In search of adrenocortical stem and progenitor cells

Endocrine Reviews

Volumn 30, Issue 3, 2009, Pages 241-243

  Kim, Alex C ^a   Barlaskar, Ferdous M ^a   Heaton, Joanne H ^a   Else, Tobias ^a   Kelly, Victoria R ^a   Krill, Kenneth T ^a   Scheys, Joshua O ^a   Simon, Derek P ^a   Trovato, Alessia ^a   Yang, Wei Hsiung ^b   Hammer, Gary D ^a,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Division of Metabolism Endocrinology and Diabetes   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INHIBIN; NOTCH RECEPTOR; NUCLEAR RECEPTOR DAX 1; SONIC HEDGEHOG PROTEIN; STEROIDOGENIC FACTOR 1; TELOMERASE; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

ADENOMATOUS POLYP; ADRENAL CORTEX; ADRENAL CORTEX CARCINOMA; ADRENAL CORTEX CELL; ADRENAL GLAND; BECKWITH WIEDEMANN SYNDROME; CANCER STEM CELL; CELL ACTIVATION; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL REGENERATION; CELLULAR DISTRIBUTION; ENDOCRINE FUNCTION; FAMILIAL CANCER; GENE EXPRESSION; GENE SILENCING; HOMEOSTASIS; HUMAN; NONHUMAN; ORGAN TRANSPLANTATION; ORGANOGENESIS; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; SOMATIC CELL; STEM CELL; STEROIDOGENESIS; TELOMERE; TISSUE SPECIFICITY;

ADRENAL CORTEX; ANIMALS; CELL DIFFERENTIATION; CLONE CELLS; HUMANS; ORGANOGENESIS; STEM CELLS;

EID: 65649085632     PISSN: 0163769X     EISSN: None     Source Type: Journal    
DOI: 10.1210/er.2008-0039     Document Type: Review

References (225)

1. Gottschau M 1883 Structur und embryonale Entwickelung der Nebennieren bei Saugethieren. Archiv fur Anat und Phys S:412-458
2. Arnold J 1866 Ein Beitrag zur feineren Struktur und dem Chemismus der Nebennieren. Virchow Arch Patholog Anatomie Physiol Klin Med 35: 64-107
3. Evelyn H-M 1927 A transitory zone in the adrenal cortex which shows age and sex relationships. Am J Anat 40:251-293
4. Keegan CE, Hammer GD 2002 Recent insights into organogenesis of the adrenal cortex. Trends Endocrinol Metab 13:200-208 (Pubitemid 36733980)
5. Else T, Hammer GD 2005 Genetic analysis of adrenal absence: agenesis and aplasia. Trends Endocrinol Metab 16:458-468 (Pubitemid 41660862)
6. Uotila UU 1940 The early embryological development of the fetal and permanent adrenal cortex in man. The Anatomical Record 76:183-203
7. Luo X, Ikeda Y, Parker KL 1994 A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77:481-490 (Pubitemid 24153989)
8. Hatano O, Takakusu A, Nomura M, Morohashi K 1996 Identical origin of adrenal cortex and gonad revealed by expression profiles of Ad4BP/SF-1. Genes Cells 1:663-671 (Pubitemid 126673156)
9. Kim AC, Hammer GD 2007 Adrenocortical cells with stem/progenitor cell properties: recent advances. Mol Cell Endocrinol 265-266:10-16
10. James RG, Kamei CN, Wang Q, Jiang R, Schultheiss TM 2006 Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells. Development 133:2995-3004 (Pubitemid 44314276)
11. Katoh-Fukui Y, Owaki A, Toyama Y, Kusaka M, Shinohara Y, Maekawa M, Toshimori K, Morohashi K 2005 Mouse polycomb M33 is required for splenic vascular and adrenal gland formation through regulating Ad4BP/SF1 expression. Blood 106:1612-1620 (Pubitemid 41208573)
12. Schnabel CA, Selleri L, Cleary ML 2003 Pbx1 is essential for adrenal development and urogenital differentiation. Genesis 37:123-130 (Pubitemid 37486873)
13. Val P, Martinez-Barbera JP, Swain A 2007 Adrenal development is initiated by Cited2 and Wt1 through modulation of Sf-1 dosage. Development 134:2349-2358 (Pubitemid 47010023)
14. Zubair M, Ishihara S, Oka S, Okumura K, Morohashi K 2006 Two-step regulation of Ad4BP/SF-1 gene transcription during fetal adrenal development: initiation by a Hox-Pbx1-Prep1 complex and maintenance via autoregulation by Ad4BP/SF-1. Mol Cell Biol 26:4111-4121 (Pubitemid 43788014)
15. Jones DL, Wagers AJ 2008 No place like home: anatomy and function of the stem cell niche. Nat Rev Mol Cell Biol 9:11-21
16. Fuchs E, Tumbar T, GuaschG2004 Socializing with the neighbors: stem cells and their niche. Cell 116:769-778 (Pubitemid 38410723)
17. Sneddon JB, Werb Z 2007 Location, location, location: the cancer stem cell niche. Cell Stem Cell 1:607-611 (Pubitemid 350215340)
18. Bassett JR, West SH 1997 Vascularization of the adrenal cortex: its possible involvement in the regulation of steroid hormone release. Microsc Res Tech 36:546-557 (Pubitemid 27203527)
19. Chamoux E, Bolduc L, Lehoux JG, Gallo-Payet N 2001 Identification of extracellular matrix components and their integrin receptors in the human fetal adrenal gland. J Clin Endocrinol Metab 86:2090-2098 (Pubitemid 32472925)
20. Magennis DP, McNicol AM 1998 Vascular patterns in the normal and pathological human adrenal cortex. Virchows Arch 433:69-73 (Pubitemid 28356479)
21. Otis M, Campbell S, Payet MD, Gallo-Payet N 2007 Expression of extracellular matrix proteins and integrins in rat adrenal gland: importance for ACTH-associated functions. J Endocrinol 193:331-347 (Pubitemid 47028686)
22. Tokunaga H 1996 Postnatal development of the blood vasculature in the rat adrenal gland: a scanning electron microscope study of microcorrosion casts. Arch Histol Cytol 59:305-315 (Pubitemid 26386514)
23. Virtanen I, Korhonen M, Petajaniemi N, Karhunen T, Thornell LE, Sorokin LM, Konttinen YT 2003 Laminin isoforms in fetal and adult human adrenal cortex. J Clin Endocrinol Metab 88:4960-4966 (Pubitemid 37361096)
24. Whetton AD, Graham GJ 1999 Homing and mobilization in the stem cell niche. Trends Cell Biol 9:233-238 (Pubitemid 29244135)
25. Weinberg WC, Howard JC, Iannaccone PM 1985 Histological demonstration of mosaicism in a series of chimeric rats produced between congenic strains. Science 227:524-527 (Pubitemid 15153176)
26. Iannaccone P, Morley S, Skimina T, Mullins J, Landini G 2003 Cord-like mosaic patches in the adrenal cortex are fractal: implications for growth and development. FASEB J 17:41-43
27. Landini G, Iannaccone PM 2000 Modeling of mosaic patterns in chimeric liver and adrenal cortex: algorithmic organogenesis? FASEB J 14:823-827
28. Kiiveri S, Liu J, Westerholm-Ormio M, Narita N, Wilson DB, Voutilainen R, Heikinheimo M 2002 Differential expression of GATA-4 and GATA-6 in fetal and adult mouse and human adrenal tissue. Endocrinology 143:3136-3143
29. Zubair M, Parker KL, Morohashi K 2008 Developmental links between the fetal and adult zones of the adrenal cortex revealed by lineage tracing. Mol Cell Biol 28:7030-7040
30. Bragulla H, Hirschberg RM, Schlotfeldt U, Stede M, Budras KD 2004 On the structure of the adrenal gland of the common seal (Phoca vitulina vitulina). Anat Histol Embryol 33:263-272
31. Rupik W 2002 Early development of the adrenal glands in the grass snake Natrix natrix L. (Lepidosauria, Serpentes). Adv Anat Embryol Cell Biol 164:I-XI, 1-102
32. Halder SK, Takemori H, Hatano O, Nonaka Y, Wada A, Okamoto M 1998 Cloning of a membrane-spanning protein with epidermal growth factor-like repeat motifs from adrenal glomerulosa cells. Endocrinology 139:3316-3328 (Pubitemid 28512364)
