-
1
-
-
33847048710
-
Alternative Vascularization Mechanisms in Cancer: Pathology and Therapeutic Implications
-
Dome, B.; Hendrix, M. J. C.; Paku, S.; Tovari, J.; Timar, J. (2007) Alternative Vascularization Mechanisms in Cancer: Pathology and Therapeutic Implications. Am. J. Pathol., 170 (1), 1-15.
-
(2007)
Am. J. Pathol
, vol.170
, Issue.1
, pp. 1-15
-
-
Dome, B.1
Hendrix, M.J.C.2
Paku, S.3
Tovari, J.4
Timar, J.5
-
2
-
-
29544449697
-
Privileged structure-based quinazolinone natural product-templated libraries: Identification of novel tubulin polymerization inhibitors
-
Liu, J. F.; Wilson, C. J.; Ye, P.; Sprague, K.; Sargent, K.; Si, Y.; Beletsky, G.; Yohannes, D.; Ng, S. C. (2006) Privileged structure-based quinazolinone natural product-templated libraries: Identification of novel tubulin polymerization inhibitors. Bioorg, Med, Chem, Lett., 16 (3), 686-90.
-
(2006)
Bioorg, Med, Chem, Lett
, vol.16
, Issue.3
, pp. 686-690
-
-
Liu, J.F.1
Wilson, C.J.2
Ye, P.3
Sprague, K.4
Sargent, K.5
Si, Y.6
Beletsky, G.7
Yohannes, D.8
Ng, S.C.9
-
5
-
-
0036980746
-
Chemical Similarity and Biological Activities
-
Kubinyi, H., (2002) Chemical Similarity and Biological Activities J. Brazilian Chem. Soc., 13 (6), 717.
-
(2002)
J. Brazilian Chem. Soc
, vol.13
, Issue.6
, pp. 717
-
-
Kubinyi, H.1
-
6
-
-
45249123879
-
Structural diversity of organic chemistry. A scaffold analysis of the CAS registry
-
Lipkus, A. H.; Yuan, Q.; Lucas, K. A.; Funk, S. A.; Bartelt, W. F., 3rd; Schenck, R. J.; Trippe, A. J. (2008) Structural diversity of organic chemistry. A scaffold analysis of the CAS registry. J. Org. Chem., 73 (12), 4443-51.
-
(2008)
J. Org. Chem
, vol.73
, Issue.12
, pp. 4443-4451
-
-
Lipkus, A.H.1
Yuan, Q.2
Lucas, K.A.3
Funk, S.A.4
Bartelt 3rd, W.F.5
Schenck, R.J.6
Trippe, A.J.7
-
7
-
-
35748970483
-
Tumor microvasculature and microenvironment: Targets for anti-angiogenesis and normalization
-
Fukumura, D.; Jain, R. K. (2007) Tumor microvasculature and microenvironment: Targets for anti-angiogenesis and normalization. Microvasc. Res., 74 (2-3), 72-84.
-
(2007)
Microvasc. Res
, vol.74
, Issue.2-3
, pp. 72-84
-
-
Fukumura, D.1
Jain, R.K.2
-
8
-
-
0842311621
-
Vascular targeting agents as cancer therapeutics
-
Thorpe, P. E., (2004) Vascular targeting agents as cancer therapeutics. Clin. Cancer Res., 10 (2), 415-27.
-
(2004)
Clin. Cancer Res
, vol.10
, Issue.2
, pp. 415-427
-
-
Thorpe, P.E.1
-
9
-
-
0028798422
-
Colchicine toxicity - clinical features and treatment. Massive overdose case report
-
Folpini, A.; Furfori, P. (1995) Colchicine toxicity - clinical features and treatment. Massive overdose case report. J. Toxicol. Clin. Toxicol., 33 (1), 71-7.
-
(1995)
J. Toxicol. Clin. Toxicol
, vol.33
, Issue.1
, pp. 71-77
-
-
Folpini, A.1
Furfori, P.2
-
10
-
-
0024605005
-
Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo
-
Rewcastle, G. W.; Atwell, G. J.; Baguley, B. C.; Calveley, S. B.; Denny, W. A. (1989) Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo. J. Med. Chem., 32 (4), 793-9.
-
(1989)
J. Med. Chem
, vol.32
, Issue.4
, pp. 793-799
-
-
Rewcastle, G.W.1
Atwell, G.J.2
Baguley, B.C.3
Calveley, S.B.4
Denny, W.A.5
-
11
-
-
44449152697
-
New tubulin targeting agents currently in clinical development
-
Carlson, R. O., (2008) New tubulin targeting agents currently in clinical development. Exp. Opin. Investig. Drugs, 17 (5), 707-22.
-
(2008)
Exp. Opin. Investig. Drugs
, vol.17
, Issue.5
, pp. 707-722
-
-
Carlson, R.O.1
-
12
-
-
34248159068
-
Small molecule vascular disrupting agents: Potential new drugs for cancer treatment
-
Cai, S. X. (2007) Small molecule vascular disrupting agents: Potential new drugs for cancer treatment. Recent Patents Anticancer Drug Discov., 2 (1), 79-101.
-
(2007)
Recent Patents Anticancer Drug Discov
, vol.2
, Issue.1
, pp. 79-101
-
-
Cai, S.X.1
-
13
-
-
0023845999
-
Colchicine and its analogues: Recent findings
-
Brossi, A.; Yeh, H. J.; Chrzanowska, M.; Wolff, J.; Hamel, E.; Lin, C. M.; Quin, F.; Suffness, M.; Silverton, J. (1988) Colchicine and its analogues: Recent findings. Med. Res. Rev., 8 (1), 77-94.
-
(1988)
Med. Res. Rev
, vol.8
, Issue.1
, pp. 77-94
-
-
Brossi, A.1
Yeh, H.J.2
Chrzanowska, M.3
Wolff, J.4
Hamel, E.5
Lin, C.M.6
Quin, F.7
Suffness, M.8
Silverton, J.9
-
14
-
-
0029902597
-
Antivascular approaches to solid tumour therapy: Evaluation of tubulin binding agents
-
Chaplin, D. J.; Pettit, G. R.; Parkins, C. S.; Hill, S. A. (1996) Antivascular approaches to solid tumour therapy: Evaluation of tubulin binding agents. Br. J. Cancer Suppl., 27, S86-8.
-
(1996)
Br. J. Cancer Suppl
, vol.27
-
-
Chaplin, D.J.1
Pettit, G.R.2
Parkins, C.S.3
Hill, S.A.4
-
15
-
-
0035262598
-
Targeting tumour vasculature: The development of combretastatin A4
-
Griggs, J.; Metcalfe, J. C.; Hesketh, R. (2001) Targeting tumour vasculature: The development of combretastatin A4. Lancet Oncol., 2 (2), 82-7.
-
(2001)
Lancet Oncol
, vol.2
, Issue.2
, pp. 82-87
-
-
Griggs, J.1
Metcalfe, J.C.2
Hesketh, R.3
-
16
-
-
0037115398
-
ZD6126: A novel vascular-targeting agent that causes selective destruction of tumor vasculature
-
Davis, P. D.; Dougherty, G. J.; Blakey, D. C.; Galbraith, S. M.; Tozer, G. M.; Holder, A. L.; Naylor, M. A.; Nolan, J.; Stratford, M. R.; Chaplin, D. J.; Hill, S. A. (2002) ZD6126: A novel vascular-targeting agent that causes selective destruction of tumor vasculature. Cancer Res., 62 (24), 7247-53.
-
(2002)
Cancer Res
, vol.62
, Issue.24
, pp. 7247-7253
-
-
Davis, P.D.1
Dougherty, G.J.2
Blakey, D.C.3
Galbraith, S.M.4
Tozer, G.M.5
Holder, A.L.6
Naylor, M.A.7
Nolan, J.8
Stratford, M.R.9
Chaplin, D.J.10
Hill, S.A.11
-
17
-
-
27544511815
-
Antineoplastic strategy: Irreversible tumor blood flow stasis induced by the combretastatin A-4 derivative AVE8062 (AC7700)
-
Hori, K. (2005) Antineoplastic strategy: Irreversible tumor blood flow stasis induced by the combretastatin A-4 derivative AVE8062 (AC7700). Chemotherapy, 51 (6), 357-60.
-
(2005)
Chemotherapy
, vol.51
, Issue.6
, pp. 357-360
-
-
Hori, K.1
-
18
-
-
36549060198
-
The new vascular disrupting agent combretastatin-A1-disodium-phosphate (OXi4503) enhances tumour response to mild hyperthermia and thermoradiosensitization
-
Hokland, S. L.; Horsman, M. R. (2007) The new vascular disrupting agent combretastatin-A1-disodium-phosphate (OXi4503) enhances tumour response to mild hyperthermia and thermoradiosensitization. Int. J. Hyperthermia, 23 (7), 599-606.
-
(2007)
Int. J. Hyperthermia
, vol.23
, Issue.7
, pp. 599-606
-
-
Hokland, S.L.1
Horsman, M.R.2
-
19
-
-
0030008570
-
Interaction of vinca alkaloids with tubulin: A comparison of vinblastine, vincristine, and vinorelbine
-
Lobert, S.; Vulevic, B.; Correia, J. J. (1996) Interaction of vinca alkaloids with tubulin: A comparison of vinblastine, vincristine, and vinorelbine. Biochemistry, 35 (21), 6806-14.
-
(1996)
Biochemistry
, vol.35
, Issue.21
, pp. 6806-6814
-
-
Lobert, S.1
Vulevic, B.2
Correia, J.J.3
-
20
-
-
0027173672
-
Vinca alkaloids: Anti-vascular effects in a murine tumour
-
Hill, S. A.; Lonergan, S. J.; Denekamp, J.; Chaplin, D. J. (1993) Vinca alkaloids: Anti-vascular effects in a murine tumour. Eur. J. Cancer, 29A (9), 1320-4.
-
(1993)
Eur. J. Cancer
, vol.29 A
, Issue.9
, pp. 1320-1324
-
-
Hill, S.A.1
Lonergan, S.J.2
Denekamp, J.3
Chaplin, D.J.4
-
22
-
-
0035150786
-
Anti-vascular effects of vinflunine in the MAC 15A transplantable adenocarcinoma model
-
Holwell, S. E.; Hill, B. T.; Bibby, M. C. (2001) Anti-vascular effects of vinflunine in the MAC 15A transplantable adenocarcinoma model. Br. J. Cancer, 84 (2), 290-5.
-
(2001)
Br. J. Cancer
, vol.84
, Issue.2
, pp. 290-295
-
-
Holwell, S.E.1
Hill, B.T.2
Bibby, M.C.3
-
23
-
-
33750075041
-
Anti-angiogenic, vascular-disrupting and anti-metastatic activities of vinflunine, the latest vinca alkaloid in clinical development
-
Kruczynski, A.; Poli, M.; Dossi, R.; Chazottes, E.; Berrichon, G.; Ricome, C.; Giavazzi, R.; Hill, B. T.; Taraboletti, G. (2006) Anti-angiogenic, vascular-disrupting and anti-metastatic activities of vinflunine, the latest vinca alkaloid in clinical development. Eur. J. Cancer, 42 (16), 2821-32.
