
  • 120
    • 0029126604 scopus 로고
    • A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phoshatase-1 is associated with insulin resistance and hypersecretion of insulin
    • Hansen L, Hansen T, Vestergaard H, et al. A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phoshatase-1 is associated with insulin resistance and hypersecretion of insulin. Hum Mol Genet 1995; 4: 1313-20.
    • (1995) Hum Mol Genet , vol.4 , pp. 1313-1320
    • Hansen, L.1    Hansen, T.2    Vestergaard, H.3
  • 121
    • 0015792424 scopus 로고
    • Effects of parabiosis of obese with diabetes and normal mice
    • Coleman D. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 1973; 9: 294-8.
    • (1973) Diabetologia , vol.9 , pp. 294-298
    • Coleman, D.1
  • 122
    • 0029066265 scopus 로고
    • Effects of the obese gene product on body weight regulation in ob/ob mice
    • Pelleymounter M, Cullen M, Baker M, et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269: 540-2.
    • (1995) Science , vol.269 , pp. 540-542
    • Pelleymounter, M.1    Cullen, M.2    Baker, M.3
  • 123
    • 0029020677 scopus 로고
    • Evidence against either a premature stop codon or the abscence of obese gene mRNA in human obesity
    • Consindine R, Consindine E, William C, et al. Evidence against either a premature stop codon or the abscence of obese gene mRNA in human obesity. J Clin Invest 1995; 95: 2986-8.
    • (1995) J Clin Invest , vol.95 , pp. 2986-2988
    • Consindine, R.1    Consindine, E.2    William, C.3
  • 124
    • 13344295079 scopus 로고    scopus 로고
    • Serum immunoreactive leptin concentrations in normal-weight and obese humans
    • Consindine R, Sinha M, Heiman M, et al. Serum immunoreactive leptin concentrations in normal-weight and obese humans. N Engl J Med 1996; 334: 292-5.
    • (1996) N Engl J Med , vol.334 , pp. 292-295
    • Consindine, R.1    Sinha, M.2    Heiman, M.3
  • 125
    • 0028845877 scopus 로고
    • Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
    • Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995; 1: 1155-61.
    • (1995) Nat Med , vol.1 , pp. 1155-1161
    • Maffei, M.1    Halaas, J.2    Ravussin, E.3
  • 126
    • 0029086176 scopus 로고
    • Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats
    • Ogawa Y, Masuzaki H, Isse N, et al. Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats. J Clin Invest 1995; 96: 1647-52.
    • (1995) J Clin Invest , vol.96 , pp. 1647-1652
    • Ogawa, Y.1    Masuzaki, H.2    Isse, N.3
  • 127
    • 2442654859 scopus 로고    scopus 로고
    • Identification and expression cloning of a leptin receptor, ob-R
    • Tartaglia L, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, ob-R. Cell 1996; 83: 1263-71.
    • (1996) Cell , vol.83 , pp. 1263-1271
    • Tartaglia, L.1    Dembski, M.2    Weng, X.3
  • 128
    • 0030039272 scopus 로고    scopus 로고
    • Abnormal splicing of the leptin receptor in diabetic mice
    • Lee G-H, Proenca R, Montez J, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379: 632-5.
    • (1996) Nature , vol.379 , pp. 632-635
    • Lee, G.-H.1    Proenca, R.2    Montez, J.3
  • 129
    • 0029098589 scopus 로고
    • The role of neuropeptide Y in the antiobesity action of the obese gene product
    • Stephens T, Basinski M, Bristow P, et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 1995; 377: 530-2.
    • (1995) Nature , vol.377 , pp. 530-532
    • Stephens, T.1    Basinski, M.2    Bristow, P.3
  • 130
    • 0029040210 scopus 로고
    • Hyperproinsulinemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity
    • Naggert J, Fricker L, Varlamov O, et al. Hyperproinsulinemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nat Genef 1995; 10 :135-42.
