Synthesis of new esters and oximes with 4-aminobicyclo[2.2.2]octane structure and evaluation of their antitrypanosomal and antiplasmodial activities

European Journal of Medicinal Chemistry

Volumn 41, Issue 8, 2006, Pages 970-977

  Seebacher, W ^a   Schlapper, C ^a   Brun, R ^b   Kaiser, M ^b   Saf, R ^c   Weis, R ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c Erzherzog Johann University   (Austria)

Author keywords

4 Aminobicyclo 2.2.2 octane derivatives; Aromatic esters; In vitro assays; O methyloximes; Plasmodium falciparum; Trypanosoma b. rhodesiense

Indexed keywords

4 DIMETHYLAMINO 6,7 DIPHENYLBICYCLO[2.2.2]OCTAN 2 YLISONICOTINATE; 4 DIMETHYLAMINO 6,7 DIPHENYLBICYCLO[2.2.2]OCTAN 2 YLNICOTINATE; 4 DIMETHYLAMINO 6,7 DIPHENYLBICYCLO[2.2.2]OCTAN 2 YLPHENYLACETATE; 6,7 DIPHENYL 4 (PIPERIDIN 1 YL)BICYCLO[2.2.2]OCT 2 YL 3 OXO 2,4 DIPHENYLBUTANOATE; 6,7 DIPHENYL 4 PIPERIDINOBICYCLO[2.2.2]OCTAN 2 YLISONICOTINATE; 6,7 DIPHENYL 4 PIPERIDINOBICYCLO[2.2.2]OCTAN 2 YLPHENYLACETATE; 6,7 DIPHENYL 4 PYRROLIDINBICYCLO[2.2.2]OCTAN 2 YLISONICOTINATE; 6,7 DIPHENYL 4 PYRROLIDINBICYCLO[2.2.2]OCTAN 2 YLNICOTINATE; 6,7 DIPHENYL 4 PYRROLIDINOBICYCLO[2.2.2]OCTAN 2 YLPHENYLACETATE; AMINO ACID DERIVATIVE; ANTIPROTOZOAL AGENT; CHLOROQUINE; MELARSOPROL; PYRIMETHAMINE; UNCLASSIFIED DRUG; 4 AMINOBICYCLO(2.2.2)OCTANE; 4-AMINOBICYCLO(2.2.2)OCTANE; ANTIMALARIAL AGENT; ANTITRYPANOSOMAL AGENT; BICYCLO COMPOUND; ESTER; OXIME;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; IC 50; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA RHODESIENSE; ANIMAL; CHEMISTRY; DRUG EFFECT; ELECTROSPRAY MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

ANIMALS; ANTIMALARIALS; BICYCLO COMPOUNDS; ESTERS; MAGNETIC RESONANCE SPECTROSCOPY; OXIMES; PLASMODIUM FALCIPARUM; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI RHODESIENSE;

EID: 33746805096     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.04.002     Document Type: Article

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