-
(2006)
Eur. J. Cancer
, vol.42
, Issue.16
, pp. 2821-2832
-
-
Kruczynski, A.1
Poli, M.2
Dossi, R.3
Chazottes, E.4
Berrichon, G.5
Ricome, C.6
Giavazzi, R.7
Hill, B.T.8
Taraboletti, G.9
-
24
-
-
33846869795
-
Flavones and Xanthenones as Vascular-Disturbing Agents
-
Siemann, D. W, Ed
-
Baguley, B. G. S. B. C. Flavones and Xanthenones as Vascular-Disturbing Agents. In Vascular Targeted Terapies in Oncology, Siemann, D. W., Ed. 2006; pp 159-178.
-
(2006)
Vascular Targeted Terapies in Oncology
, pp. 159-178
-
-
Baguley, B.G.S.B.C.1
-
25
-
-
0038576231
-
5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: Phase I clinical and pharmacokinetic study
-
Rustin, G. J.; Bradley, C.; Galbraith, S.; Stratford, M.; Loadman, P.; Waller, S.; Bellenger, K.; Gumbrell, L.; Folkes, L.; Halbert, G. (2003) 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: Phase I clinical and pharmacokinetic study. Br. J. Cancer 88 (8), 1160-7.
-
(2003)
Br. J. Cancer
, vol.88
, Issue.8
, pp. 1160-1167
-
-
Rustin, G.J.1
Bradley, C.2
Galbraith, S.3
Stratford, M.4
Loadman, P.5
Waller, S.6
Bellenger, K.7
Gumbrell, L.8
Folkes, L.9
Halbert, G.10
-
26
-
-
4344647867
-
Tumor selective antivascular effects of the novel antimitotic compound ABT-751: An in vivo rat regional hemodynamic study
-
Segreti, J. A.; Polakowski, J. S.; Koch, K. A.; Marsh, K. C.; Bauch, J. L.; Rosenberg, S. H.; Sham, H. L.; Cox, B. F.; Reinhart, G. A. (2004) Tumor selective antivascular effects of the novel antimitotic compound ABT-751: An in vivo rat regional hemodynamic study. Cancer Chemother. Pharmacol., 54 (3), 273-81.
-
(2004)
Cancer Chemother. Pharmacol
, vol.54
, Issue.3
, pp. 273-281
-
-
Segreti, J.A.1
Polakowski, J.S.2
Koch, K.A.3
Marsh, K.C.4
Bauch, J.L.5
Rosenberg, S.H.6
Sham, H.L.7
Cox, B.F.8
Reinhart, G.A.9
-
27
-
-
34147101261
-
Tumor-specific antivascular effect of TZT-1027 (Soblidotin) elucidated by magnetic resonance imaging and confocal laser scanning microscopy
-
Natsume, T.; Watanabe, J.; Ogawa, K.; Yasumura, K.; Kobayashi, M. (2007) Tumor-specific antivascular effect of TZT-1027 (Soblidotin) elucidated by magnetic resonance imaging and confocal laser scanning microscopy. Cancer Sci., 98 (4), 598-604.
-
(2007)
Cancer Sci
, vol.98
, Issue.4
, pp. 598-604
-
-
Natsume, T.1
Watanabe, J.2
Ogawa, K.3
Yasumura, K.4
Kobayashi, M.5
-
28
-
-
34250859583
-
MPC-6827: A small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps
-
Kasibhatla, S.; Baichwal, V.; Cai, S. X.; Roth, B.; Skvortsova, I.; Skvortsov, S.; Lukas, P.; English, N. M.; Sirisoma, N.; Drewe, J.; Pervin, A.; Tseng, B.; Carlson, R. O.; Pleiman, C. M., MPC-6827: A small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res., 67 (12), 5865-71.
-
Cancer Res
, vol.67
, Issue.12
, pp. 5865-5871
-
-
Kasibhatla, S.1
Baichwal, V.2
Cai, S.X.3
Roth, B.4
Skvortsova, I.5
Skvortsov, S.6
Lukas, P.7
English, N.M.8
Sirisoma, N.9
Drewe, J.10
Pervin, A.11
Tseng, B.12
Carlson, R.O.13
Pleiman, C.M.14
-
29
-
-
33646118484
-
NPI-2358 is a tubulin-depolymerizing agent: In-vitro evidence for activity as a tumor vascular-disrupting agent
-
Nicholson, B.; Lloyd, G. K.; Miller, B. R.; Palladino, M. A.; Kiso, Y.; Hayashi, Y.; Neuteboom, S. T. (2006) NPI-2358 is a tubulin-depolymerizing agent: In-vitro evidence for activity as a tumor vascular-disrupting agent. Anticancer Drugs, 17 (1), 25-31.
-
(2006)
Anticancer Drugs
, vol.17
, Issue.1
, pp. 25-31
-
-
Nicholson, B.1
Lloyd, G.K.2
Miller, B.R.3
Palladino, M.A.4
Kiso, Y.5
Hayashi, Y.6
Neuteboom, S.T.7
-
30
-
-
27944450310
-
Preclinical studies of the novel vascular disrupting agent MN-029
-
Shi, W.; Siemann, D. W. (2005) Preclinical studies of the novel vascular disrupting agent MN-029. Anticancer Res., 25(6B), 3899-904.
-
(2005)
Anticancer Res
, vol.25
, Issue.6 B
, pp. 3899-3904
-
-
Shi, W.1
Siemann, D.W.2
-
31
-
-
48949087080
-
ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo
-
Moser, C.; Lang, S. A.; Mori, A.; Hellerbrand, C.; Schlitt, H. J.; Geissler, E. K.; Fogler, W. E.; Stoeltzing, O. (2008) ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo. BMC Cancer, 8, 206.
-
(2008)
BMC Cancer
, vol.8
, pp. 206
-
-
Moser, C.1
Lang, S.A.2
Mori, A.3
Hellerbrand, C.4
Schlitt, H.J.5
Geissler, E.K.6
Fogler, W.E.7
Stoeltzing, O.8
-
32
-
-
33947302866
-
Drug evaluation: ADH-1, an N-cadherin antagonist targeting cancer vascularization
-
Kelland, L. (2007) Drug evaluation: ADH-1, an N-cadherin antagonist targeting cancer vascularization. Curr. Opin. Mol. Ther., 9(1), 86-91.
-
(2007)
Curr. Opin. Mol. Ther
, vol.9
, Issue.1
, pp. 86-91
-
-
Kelland, L.1
-
33
-
-
27744607653
-
Patupilone Induced Vascular Disruption in Orthotopic Rodent Tumor Models Detected by Magnetic Resonance Imaging and Interstitial Fluid Pressure
-
Ferretti, S.; Allegrini, P. R.; O'Reilly, T.; Schnell, C.; Stumm, M.; Wartmann, M.; Wood, J.; McSheehy, P. M. J. (2005) Patupilone Induced Vascular Disruption in Orthotopic Rodent Tumor Models Detected by Magnetic Resonance Imaging and Interstitial Fluid Pressure. Clin. Cancer Res., 11(21), 7773-7784.
-
(2005)
Clin. Cancer Res
, vol.11
, Issue.21
, pp. 7773-7784
-
-
Ferretti, S.1
Allegrini, P.R.2
O'Reilly, T.3
Schnell, C.4
Stumm, M.5
Wartmann, M.6
Wood, J.7
McSheehy, P.M.J.8
-
34
-
-
0030272619
-
Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agents
-
ter Haar, E.; Rosenkranz, H. S.; Hamel, E.; Day, B. W. (1996) Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agents. Bioorg. Med. Chem., 4(10), 1659-1671.
-
(1996)
Bioorg. Med. Chem
, vol.4
, Issue.10
, pp. 1659-1671
-
-
ter Haar, E.1
Rosenkranz, H.S.2
Hamel, E.3
Day, B.W.4
-
35
-
-
10744231706
-
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
-
Mabjeesh, N. J.; Escuin, D.; LaVallee, T. M.; Pribluda, V. S.; Swartz, G. M.; Johnson, M. S.; Willard, M. T.; Zhong, H.; Simons, J. W.; Giannakakou, P. (2003) 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell, 3(4), 363-75.
-
(2003)
Cancer Cell
, vol.3
, Issue.4
, pp. 363-375
-
-
Mabjeesh, N.J.1
Escuin, D.2
LaVallee, T.M.3
Pribluda, V.S.4
Swartz, G.M.5
Johnson, M.S.6
Willard, M.T.7
Zhong, H.8
Simons, J.W.9
Giannakakou, P.10
-
36
-
-
33749578369
-
2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules
-
Kamath, K.; Okouneva, T.; Larson, G.; Panda, D.; Wilson, L.; Jordan, M. A. (2006) 2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules. Mol. Cancer Ther., 5(9), 2225-33.
-
(2006)
Mol. Cancer Ther
, vol.5
, Issue.9
, pp. 2225-2233
-
-
Kamath, K.1
Okouneva, T.2
Larson, G.3
Panda, D.4
Wilson, L.5
Jordan, M.A.6
-
37
-
-
0035133804
-
D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral activity in vivo, shows efficacy toward multidrug-resistant tumor cells, and lacks neurotoxicity
-
Bacher, G.; Nickel, B.; Emig, P.; Vanhoefer, U.; Seeber, S.; Shandra, A.; Klenner, T.; Beckers, T. (2001) D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral activity in vivo, shows efficacy toward multidrug-resistant tumor cells, and lacks neurotoxicity. Cancer Res., 61(1), 392-9.
-
(2001)
Cancer Res
, vol.61
, Issue.1
, pp. 392-399
-
-
Bacher, G.1
Nickel, B.2
Emig, P.3
Vanhoefer, U.4
Seeber, S.5
Shandra, A.6
Klenner, T.7
Beckers, T.8
-
38
-
-
11244283696
-
Phase II trial of dolastatin-10, a novel anti-tubulin agent, in metastatic soft tissue sarcomas
-
von Mehren, M.; Balcerzak, S. P.; Kraft, A. S.; Edmonson, J. H.; Okuno, S. H.; Davey, M.; McLaughlin, S.; Beard, M. T.; Rogatko, A. (2004) Phase II trial of dolastatin-10, a novel anti-tubulin agent, in metastatic soft tissue sarcomas. Sarcoma, 8(4), 107-11.
-
(2004)
Sarcoma
, vol.8
, Issue.4
, pp. 107-111
-
-
von Mehren, M.1
Balcerzak, S.P.2
Kraft, A.S.3
Edmonson, J.H.4
Okuno, S.H.5
Davey, M.6
McLaughlin, S.7
Beard, M.T.8
Rogatko, A.9
-
39
-
-
34248592567
-
Mechanism of action of the microtubule-targeted antimitotic depsipeptide tasidotin (formerly ILX651) and its major metabolite tasidotin C-carboxylate
-
Ray, A.; Okouneva, T.; Manna, T.; Miller, H. P.; Schmid, S.; Arthaud, L.; Luduena, R.; Jordan, M. A.; Wilson, L. (2007) Mechanism of action of the microtubule-targeted antimitotic depsipeptide tasidotin (formerly ILX651) and its major metabolite tasidotin C-carboxylate. Cancer Res., 67(8), 3767-76.
-
(2007)
Cancer Res
, vol.67
, Issue.8
, pp. 3767-3776
-
-
Ray, A.1
Okouneva, T.2
Manna, T.3
Miller, H.P.4
Schmid, S.5
Arthaud, L.6
Luduena, R.7
Jordan, M.A.8
Wilson, L.9
-
40
-
-
0036463981
-
Profiling novel sulfonamide antitumor agents with cell-based phenotypic screens and array-based gene expression analysis
-
Yokoi, A.; Kuromitsu, J.; Kawai, T.; Nagasu, T.; Sugi, N. H.; Yoshimatsu, K.; Yoshino, H.; Owa, T. (2002) Profiling novel sulfonamide antitumor agents with cell-based phenotypic screens and array-based gene expression analysis. Mol. Cancer Ther., 1(4), 275-86.