    • (1995) Nat Genef , vol.10 , pp. 135-142
    • Naggert, J.1    Fricker, L.2    Varlamov, O.3
  • 131
    • 0024470363 scopus 로고
    • Molecular characterization of the human beta-3-adrenergic receptor
    • Emorine L, Marullo S, Briend-Sutren M, et al. Molecular characterization of the human beta-3-adrenergic receptor. Science 1989; 245: 1118-21.
    • (1989) Science , vol.245 , pp. 1118-1121
    • Emorine, L.1    Marullo, S.2    Briend-Sutren, M.3
  • 132
    • 0027731309 scopus 로고
    • Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
    • Lowell B, Susulic V, Hamman A, et al. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 1993; 366: 740-2.
    • (1993) Nature , vol.366 , pp. 740-742
    • Lowell, B.1    Susulic, V.2    Hamman, A.3
  • 133
    • 0029084088 scopus 로고
    • Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta3-adrenergic-receptor gene
    • Walston J, Silver K, Bogardus C, et al. Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta3-adrenergic-receptor gene. N Engl J Med 1995; 333: 343-7.
    • (1995) N Engl J Med , vol.333 , pp. 343-347
    • Walston, J.1    Silver, K.2    Bogardus, C.3
  • 134
    • 0028978910 scopus 로고
    • Genetic variation in the beta3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity
    • Clément K, Vaisse C, Manning B, et al. Genetic variation in the beta3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. New Engl J Med 1995; 333: 352-4.
    • (1995) New Engl J Med , vol.333 , pp. 352-354
    • Clément, K.1    Vaisse, C.2    Manning, B.3
  • 135
    • 0028978913 scopus 로고
    • Association of a polymorphism in the beta-3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns
    • Widèn E, Lehto M, Kanninen T, Walston J, Shuldiner A, Groop L. Association of a polymorphism in the beta-3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns. N Engl J Med 1995; 333: 348-51.
    • (1995) N Engl J Med , vol.333 , pp. 348-351
    • Widèn, E.1    Lehto, M.2    Kanninen, T.3    Walston, J.4    Shuldiner, A.5    Groop, L.6
  • 136
    • 9044228020 scopus 로고    scopus 로고
    • Association of Trp64Arg mutation of the beta3-adrenergic receptor with NIDDM and body weight gain
    • Fujisawa T, Ikegami H, Yamato E, et al. Association of Trp64Arg mutation of the beta3-adrenergic receptor with NIDDM and body weight gain. Diabetologia 1996; 39: 349-52.
    • (1996) Diabetologia , vol.39 , pp. 349-352
    • Fujisawa, T.1    Ikegami, H.2    Yamato, E.3
  • 137
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance
    • Hotamisigil G, Arner P, Caro J, Atkinson R, Spiegelman B. Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance. J Clin Invest 1995; 95: 2409-15.
    • (1995) J Clin Invest , vol.95 , pp. 2409-2415
    • Hotamisigil, G.1    Arner, P.2    Caro, J.3    Atkinson, R.4    Spiegelman, B.5
  • 138
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance
    • Hotamisligil G, Shargill N, Spiegelman B. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 1993; 259: 87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.1    Shargill, N.2    Spiegelman, B.3
  • 140
    • 0030028606 scopus 로고    scopus 로고
    • The expression of TNF-alpha by human muscle. Relationship to insulin resistance
    • Saghizadeh M, Ong J, Garvey W, Henry R, Kern P. The expression of TNF-alpha by human muscle. Relationship to insulin resistance. J Clin Invest 1996; 97: 1111-6.
    • (1996) J Clin Invest , vol.97 , pp. 1111-1116
    • Saghizadeh, M.1    Ong, J.2    Garvey, W.3    Henry, R.4    Kern, P.5
  • 141
    • 0029145667 scopus 로고
    • Linkage between obesity and a marker near the tumor necrosis factor alpha locus in Pima Indians
    • Norman R, Bogardus C, Ravussin E. Linkage between obesity and a marker near the tumor necrosis factor alpha locus in Pima Indians. J Clin Invest 1995; 96: 158-62.