33. Vinson GP, Whitehouse B, Hinson J 1992 The adrenal cortex. Upper Saddle River, NJ: Prentice Hall Inc.
34. Mitani F, Mukai K, Miyamoto H, Suematsu M, Ishimura Y 1999 Development of functional zonation in the rat adrenal cortex. Endocrinology 140:3342-3353 (Pubitemid 30650654)
35. Mitani F, Mukai K, Miyamoto H, Suematsu M, Ishimura Y 2003 The undifferentiated cell zone is a stem cell zone in adult rat adrenal cortex. Biochim Biophys Acta 1619:317-324 (Pubitemid 36160609)
36. Mitani F, Suzuki H, Hata J, Ogishima T, Shimada H, Ishimura Y 1994 A novel cell layer without corticosteroid-synthesizing enzymes in rat adrenal cortex: histochemical detection and possible physiological role. Endocrinology 135:431-438 (Pubitemid 24203848)
37. Baker BL 1952 A comparison of the histological changes induced by experimental hyperadrenocorticalism and inanition. Recent Prog Horm Res 7:331
38. Beuschlein F, Mutch C, Bavers DL, Ulrich-Lai YM, Engeland WC, Keegan C, Hammer GD 2002 Steroidogenic factor-1 is essential for compensatory adrenal growth following unilateral adrenalectomy. Endocrinology 143:3122-3135
39. Pignatelli D, Ferreira J, Vendeira P, Magalhaes MC, Vinson GP 2002 Proliferation of capsular stem cells induced by ACTH in the rat adrenal cortex. Endocr Res 28:683-691 (Pubitemid 36042537)
40. Race GJ, Green RF 1955 Studies on zonation and regeneration of the adrenal cortex of the rat; effects of sodium restriction, potassium intoxication, corticotropin, and orchiectomy when studied with colchicine. AMA Arch Pathol 59:578-586
41. Zajicek G, Ariel I, Arber N 1986 The streaming adrenal cortex: direct evidence of centripetal migration of adrenocytes by estimation of cell turnover rate. J Endocrinol 111:477-482 (Pubitemid 17207239)
42. Ogishima T, Suzuki H, Hata J, Mitani F, Ishimura Y 1992 Zone-specific expression of aldosterone synthase cytochrome P-450 and cytochrome P-45011 β in rat adrenal cortex: histochemical basis for the functional zonation. Endocrinology 130:2971-2977
43. Wright NA, Voncina D, Morley AR 1973 An attempt to demonstrate cell migration from the zona glomerulosa in the prepubertal male rat adrenal cortex. J Endocrinol 59:451-459
44. Thomas M, Northrup SR, Hornsby PJ 1997 Adrenocortical tissue formed by transplantation of normal clones of bovine adrenocortical cells in scid mice replaces the essential functions of the animals' adrenal glands. Nat Med 3:978-983 (Pubitemid 27391951)
45. Thomas M, Hornsby PJ 1999 Transplantation of primary bovine adrenocortical cells into scid mice. Mol Cell Endocrinol 153:125-136 (Pubitemid 29339163)
46. Thomas M, Yang L, Hornsby PJ 2000 Formation of functional tissue from transplanted adrenocortical cells expressing telomerase reverse transcriptase. Nat Biotechnol 18:39-42 (Pubitemid 30041169)
47. Thomas M, Hawks CL, Hornsby PJ 2003 Adrenocortical cell transplantation in scid mice: the role of the host animals' adrenal glands. J Steroid Biochem Mol Biol 85:285-290 (Pubitemid 37011104)
48. Nickerson PA, Brownie AC, Skelton FR 1969 An electron microscopic study of the regenerating adrenal gland during the development of adrenal regeneration hypertension. Am J Pathol 57:335-364
49. Pellegrino C, Ricci PD, Tongiani R 1963 A quantitative cytochemical and physiological study of the rat adrenal cortex in hypertrophy after unilateral adrenalectomy. Exp Cell Res 31:167-182
50. Perrone RD, Bengele HH, Alexander EA 1986 Sodium retention after adrenal enucleation. Am J Physiol 250:E1-E12 (Pubitemid 16113979)
51. Skelton FR 1959 Adrenal regeneration and adrenal-regeneration hypertension. Physiol Rev 39:162-182
52. Coll AP, Challis BG, Yeo GS, Snell K, Piper SJ, Halsall D, Thresher RR, O'Rahilly S 2004 The effects of proopiomelanocortin deficiency on murine adrenal development and responsiveness to adrenocorticotropin. Endocrinology 145:4721-4727 (Pubitemid 39281466)
53. Karpac J, Ostwald D, Bui S, Hunnewell P, Shankar M, Hochgeschwender U 2005 Development, maintenance, and function of the adrenal gland in early postnatal proopiomelanocortinnull mutant mice. Endocrinology 146:2555-2562 (Pubitemid 40695558)
54. Krude H, Biebermann H, Luck W, Horn R, Brabant G, Gruters A 1998 Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 19:155-157 (Pubitemid 28248796)
55. Krude H, Gruters A 2000 Implications of proopiomelanocortin (POMC) mutations in humans: the POMC deficiency syndrome. Trends Endocrinol Metab 11:15-22 (Pubitemid 30395455)
56. Metherell LA, Chapple JP, Cooray S, David A, Becker C, Ruschendorf F, Naville D, Begeot M, Khoo B, Nurnberg P, Huebner A, Cheetham ME, Clark AJ 2005 Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2. Nat Genet 37:166-170
57. Hu MC, Chou SJ, Huang YY, Hsu NC, Li H, Chung BC 1999 Tissue-specific, hormonal, and developmental regulation of SCC-LacZ expression in transgenic mice leads to adrenocortical zone characterization. Endocrinology 140:5609-5618 (Pubitemid 30645348)
58. Iannaccone PM, Weinberg WC 1987 The histogenesis of the rat adrenal cortex: a study based on histologic analysis of mosaic pattern in chimeras. J Exp Zool 243:217-223
59. Iannaccone PM 1987 The study of mammalian organogenesis by mosaic pattern analysis. Cell Differ 21:79-91 (Pubitemid 17115821)
60. Morley SD, Viard I, Chung BC, Ikeda Y, Parker KL, Mullins JJ 1996 Variegated expression of a mouse steroid 21-hydroxylase/β-galactosidase transgene suggests centripetal migration of adrenocortical cells. Mol Endocrinol 10:585-598 (Pubitemid 26142584)
