Epimers of bicyclo[2.2.2]octan-2-ol derivatives with antiprotozoal activity

European Journal of Medicinal Chemistry

Volumn 43, Issue 4, 2008, Pages 800-807

  Schlapper, Christian ^a   Seebacher, Werner ^a   Kaiser, Marcel ^b   Brun, Reto ^b   Saf, Robert ^c   Weis, Robert ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c Erzherzog Johann University   (Austria)

Author keywords

4 Aminobicyclo 2.2.2 octane derivative; Bicyclo octylester; Epimerization; In vitro assay; Plasmodium falciparum; Trypanosoma brucei rhodesiense

Indexed keywords

4 DIMETHYLAMINO 6,7 DIPHENYLBICYCLO[2.2.2]OCTAN 2 YL ISONICOTINATE; 4 DIMETHYLAMINO 6,7 DIPHENYLBICYCLO[2.2.2]OCTAN 2 YL NICOTINATE; 6,7 DIPHENYL 4 PYRROLIDINOBICYCLO[2.2.2]OCTAN 2 YL 4 CHLOROBENZOATE; 6,7 DIPHENYL 4 PYRROLIDINOBICYCLO[2.2.2]OCTAN 2 YL BENZOATE; ANTIPROTOZOAL AGENT; BICYCLO[2.2.2]OCTAN 2 OL DERIVATIVE; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; EPIMERIZATION; MALARIA; NONHUMAN; PLASMODIUM FALCIPARUM; RAT; TRYPANOSOMA RHODESIENSE;

ANIMALS; ANTIPROTOZOAL AGENTS; BICYCLO COMPOUNDS; MAGNETIC RESONANCE SPECTROSCOPY; PLASMODIUM FALCIPARUM; SPECTROPHOTOMETRY, ULTRAVIOLET; TRYPANOSOMA BRUCEI BRUCEI;

EID: 41249091440     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.06.007     Document Type: Article

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