    • (1995) J Clin Invest , vol.96 , pp. 158-162
    • Norman, R.1    Bogardus, C.2    Ravussin, E.3
  • 142
    • 0021213899 scopus 로고
    • Brown adipose tissue thermogenesis, energy balance and obesity
    • Himms-Hagen J. Brown adipose tissue thermogenesis, energy balance and obesity. Can J Biochem Cell Biol 1984; 62: 610-7.
    • (1984) Can J Biochem Cell Biol , vol.62 , pp. 610-617
    • Himms-Hagen, J.1
  • 143
    • 0028865142 scopus 로고
    • Expression of the imtochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
    • Kopecky J, Clarke G, Enerbäck S, Spiegelman B, Kozak L. Expression of the imtochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J Clin Invest 1995; 96: 2914-23.
    • (1995) J Clin Invest , vol.96 , pp. 2914-2923
    • Kopecky, J.1    Clarke, G.2    Enerbäck, S.3    Spiegelman, B.4    Kozak, L.5
  • 144
    • 13344282056 scopus 로고    scopus 로고
    • A role for glucagon-like-peptide-1 in the central regulation of feeding
    • Turton M, O'Shea D, Gunn I, et al. A role for glucagon-like-peptide-1 in the central regulation of feeding. Nature 1996; 379: 69-72.
    • (1996) Nature , vol.379 , pp. 69-72
    • Turton, M.1    O'Shea, D.2    Gunn, I.3
  • 145
    • 0027207752 scopus 로고
    • Genetic susceptibility to non-insulin-dependent diabetes mellitus and glucose intolerance are located in HLA region
    • Tuomilehto-Wolf E, Tuomilehto J, Hitman G, et al. Genetic susceptibility to non-insulin-dependent diabetes mellitus and glucose intolerance are located in HLA region. BMJ 1993; 307: 155-9.
    • (1993) BMJ , vol.307 , pp. 155-159
    • Tuomilehto-Wolf, E.1    Tuomilehto, J.2    Hitman, G.3
  • 146
    • 0022868048 scopus 로고
    • Relationship between beta-cell function and HLA-antigens in patients with type 2 diabetes
    • Groop L, Groop P, Koskimies S. Relationship between beta-cell function and HLA-antigens in patients with type 2 diabetes. Diabetologia 1986; 29: 757-60.
    • (1986) Diabetologia , vol.29 , pp. 757-760
    • Groop, L.1    Groop, P.2    Koskimies, S.3
  • 147
    • 0027526457 scopus 로고
    • HLA-associated susceptibility to type 2 diabetes mellitus: The Wadena city health study
    • Rich S, French L, Sprafka J, Clements J, Goetz F. HLA-associated susceptibility to type 2 diabetes mellitus: the Wadena city health study. Diabetologia 1993; 36: 234-8.
    • (1993) Diabetologia , vol.36 , pp. 234-238
    • Rich, S.1    French, L.2    Sprafka, J.3    Clements, J.4    Goetz, F.5
  • 148
    • 26844491813 scopus 로고
    • Genetic susceptibility to non-insulin-dependent diabetes mellitus
    • Groop L, Bottazzo G. Genetic susceptibility to non-insulin-dependent diabetes mellitus. BMJ 1994; 308: 504.
    • (1994) BMJ , vol.308 , pp. 504
    • Groop, L.1    Bottazzo, G.2
  • 149
    • 26844528283 scopus 로고    scopus 로고
    • Sharing an HLA-haplotype with an IDDM-relative influences insulin secretion in NIDDM and IGT
    • Li H, Tuomi T, Orho M, Groop L. Sharing an HLA-haplotype with an IDDM-relative influences insulin secretion in NIDDM and IGT. Diabetes 1996; 45: 296A.
    • (1996) Diabetes , vol.45
    • Li, H.1    Tuomi, T.2    Orho, M.3    Groop, L.4
  • 150
    • 0027933734 scopus 로고
    • A genome-wide search for human type 1 diabetes-susceptibility genes
    • Davies J, Kawaguchi Y, Bennett S, et al. A genome-wide search for human type 1 diabetes-susceptibility genes. Nature 1994; 371: 130-6.