61. Morohashi K, Honda S, Inomata Y, Handa H, Omura T 1992 A common trans-acting factor, Ad4-binding protein, to the promoters of steroidogenic P-450s. J Biol Chem 267:17913-17919
62. Morohashi KI, Omura T 1996 Ad4BP/SF-1, a transcription factor essential for the transcription of steroidogenic cytochrome P450 genes and for the establishment of the reproductive function. FASEB J 10:1569-1577 (Pubitemid 27043773)
63. Ikeda Y, Lala DS, Luo X, Kim E, Moisan MP, Parker KL 1993 Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. Mol Endocrinol 7:852-860 (Pubitemid 23220635)
64. Val P, Lefrancois-Martinez AM, Veyssiere G, Martinez A 2003 SF-1 a key player in the development and differentiation of steroidogenic tissues. Nucl Recept 1:8 (Pubitemid 39130372)
65. Sadovsky Y, Crawford PA, Woodson KG, Polish JA, Clements MA, Tourtellotte LM, Simburger K, Milbrandt J 1995 Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids. Proc Natl Acad Sci USA 92:10939-10943
66. Rice KL, Hormaeche I, Licht JD 2007 Epigenetic regulation of normal and malignant hematopoiesis. Oncogene 26:6697-6714 (Pubitemid 47585096)
67. Hammer GD, Krylova I, Zhang Y, Darimont BD, Simpson K, Weigel NL, Ingraham HA 1999 Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress. Mol Cell 3:521-526 (Pubitemid 29292609)
68. Sewer MB, Waterman MR 2002 Adrenocorticotropin/cyclic adenosine 3′,5′-monophosphate-mediated transcription of the human CYP17 gene in the adrenal cortex is dependent on phosphatase activity. Endocrinology 143:1769-1777 (Pubitemid 34415892)
69. Shang Y, Hu X, DiRenzo J, Lazar MA, Brown M 2000 Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 103:843-852
70. Metivier R, Penot G, Hubner MR, Reid G, Brand H, Kos M, Gannon F 2003 Estrogen receptor-α directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell 115:751-763 (Pubitemid 38030303)
71. Winnay JN, Hammer GD 2006 Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation. Mol Endocrinol 20:147-166 (Pubitemid 43011677)
72. Chen WY, Lee WC, Hsu NC, Huang F, Chung BC 2004 SUMO modification of repression domains modulates function of nuclear receptor 5A1 (steroidogenic factor-1). J Biol Chem 279:38730-38735 (Pubitemid 39296031)
73. Komatsu T, Mizusaki H, Mukai T, Ogawa H, Baba D, Shirakawa M, Hatakeyama S, Nakayama KI, Yamamoto H, Kikuchi A, Morohashi K 2004 Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9. Mol Endocrinol 18:2451-2462 (Pubitemid 39335980)
74. Lee MB, Lebedeva LA, Suzawa M, Wadekar SA, Desclozeaux M, Ingraham HA 2005 The DEAD-box protein DP103 (Ddx20 or Gemin-3) represses orphan nuclear receptor activity via SUMO modification. Mol Cell Biol 25:1879-1890
75. Lewis AE, Rusten M, Hoivik EA, Vikse EL, Hansson ML, Wallberg AE, Bakke M 2008 Phosphorylation of steroidogenic factor 1 is mediated by cyclin-dependent kinase 7. Mol Endocrinol 22:91-104
76. Campbell LA, Faivre EJ, Show MD, Ingraham JG, Flinders J, Gross JD, Ingraham HA 2008 Decreased recognition of SUMO-sensitive target genes following modification of SF-1 (NR5A1). Mol Cell Biol 28:7476-7486
77. Yang WH, Heaton JH, Brevig H, Mukherjee S, Iniguez-Lluhi JA, Hammer GD 2009 SUMOylation inhibits SF-1 activity by reducing CDK7 mediated serine 203 phosphorylation. Mol Cell Biol 29:613-625
78. Urs AN, Dammer E, Sewer MB 2006 Sphingosine regulates the transcription of CYP17 by binding to steroidogenic factor-1. Endocrinology 147:5249-5258
79. Urs AN, Dammer E, Kelly S, Wang E, Merrill Jr AH, Sewer MB 2007 Steroidogenic factor-1 is a sphingolipid binding protein. Mol Cell Endocrinol 265-266:174-178
80. Wang W, Zhang C, Marimuthu A, Krupka HI, Tabrizizad M, Shelloe R, Mehra U, Eng K, Nguyen H, Settachatgul C, Powell B, Milburn MV, West BL 2005 The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1. Proc Natl Acad Sci USA 102:7505-7510 (Pubitemid 40741001)
81. Li Y, Choi M, Cavey G, Daugherty J, Suino K, Kovach A, Bingham NC, Kliewer SA, Xu HE 2005 Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1. Mol Cell 17:491-502 (Pubitemid 40269114)
82. Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA 2005 Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell 120:343-355 (Pubitemid 40222429)
83. Zanaria E, Muscatelli F, Bardoni B, Strom TM, Guioli S, Guo W, Lalli E, Moser C, Walker AP, McCabe ER, Meitinger T, Monaco AP, Sassone-Corsi P, Camerino G 1994 An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita. Nature 372:635-641
84. Muscatelli F, Strom TM, Walker AP, Zanaria E, Recan D, Meindl A, Bardoni B, Guioli S, Zehetner G, Rabl W, Schwarz HP, Kaplan JC, Camerino G, Meitinger T, Monaco AP 1994 Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. Nature 372:672-676
85. Achermann JC, Ito M, Ito M, Hindmarsh PC, Jameson JL 1999 A mutation in the gene encoding steroidogenic factor-1 causes XY sex reversal and adrenal failure in humans. Nat Genet 22:125-126 (Pubitemid 29264799)
86. Biason-Lauber A, Schoenle EJ 2000 Apparently normal ovarian differentiation in a prepubertal girl with transcriptionally inactive steroidogenic factor 1 (NR5A1/SF-1) and adrenocortical insufficiency. Am J Hum Genet 67:1563-1568
87. Phelan JK, McCabe ER 2001 Mutations in NR0B1 (DAX1) and NR5A1 (SF1) responsible for adrenal hypoplasia congenita. Hum Mutat 18:472-487 (Pubitemid 33131550)
88. Lalli E, Sassone-Corsi P 2003 DAX-1, an unusual orphan receptor at the crossroads of steroidogenic function and sexual differentiation. Mol Endocrinol 17:1445-1453 (Pubitemid 36930462)