-
(2002)
Mol. Cancer Ther
, vol.1
, Issue.4
, pp. 275-286
-
-
Yokoi, A.1
Kuromitsu, J.2
Kawai, T.3
Nagasu, T.4
Sugi, N.H.5
Yoshimatsu, K.6
Yoshino, H.7
Owa, T.8
-
41
-
-
3042740981
-
BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo
-
Kuo, C. C.; Hsieh, H. P.; Pan, W. Y.; Chen, C. P.; Liou, J. P.; Lee, S. J.; Chang, Y. L.; Chen, L. T.; Chen, C. T.; Chang, J. Y. (2004) BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo. Cancer Res., 64(13), 4621-8.
-
(2004)
Cancer Res
, vol.64
, Issue.13
, pp. 4621-4628
-
-
Kuo, C.C.1
Hsieh, H.P.2
Pan, W.Y.3
Chen, C.P.4
Liou, J.P.5
Lee, S.J.6
Chang, Y.L.7
Chen, L.T.8
Chen, C.T.9
Chang, J.Y.10
-
42
-
-
33751102419
-
Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin
-
Dabydeen, D. A.; Burnett, J. C.; Bai, R.; Verdier-Pinard, P.; Hickford, S. J.; Pettit, G. R.; Blunt, J. W.; Munro, M. H.; Gussio, R.; Hamel, E. (2006) Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin. Mol. Pharmacol., 70(6), 1866-75.
-
(2006)
Mol. Pharmacol
, vol.70
, Issue.6
, pp. 1866-1875
-
-
Dabydeen, D.A.1
Burnett, J.C.2
Bai, R.3
Verdier-Pinard, P.4
Hickford, S.J.5
Pettit, G.R.6
Blunt, J.W.7
Munro, M.H.8
Gussio, R.9
Hamel, E.10
-
43
-
-
29344454439
-
Hybrids of the hemiasterlin analogue taltobulin and the dolastatins are potent antimicrotubule agents
-
Zask, A.; Kaplan, J.; Musto, S.; Loganzo, F. (2005) Hybrids of the hemiasterlin analogue taltobulin and the dolastatins are potent antimicrotubule agents. J. Am. Chem. Soc., 127(50), 17667-71.
-
(2005)
J. Am. Chem. Soc
, vol.127
, Issue.50
, pp. 17667-17671
-
-
Zask, A.1
Kaplan, J.2
Musto, S.3
Loganzo, F.4
-
44
-
-
18844453704
-
Oncolytic drug, Tubulin polymerization inhibitor, Antimitotic drug
-
Ayral-Kaloustian, S., Zask, A., Taltobulin. Oncolytic drug, Tubulin polymerization inhibitor, Antimitotic drug. Drugs Future 2005, 30 (3), 254-260.
-
(2005)
Drugs Future
, vol.30
, Issue.3
, pp. 254-260
-
-
Kaloustian, A.1
Zask, S.2
Taltobulin, A.3
-
45
-
-
2942616949
-
A new family of quinoline and quinoxaline analogues of combretastatins
-
Perez-Melero, C.; Maya, A. B.; del Rey, B.; Pelaez, R.; Caballero, E.; Medarde, M., A new family of quinoline and quinoxaline analogues of combretastatins. Bioorg. Med. Chem. Lett. 2004, 14 (14), 3771-4.
-
(2004)
Bioorg. Med. Chem. Lett
, vol.14
, Issue.14
, pp. 3771-3774
-
-
Perez-Melero, C.1
Maya, A.B.2
del Rey, B.3
Pelaez, R.4
Caballero, E.5
Medarde, M.6
-
46
-
-
21744462039
-
Synthesis and biological activity of mustard derivatives of combretastatins
-
Coggiola, B.; Pagliai, F.; Allegrone, G.; Genazzani, A. A.; Tron, G. C. (2005) Synthesis and biological activity of mustard derivatives of combretastatins. Bioorg. Med. Chem. Lett., 15 (15), 3551-4.
-
(2005)
Bioorg. Med. Chem. Lett
, vol.15
, Issue.15
, pp. 3551-3554
-
-
Coggiola, B.1
Pagliai, F.2
Allegrone, G.3
Genazzani, A.A.4
Tron, G.C.5
-
47
-
-
34249323026
-
Synthesis and biological activity of naphthalene analogues of phenstatins: Naphthylphenstatins
-
Alvarez, C.; Alvarez, R.; Corchete, P.; Perez-Melero, C.; Pelaez, R.; Medarde, M. (2007) Synthesis and biological activity of naphthalene analogues of phenstatins: Naphthylphenstatins. Bioorg. Med. Chem. Lett., 17(12), 3417-20.
-
(2007)
Bioorg. Med. Chem. Lett
, vol.17
, Issue.12
, pp. 3417-3420
-
-
Alvarez, C.1
Alvarez, R.2
Corchete, P.3
Perez-Melero, C.4
Pelaez, R.5
Medarde, M.6
-
48
-
-
27644449720
-
Synthetic approach to enyne and enediyne analogues of anticancer agents
-
Provot, O.; Giraud, A.; Peyrat, J.-F.; Alami, M.; Brion, J.-D. (2005) Synthetic approach to enyne and enediyne analogues of anticancer agents. Tetrahedron Lett., 46(49), 8547-8550.
-
(2005)
Tetrahedron Lett
, vol.46
, Issue.49
, pp. 8547-8550
-
-
Provot, O.1
Giraud, A.2
Peyrat, J.-F.3
Alami, M.4
Brion, J.-D.5
-
49
-
-
1842741030
-
Examination of the 1,4-disubstituted azetidinone ring system as a template for combretastatin A-4 conformationally restricted analogue design
-
Sun, L.; Vasilevich, N. I.; Fuselier, J. A.; Hocart, S. J.; Coy, D. H. (2004) Examination of the 1,4-disubstituted azetidinone ring system as a template for combretastatin A-4 conformationally restricted analogue design. Bioorg. Med. Chem. Lett., 14(9), 2041-6.
-
(2004)
Bioorg. Med. Chem. Lett
, vol.14
, Issue.9
, pp. 2041-2046
-
-
Sun, L.1
Vasilevich, N.I.2
Fuselier, J.A.3
Hocart, S.J.4
Coy, D.H.5
-
50
-
-
0033575722
-
Synthesis and pharmacological activity of diarylindole derivatives. Cytotoxic agents based on combretastatins
-
Medarde, M.; Ramos, A. C.; Caballero, E.; Pelaez-Lamamie de Clairac, R.; Lopez, J. L.; Gravalos, D. G.; Feliciano, A. S. (1999) Synthesis and pharmacological activity of diarylindole derivatives. Cytotoxic agents based on combretastatins. Bioorg. Med. Chem. Lett., 9(16), 2303-8.
-
(1999)
Bioorg. Med. Chem. Lett
, vol.9
, Issue.16
, pp. 2303-2308
-
-
Medarde, M.1
Ramos, A.C.2
Caballero, E.3
Pelaez-Lamamie de Clairac, R.4
Lopez, J.L.5
Gravalos, D.G.6
Feliciano, A.S.7
-
51
-
-
34247249906
-
Vascular disrupting agents in clinical development
-
Hinnen, P.; Eskens, F. A. (2007) Vascular disrupting agents in clinical development. Br. J. Cancer, 96(8), 1159-65.
-
(2007)
Br. J. Cancer
, vol.96
, Issue.8
, pp. 1159-1165
-
-
Hinnen, P.1
Eskens, F.A.2
-
52
-
-
0036733754
-
Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis
-
Pan, Q.; Kleer, C. G.; van Golen, K. L.; Irani, J.; Bottema, K. M.; Bias, C.; De Carvalho, M.; Mesri, E. A.; Robins, D. M.; Dick, R. D.; Brewer, G. J.; Merajver, S. D. (2002) Copper deficiency induced by tetrathiomolybdate suppresses tumor growth and angiogenesis. Cancer Res., 62(17), 4854-9.
-
(2002)
Cancer Res
, vol.62
, Issue.17
, pp. 4854-4859
-
-
Pan, Q.1
Kleer, C.G.2
van Golen, K.L.3
Irani, J.4
Bottema, K.M.5
Bias, C.6
De Carvalho, M.7
Mesri, E.A.8
Robins, D.M.9
Dick, R.D.10
Brewer, G.J.11
Merajver, S.D.12
-
53
-
-
46249085475
-
Phase II multicenter study of larotaxel (XRP9881), a novel taxoid, in patients with metastatic breast cancer who previously received taxane-based therapy
-
Dieras, V.; Limentani, S.; Romieu, G.; Tubiana-Hulin, M.; Lortholary, A.; Kaufman, P.; Girre, V.; Besenval, M.; Valero, V. (2008) Phase II multicenter study of larotaxel (XRP9881), a novel taxoid, in patients with metastatic breast cancer who previously received taxane-based therapy. Ann. Oncol., 19(7), 1255-60.
-
(2008)
Ann. Oncol
, vol.19
, Issue.7
, pp. 1255-1260
-
-
Dieras, V.1
Limentani, S.2
Romieu, G.3
Tubiana-Hulin, M.4
Lortholary, A.5
Kaufman, P.6
Girre, V.7
Besenval, M.8
Valero, V.9
-
54
-
-
0642349139
-
MAC-321, a novel taxane with greater efficacy than paclitaxel and docetaxel in vitro and in vivo
-
Sampath, D.; Discafani, C. M.; Loganzo, F.; Beyer, C.; Liu, H.; Tan, X.; Musto, S.; Annable, T.; Gallagher, P.; Rios, C.; Greenberger, L. M. (2003) MAC-321, a novel taxane with greater efficacy than paclitaxel and docetaxel in vitro and in vivo. Mol. Cancer Ther., 2(9), 873-84.
-
(2003)
Mol. Cancer Ther
, vol.2
, Issue.9
, pp. 873-884
-
-
Sampath, D.1
Discafani, C.M.2
Loganzo, F.3
Beyer, C.4
Liu, H.5
Tan, X.6
Musto, S.7
Annable, T.8
Gallagher, P.9
Rios, C.10
Greenberger, L.M.11
-
55
-
-
16844381714
-
Antiangiogenic concentrations of paclitaxel induce an increase in microtubule dynamics in endothelial cells but not in cancer cells
-
Pasquier, E.; Honore, S.; Pourroy, B.; Jordan, M. A.; Lehmann, M.; Briand, C.; Braguer, D. (2005) Antiangiogenic concentrations of paclitaxel induce an increase in microtubule dynamics in endothelial cells but not in cancer cells. Cancer Res., 65(6), 2433-40.
-
(2005)
Cancer Res
, vol.65
, Issue.6
, pp. 2433-2440
-
-
Pasquier, E.1
Honore, S.2
Pourroy, B.3
Jordan, M.A.4
Lehmann, M.5
Briand, C.6
Braguer, D.7
-
56
-
-
0036167860
-
Docetaxel versus paclitaxel for antiangiogenesis
-
Vacca, A.; Ribatti, D.; Iurlaro, M.; Merchionne, F.; Nico, B.; Ria, R.; Dammacco, F., Docetaxel versus paclitaxel for antiangiogenesis. J. Hematother. Stem Cell Res., 11(1), 103-18.