    • (1994) Nature , vol.371 , pp. 130-136
    • Davies, J.1    Kawaguchi, Y.2    Bennett, S.3
  • 151
    • 0028070552 scopus 로고
    • Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q
    • Hashimoto L, Habita C, Beressi J, et al. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q. Nature 1994; 371: 161-4.
    • (1994) Nature , vol.371 , pp. 161-164
    • Hashimoto, L.1    Habita, C.2    Beressi, J.3
  • 152
    • 0020664519 scopus 로고
    • Polymorphism in the 5′-flanking region of the human insulin gene: A genetic marker for non-insulin-dependent diabetes mellitus
    • Rotwein P, Chirgwin J, Province M, et al. Polymorphism in the 5′-flanking region of the human insulin gene: a genetic marker for non-insulin-dependent diabetes mellitus. N Engl J Med 1983; 308: 65-71.
    • (1983) N Engl J Med , vol.308 , pp. 65-71
    • Rotwein, P.1    Chirgwin, J.2    Province, M.3
  • 153
    • 0028871202 scopus 로고
    • Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus
    • Bennett S, Lucassen A, Gough S, et al. Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nat Genet 1995; 9: 284-92.
    • (1995) Nat Genet , vol.9 , pp. 284-292
    • Bennett, S.1    Lucassen, A.2    Gough, S.3
  • 154
    • 0028881617 scopus 로고
    • The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription
    • Kennedy G, German M, Rutter W. The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription. Nat Genet 1995; 9: 293-8.
    • (1995) Nat Genet , vol.9 , pp. 293-298
    • Kennedy, G.1    German, M.2    Rutter, W.3
  • 155
    • 0028328317 scopus 로고
    • A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA
    • Kadowaki T, Kadowaki H, Mori Y, et al. A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA. N Engl J Med 1994; 330: 962-8.
    • (1994) N Engl J Med , vol.330 , pp. 962-968
    • Kadowaki, T.1    Kadowaki, H.2    Mori, Y.3
  • 156
    • 0026906885 scopus 로고
    • Mutation in mitochondrial tRNA Leu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness
    • van den Ouwenland J, Lemkes H, Ruitenbeek W, et al. Mutation in mitochondrial tRNA (Leu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness. Nat Genet 1992; 1: 368-71.
    • (1992) Nat Genet , vol.1 , pp. 368-371
    • Van Den Ouwenland, J.1    Lemkes, H.2    Ruitenbeek, W.3
  • 157
    • 0026032055 scopus 로고
    • Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q
    • Bell G, Xiang K-S, Newman M, et al. Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q. Proc Natl Acad Sci USA 1991; 88: 1484-8.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 1484-1488
    • Bell, G.1    Xiang, K.-S.2    Newman, M.3
  • 158
    • 0029002588 scopus 로고
    • Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20
    • Byrne M, Sturis J, Fajans S, et al. Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20. Diabetes 1995; 44: 699-704.
    • (1995) Diabetes , vol.44 , pp. 699-704
    • Byrne, M.1    Sturis, J.2    Fajans, S.3
  • 159
    • 0027410865 scopus 로고
    • Glucokinase mutations associated with non-insulin-dependent diabetes mellitus (type II) have decreased enzymatic activity: Implications for structure/functions relationships
    • Gidh-Jain M, Takeda J, Wu L, et al. Glucokinase mutations associated with non-insulin-dependent diabetes mellitus (type II) have decreased enzymatic activity: implications for structure/functions relationships. Proc Natl Acad Sci USA 1993; 90: 1932-6.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1932-1936
    • Gidh-Jain, M.1    Takeda, J.2    Wu, L.3
  • 160
    • 0026754672 scopus 로고
    • Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young
    • Velho G, Froguel P, Clement K, et al. Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young. Lancet 1992; 340: 444-8.
    • (1992) Lancet , vol.340 , pp. 444-448
    • Velho, G.1    Froguel, P.2    Clement, K.3
  • 161
    • 0029024314 scopus 로고
    • Cloning of the beta-cell high-affinity sulfonylurea receptor: A regulator of insulin secretion
    • Aguilar-Bryan L, Nichols C, Wechsler S, et al. Cloning of the beta-cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science 1995; 268: 423-5.
