Synthesis and evaluation of the antitrypanosomal and antiplasmodial activities of new 4-aminobicyclo[2.2.2]octane derivatives

European Journal of Medicinal Chemistry

Volumn 40, Issue 9, 2005, Pages 888-896

  Seebacher, Werner ^a   Brun, Reto ^b   Kaiser, Marcel ^b   Saf, Robert ^c   Weis, Robert ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c Erzherzog Johann University   (Austria)

Author keywords

4 Aminobicyclo 2.2.2 octane derivatives; 4 Methylthiosemicarbazones; Aromatic esters; In vitro assays; Plasmodium falciparum; Trypanosoma b. rhodesiense

Indexed keywords

4 DIMETHYLAMINO 6,7 DIPHENYLBICYCLO[2.2.2]OCTAN 2 ONE 4' METHYLTHIOSEMICARBAZONE; 4 DIMETHYLAMINO 6,7 DIPHENYLBICYCLO[2.2.2]OCTAN 2 YL [3,4 (METHYLENEDIOXY)PHENYLACETATE]; 4 MORPHOLINO 6,7 DIPHENYLBICYCLO[2.2.2]OCTAN 2 ONE 4' METHYLTHIOSEMICARBAZONE; 6,7 DIPHENYL 4 PIPERIDINOBICYCLO[2.2.2]OCTAN 2 ONE 4' METHYLTHIOSEMICARBAZONE; 6,7 DIPHENYL 4 PIPERIDINOBICYCLO[2.2.2]OCTAN 2 YL [3,4 (METHYLENEDIOXY) PHENYLACETATE]; 6,7 DIPHENYL 4 PYRROLIDINOBICYCLO[2.2.2]OCTAN 2 YL [3,4 (METHYLENEDIOXY)PHENYLACETATE]; ARTEMISININ; BICYCLO[2.2.2]OCTANE DERIVATIVE; CHLOROQUINE; MEFLOQUINE; MELARSOPROL; PYRIMETHAMINE; SURAMIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBIOTIC RESISTANCE; ANTIMALARIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG SCREENING; DRUG SYNTHESIS; GENETIC STRAIN; NONHUMAN; PLASMODIUM FALCIPARUM; PLATE COUNT; RAT; TRYPANOSOMA RHODESIENSE;

ANIMALS; ANTIMALARIALS; BICYCLO COMPOUNDS; CELL LINE; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; MYOBLASTS, SKELETAL; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; RATS; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI RHODESIENSE;

EID: 25444449236     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.03.018     Document Type: Article

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