89. Bland ML, Jamieson CA, Akana SF, Bornstein SR, Eisenhofer G, Dallman MF, Ingraham HA 2000 Haploinsufficiency of steroidogenic factor-1 in mice disrupts adrenal development leading to an impaired stress response. Proc Natl Acad Sci USA 97:14488-14493 (Pubitemid 32016603)
90. Bland ML, Fowkes RC, Ingraham HA 2004 Differential requirement for steroidogenic factor-1 gene dosage in adrenal development versus endocrine function. Mol Endocrinol 18:941-952 (Pubitemid 38429483)
91. Doghman M, Karpova T, Rodrigues GA, Arhatte M, De Moura J, Cavalli LR, Virolle V, Barbry P, Zambetti GP, Figueiredo BC, Heckert LL, Lalli E 2007 Increased steroidogenic factor-1 dosage triggers adrenocortical cell proliferation and cancer. Mol Endocrinol 21:2968-2987 (Pubitemid 350223508)
92. Lichtenauer UD, Duchniewicz M, Kolanczyk M, Hoeflich A, Hahner S, Else T, Bicknell AB, Zemojtel T, Stallings NR, Schulte DM, Kamps MP, Hammer GD, Scheele JS, Beuschlein F 2007 Pre-B-cell transcription factor 1 and steroidogenic factor 1 synergistically regulate adrenocortical growth and steroidogenesis. Endocrinology 148:693-704 (Pubitemid 46143171)
93. Babu PS, Bavers DL, Beuschlein F, Shah S, Jeffs B, Jameson JL, Hammer GD 2002 Interaction between Dax-1 and steroidogenic factor-1 in vivo: increased adrenal responsiveness to ACTH in the absence of Dax-1. Endocrinology 143:665-673 (Pubitemid 34107222)
94. Niakan KK, Davis EC, Clipsham RC, Jiang M, Dehart DB, Sulik KK, McCabe ER 2006 Novel role for the orphan nuclear receptor Dax1 in embryogenesis, different from steroidogenesis. Mol Genet Metab 88:261-271 (Pubitemid 43963432)
95. Lu TT, Makishima M, Repa JJ, Schoonjans K, Kerr TA, Auwerx J, Mangelsdorf DJ 2000 Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell 6:507-515
96. del Castillo-Olivares A, Gil G 2000 α1-Fetoprotein transcription factor is required for the expression of sterol 12α-hydroxylase, the specific enzyme for cholic acid synthesis. Potential role in the bile acid-mediated regulation of gene transcription. J Biol Chem 275:17793-17799
97. Nitta M, Ku S, Brown C, Okamoto AY, Shan B 1999 CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7α-hydroxylase gene. Proc Natl Acad Sci USA 96:6660-6665 (Pubitemid 29274939)
98. Johansson L, Thomsen JS, Damdimopoulos AE, Spyrou G, Gustafsson JA, Treuter E 1999 The orphan nuclear receptor SHP inhibits agonist-dependent transcriptional activity of estrogen receptors ERα and ERβ. J Biol Chem 274:345-353 (Pubitemid 29035068)
99. Lee YK, Parker KL, Choi HS, Moore DD 1999 Activation of the promoter of the orphan receptor SHP by orphan receptors that bind DNA as monomers. J Biol Chem 274:20869-20873 (Pubitemid 129519583)
100. Seol W, Choi HS, Moore DD 1996 An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science 272:1336-1339 (Pubitemid 26199974)
101. Gummow BM, Scheys JO, Cancelli VR, Hammer GD 2006 Reciprocal regulation of a glucocorticoid receptor-steroidogenic factor-1 transcription complex on the Dax-1 promoter by glucocorticoids and adrenocorticotropic hormone in the adrenal cortex. Mol Endocrinol 20:2711-2723
102. Lin L, Gu WX, Ozisik G, To WS, Owen CJ, Jameson JL, Achermann JC 2006 Analysis of DAX1 (NR0B1) and steroidogenic factor-1 (NR5A1) in children and adults with primary adrenal failure: ten years' experience. J Clin Endocrinol Metab 91:3048-3054 (Pubitemid 44271754)
103. Achermann JC, Silverman BL, Habiby RL, Jameson JL 2000 Presymptomatic diagnosis of X-linked adrenal hypoplasia congenita by analysis of DAX1. J Pediatr 137:878-881
104. Peter M, Viemann M, Partsch CJ, Sippell WG 1998 Congenital adrenal hypoplasia: clinical spectrum, experience with hormonal diagnosis, and report on new point mutations of the DAX-1 gene. J Clin Endocrinol Metab 83:2666-2674 (Pubitemid 28493758)
105. Ito M, Yu R, Jameson JL 1997 DAX-1 inhibits SF-1-mediated transactivation via a carboxy-terminal domain that is deleted in adrenal hypoplasia congenita. Mol Cell Biol 17:1476-1483 (Pubitemid 27097377)
106. Crawford PA, Dorn C, Sadovsky Y, Milbrandt J 1998 Nuclear receptor DAX-1 recruits nuclear receptor corepressor N-CoR to steroidogenic factor 1. Mol Cell Biol 18:2949-2956 (Pubitemid 28183464)
107. Ito M, Park Y, Weck J, Mayo KE, Jameson JL 2000 Synergistic activation of the inhibin α-promoter by steroidogenic factor-1 and cyclic adenosine 3′,5′-monophosphate. Mol Endocrinol 14:66-81 (Pubitemid 32260328)
108. Jorgensen JS, Nilson JH 2001 AR suppresses transcription of the LHβ subunit by interacting with steroidogenic factor-1. Mol Endocrinol 15:1505-1516 (Pubitemid 32826403)
109. Liu Z, Simpson ER 1997 Steroidogenic factor 1 (SF-1) and SP1 are required for regulation of bovine CYP11A gene expression in bovine luteal cells and adrenal Y1 cells. Mol Endocrinol 11:127-137 (Pubitemid 27057426)
110. Rui X, Tsao J, Scheys JO, Hammer GD, Schimmer BP 2008 Contributions of Sp1 and steroidogenic factor 1 to Adcy4 expression in Y1 mouse adrenal cells. Endocrinology 149:3668-3678
111. Hossain A, Li C, Saunders GF 2004 Generation of two distinct functional isoforms of dosage-sensitive sex reversal-adrenal hypoplasia congenita-critical region on the X chromosome gene 1 (DAX-1) by alternative splicing. Mol Endocrinol 18:1428-1437 (Pubitemid 38692180)
112. Blank U, Karlsson G, Karlsson S 2008 Signaling pathways governing stem-cell fate. Blood 111:492-503
113. Jeays-Ward K, Hoyle C, Brennan J, Dandonneau M, Alldus G, Capel B, Swain A 2003 Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad. Development 130:3663-3670 (Pubitemid 37039072)