    • (1995) Science , vol.268 , pp. 423-425
    • Aguilar-Bryan, L.1    Nichols, C.2    Wechsler, S.3
  • 162
    • 9344248748 scopus 로고
    • Reconstitution of I KATP: An inward rectifier subunit plus the sulfonylurea receptor
    • Inagaki N, Gonol T, Clement JI, et al. Reconstitution of I KATP: an inward rectifier subunit plus the sulfonylurea receptor. Science 1995; 268: 423-6.
    • (1995) Science , vol.268 , pp. 423-426
    • Inagaki, N.1    Gonol, T.2    Clement, J.I.3
  • 163
    • 13344259308 scopus 로고    scopus 로고
    • Identification of microsatellite markers near the human genes encoding the beta-cell ATP-sensitivie K channel and linkage studies with NIDDM in Japanese
    • Iwasaki N, Kawamura M, Yamagata K, et al. Identification of microsatellite markers near the human genes encoding the beta-cell ATP-sensitivie K channel and linkage studies with NIDDM in Japanese. Diabetes 1996; 45: 267-9.
    • (1996) Diabetes , vol.45 , pp. 267-269
    • Iwasaki, N.1    Kawamura, M.2    Yamagata, K.3
  • 164
  • 165
    • 0029006993 scopus 로고
    • No evidence for mutations in a putative beta-cell ATP-sensitive K-channel subunit in MODY, NIDDM or GDM
    • Zhang Y, Warren-Perry M, Sakura H, et al. No evidence for mutations in a putative beta-cell ATP-sensitive K-channel subunit in MODY, NIDDM or GDM. Diabetes 1995; 44: 597-600.
    • (1995) Diabetes , vol.44 , pp. 597-600
    • Zhang, Y.1    Warren-Perry, M.2    Sakura, H.3
  • 166
    • 0343602237 scopus 로고    scopus 로고
    • Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channels
    • émmälä C, Moorehouse A, Gribble F, et al. Promiscuous coupling between the sulphonylurea receptor and inwardly rectifying potassium channels. Nature 1996; 379: 545-8.
    • (1996) Nature , vol.379 , pp. 545-548
    • Émmälä, C.1    Moorehouse, A.2    Gribble, F.3
  • 167
    • 0028848010 scopus 로고
    • A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus
    • Hager J, Hansen L, Vaisse C, et al. A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus. Nat Genet 1995; 9: 299-304.
    • (1995) Nat Genet , vol.9 , pp. 299-304
    • Hager, J.1    Hansen, L.2    Vaisse, C.3
  • 168
    • 0029051799 scopus 로고
    • Lack of association between the Gly40Ser polymorphism in the glucagon receptor gene and NIDDM in Finland
    • Huang X, Orho M, Lehto M, Groop L. Lack of association between the Gly40Ser polymorphism in the glucagon receptor gene and NIDDM in Finland. Diabetologia 1995; 38: 1246-8.
    • (1995) Diabetologia , vol.38 , pp. 1246-1248
    • Huang, X.1    Orho, M.2    Lehto, M.3    Groop, L.4
  • 169
    • 0029098051 scopus 로고
    • A mutation in the glucagon receptor gene (Gly40Ser): Heterogeneity in the association with diabetes mellitus
    • Fujisawa T, Ikegami H, Yamato E, et al. A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus. Diabetologia 1995; 38: 983-5.
    • (1995) Diabetologia , vol.38 , pp. 983-985
    • Fujisawa, T.1    Ikegami, H.2    Yamato, E.3
  • 170
    • 0030031579 scopus 로고    scopus 로고
    • Genetic analysis of NIDDM. The study of quantitative traits
    • Ghosh S, Schork N. Genetic analysis of NIDDM. The study of quantitative traits. Diabetes 1996; 45: 1-14.
