Bicyclo[2.2.2]octyl esters of dialkylamino acids as antiprotozoals

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 16, 2007, Pages 5543-5550

  Schlapper, Christian ^a   Seebacher, Werner ^a   Kaiser, Marcel ^b   Brun, Reto ^b   Saf, Robert ^c   Weis, Robert ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c Erzherzog Johann University   (Austria)

Author keywords

4 Aminobicyclo 2.2.2 octane derivatives; Amino acids; Plasmodium falciparum; Trypanosoma brucei rhodesiense

Indexed keywords

4 DIMETHYLAMINO 6,7 DIPHENYLBICYCLO[2.2.2]OCTAN 2 OL; 4 DIMETHYLAMINO 6,7 DIPHENYLBICYCLO[2.2.2]OCTAN 2 YLCINNAMOATE; 4 PIPERIDINO 6,7 DIPHENYLBICYCLO[2.2.2]OCTAN 2 OL; 4 PYRROLIDINO 6,7 DIPHENYLBICYCLO[2.2.2]OCTAN 2 OL; 6,7 DIPHENYL 4 DIMETHYLAMINOBICYCLO[2.2.2]OCTAN 2 YL 2' DIETHYLAMINOACETATE; 6,7 DIPHENYL 4 DIMETHYLAMINOBICYCLO[2.2.2]OCTAN 2 YL 2' PIPERIDINOACETATE; 6,7 DIPHENYL 4 DIMETHYLAMINOBICYCLO[2.2.2]OCTAN 2 YL 2' PYRROLIDINOACETATE; 6,7 DIPHENYL 4 PIPERIDINOBICYCLO[2.2.2]OCTAN 2 YL 2' DIETHYLAMINOACETATE; 6,7 DIPHENYL 4 PIPERIDINOBICYCLO[2.2.2]OCTAN 2 YL 2' PIPERIDINOACETATE; 6,7 DIPHENYL 4 PIPERIDINOBICYCLO[2.2.2]OCTAN 2 YL 2' PYRROLIDINOACETATE; 6,7 DIPHENYL 4 PIPERIDINOBICYCLO[2.2.2]OCTAN 2 YLCINNAMOATE; 6,7 DIPHENYL 4 PYRROLIDINOBICYCLO[2.2.2]OCTAN 2 YL 2' DIETHYLAMINOACETATE; 6,7 DIPHENYL 4 PYRROLIDINOBICYCLO[2.2.2]OCTAN 2 YL 2' PIPERIDINOACETATE; 6,7 DIPHENYL 4 PYRROLIDINOBICYCLO[2.2.2]OCTAN 2 YL 2' PYRROLIDINOACETATE; 6,7 DIPHENYL 4 PYRROLIDINOBICYCLO[2.2.2]OCTAN 2 YLCINNAMOATE; ANTIPROTOZOAL AGENT; ARTEMISININ; BICYCLO[2.2.2]OCTANE DERIVATIVE; CHLOROQUINE; GLYCINE DERIVATIVE; MELARSOPROL; PYRIMETHAMINE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG STRUCTURE; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA RHODESIENSE;

ALKYLATION; AMINO ACIDS; ANIMALS; ANTIPROTOZOAL AGENTS; BICYCLO COMPOUNDS; ESTERS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA BRUCEI RHODESIENSE;

PLASMODIUM FALCIPARUM; TRYPANOSOMA BRUCEI RHODESIENSE;

EID: 34250714507     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.05.042     Document Type: Article

References (20)

1. Bohannon J. Science 311 (2006) 599
2. World Health Report 2004, Statistical Annex Table 2.
3. Tripathi R.P., Mishra R.C., Dwivedi N., Tewari N., and Verma S.S. Curr. Med. Chem. 12 (2005) 2643-2659
4. Meshnick S.R.R. Int. J. Parasit. 32 (2002) 1655-1660
5. Uhlemann A.C., Cameron A., Eckstein-Ludwig U., Fischbarg J., Iserovich P., Zuniga F.A., East M., Lee A., Brady L., Haynes R.K., and Krishna S. Nat. Struct. Mol. Biol. 12 (2005) 628-629
6. Jambou R., Legrand E., Niang M., Khim N., Lim P., Volney B., Ekala M.T., Bouchier C., Esterre P., Fandour T., and Mercereau-Pujialon O. Lancet 366 (2005) 1908-1909
7. Mutabingwa T.K. Acta Trop. 95 (2005) 305-315
8. Kennedy P.G.E. J. Clin. Invest. 113 (2004) 496-504
9. Croft S.L., Barrett M.P., and Urbina J.A. Trends Parasitol. 21 (2005) 508-512
10. Gutteridge W.E. Brit. Med. Bull. 41 (1985) 162
11. Doua F., and Yapo F.B. Acta Trop. 54 (1993) 163
12. Kennedy P.G.E. Int. J. Parasitol. 36 (2006) 505-512
13. Weis R., Brun R., Saf R., and Seebacher W. Monatsh. Chem. 134 (2003) 1019-1026
14. Seebacher W., Brun R., Kaiser M., Saf R., and Weis R. Eur. J. Med. Chem. 40 (2005) 888-896
15. Seebacher W., Schlapper C., Brun R., Kaiser M., Saf R., and Weis R. Eur. J. Pharm. Sci. 24 (2005) 281-289
16. Weis R., Schlapper C., Brun R., Kaiser M., and Seebacher W. Eur. J. Pharm. Sci. 28 (2006) 361-368
17. Weis R., Schweiger K., Seebacher W., and Belaj F. Tetrahedron 54 (1998) 14015-14022
18. Matile H., and Pink J.R.L. In: Lefkovits I., and Pernis B. (Eds). Immunological Methods (1990), Academic Press, San Diego 221-234
19. Baltz T., Baltz D., Giroud C., and Crockett J. EMBO J. 4 (1985) 1273-1277
20. Räz B., Iten M., Grether-Bühler Y., Kaminsky R., and Brun R. Acta Trop. 68 (1997) 139-147