-
J. Hematother. Stem Cell Res
, vol.11
, Issue.1
, pp. 103-118
-
-
Vacca, A.1
Ribatti, D.2
Iurlaro, M.3
Merchionne, F.4
Nico, B.5
Ria, R.6
Dammacco, F.7
-
57
-
-
18844462763
-
Oral efficacy and bioavailability of a novel taxane
-
Polizzi, D.; Pratesi, G.; Monestiroli, S.; Tortoreto, M.; Zunino, F.; Bombardelli, E.; Riva, A.; Morazzoni, P.; Colombo, T.; D'Incalci, M.; Zucchetti, M. (2000) Oral efficacy and bioavailability of a novel taxane. Clin. Cancer Res., 6(5), 2070-4.
-
(2000)
Clin. Cancer Res
, vol.6
, Issue.5
, pp. 2070-2074
-
-
Polizzi, D.1
Pratesi, G.2
Monestiroli, S.3
Tortoreto, M.4
Zunino, F.5
Bombardelli, E.6
Riva, A.7
Morazzoni, P.8
Colombo, T.9
D'Incalci, M.10
Zucchetti, M.11
-
58
-
-
2342455797
-
Antitumour and antiangiogenic effects of IDN 5390, a novel C-seco taxane, in a paclitaxel-resistant human ovarian tumour xenograft
-
Petrangolini, G.; Cassinelli, G.; Pratesi, G.; Tortoreto, M.; Favini, E.; Supino, R.; Lanzi, C.; Belluco, S.; Zunino, F. (2004) Antitumour and antiangiogenic effects of IDN 5390, a novel C-seco taxane, in a paclitaxel-resistant human ovarian tumour xenograft. Br. J. Cancer, 90(7), 1464-8.
-
(2004)
Br. J. Cancer
, vol.90
, Issue.7
, pp. 1464-1468
-
-
Petrangolini, G.1
Cassinelli, G.2
Pratesi, G.3
Tortoreto, M.4
Favini, E.5
Supino, R.6
Lanzi, C.7
Belluco, S.8
Zunino, F.9
-
59
-
-
33845617558
-
Drug evaluation: Tesetaxel - an oral semisynthetic taxane derivative
-
Roche, M.; Kyriakou, H.; Seiden, M. (2006) Drug evaluation: Tesetaxel - an oral semisynthetic taxane derivative. Curr. Opin. Investig. Drugs, 7(12), 1092-9.
-
(2006)
Curr. Opin. Investig. Drugs
, vol.7
, Issue.12
, pp. 1092-1099
-
-
Roche, M.1
Kyriakou, H.2
Seiden, M.3
-
60
-
-
33646172454
-
Novel formulations of taxanes: A review. Old wine in a new bottle?
-
Hennenfent, K. L.; Govindan, R. (2006) Novel formulations of taxanes: A review. Old wine in a new bottle? Ann. Oncol. 17(5), 735-49.
-
(2006)
Ann. Oncol
, vol.17
, Issue.5
, pp. 735-749
-
-
Hennenfent, K.L.1
Govindan, R.2
-
61
-
-
38449120471
-
Novel tubulin-targeting agents: Anticancer activity and pharmacologic profile of epothilones and related analogues
-
x] Suppl 5, v9-15
-
Fumoleau, P.; Coudert, B.; Isambert, N.; Ferrant, E. (2007) Novel tubulin-targeting agents: Anticancer activity and pharmacologic profile of epothilones and related analogues. Ann. Oncol., [x 18 x] Suppl 5, v9-15.
-
(2007)
Ann. Oncol
, vol.10
, pp. 18
-
-
Fumoleau, P.1
Coudert, B.2
Isambert, N.3
Ferrant, E.4
-
62
-
-
48549095021
-
Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopilone
-
Hoffmann, J.; Vitale, I.; Buchmann, B.; Galluzzi, L.; Schwede, W.; Senovilla, L.; Skuballa, W.; Vivet, S.; Lichtner, R. B.; Vicencio, J. M.; Panaretakis, T.; Siemeister, G.; Lage, H.; Nanty, L.; Hammer, S.; Mittelstaedt, K.; Winsel, S.; Eschenbrenner, J.; Castedo, M.; Demarche, C.; Klar, U.; Kroemer, G. (2008) Improved cellular pharmacokinetics and pharmacodynamics underlie the wide anticancer activity of sagopilone. Cancer Res., 68(13), 5301-8.
-
(2008)
Cancer Res
, vol.68
, Issue.13
, pp. 5301-5308
-
-
Hoffmann, J.1
Vitale, I.2
Buchmann, B.3
Galluzzi, L.4
Schwede, W.5
Senovilla, L.6
Skuballa, W.7
Vivet, S.8
Lichtner, R.B.9
Vicencio, J.M.10
Panaretakis, T.11
Siemeister, G.12
Lage, H.13
Nanty, L.14
Hammer, S.15
Mittelstaedt, K.16
Winsel, S.17
Eschenbrenner, J.18
Castedo, M.19
Demarche, C.20
Klar, U.21
Kroemer, G.22
more..
-
63
-
-
65649123265
-
Epothilone B is a more potent antiangiogenic than paclitaxel in a human tumor-based angiogenesis model
-
James, M. L.; Maxwell, P. J.; Catherine, T. A.; Brian, M. G.; Jessica, L. T.; John, R.; Paul, M.; Yi-Zarn, W.; Eugene, A. W. (2004) Epothilone B is a more potent antiangiogenic than paclitaxel in a human tumor-based angiogenesis model. J. Am. College Surg., 199(3), 90.
-
(2004)
J. Am. College Surg
, vol.199
, Issue.3
, pp. 90
-
-
James, M.L.1
Maxwell, P.J.2
Catherine, T.A.3
Brian, M.G.4
Jessica, L.T.5
John, R.6
Paul, M.7
Yi-Zarn, W.8
Eugene, A.W.9
-
64
-
-
33947717002
-
Anticancer drugs from nature - natural products as a unique source of new microtubule-stabilizing agents
-
Altmann, K. H.; Gertsch, J. (2007) Anticancer drugs from nature - natural products as a unique source of new microtubule-stabilizing agents. Nat. Prod. Rep., 24(2), 327-57.
-
(2007)
Nat. Prod. Rep
, vol.24
, Issue.2
, pp. 327-357
-
-
Altmann, K.H.1
Gertsch, J.2
-
65
-
-
33646024540
-
P-565 A Phase II study of KOS-862 (Epothilone D) as second-linetherapy in non-small cell lung cancer
-
Rizvi, N.; Villalona-Calero, M.; Lynch, T.; Yee, L.; Gabrail, N.; Sandler, A.; Cropp, G.; Graham, M.; Palmer, G. (2005) P-565 A Phase II study of KOS-862 (Epothilone D) as second-linetherapy in non-small cell lung cancer. Lung Cancer, 49(Supplement 2), S266-S267.
-
(2005)
Lung Cancer
, vol.49
, Issue.SUPPL.EMENT 2
-
-
Rizvi, N.1
Villalona-Calero, M.2
Lynch, T.3
Yee, L.4
Gabrail, N.5
Sandler, A.6
Cropp, G.7
Graham, M.8
Palmer, G.9
-
66
-
-
27644559079
-
-
Cho, Y. S.; Wu, K.-D.; Moore, M. A. S.; Chou, T.-C.; Danishefsky, S. J., Second generation epothilones: Discovery of fludelone and its extraordinary antitumor properties. 2005, 30 (7), 737.
-
Cho, Y. S.; Wu, K.-D.; Moore, M. A. S.; Chou, T.-C.; Danishefsky, S. J., Second generation epothilones: Discovery of fludelone and its extraordinary antitumor properties. 2005, 30 (7), 737.
-
-
-
-
67
-
-
0034895987
-
BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy
-
Lee, F. Y.; Borzilleri, R.; Fairchild, C. R.; Kim, S. H.; Long, B. H.; Reventos-Suarez, C.; Vite, G. D.; Rose, W. C.; Kramer, R. A. (2001) BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clin. Cancer Res., 7(5), 1429-37.
-
(2001)
Clin. Cancer Res
, vol.7
, Issue.5
, pp. 1429-1437
-
-
Lee, F.Y.1
Borzilleri, R.2
Fairchild, C.R.3
Kim, S.H.4
Long, B.H.5
Reventos-Suarez, C.6
Vite, G.D.7
Rose, W.C.8
Kramer, R.A.9
-
68
-
-
7444239715
-
Targeting ErbB receptor signaling: A pan-ErbB approach to cancer
-
Britten, C. D. (2004) Targeting ErbB receptor signaling: A pan-ErbB approach to cancer. Mol. Cancer Ther., 3(10), 1335-42.
-
(2004)
Mol. Cancer Ther
, vol.3
, Issue.10
, pp. 1335-1342
-
-
Britten, C.D.1
-
69
-
-
35448955219
-
Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor
-
Jani, J. P.; Finn, R. S.; Campbell, M.; Coleman, K. G.; Connell, R. D.; Currier, N.; Emerson, E. O.; Floyd, E.; Harriman, S.; Kath, J. C.; Morris, J.; Moyer, J. D.; Pustilnik, L. R.; Rafidi, K.; Ralston, S.; Rossi, A. M.; Steyn, S. J.; Wagner, L.; Winter, S. M.; Bhattacharya, S. K. (2007) Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor. Cancer Res., 67(20), 9887-93.
-
(2007)
Cancer Res
, vol.67
, Issue.20
, pp. 9887-9893
-
-
Jani, J.P.1
Finn, R.S.2
Campbell, M.3
Coleman, K.G.4
Connell, R.D.5
Currier, N.6
Emerson, E.O.7
Floyd, E.8
Harriman, S.9
Kath, J.C.10
Morris, J.11
Moyer, J.D.12
Pustilnik, L.R.13
Rafidi, K.14
Ralston, S.15
Rossi, A.M.16
Steyn, S.J.17
Wagner, L.18
Winter, S.M.19
Bhattacharya, S.K.20
more..
-
70
-
-
38949156179
-
Effects of AZD2171 and vandetanib (ZD6474, Zactima) on haemodynamic variables in an SW620 human colon tumour model: An investigation using dynamic contrast-enhanced MRI and the rapid clearance blood pool contrast agent, P792 (gadomelitol)
-
Bradley, D. P.; Tessier, J. L.; Checkley, D.; Kuribayashi, H.; Waterton, J. C.; Kendrew, J.; Wedge, S. R. (2008) Effects of AZD2171 and vandetanib (ZD6474, Zactima) on haemodynamic variables in an SW620 human colon tumour model: An investigation using dynamic contrast-enhanced MRI and the rapid clearance blood pool contrast agent, P792 (gadomelitol). NMR Biomed., 21(1), 42-52.
-
(2008)
NMR Biomed
, vol.21
, Issue.1
, pp. 42-52
-
-
Bradley, D.P.1
Tessier, J.L.2
Checkley, D.3
Kuribayashi, H.4
Waterton, J.C.5
Kendrew, J.6
Wedge, S.R.7
-
71
-
-
34447299692
-
EGFR targeting of solid tumors
-
Rocha-Lima, C. M.; Soares, H. P.; Raez, L. E.; Singal, R. (2007) EGFR targeting of solid tumors. Cancer Control, 14(3), 295-304.