    • (1996) Diabetes , vol.45 , pp. 1-14
    • Ghosh, S.1    Schork, N.2
  • 171
    • 0028940934 scopus 로고
    • An amino acid Substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation and insulin resistance
    • Baier L, Sacchettini J, Knowler W, et al. An amino acid Substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation and insulin resistance. J Clin Invest 1995; 95: 1281-7.
    • (1995) J Clin Invest , vol.95 , pp. 1281-1287
    • Baier, L.1    Sacchettini, J.2    Knowler, W.3
  • 172
    • 0028783969 scopus 로고
    • Evidence for linkage of postchallenge insulin levels with intestinal fatty-acid-binding protein (FAB2) in Mexican Americans
    • Mitchell B, Kammerer C, O'Connell P, et al. Evidence for linkage of postchallenge insulin levels with intestinal fatty-acid-binding protein (FAB2) in Mexican Americans. Diabetes 1995; 44: 1046-53.
    • (1995) Diabetes , vol.44 , pp. 1046-1053
    • Mitchell, B.1    Kammerer, C.2    O'Connell, P.3
  • 173
    • 0028340977 scopus 로고
    • Chromosome 4q locus associated with insulin resistance in Pima Indians. Studies in three European populations
    • Humphreys P, McCarthy M, Tuomilehto J, et al. Chromosome 4q locus associated with insulin resistance in Pima Indians. Studies in three European populations. Diabetes 1994; 43: 800-4.
    • (1994) Diabetes , vol.43 , pp. 800-804
    • Humphreys, P.1    McCarthy, M.2    Tuomilehto, J.3
  • 174
    • 0028947513 scopus 로고
    • Evidence for linkage between a region on chromosome 1p and the acute insulin response in Pima Indians
    • Thompson D, Janssen R, Ossowski V, Prochazka M, Knowler W, Bogardus C. Evidence for linkage between a region on chromosome 1p and the acute insulin response in Pima Indians. Diabetes 1995; 44: 478-81.
    • (1995) Diabetes , vol.44 , pp. 478-481
    • Thompson, D.1    Janssen, R.2    Ossowski, V.3    Prochazka, M.4    Knowler, W.5    Bogardus, C.6
  • 175
    • 0030029606 scopus 로고    scopus 로고
    • Linkage studies of NIDDM with 23 chromosome 11 markers in a sample of whites of Northern European descent
    • Elbein S, Bragg K, Hoffman M, Mayorga A, Leppert M. Linkage studies of NIDDM with 23 chromosome 11 markers in a sample of whites of Northern European descent. Diabetes 1996; 45: 370-5.
    • (1996) Diabetes , vol.45 , pp. 370-375
    • Elbein, S.1    Bragg, K.2    Hoffman, M.3    Mayorga, A.4    Leppert, M.5
  • 176
    • 9044243415 scopus 로고    scopus 로고
    • A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2
    • Hanis C, Boerwinkle E, Chakraborty R, et al. A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. Nat Genet 1996; 13: 161-6.
    • (1996) Nat Genet , vol.13 , pp. 161-166
    • Hanis, C.1    Boerwinkle, E.2    Chakraborty, R.3
  • 177
    • 16044374799 scopus 로고    scopus 로고
    • Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families
    • Mahtani M, Widen E, Lehto M, et al. Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nat Genet 1996: 90-4.
    • (1996) Nat Genet , pp. 90-94
    • Mahtani, M.1    Widen, E.2    Lehto, M.3
  • 178
    • 0028877463 scopus 로고
    • Genetic dissection of complex traits', guidelines for interpreting and reporting linkage results
    • Lander E, Kruglyak L. Genetic dissection of complex traits', guidelines for interpreting and reporting linkage results. Nat Genet 1995; 11: 241-7.
    • (1995) Nat Genet , vol.11 , pp. 241-247
    • Lander, E.1    Kruglyak, L.2
  • 179
    • 0028090414 scopus 로고
    • Genetic dissection of complex traits
    • Lander E, Schork N. Genetic dissection of complex traits. Science 1994; 265: 2037-48.
    • (1994) Science , vol.265 , pp. 2037-2048
    • Lander, E.1    Schork, N.2


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