114. Kim AC, Reuter AL, Zubair M, Else T, Serecky K, Bingham NC, Lavery GG, Parker KL, Hammer GD 2008 Targeted disruption of β-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex. Development 135:2593-2602
115. Dreesen O, Brivanlou AH 2007 Signaling pathways in cancer and embryonic stem cells. Stem Cell Rev 3:7-17 (Pubitemid 47472808)
116. Glasgow E, Mishra L 2008 Transforming growth factor-β signaling and ubiquitinators in cancer. Endocr Relat Cancer 15:59-72
117. Matzuk MM, Finegold MJ, Mather JP, Krummen L, Lu H, Bradley A 1994 Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice. Proc Natl Acad Sci USA 91:8817-8821
118. Beuschlein F, Looyenga BD, Bleasdale SE, Mutch C, Bavers DL, Parlow AF, Nilson JH, Hammer GD 2003 Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice. Mol Cell Biol 23:3951-3964 (Pubitemid 36597473)
119. Looyenga BD, Hammer GD 2006 Origin and identity of adrenocortical tumors in inhibin knockout mice: implications for cellular plasticity in the adrenal cortex. Mol Endocrinol 20:2848-2863
120. Looyenga BD, Hammer GD 2007 Genetic removal of Smad3 from inhibin-null mice attenuates tumor progression by uncoupling extracellular mitogenic signals from the cell cycle machinery. Mol Endocrinol 21:2440-2457 (Pubitemid 47529357)
121. Allolio B, Fassnacht M 2006 Clinical review: adrenocortical carcinoma: clinical update. J Clin Endocrinol Metab 91:2027-2037 (Pubitemid 43854976)
122. Barlaskar FM, Hammer GD 2007 The molecular genetics of adrenocortical carcinoma. Rev Endocr Metab Disord 8:343-348
123. Libe R, Fratticci A, Bertherat J 2007 Adrenocortical cancer: pathophysiology and clinical management. Endocr Relat Cancer 14:13-28 (Pubitemid 47521719)
124. Lobo NA, Shimono Y, Qian D, Clarke MF 2007 The biology of cancer stem cells. Annu Rev Cell Dev Biol 23:675-699
125. Feinberg AP, Ohlsson R, Henikoff S 2006 The epigenetic progenitor origin of human cancer. Nat Rev Genet 7:21-33 (Pubitemid 41828945)
126. Weksberg R, Shuman C, Smith AC 2005 Beckwith-Wiedemann syndrome. Am J Med Genet C Semin Med Genet 137C:12-23
127. Enklaar T, Zabel BU, Prawitt D 2006 Beckwith-Wiedemann syndrome: multiple molecular mechanisms. Expert Rev Mol Med 8:1-19 (Pubitemid 44314282)
128. Liu J, Kahri AI, Heikkila P, Ilvesmaki V, Voutilainen R 1995 H19 and insulin-like growth factor-II gene expression in adrenal tumors and cultured adrenal cells. J Clin Endocrinol Metab 80:492-496
129. Gao ZH, Suppola S, Liu J, Heikkila P, Janne J, Voutilainen R 2002 Association of H19 promoter methylation with the expression of H19 and IGF-II genes in adrenocortical tumors. J Clin Endocrinol Metab 87:1170-1176 (Pubitemid 36121083)
130. Giordano TJ, Thomas DG, Kuick R, Lizyness M, Misek DE, Smith AL, Sanders D, Aljundi RT, Gauger PG, Thompson NW, Taylor JM, Hanash SM 2003 Distinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis. Am J Pathol 162:521-531 (Pubitemid 36267859)
131. Sun FL, Dean WL, Kelsey G, Allen ND, Reik W 1997 Transactivation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome. Nature 389:809-815 (Pubitemid 27462968)
132. Weber MM, Fottner C, Schmidt P, Brodowski KM, Gittner K, Lahm H, Engelhardt D, Wolf E 1999 Postnatal overexpression of insulin-like growth factor II in transgenic mice is associated with adrenocortical hyperplasia and enhanced steroidogenesis. Endocrinology 140:1537-1543 (Pubitemid 29149219)
133. Nakae J, Kido Y, Accili D 2001 Distinct and overlapping functions of insulin and IGF-I receptors. Endocr Rev 22:818-835 (Pubitemid 34214297)
134. Han VK, Lu F, Bassett N, Yang KP, Delhanty PJ, Challis JR 1992 Insulin-like growth factor-II (IGF-II) messenger ribonucleic acid is expressed in steroidogenic cells of the developing ovine adrenal gland: evidence of an autocrine/paracrine role for IGF-II. Endocrinology 131:3100-3109
135. Bendall SC, Stewart MH, Menendez P, George D, Vijayaragavan K, Werbowetski-Ogilvie T, Ramos-Mejia V, Rouleau A, Yang J, Bosse M, Lajoie G, Bhatia M 2007 IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro. Nature 448:1015-1021 (Pubitemid 47345578)
136. Almeida MQ, Fragoso MC, Lotfi CF, Santos MG, Nishi MY, Costa MH, Lerario AM, Maciel CC, Mattos GE, Jorge AA, Mendonca BB, Latronico AC 2008 Expression of insulin-like growth factor-II and its receptor in pediatric and adult adrenocortical tumors. J Clin Endocrinol Metab 93:3524-3531
137. Barlaskar FM, Spalding AC, Heaton JH, Kuick R, Kim AC, Thomas DG, Giordano TJ, Ben-Josef E, Hammer GD 2009 Preclinical targeting of the type 1 insulin-like growth factor receptor in adrenocortical carcinoma. J Clin Endocrinol Metab 94:204-212
138. Kinzler KW, Nilbert MC, Su LK, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hedge P, McKechnie D, Finniear R, Markham A, Groffen J, Boguski MS, Altschul SF, Horii A, Ando H, Miyoshi Y, Miki Y, Nishisho I, Nakumura Y 1991 Identification of FAP locus genes from chromosome 5q21. Science 253:661-665 (Pubitemid 21917199)
139. Groden J, Thliveris A, Samowitz W, Carlson M, Gelbert L, Albertsen H, Joslyn G, Stevens J, Spirio L, Robertson M, Sargeant L, Krapcho K, Wolff E, Burt R, Hughes JP, Warrington J, Mc Pherson J, Wasmuth J, Paslier DL, Abderrahim H, Cohen OD, Leppert M, White R 1991 Identification and characterization of the familial adenomatous polyposis coli gene. Cell 66:589-600 (Pubitemid 21916922)