-
(2007)
Cancer Control
, vol.14
, Issue.3
, pp. 295-304
-
-
Rocha-Lima, C.M.1
Soares, H.P.2
Raez, L.E.3
Singal, R.4
-
72
-
-
34547100778
-
Discovery and validation of biomarkers that respond to treatment with brivanib alaninate, a small-molecule VEGFR-2/FGFR-1 antagonist
-
Ayers, M.; Fargnoli, J.; Lewin, A.; Wu, Q.; Platero, J. S. (2007) Discovery and validation of biomarkers that respond to treatment with brivanib alaninate, a small-molecule VEGFR-2/FGFR-1 antagonist. Cancer Res., 67 (14), 6899-906.
-
(2007)
Cancer Res
, vol.67
, Issue.14
, pp. 6899-6906
-
-
Ayers, M.1
Fargnoli, J.2
Lewin, A.3
Wu, Q.4
Platero, J.S.5
-
73
-
-
49849096075
-
SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells
-
Vultur, A.; Buettner, R.; Kowolik, C.; Liang, W.; Smith, D.; Boschelli, F.; Jove, R. (2008) SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells. Mol. Cancer Ther., 7(5), 1185-94.
-
(2008)
Mol. Cancer Ther
, vol.7
, Issue.5
, pp. 1185-1194
-
-
Vultur, A.1
Buettner, R.2
Kowolik, C.3
Liang, W.4
Smith, D.5
Boschelli, F.6
Jove, R.7
-
74
-
-
17144430520
-
Recent Advances in the Systemic Therapy of Metastatic Colorectal Cancer
-
Jefford, M.; Zalcberg, J. (2005) Recent Advances in the Systemic Therapy of Metastatic Colorectal Cancer. Am. J. Cancer, 4(1), 14-34.
-
(2005)
Am. J. Cancer
, vol.4
, Issue.1
, pp. 14-34
-
-
Jefford, M.1
Zalcberg, J.2
-
75
-
-
2542582261
-
Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase
-
Rabindran, S. K.; Discafani, C. M.; Rosfjord, E. C.; Baxter, M.; Floyd, M. B.; Golas, J.; Hallett, W. A.; Johnson, B. D.; Nilakantan, R.; Overbeek, E.; Reich, M. F.; Shen, R.; Shi, X.; Tsou, H. R.; Wang, Y. F.; Wissner, A. (2004) Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res., 64(11), 3958-65.
-
(2004)
Cancer Res
, vol.64
, Issue.11
, pp. 3958-3965
-
-
Rabindran, S.K.1
Discafani, C.M.2
Rosfjord, E.C.3
Baxter, M.4
Floyd, M.B.5
Golas, J.6
Hallett, W.A.7
Johnson, B.D.8
Nilakantan, R.9
Overbeek, E.10
Reich, M.F.11
Shen, R.12
Shi, X.13
Tsou, H.R.14
Wang, Y.F.15
Wissner, A.16
-
76
-
-
49449089326
-
Anti-tumor effect of E7080, a novel angiogenesis inhibitor]
-
Koyama, N.; Magario, N.; Yamamoto, Y.; Matsui, J.; Tsuruoka, A. (2008) [Anti-tumor effect of E7080, a novel angiogenesis inhibitor]. Nippon Yakurigaku Zasshi, 132(2), 100-4.
-
(2008)
Nippon Yakurigaku Zasshi
, vol.132
, Issue.2
, pp. 100-104
-
-
Koyama, N.1
Magario, N.2
Yamamoto, Y.3
Matsui, J.4
Tsuruoka, A.5
-
77
-
-
34548814434
-
Mitotic drug targets and the development of novel anti-mitotic anticancer drugs
-
Schmidt, M.; Bastians, H. (2007) Mitotic drug targets and the development of novel anti-mitotic anticancer drugs. Drug Resist. Updat, 10(4-5), 162-81.
-
(2007)
Drug Resist. Updat
, vol.10
, Issue.4-5
, pp. 162-181
-
-
Schmidt, M.1
Bastians, H.2
-
78
-
-
42049123226
-
TTI-237: A novel microtubule-active compound with in vivo antitumor activity
-
Beyer, C. F.; Zhang, N.; Hernandez, R.; Vitale, D.; Lucas, J.; Nguyen, T.; Discafani, C.; Ayral-Kaloustian, S.; Gibbons, J. J. (2008) TTI-237: a novel microtubule-active compound with in vivo antitumor activity. Cancer Res., 68(7), 2292-300.
-
(2008)
Cancer Res
, vol.68
, Issue.7
, pp. 2292-2300
-
-
Beyer, C.F.1
Zhang, N.2
Hernandez, R.3
Vitale, D.4
Lucas, J.5
Nguyen, T.6
Discafani, C.7
Ayral-Kaloustian, S.8
Gibbons, J.J.9
-
79
-
-
33747081035
-
Bundling next-generation cancer therapies for synergy
-
Kling, J. (2006) Bundling next-generation cancer therapies for synergy. Nat. Biotechnol., 24(8), 871-2.
-
(2006)
Nat. Biotechnol
, vol.24
, Issue.8
, pp. 871-872
-
-
Kling, J.1
-
80
-
-
36049026182
-
Role of anti-angiogenesis agents in treating NSCLC: Focus on bevacizumab and VEGFR tyrosine kinase inhibitors
-
Cabebe, E.; Wakelee, H. (2007) Role of anti-angiogenesis agents in treating NSCLC: Focus on bevacizumab and VEGFR tyrosine kinase inhibitors. Curr. Treat Options Oncol., 8(1), 15-27.
-
(2007)
Curr. Treat Options Oncol
, vol.8
, Issue.1
, pp. 15-27
-
-
Cabebe, E.1
Wakelee, H.2
-
81
-
-
0027438574
-
Antitumor effects of angiogenesis inhibitor TNP-470 in rabbits bearing VX-2 carcinoma by arterial administration of microspheres and oil solution
-
Kamei, S.; Okada, H.; Inoue, Y.; Yoshioka, T.; Ogawa, Y.; Toguchi, H. (1993) Antitumor effects of angiogenesis inhibitor TNP-470 in rabbits bearing VX-2 carcinoma by arterial administration of microspheres and oil solution. J. Pharmacol. Exp. Ther., 264(1), 469-74.
-
(1993)
J. Pharmacol. Exp. Ther
, vol.264
, Issue.1
, pp. 469-474
-
-
Kamei, S.1
Okada, H.2
Inoue, Y.3
Yoshioka, T.4
Ogawa, Y.5
Toguchi, H.6
-
82
-
-
33947732977
-
Angiogenesis: An organizing principle for drug discovery?
-
Folkman, J. (2007) Angiogenesis: An organizing principle for drug discovery? Nat. Rev. Drug Discov., 6(4), 273-86.
-
(2007)
Nat. Rev. Drug Discov
, vol.6
, Issue.4
, pp. 273-286
-
-
Folkman, J.1
-
83
-
-
0036145292
-
The antiangiogenic agents SU5416 and SU6668 increase the antitumor effects of fractionated irradiation
-
Ning, S.; Laird, D.; Cherrington, J. M.; Knox, S. J. (2002) The antiangiogenic agents SU5416 and SU6668 increase the antitumor effects of fractionated irradiation. Radiat. Res., 157 (1), 45-51.
-
(2002)
Radiat. Res
, vol.157
, Issue.1
, pp. 45-51
-
-
Ning, S.1
Laird, D.2
Cherrington, J.M.3
Knox, S.J.4
-
84
-
-
34250704834
-
Sorafenib inhibits the angiogenesis and growth of orthotopic anaplastic thyroid carcinoma xenografts in nude mice
-
Kim, S.; Yazici, Y. D.; Calzada, G.; Wang, Z. Y.; Younes, M. N.; Jasser, S. A.; El-Naggar, A. K.; Myers, J. N. (2007) Sorafenib inhibits the angiogenesis and growth of orthotopic anaplastic thyroid carcinoma xenografts in nude mice. Mol. Cancer Ther., 6(6), 1785-92.
-
(2007)
Mol. Cancer Ther
, vol.6
, Issue.6
, pp. 1785-1792
-
-
Kim, S.1
Yazici, Y.D.2
Calzada, G.3
Wang, Z.Y.4
Younes, M.N.5
Jasser, S.A.6
El-Naggar, A.K.7
Myers, J.N.8
-
85
-
-
48249133585
-
Targeting the c-MET signaling pathway for cancer therapy
-
Liu, X.; Yao, W.; Newton, R. C.; Scherle, P. A. (2008) Targeting the c-MET signaling pathway for cancer therapy. Exp. Opin. Investig. Drugs, 17(7), 997-1011.
-
(2008)
Exp. Opin. Investig. Drugs
, vol.17
, Issue.7
, pp. 997-1011
-
-
Liu, X.1
Yao, W.2
Newton, R.C.3
Scherle, P.A.4
-
86
-
-
33646586669
-
-
Albert, D. H.; Tapang, P.; Magoc, T. J.; Pease, L. J.; Reuter, D. R.; Wei, R. Q.; Li, J.; Guo, J.; Bousquet, P. F.; Ghoreishi-Haack, N. S.; Wang, B.; Bukofzer, G. T.; Wang, Y. C.; Stavropoulos, J. A.; Hartandi, K.; Niquette, A. L.; Soni, N.; Johnson, E. F.; McCall, J. O.; Bouska, J. J.; Luo, Y.; Donawho, C. K.; Dai, Y.; Marcotte, P. A.; Glaser, K. B.; Michaelides, M. R.; Davidsen, S. K. (2006) Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Mol. Cancer Ther., 5(4), 995-1006.
-
Albert, D. H.; Tapang, P.; Magoc, T. J.; Pease, L. J.; Reuter, D. R.; Wei, R. Q.; Li, J.; Guo, J.; Bousquet, P. F.; Ghoreishi-Haack, N. S.; Wang, B.; Bukofzer, G. T.; Wang, Y. C.; Stavropoulos, J. A.; Hartandi, K.; Niquette, A. L.; Soni, N.; Johnson, E. F.; McCall, J. O.; Bouska, J. J.; Luo, Y.; Donawho, C. K.; Dai, Y.; Marcotte, P. A.; Glaser, K. B.; Michaelides, M. R.; Davidsen, S. K. (2006) Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Mol. Cancer Ther., 5(4), 995-1006.
-
-
-
-
87
-
-
0035293380
-
Angiogenesis inhibitor TNP-470 reduces human pancreatic cancer growth
-
Hotz, H. G.; Reber, H. A.; Hotz, B.; Sanghavi, P. C.; Yu, T.; Foitzik, T.; Buhr, H. J.; Hines, O. J. (2001) Angiogenesis inhibitor TNP-470 reduces human pancreatic cancer growth. J. Gastrointest. Surg. 5(2), 131-8.
-
(2001)
J. Gastrointest. Surg
, vol.5
, Issue.2
, pp. 131-138
-
-
Hotz, H.G.1
Reber, H.A.2
Hotz, B.3
Sanghavi, P.C.4
Yu, T.5
Foitzik, T.6
Buhr, H.J.7
Hines, O.J.8
-
88
-
-
1442299844
-
Development of parenteral formulation for a novel angiogenesis inhibitor, CKD-732 through complexation with hydroxypropyl-beta-cyclodextrin
-
Kim, J. H.; Lee, S. K.; Ki, M. H.; Choi, W. K.; Ahn, S. K.; Shin, H. J.; Hong, C. I. (2004) Development of parenteral formulation for a novel angiogenesis inhibitor, CKD-732 through complexation with hydroxypropyl-beta-cyclodextrin. Int. J. Pharm., 272(1-2), 79-89.
