New bicyclic amines: Synthesis and SARs of their action against the causative organisms of malaria and sleeping sickness

Current Medicinal Chemistry

Volumn 16, Issue 11, 2009, Pages 1426-1441

  Weis, R ^a   Seebacher, We ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

Antiplasmodial activity; Antitrypanosomal activity; Bicyclic amines; In vitro microplate assays; In vivo assays; Structure activity relationships

Indexed keywords

3 CHLOROPERBENZOIC ACID; 3BETA (4 FLUOROPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; ACRYLONITRILE; AMINE; ANTIMALARIAL AGENT; ANTITRYPANOSOMAL AGENT; ARTEMISININ; AZABICYCLO DERIVATIVE; BENZOIC ACID DERIVATIVE; BENZYLIDENEACETONE; BICYCLO[2.2.2]OCTANE DERIVATIVE; CHLOROQUINE; CYCLOHEXANONE DERIVATIVE; EFLORNITHINE; ETHYL ACETOACETIC ACID; HYDRAZONE DERIVATIVE; ISOTHIOCYANIC ACID DERIVATIVE; KETONE DERIVATIVE; MELARSOPROL; NICOTINIC ACID; OXIME DERIVATIVE; PENTAMIDINE; PHENYLACETONE; PIMELIC ACID DERIVATIVE; PIPERIDINE DERIVATIVE; PYRIMETHAMINE; PYRROLIDINE DERIVATIVE; SURAMIN; TOLUENESULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AFRICAN TRYPANOSOMIASIS; ANTIBIOTIC RESISTANCE; ANTIPROTOZOAL ACTIVITY; BECKMANN REARRANGEMENT; CYTOTOXICITY; DIELS ALDER REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; IN VITRO STUDY; MALARIA; NONHUMAN; PATHOGENESIS; PLASMODIUM FALCIPARUM; REVIEW; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SURVIVAL RATE; TRYPANOSOMA RHODESIENSE;

AMINES; ANIMALS; ANTIMALARIALS; ANTIPROTOZOAL AGENTS; BICYCLO COMPOUNDS; HUMANS; MALARIA; PLASMODIUM FALCIPARUM; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMIASIS, AFRICAN;

EID: 65649122656     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986709787846479     Document Type: Review

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