140. Naylor EW, Gardner EJ 1981 Adrenal adenomas in a patient with Gardner's syndrome. Clin Genet 20:67-73 (Pubitemid 11013012)
141. Naylor EW, Lebenthal E 1980 Gardner's syndrome. Recent developments in research and management. Dig Dis Sci 25:945-959
142. Painter TA, Jagelman DG 1985 Adrenal adenomas and adrenal carcinomas in association with hereditary adenomatosis of the colon and rectum. Cancer 55:2001-2004
143. Fearnhead NS, Britton MP, Bodmer WF 2001 The ABC of APC. Hum Mol Genet 10:721-733 (Pubitemid 32331581)
144. Aoki K, Taketo MM 2007 Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene. J Cell Sci 120:3327-3335 (Pubitemid 350028340)
145. Tissier F, Cavard C, Groussin L, Perlemoine K, Fumey G, Hagnere AM, Rene-Corail F, Jullian E, Gicquel C, Bertagna X, Vacher-Lavenu MC, Perret C, Bertherat J 2005 Mutations of β-catenin in adrenocortical tumors: activation of the Wnt signaling pathway is a frequent event in both benign and malignant adrenocortical tumors. Cancer Res 65:7622-7627 (Pubitemid 41297234)
146. Huelsken J, Birchmeier W 2001 New aspects of Wnt signaling pathways in higher vertebrates. Curr Opin Genet Dev 11:547-553 (Pubitemid 32800729)
147. Iwakuma T, Lozano G, Flores ER 2005 Li-Fraumeni syndrome: a p53 family affair. Cell Cycle 4:865-867 (Pubitemid 41359746)
148. Ljungman M 2000 Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress. Neoplasia 2:208-225
149. Xu Y 2005 A new role for p53 in maintaining genetic stability in embryonic stem cells. Cell Cycle 4:363-364 (Pubitemid 41359715)
150. Prochazkova J, Lichnovsky V, Kylarova D, Erdosova B, Vranka P 2004 Involvement of p53 and Bcl-2 family proteins in regulating programmed cell death and proliferation in human embryogenesis. Gen Physiol Biophys 23:209-229 (Pubitemid 39136240)
151. Keegan CE, Hutz JE, Else T, Adamska M, Shah SP, Kent AE, Howes JM, Beamer WG, HammerGD2005 Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Hum Mol Genet 14:113-123 (Pubitemid 40123467)
152. Bianchi A, Shore D 2008 How telomerase reaches its end: mechanism of telomerase regulation by the telomeric complex. Mol Cell 31:153-165
153. Deng Y, Chan SS, Chang S 2008 Telomere dysfunction and tumour suppression: the senescence connection. Nat Rev Cancer 8:450-458
154. Calado RT, Young NS 2008 Telomere maintenance and human bone marrow failure. Blood 111:4446-4455
155. Else T, Giordano TJ, Hammer GD 2008 Evaluation of telomere length maintenance mechanisms in adrenocortical carcinoma. J Clin Endocrinol Metab 93:1442-1449
156. Nomura M, Bartsch S, Nawata H, Omura T, Morohashi K 1995 An E box element is required for the expression of the ad4bp gene, a mammalian homologue of ftz-f1 gene, which is essential for adrenal and gonadal development. J Biol Chem 270:7453-7461
157. Woodson KG, Crawford PA, Sadovsky Y, Milbrandt J 1997 Characterization of the promoter of SF-1, an orphan nuclear receptor required for adrenal and gonadal development. Mol Endocrinol 11:117-126 (Pubitemid 27057425)
158. Harris AN, Mellon PL 1998 The basic helix-loop-helix, leucine zipper transcription factor, USF (upstream stimulatory factor), is a key regulator of SF-1 (steroidogenic factor-1) gene expression in pituitary gonadotrope and steroidogenic cells. Mol Endocrinol 12:714-726 (Pubitemid 30659073)
159. Hoivik EA, Aumo L, Aesoy R, Lillefosse H, Lewis AE, Perrett RM, Stallings NR, Hanley NA, Bakke M 2008 DNA methylation controls cell type specific expression of steroidogenic factor 1. Endocrinology 149:5599-5609
160. Utsunomiya H, Cheng YH, Lin Z, Reierstad S, Yin P, Attar E, Xue Q, Imir G, Thung S, Trukhacheva E, Suzuki T, Sasano H, Kim JJ, Yaegashi N, Bulun SE 2008 Upstream stimulatory factor-2 regulates steroidogenic factor-1 expression in endometriosis. Mol Endocrinol 22:904-914
161. Figueiredo BC, Cavalli LR, Pianovski MA, Lalli E, Sandrini R, Ribeiro RC, Zambetti G, DeLacerda L, Rodrigues GA, Haddad BR 2005 Amplification of the steroidogenic factor 1 gene in childhood adrenocortical tumors. J Clin Endocrinol Metab 90:615-619 (Pubitemid 40279170)
162. Pianovski MA, Cavalli LR, Figueiredo BC, Santos SC, Doghman M, Ribeiro RC, Oliveira AG, Michalkiewicz E, Rodrigues GA, Zambetti G, Haddad BR, Lalli E 2006 SF-1 overexpression in childhood adrenocortical tumours. Eur J Cancer 42:1040-1043
163. Bielinska M, Parviainen H, Porter-Tinge SB, Kiiveri S, Genova E, Rahman N, Huhtaniemi IT, Muglia LJ, Heikinheimo M, Wilson DB 2003 Mouse strain susceptibility to gonadectomy-induced adrenocortical tumor formation correlates with the expression of GATA-4 and luteinizing hormone receptor. Endocrinology 144:4123-4133 (Pubitemid 37088768)
164. Lu J, Richardson JA, Olson EN 1998 Capsulin: a novel bHLH transcription factor expressed in epicardial progenitors and mesenchyme of visceral organs. Mech Dev 73:23-32 (Pubitemid 28218540)
165. Quaggin SE, Vanden Heuvel GB, Igarashi P 1998 Pod-1, a mesoderm-specific basic-helix-loop-helix protein expressed in mesenchymal and glomerular epithelial cells in the developing kidney. Mech Dev 71:37-48 (Pubitemid 28153517)
166. Tamura M, Kanno Y, Chuma S, Saito T, Nakatsuji N 2001 Pod-1/capsulin shows a sex- and stage-dependent expression pattern in the mouse gonad development and represses expression of Ad4BP/SF-1. Mech Dev 102:135-144 (Pubitemid 32273593)
167. Cui S, Ross A, Stallings N, Parker KL, Capel B, Quaggin SE 2004 Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice. Development 131:4095-4105 (Pubitemid 39232167)