-
(2004)
Int. J. Pharm
, vol.272
, Issue.1-2
, pp. 79-89
-
-
Kim, J.H.1
Lee, S.K.2
Ki, M.H.3
Choi, W.K.4
Ahn, S.K.5
Shin, H.J.6
Hong, C.I.7
-
89
-
-
38149059827
-
Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34+ cells
-
Moutouh-de Parseval, L. A.; Verhelle, D.; Glezer, E.; Jensen-Pergakes, K.; Ferguson, G. D.; Corral, L. G.; Morris, C. L.; Muller, G.; Brady, H.; Chan, K. (2008) Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34+ cells. J. Clin. Invest., 118(1), 248-58.
-
(2008)
J. Clin. Invest
, vol.118
, Issue.1
, pp. 248-258
-
-
Moutouh-de Parseval, L.A.1
Verhelle, D.2
Glezer, E.3
Jensen-Pergakes, K.4
Ferguson, G.D.5
Corral, L.G.6
Morris, C.L.7
Muller, G.8
Brady, H.9
Chan, K.10
-
90
-
-
33746336252
-
Thalidomide and lenalidomide in the treatment of multiple myeloma
-
Kumar, S.; Rajkumar, S. V. (2006) Thalidomide and lenalidomide in the treatment of multiple myeloma. Eur. J. Cancer, 42(11), 1612-22.
-
(2006)
Eur. J. Cancer
, vol.42
, Issue.11
, pp. 1612-1622
-
-
Kumar, S.1
Rajkumar, S.V.2
-
91
-
-
0036682030
-
Cilengitide targeting of alpha (v)beta(3) integrin receptor synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenografts
-
Burke, P. A.; DeNardo, S. J.; Miers, L. A.; Lamborn, K. R.; Matzku, S.; DeNardo, G. L. (2002) Cilengitide targeting of alpha (v)beta(3) integrin receptor synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenografts. Cancer Res., 62(15), 4263-72.
-
(2002)
Cancer Res
, vol.62
, Issue.15
, pp. 4263-4272
-
-
Burke, P.A.1
DeNardo, S.J.2
Miers, L.A.3
Lamborn, K.R.4
Matzku, S.5
DeNardo, G.L.6
-
92
-
-
0032143275
-
Tryprostatin A, a specific and novel inhibitor of microtubule assembly
-
Usui, T.; Kondoh, M.; Cui, C. B.; Mayumi, T.; Osada, H. (1998) Tryprostatin A, a specific and novel inhibitor of microtubule assembly. Biochem. J., 333(Pt 3), 543-8.
-
(1998)
Biochem. J
, vol.333
, Issue.PART 3
, pp. 543-548
-
-
Usui, T.1
Kondoh, M.2
Cui, C.B.3
Mayumi, T.4
Osada, H.5
-
93
-
-
23844521568
-
-
Graff, J. R.; McNulty, A. M.; Hanna, K. R.; Konicek, B. W.; Lynch, R. L.; Bailey, S. N.; Banks, C.; Capen, A.; Goode, R.; Lewis, J. E.; Sams, L.; Huss, K. L.; Campbell, R. M.; Iversen, P. W.; Neubauer, B. L.; Brown, T. J.; Musib, L.; Geeganage, S.; Thornton, D. (2005) The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res., 65(16), 7462-9.
-
Graff, J. R.; McNulty, A. M.; Hanna, K. R.; Konicek, B. W.; Lynch, R. L.; Bailey, S. N.; Banks, C.; Capen, A.; Goode, R.; Lewis, J. E.; Sams, L.; Huss, K. L.; Campbell, R. M.; Iversen, P. W.; Neubauer, B. L.; Brown, T. J.; Musib, L.; Geeganage, S.; Thornton, D. (2005) The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res., 65(16), 7462-9.
-
-
-
-
94
-
-
34250703569
-
Classical PKC isoforms in cancer
-
Martiny-Baron, G.; Fabbro, D. (2007) Classical PKC isoforms in cancer. Pharmacol. Res., 55(6), 477-86.
-
(2007)
Pharmacol. Res
, vol.55
, Issue.6
, pp. 477-486
-
-
Martiny-Baron, G.1
Fabbro, D.2
-
95
-
-
0029871879
-
Protein kinase C isoenzymes, p53, accumulation of rhodamine 123, glutathione-S-transferase, topoisomerase II and MRP in multidrug resistant cell lines
-
Utz, I.; Gekeler, V.; Ise, W.; Beck, J.; Spitaler, M.; Grunicke, H.; Hofmann, J. (1996) Protein kinase C isoenzymes, p53, accumulation of rhodamine 123, glutathione-S-transferase, topoisomerase II and MRP in multidrug resistant cell lines. Anticancer Res., 16(1), 289-96.
-
(1996)
Anticancer Res
, vol.16
, Issue.1
, pp. 289-296
-
-
Utz, I.1
Gekeler, V.2
Ise, W.3
Beck, J.4
Spitaler, M.5
Grunicke, H.6
Hofmann, J.7
-
96
-
-
67649135833
-
A phase I trial of PTK787/ZK222584 in combination with pemetrexed and cisplatin in patients with advanced solid tumors
-
Sharma, S.; Freeman, B.; Turner, J.; Symanowski, J.; Manno, P.; Berg, W.; Vogelzang, N. (2008) A phase I trial of PTK787/ZK222584 in combination with pemetrexed and cisplatin in patients with advanced solid tumors. Invest. New Drugs.
-
(2008)
Invest. New Drugs
-
-
Sharma, S.1
Freeman, B.2
Turner, J.3
Symanowski, J.4
Manno, P.5
Berg, W.6
Vogelzang, N.7
-
97
-
-
46449117698
-
Motesanib diphosphate in progressive differentiated thyroid cancer
-
Sherman, S. I.; Wirth, L. J.; Droz, J. P.; Hofmann, M.; Bastholt, L.; Martins, R. G.; Licitra, L.; Eschenberg, M. J.; Sun, Y. N.; Juan, T.; Stepan, D. E.; Schlumberger, M. J. (2008) Motesanib diphosphate in progressive differentiated thyroid cancer. N Engl. J. Med., 359(1), 31-42.
-
(2008)
N Engl. J. Med
, vol.359
, Issue.1
, pp. 31-42
-
-
Sherman, S.I.1
Wirth, L.J.2
Droz, J.P.3
Hofmann, M.4
Bastholt, L.5
Martins, R.G.6
Licitra, L.7
Eschenberg, M.J.8
Sun, Y.N.9
Juan, T.10
Stepan, D.E.11
Schlumberger, M.J.12
-
98
-
-
44649151405
-
Axitinib, a novel anti-angiogenic drug with promising activity in various solid tumors
-
Choueiri, T. K. (2008) Axitinib, a novel anti-angiogenic drug with promising activity in various solid tumors. Curr. Opin. Investig. Drugs, 9(6), 658-71.
-
(2008)
Curr. Opin. Investig. Drugs
, vol.9
, Issue.6
, pp. 658-671
-
-
Choueiri, T.K.1
-
99
-
-
0038782392
-
Fenretinide as an anti-angiogenic agent in neuroblastoma
-
Ribatti, D.; Raffaghello, L.; Marimpietri, D.; Cosimo, E.; Montaldo, P. G.; Nico, B.; Vacca, A.; Ponzoni, M. (2003) Fenretinide as an anti-angiogenic agent in neuroblastoma. Cancer Lett., 197(1-2), 181-4.
-
(2003)
Cancer Lett
, vol.197
, Issue.1-2
, pp. 181-184
-
-
Ribatti, D.1
Raffaghello, L.2
Marimpietri, D.3
Cosimo, E.4
Montaldo, P.G.5
Nico, B.6
Vacca, A.7
Ponzoni, M.8
-
100
-
-
34547922452
-
Targeting the function of the HER2 oncogene in human cancer therapeutics
-
Moasser, M. M. (2007) Targeting the function of the HER2 oncogene in human cancer therapeutics. Oncogene, 26(46), 6577-92.
-
(2007)
Oncogene
, vol.26
, Issue.46
, pp. 6577-6592
-
-
Moasser, M.M.1
-
101
-
-
0036828258
-
Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium
-
Funahashi, Y.; Sugi, N. H.; Semba, T.; Yamamoto, Y.; Hamaoka, S.; Tsukahara-Tamai, N.; Ozawa, Y.; Tsuruoka, A.; Nara, K.; Takahashi, K.; Okabe, T.; Kamata, J.; Owa, T.; Ueda, N.; Haneda, T.; Yonaga, M.; Yoshimatsu, K.; Wakabayashi, T. (2002) Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. Cancer Res., 62(21), 6116-23.
-
(2002)
Cancer Res
, vol.62
, Issue.21
, pp. 6116-6123
-
-
Funahashi, Y.1
Sugi, N.H.2
Semba, T.3
Yamamoto, Y.4
Hamaoka, S.5
Tsukahara-Tamai, N.6
Ozawa, Y.7
Tsuruoka, A.8
Nara, K.9
Takahashi, K.10
Okabe, T.11
Kamata, J.12
Owa, T.13
Ueda, N.14
Haneda, T.15
Yonaga, M.16
Yoshimatsu, K.17
Wakabayashi, T.18
-
102
-
-
34249324494
-
An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms
-
Zou, H. Y.; Li, Q.; Lee, J. H.; Arango, M. E.; McDonnell, S. R.; Yamazaki, S.; Koudriakova, T. B.; Alton, G.; Cui, J. J.; Kung, P. P.; Nambu, M. D.; Los, G.; Bender, S. L.; Mroczkowski, B.; Christensen, J. G. (2007) An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res., 67(9), 4408-17.
-
(2007)
Cancer Res
, vol.67
, Issue.9
, pp. 4408-4417
-
-
Zou, H.Y.1
Li, Q.2
Lee, J.H.3
Arango, M.E.4
McDonnell, S.R.5
Yamazaki, S.6
Koudriakova, T.B.7
Alton, G.8
Cui, J.J.9
Kung, P.P.10
Nambu, M.D.11
Los, G.12
Bender, S.L.13
Mroczkowski, B.14
Christensen, J.G.15
-
103
-
-
34248192988
-
The quinoline-3-carboxamide anti-angiogenic agent, tasquinimod, enhances the anti-prostate cancer efficacy of androgen ablation and taxotere without effecting serum PSA directly in human xenografts
-
Dalrymple, S. L.; Becker, R. E.; Isaacs, J. T. (2007) The quinoline-3-carboxamide anti-angiogenic agent, tasquinimod, enhances the anti-prostate cancer efficacy of androgen ablation and taxotere without effecting serum PSA directly in human xenografts. Prostate, 67(7), 790-7.
-
(2007)
Prostate
, vol.67
, Issue.7
, pp. 790-797
-
-
Dalrymple, S.L.1
Becker, R.E.2
Isaacs, J.T.3
-
104
-
-
38849209802
-
Therapeutic area crossroads: Anti-angiogenesis
-
Million, R. P. (2008) Therapeutic area crossroads: Anti-angiogenesis. Nat. Rev. Drug Discov., 7(2), 115-116.