168. Quaggin SE, Schwartz L, Cui S, Igarashi P, Deimling J, Post M, Rossant J 1999 The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis. Development 126:5771-5783 (Pubitemid 30035024)
169. Xie K, Abbruzzese JL 2003 Developmental biology informs cancer: the emerging role of the hedgehog signaling pathway in upper gastrointestinal cancers. Cancer Cell 4:245-247 (Pubitemid 37329787)
170. Han YG, Spassky N, Romaguera-Ros M, Garcia-Verdugo JM, Aguilar A, Schneider-Maunoury S, Alvarez-Buylla A 2008 Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells. Nat Neurosci 11:277-284
171. Komada M, Saitsu H, Kinboshi M, Miura T, Shiota K, Ishibashi M 2008 Hedgehog signaling is involved in development of the neocortex. Development 135:2717-2727
172. Passman JN, Dong XR, Wu SP, Maguire CT, Hogan KA, Bautch VL, Majesky MW 2008 A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells. Proc Natl Acad Sci USA 105:9349-9354
173. Spassky N, Han YG, Aguilar A, Strehl L, Besse L, Laclef C, Ros MR, Garcia-Verdugo JM, Alvarez-Buylla A 2008 Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool. Dev Biol 317:246-259
174. Yang ZJ, Ellis T, Markant SL, Read TA, Kessler JD, Bourboulas M, Schuller U, Machold R, Fishell G, Rowitch DH, Wainwright BJ, Wechsler-Reya RJ 2008 Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell 14:135-145
175. Lee CJ, Dosch J, Simeone DM 2008 Pancreatic cancer stem cells. J Clin Oncol 26:2806-2812
176. Brellier F, Bergoglio V, Valin A, Barnay S, Chevallier-Lagente O, Vielh P, Spatz A, Gorry P, Avril MF, Magnaldo T 2008 Heterozygous mutations in the tumor suppressor gene PATCHED provoke basal cell carcinoma-like features in human organotypic skin cultures. Oncogene 27:6601-6606
177. Yanagi S, Kishimoto H, Kawahara K, Sasaki T, Sasaki M, Nishio M, Yajima N, Hamada K, Horie Y, Kubo H, Whitsett JA, Mak TW, Nakano T, Nakazato M, Suzuki A 2007 Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J Clin Invest 117:2929-2940 (Pubitemid 47529623)
178. Dentice M, Luongo C, Huang S, Ambrosio R, Elefante A, Mirebeau-Prunier D, Zavacki AM, Fenzi G, Grachtchouk M, Hutchin M, Dlugosz AA, Bianco AC, Missero C, Larsen PR, Salvatore D 2007 Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes. Proc Natl Acad Sci USA 104:14466-14471 (Pubitemid 350003284)
179. Bitgood MJ, Shen L, McMahon AP 1996 Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr Biol 6:298-304 (Pubitemid 3035912)
180. Clark AM, Garland KK, Russell LD 2000 Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules. Biol Reprod 63:1825-1838
181. Pierucci-Alves F, Clark AM, Russell LD 2001 A developmental study of the Desert hedgehog-null mouse testis. Biol Reprod 65:1392-1402 (Pubitemid 33031496)
182. Yao HH, Whoriskey W, Capel B 2002 Desert hedgehog/patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis. Genes Dev 16:1433-1440 (Pubitemid 34615095)
183. Wijgerde M, Ooms M, Hoogerbrugge JW, Grootegoed JA 2005 Hedgehog signaling in mouse ovary: Indian hedgehog and desert hedgehog from granulosa cells induce target gene expression in developing theca cells. Endocrinology 146:3558-3566
184. Canto P, Soderlund D, Reyes E, Mendez JP 2004 Mutations in the desert hedgehog (DHH) gene in patients with 46,XY complete pure gonadal dysgenesis. J Clin Endocrinol Metab 89:4480-4483 (Pubitemid 39244458)
185. Canto P, Vilchis F, Soderlund D, Reyes E, Mendez JP 2005 A heterozygous mutation in the desert hedgehog gene in patients with mixed gonadal dysgenesis. Mol Hum Reprod 11:833-836 (Pubitemid 43205492)
186. Umehara F, Tate G, Itoh K, Yamaguchi N, Douchi T, Mitsuya T, Osame M 2000 A novel mutation of desert hedgehog in a patient with 46,XY partial gonadal dysgenesis accompanied by minifascicular neuropathy. Am J Hum Genet 67:1302-1305
187. Kang S, Graham Jr JM, Olney AH, Biesecker LG 1997 GLI3 frameshift mutations cause autosomal dominant Pallister-Hall syndrome. Nat Genet 15:266-268 (Pubitemid 27098719)
188. Andersson HC, Frentz J, Martinez JE, Tuck-Muller CM, Bellizaire J 1999 Adrenal insufficiency in Smith-Lemli-Opitz syndrome. Am J Med Genet 82:382-384 (Pubitemid 29096146)
189. Chemaitilly W, Goldenberg A, Baujat G, Thibaud E, Cormier-Daire V, Abadie V 2003 Adrenal insufficiency and abnormal genitalia in a 46XX female with Smith-Lemli-Opitz syndrome. Horm Res 59:254-256 (Pubitemid 36506414)
190. Bose J, Grotewold L, Ruther U 2002 Pallister-Hall syndrome phenotype in mice mutant for Gli3. Hum Mol Genet 11:1129-1135 (Pubitemid 34521093)
191. Bitgood MJ, McMahon AP 1995 Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol 172:126-138
192. King PJ, Guasti L, Laufer E 2008 Hedgehog signalling in endocrine development and disease. J Endocrinol 198:439-450
193. Agrawal N, Dasaradhi PV, Mohmmed A, Malhotra P, Bhatnagar RK, Mukherjee SK 2003 RNA interference: biology, mechanism, and applications. Microbiol Mol Biol Rev 67:657-685 (Pubitemid 37549773)
194. Du T, Zamore PD 2005 microPrimer: the biogenesis and function of microRNA. Development 132:4645-4652 (Pubitemid 41685275)
195. Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, Li MZ, Mills AA, Elledge SJ, Anderson KV, Hannon GJ 2003 Dicer is essential for mouse development. Nat Genet 35:215-217 (Pubitemid 37363172)
196. Andl T, Murchison EP, Liu F, Zhang Y, Yunta-Gonzalez M, Tobias JW, Andl CD, Seykora JT, Hannon GJ, Millar SE 2006 The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol 16:1041-1049 (Pubitemid 43744365)