-
(2008)
Nat. Rev. Drug Discov
, vol.7
, Issue.2
, pp. 115-116
-
-
Million, R.P.1
-
105
-
-
0037149539
-
Tumour biology: Herceptin acts as an anti-angiogenic cocktail
-
Izumi, Y.; Xu, L.; di Tomaso, E.; Fukumura, D.; Jain, R. K. (2002) Tumour biology: Herceptin acts as an anti-angiogenic cocktail. Nature, 416(6878), 279-80.
-
(2002)
Nature
, vol.416
, Issue.6878
, pp. 279-280
-
-
Izumi, Y.1
Xu, L.2
di Tomaso, E.3
Fukumura, D.4
Jain, R.K.5
-
106
-
-
34247494559
-
Bevacizumab as a potent inhibitor of inflammatory corneal angiogenesis and lymphangiogenesis
-
Bock, F.; Onderka, J.; Dietrich, T.; Bachmann, B.; Kruse, F. E.; Paschke, M.; Zahn, G.; Cursiefen, C. (2007) Bevacizumab as a potent inhibitor of inflammatory corneal angiogenesis and lymphangiogenesis. Invest. Ophthalmol. Vis. Sci., 48(6), 2545-52.
-
(2007)
Invest. Ophthalmol. Vis. Sci
, vol.48
, Issue.6
, pp. 2545-2552
-
-
Bock, F.1
Onderka, J.2
Dietrich, T.3
Bachmann, B.4
Kruse, F.E.5
Paschke, M.6
Zahn, G.7
Cursiefen, C.8
-
107
-
-
22344455695
-
-
Pegaptanib sodium (Macugen) for macular degeneration. Med. Lett., Drugs Ther., 47 (1212), 55-6.
-
Pegaptanib sodium (Macugen) for macular degeneration. Med. Lett., Drugs Ther., 47 (1212), 55-6.
-
-
-
-
108
-
-
0034090586
-
Regulation of vascular growth and regression by matrix metalloproteinases in the rat aorta model of angiogenesis
-
Zhu, W. H.; Guo, X.; Villaschi, S.; Francesco Nicosia, R. (2000) Regulation of vascular growth and regression by matrix metalloproteinases in the rat aorta model of angiogenesis. Lab. Invest., 80(4), 545-55.
-
(2000)
Lab. Invest
, vol.80
, Issue.4
, pp. 545-555
-
-
Zhu, W.H.1
Guo, X.2
Villaschi, S.3
Francesco Nicosia, R.4
-
109
-
-
1942538556
-
The matrix metalloproteinase inhibitor prinomastat enhances photodynamic therapy responsiveness in a mouse tumor model
-
Ferrario, A.; Chantrain, C. F.; von Tiehl, K.; Buckley, S.; Rucker, N.; Shalinsky, D. R.; Shimada, H.; DeClerck, Y. A.; Gomer, C. J. (2004) The matrix metalloproteinase inhibitor prinomastat enhances photodynamic therapy responsiveness in a mouse tumor model. Cancer Res., 64(7), 2328-32.
-
(2004)
Cancer Res
, vol.64
, Issue.7
, pp. 2328-2332
-
-
Ferrario, A.1
Chantrain, C.F.2
von Tiehl, K.3
Buckley, S.4
Rucker, N.5
Shalinsky, D.R.6
Shimada, H.7
DeClerck, Y.A.8
Gomer, C.J.9
-
110
-
-
0036211156
-
Antiangiogenic and antimetastatic properties of Neovastat (AE-941), an orally active extract derived from cartilage tissue
-
Dupont, E.; Falardeau, P.; Mousa, S. A.; Dimitriadou, V.; Pepin, M. C.; Wang, T.; Alaoui-Jamali, M. A. (2002) Antiangiogenic and antimetastatic properties of Neovastat (AE-941), an orally active extract derived from cartilage tissue. Clin. Exp. Metastasis, 19(2), 145-53.
-
(2002)
Clin. Exp. Metastasis
, vol.19
, Issue.2
, pp. 145-153
-
-
Dupont, E.1
Falardeau, P.2
Mousa, S.A.3
Dimitriadou, V.4
Pepin, M.C.5
Wang, T.6
Alaoui-Jamali, M.A.7
-
111
-
-
49249110986
-
Tetrathiomolybdate, a copper chelator for the treatment of Wilson disease, pulmonary fibrosis and other indications
-
Medici, V.; Sturniolo, G. C. (2008) Tetrathiomolybdate, a copper chelator for the treatment of Wilson disease, pulmonary fibrosis and other indications. IDrugs, 11(8), 592-606.
-
(2008)
IDrugs
, vol.11
, Issue.8
, pp. 592-606
-
-
Medici, V.1
Sturniolo, G.C.2
-
112
-
-
33748340865
-
Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1
-
Juarez, J. C.; Betancourt, O., Jr.; Pirie-Shepherd, S. R.; Guan, X.; Price, M. L.; Shaw, D. E.; Mazar, A. P.; Donate, F. (2006) Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1. Clin. Cancer Res., 12(16), 4974-82.
-
(2006)
Clin. Cancer Res
, vol.12
, Issue.16
, pp. 4974-4982
-
-
Juarez, J.C.1
Betancourt Jr., O.2
Pirie-Shepherd, S.R.3
Guan, X.4
Price, M.L.5
Shaw, D.E.6
Mazar, A.P.7
Donate, F.8
-
113
-
-
23144467529
-
Phase 2 trial of copper depletion and penicillamine as antiangiogenesis therapy of glioblastoma
-
Brem, S.; Grossman, S. A.; Carson, K. A.; New, P.; Phuphanich, S.; Alavi, J. B.; Mikkelsen, T.; Fisher, J. D. (2005) Phase 2 trial of copper depletion and penicillamine as antiangiogenesis therapy of glioblastoma. Neurooncology, 7(3), 246-53.
-
(2005)
Neurooncology
, vol.7
, Issue.3
, pp. 246-253
-
-
Brem, S.1
Grossman, S.A.2
Carson, K.A.3
New, P.4
Phuphanich, S.5
Alavi, J.B.6
Mikkelsen, T.7
Fisher, J.D.8
-
114
-
-
0037058676
-
The copper chelator trientine has an antiangiogenic effect against hepatocellular carcinoma, possibly through inhibition of interleukin-8 production
-
Moriguchi, M.; Nakajima, T.; Kimura, H.; Watanabe, T.; Takashima, H.; Mitsumoto, Y.; Katagishi, T.; Okanoue, T.; Kagawa, K. (2002) The copper chelator trientine has an antiangiogenic effect against hepatocellular carcinoma, possibly through inhibition of interleukin-8 production. Int. J. Cancer, 102(5), 445-52.
-
(2002)
Int. J. Cancer
, vol.102
, Issue.5
, pp. 445-452
-
-
Moriguchi, M.1
Nakajima, T.2
Kimura, H.3
Watanabe, T.4
Takashima, H.5
Mitsumoto, Y.6
Katagishi, T.7
Okanoue, T.8
Kagawa, K.9
-
115
-
-
1642321097
-
Evaluating antiangiogenesis agents in the clinic: The eastern cooperative oncology group portfolio of clinical trials
-
Sparano, J. A.; Gray, R.; Giantonio, B.; O'Dwyer, P.; Comis, R. L. (2004) Evaluating antiangiogenesis agents in the clinic: The eastern cooperative oncology group portfolio of clinical trials. Clin. Cancer Res., 10(4), 1206-11.
-
(2004)
Clin. Cancer Res
, vol.10
, Issue.4
, pp. 1206-1211
-
-
Sparano, J.A.1
Gray, R.2
Giantonio, B.3
O'Dwyer, P.4
Comis, R.L.5
-
116
-
-
40949123806
-
New taxanes in development
-
Ferlini, C.; Gallo, D.; Scambia, G. (2008) New taxanes in development. Exp. Opin. Investig. Drugs, 17(3), 335-47.
-
(2008)
Exp. Opin. Investig. Drugs
, vol.17
, Issue.3
, pp. 335-347
-
-
Ferlini, C.1
Gallo, D.2
Scambia, G.3
-
117
-
-
45549107529
-
-
Donovan, D.; Vahdat, L. T. (2008) Epothilones: Clinical update and future directions. Oncology (Williston Park), 22(4), 408-16; discussion 416, 421, 424 passim.
-
Donovan, D.; Vahdat, L. T. (2008) Epothilones: Clinical update and future directions. Oncology (Williston Park), 22(4), 408-16; discussion 416, 421, 424 passim.
-
-
-
-
118
-
-
19344378137
-
Vascular disrupting agents: A new class of drug in cancer therapy
-
Gaya, A. M.; Rustin, G. J. (2005)Vascular disrupting agents: A new class of drug in cancer therapy. Clin. Oncol. (R. Coll. Radiol.), 17(4), 277-90.
-
(2005)
Clin. Oncol. (R. Coll. Radiol.)
, vol.17
, Issue.4
, pp. 277-290
-
-
Gaya, A.M.1
Rustin, G.J.2
-
119
-
-
33748869678
-
Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies
-
Horsman, M. R.; Siemann, D. W. (2006) Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies. Cancer Res., 66(24), 11520-39.
-
(2006)
Cancer Res
, vol.66
, Issue.24
, pp. 11520-11539
-
-
Horsman, M.R.1
Siemann, D.W.2
-
120
-
-
7444259131
-
Efficacy of combined antiangiogenic and vascular disrupting agents in treatment of solid tumors
-
Siemann, D. W.; Shi, W. (2004) Efficacy of combined antiangiogenic and vascular disrupting agents in treatment of solid tumors. Int. J. Radiat. Oncol. Biol. Phys., 60(4), 1233-40.
-
(2004)
Int. J. Radiat. Oncol. Biol. Phys
, vol.60
, Issue.4
, pp. 1233-1240
-
-
Siemann, D.W.1
Shi, W.2
-
121
-
-
33751583518
-
Drug insight: Vascular disrupting agents and angiogenesis - novel approaches for drug delivery
-
Cooney, M. M.; van Heeckeren, W.; Bhakta, S.; Ortiz, J.; Remick, S. C. (2006) Drug insight: Vascular disrupting agents and angiogenesis - novel approaches for drug delivery. Nat. Clin. Pract. Oncol., 3(12), 682-92.
-
(2006)
Nat. Clin. Pract. Oncol
, vol.3
, Issue.12
, pp. 682-692
-
-
Cooney, M.M.1
van Heeckeren, W.2
Bhakta, S.3
Ortiz, J.4
Remick, S.C.5
-
122
-
-
34250783159
-
-
Hait, W. N.; Rubin, E.; Alli, E.; Goodin, S., Tubulin Targeting Agents. 2007, 2 (1), 1-18.
-
(2007)
Tubulin Targeting Agents
, vol.2
, Issue.1
, pp. 1-18
-
-
Hait, W.N.1
Rubin, E.2
Alli, E.3
Goodin, S.4
-
123
-
-
20044379059
-
Review: Tubulin function, action of antitubulin drugs, and new drug development
-
Pellegrini, F.; Budman, D. R. (2005) Review: Tubulin function, action of antitubulin drugs, and new drug development. Cancer Invest., 23(3), 264-73.
-
(2005)
Cancer Invest
, vol.23
, Issue.3
, pp. 264-273
-
-
Pellegrini, F.1
Budman, D.R.2
-
124
-
-
33750701126
-
Drug target interaction of tubulin-binding drugs in cancer therapy
-
Sengupta, S.; Thomas, S. A. (2006) Drug target interaction of tubulin-binding drugs in cancer therapy. Exp. Rev. Anticancer Ther., 6(10), 1433-47.
-
(2006)
Exp. Rev. Anticancer Ther
, vol.6
, Issue.10
, pp. 1433-1447
-
-
Sengupta, S.1
Thomas, S.A.2
-
125
-
-
0141774441
-
Tubulin and microtubules as targets for anticancer drugs
-
Hadfield, J. A.; Ducki, S.; Hirst, N.; McGown, A. T. (2003) Tubulin and microtubules as targets for anticancer drugs. Prog. Cell Cycle Res., 5, 309-25.
-
(2003)
Prog. Cell Cycle Res
, vol.5
, pp. 309-325
-
-
Hadfield, J.A.1
Ducki, S.2
Hirst, N.3
McGown, A.T.4
-
126
-
-
0034844674
-
Physiochemical aspects of tubulin-interacting antimitotic drugs
-
Correia, J. J.; Lobert, S. (2001) Physiochemical aspects of tubulin-interacting antimitotic drugs. Curr. Pharm. Des., 7(13), 1213-28.
-
(2001)
Curr. Pharm. Des
, vol.7
, Issue.13
, pp. 1213-1228
-
-
Correia, J.J.1
Lobert, S.2
-
127
-
-
0036282385
-
The biology of the combretastatins as tumour vascular targeting agents
-
Tozer, G. M.; Kanthou, C.; Parkins, C. S.; Hill, S. A. (2002) The biology of the combretastatins as tumour vascular targeting agents. Int. J. Exp. Pathol., 83(1), 21-38.
-
(2002)
Int. J. Exp. Pathol
, vol.83
, Issue.1
, pp. 21-38
-
-
Tozer, G.M.1
Kanthou, C.2
Parkins, C.S.3
Hill, S.A.4
-
128
-
-
24944515311
-
A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach
-
Nguyen, T. L.; McGrath, C.; Hermone, A. R.; Burnett, J. C.; Zaharevitz, D. W.; Day, B. W.; Wipf, P.; Hamel, E.; Gussio, R. (2005) A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach. J. Med. Chem., 48(19), 6107-16.
-
(2005)
J. Med. Chem
, vol.48
, Issue.19
, pp. 6107-6116
-
-
Nguyen, T.L.1
McGrath, C.2
Hermone, A.R.3
Burnett, J.C.4
Zaharevitz, D.W.5
Day, B.W.6
Wipf, P.7
Hamel, E.8
Gussio, R.9
-
129
-
-
0030791178
-
-
Laura K. Shawver, k. E. L., T. Anne T. Fong, Gerald McMahon, Greg D. Plowman, Laurie M. Strawn. Drug Discov. Today, 1997, 2 (2), 50-63.
-
Laura K. Shawver, k. E. L., T. Anne T. Fong, Gerald McMahon, Greg D. Plowman, Laurie M. Strawn. Drug Discov. Today, 1997, 2 (2), 50-63.
-
-
-
-
130
-
-
4043130417
-
Receptor tyrosine kinase inhibitors as anti-angiogenic agents
-
Kim, D. W.; Lu, B.; Hallahan, D. E. (2004) Receptor tyrosine kinase inhibitors as anti-angiogenic agents. Curr. Opin. Investig. Drugs, 5(6), 597-604.
-
(2004)
Curr. Opin. Investig. Drugs
, vol.5
, Issue.6
, pp. 597-604
-
-
Kim, D.W.1
Lu, B.2
Hallahan, D.E.3
-
131
-
-
0036780251
-
Clinical translation of angiogenesis inhibitors
-
Kerbel, R.; Folkman, J. (2002) Clinical translation of angiogenesis inhibitors. Nat. Rev. Cancer, 2(10), 727-39.
-
(2002)
Nat. Rev. Cancer
, vol.2
, Issue.10
, pp. 727-739
-
-
Kerbel, R.1
Folkman, J.2
-
132
-
-
0034778447
-
EGFR and cancer prognosis
-
Nicholson, R. I.; Gee, J. M.; Harper, M. E. (2001) EGFR and cancer prognosis. Eur. J. Cancer, 37 Suppl 4, S9-15.
-
(2001)
Eur. J. Cancer
, vol.37
, Issue.SUPPL. 4
-
-
Nicholson, R.I.1
Gee, J.M.2
Harper, M.E.3
-
133
-
-
0842329999
-
Angiogenesis inhibitors in clinical development; where are we now and where are we going?
-
Eskens, F. A. (2004) Angiogenesis inhibitors in clinical development; where are we now and where are we going? Br. J. Cancer, 90(1), 1-7.
-
(2004)
Br. J. Cancer
, vol.90
, Issue.1
, pp. 1-7
-
-
Eskens, F.A.1
-
134
-
-
4644364508
-
The histone deacetylase inhibitor NVP-LAQ824 inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584
-
Qian, D. Z.; Wang, X.; Kachhap, S. K.; Kato, Y.; Wei, Y.; Zhang, L.; Atadja, P.; Pili, R. (2004) The histone deacetylase inhibitor NVP-LAQ824 inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584. Cancer Res., 64(18), 6626-34.
-
(2004)
Cancer Res
, vol.64
, Issue.18
, pp. 6626-6634
-
-
Qian, D.Z.1
Wang, X.2
Kachhap, S.K.3
Kato, Y.4
Wei, Y.5
Zhang, L.6
Atadja, P.7
Pili, R.8
-
135
-
-
4043113512
-
Anti-angiogenic effects of thalidomide: Expression of apoptosis-inducible active-caspase-3 in a three-dimensional collagen gel culture of aorta
-
Fujita, K.; Asami, Y.; Tanaka, K.; Akita, M.; Merker, H. J. (2004) Anti-angiogenic effects of thalidomide: Expression of apoptosis-inducible active-caspase-3 in a three-dimensional collagen gel culture of aorta. Histochem. Cell Biol., 122(1), 27-33.
-
(2004)
Histochem. Cell Biol
, vol.122
, Issue.1
, pp. 27-33
-
-
Fujita, K.1
Asami, Y.2
Tanaka, K.3
Akita, M.4
Merker, H.J.5
-
136
-
-
0034937998
-
Copper control as an antiangiogenic anticancer therapy: Lessons from treating Wilson's disease
-
Brewer, G. J. (2001) Copper control as an antiangiogenic anticancer therapy: Lessons from treating Wilson's disease. Exp. Biol. Med. (Maywood), 226(7), 665-73.
-
(2001)
Exp. Biol. Med. (Maywood)
, vol.226
, Issue.7
, pp. 665-673
-
-
Brewer, G.J.1
-
137
-
-
0034256094
-
Inhibition of tumor angiogenesis by synthetic receptor tyrosine kinase inhibitors
-
Sun, L.; McMahon, G. (2000) Inhibition of tumor angiogenesis by synthetic receptor tyrosine kinase inhibitors. Drug Discov. Today, 5(8), 344-353.
-
(2000)
Drug Discov. Today
, vol.5
, Issue.8
, pp. 344-353
-
-
Sun, L.1
McMahon, G.2
-
138
-
-
12944277104
-
A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells
-
Giannakakou, P.; Gussio, R.; Nogales, E.; Downing, K. H.; Zaharevitz, D.; Bollbuck, B.; Poy, G.; Sackett, D.; Nicolaou, K. C.; Fojo, T. (2000)A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells. Proc. Natl. Acad. Sci. USA, 97(6), 2904-9.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, Issue.6
, pp. 2904-2909
-
-
Giannakakou, P.1
Gussio, R.2
Nogales, E.3
Downing, K.H.4
Zaharevitz, D.5
Bollbuck, B.6
Poy, G.7
Sackett, D.8
Nicolaou, K.C.9
Fojo, T.10
-
139
-
-
0346690415
-
The pleiotropic effects of HMG-CoA reductase inhibitors: Their role in osteoporosis and dementia
-
Waldman, A.; Kritharides, L. (2003) The pleiotropic effects of HMG-CoA reductase inhibitors: Their role in osteoporosis and dementia. Drugs, 63(2), 139-52.
-
(2003)
Drugs
, vol.63
, Issue.2
, pp. 139-152
-
-
Waldman, A.1
Kritharides, L.2
-
140
-
-
0025076479
-
Role of tumor necrosis factor in flavone acetic acid-induced tumor vasculature shutdown
-
Mahadevan, V.; Malik, S. T.; Meager, A.; Fiers, W.; Lewis, G. P.; Hart, I. R. (1990) Role of tumor necrosis factor in flavone acetic acid-induced tumor vasculature shutdown. Cancer Res., 50(17), 5537-42.
-
(1990)
Cancer Res
, vol.50
, Issue.17
, pp. 5537-5542
-
-
Mahadevan, V.1
Malik, S.T.2
Meager, A.3
Fiers, W.4
Lewis, G.P.5
Hart, I.R.6
-
141
-
-
0032126120
-
Antitumour activity of the novel immune modulator 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice lacking the interferon-gamma receptor
-
Pang, J. H.; Cao, Z.; Joseph, W. R.; Baguley, B. C.; Ching, L. M. (1998) Antitumour activity of the novel immune modulator 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice lacking the interferon-gamma receptor. Eur. J. Cancer, 34(8), 1282-9.
-
(1998)
Eur. J. Cancer
, vol.34
, Issue.8
, pp. 1282-1289
-
-
Pang, J.H.1
Cao, Z.2
Joseph, W.R.3
Baguley, B.C.4
Ching, L.M.5
-
142
-
-
25144483821
-
Phase 1 study of ABT-751, a novel microtubule inhibitor, in patients with refractory hematologic malignancies
-
Yee, K. W.; Hagey, A.; Verstovsek, S.; Cortes, J.; Garcia-Manero, G.; O'Brien, S. M.; Faderl, S.; Thomas, D.; Wierda, W.; Kornblau, S.; Ferrajoli, A.; Albitar, M.; McKeegan, E.; Grimm, D. R.; Mueller, T.; Holley-Shanks, R. R.; Sahelijo, L.; Gordon, G. B.; Kantarjian, H. M.; Giles, F. J. (2005) Phase 1 study of ABT-751, a novel microtubule inhibitor, in patients with refractory hematologic malignancies. Clin. Cancer Res., 11(18), 6615-24.
-
(2005)
Clin. Cancer Res
, vol.11
, Issue.18
, pp. 6615-6624
-
-
Yee, K.W.1
Hagey, A.2
Verstovsek, S.3
Cortes, J.4
Garcia-Manero, G.5
O'Brien, S.M.6
Faderl, S.7
Thomas, D.8
Wierda, W.9
Kornblau, S.10
Ferrajoli, A.11
Albitar, M.12
McKeegan, E.13
Grimm, D.R.14
Mueller, T.15
Holley-Shanks, R.R.16
Sahelijo, L.17
Gordon, G.B.18
Kantarjian, H.M.19
Giles, F.J.20
more..
-
143
-
-
0032762952
-
Antiangiogenesis is produced by nontoxic doses of vinblastine
-
Vacca, A.; Iurlaro, M.; Ribatti, D.; Minischetti, M.; Nico, B.; Ria, R.; Pellegrino, A.; Dammacco, F. (1999) Antiangiogenesis is produced by nontoxic doses of vinblastine. Blood, 94 (12), 4143-55.
-
(1999)
Blood
, vol.94
, Issue.12
, pp. 4143-4155
-
-
Vacca, A.1
Iurlaro, M.2
Ribatti, D.3
Minischetti, M.4
Nico, B.5
Ria, R.6
Pellegrino, A.7
Dammacco, F.8
|