197. Harris KS, Zhang Z, McManus MT, Harfe BD, Sun X 2006 Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci USA 103:2208-2213 (Pubitemid 43271648)
198. O'Rourke JR, Georges SA, Seay HR, Tapscott SJ, McManus MT, Goldhamer DJ, Swanson MS, Harfe BD 2007 Essential role for Dicer during skeletal muscle development. Dev Biol 311:359-368 (Pubitemid 350046531)
199. Yi R, O'Carroll D, Pasolli HA, Zhang Z, Dietrich FS, Tarakhovsky A, Fuchs E 2006 Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet 38:356-362 (Pubitemid 43315760)
200. Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D 2007 Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell 129:303-317 (Pubitemid 46574975)
201. Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P, Soond DR, van Dongen S, Grocock RJ, Das PP, Miska EA, Vetrie D, Okkenhaug K, Enright AJ, Dougan G, Turner M, Bradley A 2007 Requirement of bic/microRNA-155 for normal immune function. Science 316:608-611 (Pubitemid 46683148)
202. van Rooij E, Sutherland LB, Qi X, Richardson JA, Hill J, Olson EN 2007 Control of stress-dependent cardiac growth and gene expression by a microRNA. Science 316:575-579 (Pubitemid 46683138)
203. Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D, Slack FJ 2005 RAS is regulated by the let-7 microRNA family. Cell 120:635-647 (Pubitemid 40343076)
204. Kumar MS, Erkeland SJ, Pester RE, Chen CY, Ebert MS, Sharp PA, Jacks T 2008 Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc Natl Acad Sci USA 105:3903-3908
205. Lee YS, Dutta A 2007 The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes Dev 21:1025-1030 (Pubitemid 46686471)
206. Mayr C, Hemann MT, Bartel DP 2007 Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science 315:1576-1579 (Pubitemid 46449474)
207. Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H, Endoh H, Harano T, Yatabe Y, Nagino M, Nimura Y, Mitsudomi T, Takahashi T 2004 Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res 64:3753-3756 (Pubitemid 38697282)
208. Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C, Huang Y, Hu X, Su F, Lieberman J, Song E 2007 let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 131:1109-1123 (Pubitemid 350235025)
209. Liang Y, Ridzon D, Wong L, Chen C 2007 Characterization of microRNA expression profiles in normal human tissues. BMC Genomics 8:166 (Pubitemid 47019476)
210. Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M, Weir DB, Choksi R, De Vita G, Frezzetti D, Trompeter HI, Hornung V, Teng G, Hartmann G, Palkovits M, Di Lauro R, Wernet P, Macino G, Rogler CE, Nagle JW, Ju J, Papavasiliou FN, Benzing T, Lichter P, Tam W, Brownstein MJ, Bosio A, Borkhardt A, Russo JJ, Sander C, Zavolan M, Tuschl T 2007 A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 129:1401-1414 (Pubitemid 46970709)
211. Bray SJ 2006 Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 7:678-689 (Pubitemid 44268213)
212. Bolos V, Grego-Bessa J, de la Pompa JL 2007 Notch signaling in development and cancer. Endocr Rev 28:339-363 (Pubitemid 46984831)
213. Dickson BC, Mulligan AM, Zhang H, Lockwood G, O'Malley FP, Egan SE, Reedijk M 2007 High-level JAG1 mRNA and protein predict poor outcome in breast cancer. Mod Pathol 20:685-693 (Pubitemid 46788875)
214. Reedijk M, Odorcic S, Chang L, Zhang H, Miller N, McCready DR, Lockwood G, Egan SE 2005 High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res 65:8530-8537 (Pubitemid 41330622)
215. Fuchs E, Segre JA 2000 Stem cells: a new lease on life. Cell 100:143-155 (Pubitemid 30046303)
216. Reya T, Clevers H 2005 Wnt signalling in stem cells and cancer. Nature 434:843-850 (Pubitemid 40558990)
217. Park IK, Qian D, Kiel M, Becker MW, Pihalja M, Weissman IL, Morrison SJ, Clarke MF 2003 Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423:302-305 (Pubitemid 40852701)
218. Bai CB, Auerbach W, Lee JS, Stephen D, Joyner AL 2002 Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development 129:4753-4761 (Pubitemid 35277202)
219. Giordano TJ, Kuick R, Else T, Gauger PG, Vinco M, Bauersfeld J, Sanders D, Thomas DG, Doherty G, Hammer G 2009 Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling. Clin Cancer Res 15:668-676
220. Xu B, Yang W-H, Gerin I, Hu C-D, Hammer GD, Koenig RJ 2009 DAX-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidgenic factor-1 in steroidogenesis. Mol Cell Bio 29:1719-1734
221. Kananen K, Markkula M, Mikola M, Rainio EM, McNeilly A, Huhtaniemi I 1996 Gonadectomy permits adrenocortical tumorigenesis in mice transgenic for the mouse inhibin α-subunit promoter/simian virus 40 T-antigen fusion gene: evidence for negative autoregulation of the inhibin α-subunit gene. Mol Endocrinol 10:1667-1677 (Pubitemid 26408754)
222. West AN, Neale GA, Pounds S, Figueredo BC, Rodriguez Galindo C, Pianovski MD, Oliveria Filho AG, Malkin D, Lalli E, Ribeiro R, Zambetti GP 2007 Gene expression profiling of Childhood adrenocortical tumors. Cancer Res 67:600-608 (Pubitemid 46192198)
223. Varrault A, Gueydan C, Delalbre A, Bellmann A, Houssami S, Aknin C, Severac D, Chotard L, Kahli M, Le Digarcher A, Pavlidis P, Journot L 2006 Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth. Dev Cell 11:711-722
224. Doghman M, Cazareth J, Lalli E 2008 The T cell factor/β-catenin antagonist PKF115-584 inhibits proliferation of adrenocortical carcinoma cells. J Clin Endocrinol Metab 93:3222-3225
225. Else T, Theisen BK, Wu Y, Hutz JE, Keegan CE, Hammer GD, Ferguson DO 2007 Tppl/Acd maintains genomic stability through a complex role in telomere protection. Chromosome Res 15:1001-1013